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Found 1 hit Enz. Inhib. hit(s) with Target = 'idh2 r140q 16 hr nadph/ nadp' and Ligand = 'BDBM280145'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
idh2 r140q 16 hr nadph/ nadp


()
BDBM280145
PNG
(US10028961, Compound 298 | US10172864, Compound 29...)
Show SMILES CC(C)Nc1nc(Nc2ccnc(c2)C(C)(F)F)nc(n1)-c1nccc(n1)C(F)(F)F
Show InChI InChI=1S/C18H17F5N8/c1-9(2)26-15-29-14(13-25-7-5-11(28-13)18(21,22)23)30-16(31-15)27-10-4-6-24-12(8-10)17(3,19)20/h4-9H,1-3H3,(H2,24,26,27,29,30,31)
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/a7.525



Agios Pharmaceuticals, Inc.

US Patent


Assay Description
Compounds are assayed for IDH2 R140Q inhibitory activity through a cofactor depletion assay. Compounds are preincubated with enzyme and cofactor, the...


US Patent US10028961 (2018)

More data for this
Ligand-Target Pair