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Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329567'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329567
PNG
(2-(5-(4-(((1S,2S)-2-(5- ethylpyridin-2- yl)cyclopr...)
Show SMILES CCc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(C)(C)O
Show InChI InChI=1S/C24H28N4O2/c1-5-16-6-8-21(26-11-16)19-10-18(19)14-30-23-20(13-25-15(2)28-23)17-7-9-22(27-12-17)24(3,4)29/h6-9,11-13,18-19,29H,5,10,14H2,1-4H3/t18-,19+/m1/s1
PDB
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PC cid
PC sid
UniChem
US Patent
0.0500n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329567
PNG
(2-(5-(4-(((1S,2S)-2-(5- ethylpyridin-2- yl)cyclopr...)
Show SMILES CCc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)C(C)(C)O
Show InChI InChI=1S/C24H28N4O2/c1-5-16-6-8-21(26-11-16)19-10-18(19)14-30-23-20(13-25-15(2)28-23)17-7-9-22(27-12-17)24(3,4)29/h6-9,11-13,18-19,29H,5,10,14H2,1-4H3/t18-,19+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
5.95n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair