Found 35 Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2' and Ligand = 'BDBM4810' TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 12.9nMAssay Description:RTK inhibitory activity of the compounds 2-12 were evaluated using human tumor cells known to express high levels of EGFR, VEGFR-2 or PDFGR-β us...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR2 in human U251 cells compound pretreated for 60 min before VEGF stimulation for 10 mins by phosphotyrosine ELISA cytoblot methodMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGF-induced VEGFR2 activation in human U251 cells pretreated for 60 mins followed by VEGF addition and measured after 10 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR-2 in human U251 cells assessed as reduction in VEGF induced phosphorylation preincubated for 60 mins followed by VEGF addition me...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISA assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 13nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 220nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 230nMAssay Description:In vitro inhibition of KDRMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 884nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of KDR (unknown origin) after 20 mins by scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) expressed in baculovirusMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 2.40E+3nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 2.43E+3nMAssay Description:Inhibition of VEGF-induced VEGFR2 autophosphorylation in human U251 cells incubated for 60 mins prior to VEGF-induction measured after 10 mins by pho...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin) expressed in human tumor cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.06E+4nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGF-induced VEGFR2 phosphorylation in human U251 cells preincubated for 60 mins followed by VEGF induction measured after 10 mins by E...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGFR2 in human U251 cells assessed as inhibition of VEGF-induced tyrosine phosphorylation incubated for 60 mins prior to VEGF-activati...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGFR2 phosphorylation in human U251 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGF-induced VEGFR2 phosphorylation in human U251 cells overexpressing Flk-1 pretreated for 60 mins prior to VEGF addition measured aft...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of VEGFR2 tyrosine kinase activity in VEGF-stimulated human U251 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of VEGFR2 in human U251 cells pretreated for 60 mins measured after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of VEGFR2 in human U251 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of human KDR incubated for 50 mins by omnia tyr peptide 8 substrate based fluorescence assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.29E+4nMAssay Description:Table 9: Compounds 1 and 2, Section D., (see FIG. 4, bottom row, far right column) each inhibit VEGFR-2 and PDGFR-β for antiangiogenic effects a...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of VEGFR2 expressed in human A431 cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 1.29E+4nMAssay Description:Inhibition of recombinant human KDR incubated for 1 hr using Tyr1 substrate by fluorimetry based Z'-LYTE-Tyr1 Peptide assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Duquesne University Of The Holy Spirit
US Patent
Duquesne University Of The Holy Spirit
US Patent
Affinity DataIC50: 8.02E+4nMpH: 7.5Assay Description:Kinase assays were performed in 96-well plates (Multiscreen Durapore, Millipore) using [γ-32P]ATP (Amersham Biosciences) and the synthetic polym...More data for this Ligand-Target Pair
