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Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329530'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329530
PNG
(1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...)
Show SMILES CCC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C23H26N4O2/c1-4-22(28)21-8-6-16(11-26-21)19-12-24-15(3)27-23(19)29-13-17-9-18(17)20-7-5-14(2)10-25-20/h5-8,10-12,17-18,22,28H,4,9,13H2,1-3H3/t17-,18+,22?/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
US Patent
0.160n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329530
PNG
(1-(5-(2-methyl-4- (((1S,2S)-2-(5- methylpyridin-2-...)
Show SMILES CCC(O)c1ccc(cn1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc(C)cn1
Show InChI InChI=1S/C23H26N4O2/c1-4-22(28)21-8-6-16(11-26-21)19-12-24-15(3)27-23(19)29-13-17-9-18(17)20-7-5-14(2)10-25-20/h5-8,10-12,17-18,22,28H,4,9,13H2,1-3H3/t17-,18+,22?/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
0.730n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair