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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4C' and Ligand = 'BDBM50228859'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228859
PNG
(CHEMBL352655)
Show SMILES Clc1ccc(Oc2ncccc2C(=O)NCc2ccccc2)cc1Cl
Show InChI InChI=1S/C19H14Cl2N2O2/c20-16-9-8-14(11-17(16)21)25-19-15(7-4-10-22-19)18(24)23-12-13-5-2-1-3-6-13/h1-11H,12H2,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.20E+3n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]cAMP (NEN NET-275) binding to Calcium-Independent Phosphodiesterase from rat brain.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
BindingDB Entry DOI: 10.7270/Q2DB843T
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C


(Rattus norvegicus)
BDBM50228859
PNG
(CHEMBL352655)
Show SMILES Clc1ccc(Oc2ncccc2C(=O)NCc2ccccc2)cc1Cl
Show InChI InChI=1S/C19H14Cl2N2O2/c20-16-9-8-14(11-17(16)21)25-19-15(7-4-10-22-19)18(24)23-12-13-5-2-1-3-6-13/h1-11H,12H2,(H,23,24)
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.90E+4n/an/an/an/an/an/a



Pfizer Central Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]rolipram binding to rat brain membranes.


J Med Chem 34: 86-9 (1991)


Article DOI: 10.1021/jm00105a015
BindingDB Entry DOI: 10.7270/Q2DB843T
More data for this
Ligand-Target Pair