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Found 1 hit Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)' and Ligand = 'BDBM335694'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335694
PNG
(US9737544, Compound 26)
Show SMILES COc1cccc(c1)C(=O)c1cc2cc(cnc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-16(10-23-24)15-6-14-8-18(22-11-19(14)21-9-15)20(25)13-4-3-5-17(7-13)26-2/h3-12H,1-2H3
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.51E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair