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Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329427'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329427
PNG
(5-(3-ethoxyphenyl)-2- methyl-6-(((1S,2S)-2- (quino...)
Show SMILES CCOc1cccc(c1)-c1cnc(C)[nH+]c1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C26H25N3O2/c1-3-30-21-9-6-8-19(13-21)23-15-27-17(2)28-26(23)31-16-20-14-22(20)25-12-11-18-7-4-5-10-24(18)29-25/h4-13,15,20,22H,3,14,16H2,1-2H3/p+1/t20-,22+/m1/s1
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
0.0400n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329427
PNG
(5-(3-ethoxyphenyl)-2- methyl-6-(((1S,2S)-2- (quino...)
Show SMILES CCOc1cccc(c1)-c1cnc(C)[nH+]c1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1
Show InChI InChI=1S/C26H25N3O2/c1-3-30-21-9-6-8-19(13-21)23-15-27-17(2)28-26(23)31-16-20-14-22(20)25-12-11-18-7-4-5-10-24(18)29-25/h4-13,15,20,22H,3,14,16H2,1-2H3/p+1/t20-,22+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.08n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair