BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM264155'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM264155
PNG
(US9714234, 30)
Show SMILES CC(=O)NCc1ccc2c(c1)[nH]c1c(ccc(-c3cccc(c3C)-n3c(=O)cc4c(F)cccn4c3=O)c21)C(N)=O
Show InChI InChI=1S/C31H24FN5O4/c1-16-19(5-3-7-25(16)37-27(39)14-26-23(32)6-4-12-36(26)31(37)41)20-10-11-22(30(33)40)29-28(20)21-9-8-18(13-24(21)35-29)15-34-17(2)38/h3-14,35H,15H2,1-2H3,(H2,33,40)(H,34,38)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 430n/an/an/an/a7.425



Bristol-Myers Squibb Company

US Patent


Assay Description
Compounds with activity against Jak2 tyrosine kinase have been observed to cause thrombocytopenia, anemia and neutropenia in human patients in clinic...


US Patent US9714234 (2017)

More data for this
Ligand-Target Pair