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Found 1 hit Enz. Inhib. hit(s) with Target = 'cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A' and Ligand = 'BDBM329616'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))
BDBM329616
PNG
(5-(6-(2H-tetrazol-5- yl)pyridin-3-yl)-4- (((1S,2S)...)
Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1-c1ccc(nc1)-c1nn[nH]n1
Show InChI InChI=1S/C21H20N8O2/c1-12-22-10-17(13-3-5-19(23-8-13)20-26-28-29-27-20)21(25-12)31-11-14-7-16(14)18-6-4-15(30-2)9-24-18/h3-6,8-10,14,16H,7,11H2,1-2H3,(H,26,27,28,29)/t14-,16+/m1/s1
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PC cid
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US Patent
0.130n/an/an/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...


US Patent US9663513 (2017)

More data for this
Ligand-Target Pair