BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase receptor UFO' and Ligand = 'BDBM246872'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246872
PNG
(US10053465, 11 | US10065963, Compound 11 | US10125...)
Show SMILES OC1CN(Cc2cc(OC3CCN(CC3)[C@H]3C[C@@](CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
Show InChI InChI=1S/C30H32F3N9O2/c31-30(32,33)25-9-19(14-40-16-22(43)17-40)10-26(39-25)44-23-2-7-41(8-3-23)21-11-29(12-21,4-5-34)42-15-20(13-38-42)27-24-1-6-35-28(24)37-18-36-27/h1,6,9-10,13,15,18,21-23,43H,2-4,7-8,11-12,14,16-17H2,(H,35,36,37)/t21-,29-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/a25



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US9708333 (2017)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246872
PNG
(US10053465, 11 | US10065963, Compound 11 | US10125...)
Show SMILES OC1CN(Cc2cc(OC3CCN(CC3)[C@H]3C[C@@](CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
Show InChI InChI=1S/C30H32F3N9O2/c31-30(32,33)25-9-19(14-40-16-22(43)17-40)10-26(39-25)44-23-2-7-41(8-3-23)21-11-29(12-21,4-5-34)42-15-20(13-38-42)27-24-1-6-35-28(24)37-18-36-27/h1,6,9-10,13,15,18,21-23,43H,2-4,7-8,11-12,14,16-17H2,(H,35,36,37)/t21-,29-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/a25



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US10053465 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM246872
PNG
(US10053465, 11 | US10065963, Compound 11 | US10125...)
Show SMILES OC1CN(Cc2cc(OC3CCN(CC3)[C@H]3C[C@@](CC#N)(C3)n3cc(cn3)-c3ncnc4[nH]ccc34)nc(c2)C(F)(F)F)C1
Show InChI InChI=1S/C30H32F3N9O2/c31-30(32,33)25-9-19(14-40-16-22(43)17-40)10-26(39-25)44-23-2-7-41(8-3-23)21-11-29(12-21,4-5-34)42-15-20(13-38-42)27-24-1-6-35-28(24)37-18-36-27/h1,6,9-10,13,15,18,21-23,43H,2-4,7-8,11-12,14,16-17H2,(H,35,36,37)/t21-,29-
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/a25



Incyte Corporation

US Patent


Assay Description
The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...


US Patent US9708333 (2017)

More data for this
Ligand-Target Pair