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Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329549'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329549
PNG
(1-(4-(4-(((1S,2S)-2-(5- ethylpyridin-2- yl)cyclopr...)
Show SMILES CCc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cn(C)nc1C(C)O
Show InChI InChI=1S/C22H27N5O2/c1-5-15-6-7-20(24-9-15)17-8-16(17)12-29-22-18(10-23-14(3)25-22)19-11-27(4)26-21(19)13(2)28/h6-7,9-11,13,16-17,28H,5,8,12H2,1-4H3/t13?,16-,17+/m1/s1
PDB
MMDB

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UniProtKB/SwissProt

B.MOAD
DrugBank
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PC cid
PC sid
UniChem
US Patent
0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329549
PNG
(1-(4-(4-(((1S,2S)-2-(5- ethylpyridin-2- yl)cyclopr...)
Show SMILES CCc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1cn(C)nc1C(C)O
Show InChI InChI=1S/C22H27N5O2/c1-5-15-6-7-20(24-9-15)17-8-16(17)12-29-22-18(10-23-14(3)25-22)19-11-27(4)26-21(19)13(2)28/h6-7,9-11,13,16-17,28H,5,8,12H2,1-4H3/t13?,16-,17+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
0.240n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair