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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4C' and Ligand = 'BDBM50228831'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228831
PNG
(CHEMBL2111610)
Show SMILES COc1ccc(cc1O[C@H]1CC2CC1C1CCCC21)C1CNC(=O)N1C
Show InChI InChI=1/C21H28N2O3/c1-23-17(11-22-21(23)24)12-6-7-18(25-2)20(9-12)26-19-10-13-8-16(19)15-5-3-4-14(13)15/h6-7,9,13-17,19H,3-5,8,10-11H2,1-2H3,(H,22,24)/t13?,14?,15?,16?,17?,19-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of [3H]- rolipram binding to phosphodiesterase 4 of rat cerebral cortex membranes.


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
BindingDB Entry DOI: 10.7270/Q2NV9MG8
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228831
PNG
(CHEMBL2111610)
Show SMILES COc1ccc(cc1O[C@H]1CC2CC1C1CCCC21)C1CNC(=O)N1C
Show InChI InChI=1/C21H28N2O3/c1-23-17(11-22-21(23)24)12-6-7-18(25-2)20(9-12)26-19-10-13-8-16(19)15-5-3-4-14(13)15/h6-7,9,13-17,19H,3-5,8,10-11H2,1-2H3,(H,22,24)/t13?,14?,15?,16?,17?,19-/s2
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 560n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of cAMP-specific calcium-independent phosphodiesterase (IPDE).


J Med Chem 34: 291-8 (1991)


Article DOI: 10.1021/jm00105a045
BindingDB Entry DOI: 10.7270/Q2NV9MG8
More data for this
Ligand-Target Pair