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Found
1
Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM112549'
Target
Tyrosine-protein kinase JAK2
(Homo sapiens (Human))
Hoffmann-La Roche
US Patent
Ligand
BDBM112549
(US8618103, I-45)
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Affinity Data
IC50: 0.859nM
pH: 7.2
Assay Description:
The kinase activity of all three JAK kinases is measured using a radioactive, end-point assay and with trace amounts of 33P-ATP.
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