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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'hdgat le' and Ligand = 'BDBM336141'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
hdgat le


(Homo sapiens (Human))
BDBM336141
PNG
(US9738658, Example 23)
Show SMILES COc1ccccc1-n1ccc2cc(cc(NC(=O)C3CC3)c12)N(CCO[Si](C)(C)C(C)(C)C)C(=O)c1c(Cl)ncnc1Cl
Show InChI InChI=1S/C32H37Cl2N5O4Si/c1-32(2,3)44(5,6)43-16-15-38(31(41)26-28(33)35-19-36-29(26)34)22-17-21-13-14-39(24-9-7-8-10-25(24)42-4)27(21)23(18-22)37-30(40)20-11-12-20/h7-10,13-14,17-20H,11-12,15-16H2,1-6H3,(H,37,40)
UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16.1n/an/an/an/an/an/a



GlaxoSmithKline LLC

US Patent


Assay Description
For inhibition of triacylglycerol product formation, 11 uL reactions were run in white Polyplate-384 (PerkinElmer6007300) starting with a 30 minute p...


US Patent US9738658 (2017)

More data for this
Ligand-Target Pair