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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM227949'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (human))
BDBM227949
PNG
(8-{[(3,4-cis-Dihydroxypyrrolidin-1-yl]methyl}-4-[(...)
Show SMILES Cc1cc(F)c(Nc2ccnc3Nc4ccc(CN5C[C@H](O)[C@H](O)C5)cc4NC(=O)c23)cc1O
Show InChI InChI=1S/C24H24FN5O4/c1-12-6-14(25)17(8-19(12)31)27-16-4-5-26-23-22(16)24(34)29-18-7-13(2-3-15(18)28-23)9-30-10-20(32)21(33)11-30/h2-8,20-21,31-33H,9-11H2,1H3,(H,29,34)(H2,26,27,28)/t20-,21+
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.578n/an/an/an/a7.0n/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
The kinase used was a recombinant fusion protein composed of N-terminal GST and a C-terminal fragment of human KDR (amino acids D807-V1356), expresse...


US Patent US10047096 (2018)

More data for this
Ligand-Target Pair