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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329543'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329543
PNG
(2-((1S,2S)-2-((2-methyl- 5-(6- (trifluoromethyl)py...)
Show SMILES Cc1ncc(-c2ccc(nc2)C(F)(F)F)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C24H19F3N4O/c1-14-28-12-19(16-7-9-22(29-11-16)24(25,26)27)23(30-14)32-13-17-10-18(17)21-8-6-15-4-2-3-5-20(15)31-21/h2-9,11-12,17-18H,10,13H2,1H3/t17-,18+/m1/s1
PDB
MMDB

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PC cid
PC sid
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US Patent
0.120n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair