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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329479'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329479
PNG
(1-(5-(4-(((1S,2S)-2-(5- methoxypyridin-2- yl)cyclo...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C1(O)CCC1
Show InChI InChI=1S/C24H26N4O3/c1-15-25-13-20(16-4-7-22(27-11-16)24(29)8-3-9-24)23(28-15)31-14-17-10-19(17)21-6-5-18(30-2)12-26-21/h4-7,11-13,17,19,29H,3,8-10,14H2,1-2H3/t17-,19+/m1/s1
PDB
MMDB

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PC cid
PC sid
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US Patent
0.120n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair