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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329577'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329577
PNG
(2-((1S,2S)-2-((2- methyl-5-(1,4- dioxaspiro[4.5]de...)
Show SMILES Cc1ncc(C2CCC3(CC2)OCCO3)c(OC[C@H]2C[C@@H]2c2ccc3ccccc3n2)n1
Show InChI InChI=1S/C26H29N3O3/c1-17-27-15-22(18-8-10-26(11-9-18)31-12-13-32-26)25(28-17)30-16-20-14-21(20)24-7-6-19-4-2-3-5-23(19)29-24/h2-7,15,18,20-21H,8-14,16H2,1H3/t20-,21+/m1/s1
PDB
MMDB

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PC cid
PC sid
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US Patent
0.0600n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair