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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK1' and Ligand = 'BDBM335511'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM335511
PNG
(US9732097, Example 20 | {1-(cis-4-{[4-(1- hydroxy-...)
Show SMILES CC(C)(O)c1cc(O[C@H]2CC[C@H](CC2)N2C[N](CC#N)(C2)n2cc(cn2)-c2ncnc3[nH]ccc23)nc(c1)C(F)(F)F
Show InChI InChI=1S/C28H31F3N9O2/c1-27(2,41)19-11-23(28(29,30)31)37-24(12-19)42-21-5-3-20(4-6-21)38-16-40(17-38,10-8-32)39-14-18(13-36-39)25-22-7-9-33-26(22)35-15-34-25/h7,9,11-15,20-21,41H,3-6,10,16-17H2,1-2H3,(H,33,34,35)/t20-,21+
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PC cid
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Article
US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in clear-bottom 96-well plate from Thermo Fisher Scientific in a final volume of 24 μL. Inhibitors were first ...


US Patent US9732097 (2017)


Article DOI: 10.1021/jm960871c
More data for this
Ligand-Target Pair