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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'insulin-degrading enzyme' and Ligand = 'BDBM314089'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme


(Homo sapiens (Human))
BDBM314089
PNG
(US9610322, 3b (trans olefin))
Show SMILES NC(=O)[C@H]1CCCCCC(=O)C(Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)CC(=O)[C@H](CC2CCCCC2)NC(=O)\C=C\C(=O)N1
Show InChI InChI=1S/C46H60N4O7/c47-45(56)37-19-11-4-12-20-40(51)38(29-33-21-23-35(24-22-33)44(55)34-17-9-3-10-18-34)50-46(57)36(27-31-13-5-1-6-14-31)30-41(52)39(28-32-15-7-2-8-16-32)49-43(54)26-25-42(53)48-37/h3,9-10,17-18,21-26,31-32,36-39H,1-2,4-8,11-16,19-20,27-30H2,(H2,47,56)(H,48,53)(H,49,54)(H,50,57)/b26-25+/t36-,37-,38?,39+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.50E+3n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
In vitro protease assays: Protease assays with IDE and neprilysin were performed using Mca-RPPGFSAFK(Dnp)-OH substrate peptide (R&D Systems, SEQ ID N...


US Patent US9610322 (2017)

More data for this
Ligand-Target Pair