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Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM146696'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146696
PNG
(US8957073, 4.30 | US9718803, 4.30)
Show SMILES CC(C)Oc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23FN4O/c1-16(2)31-21-12-18(11-20(26)13-21)24-25(28-10-9-27-24)19-14-30(15-19)23-8-7-17-5-3-4-6-22(17)29-23/h3-13,16,19H,14-15H2,1-2H3
PDB
MMDB

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KEGG

UniProtKB/SwissProt

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DrugBank
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0110n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 L of serial diluted PDE10A (BPS Bioscien...


US Patent US9718803 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM146696
PNG
(US8957073, 4.30 | US9718803, 4.30)
Show SMILES CC(C)Oc1cc(F)cc(c1)-c1nccnc1C1CN(C1)c1ccc2ccccc2n1
Show InChI InChI=1S/C25H23FN4O/c1-16(2)31-21-12-18(11-20(26)13-21)24-25(28-10-9-27-24)19-14-30(15-19)23-8-7-17-5-3-4-6-22(17)29-23/h3-13,16,19H,14-15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 0.0110n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...


US Patent US8957073 (2015)


BindingDB Entry DOI: 10.7270/Q2PR7TPZ
More data for this
Ligand-Target Pair