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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329520'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329520
PNG
(2-((1S,2S)-2-((5- (imidazo[1,2-a]pyridin-3- yl)-2-...)
Show SMILES Cc1ncc(-c2cnc3ccccn23)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C25H21N5O/c1-16-26-13-20(23-14-27-24-8-4-5-11-30(23)24)25(28-16)31-15-18-12-19(18)22-10-9-17-6-2-3-7-21(17)29-22/h2-11,13-14,18-19H,12,15H2,1H3/t18-,19+/m1/s1
PDB
MMDB

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PC cid
PC sid
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US Patent
0.0600n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair