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Found 4 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase SYK' and Ligand = 'BDBM50068779'
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)
Affinity DataIC50:  430nMpH: 7.4 T: 2°CAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)
Affinity DataIC50:  430nMAssay Description:Several 2,4-pyrimidinediamine compounds were tested for the ability to inhibit Syk kinase catalyzed phosphorylation of a peptide substrate in a bioch...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)
Affinity DataEC50:  1.00E+4nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in ionomycin-induced calcium mobilization mediated degranulation by tryptase rele...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM50068779(CHEMBL3402397 | US10828301, Compound R945071 | US9...)
Affinity DataEC50:  210nMAssay Description:Inhibition of SYK in human mast cell cultures assessed as reduction in IgE-induced FCepsilonR1 mediated degranulation by tryptase release assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed