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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'insulin-degrading enzyme isoform 1 precursor' and Ligand = 'BDBM209043'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens (Human))
BDBM209043
PNG
(US9243038, 17)
Show SMILES NC(=O)C1CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC(=O)CNC(=O)\C=C\C(=O)N1
Show InChI InChI=1S/C37H46N6O7/c38-35(48)28-13-7-8-20-39-36(49)29(22-25-14-16-27(17-15-25)34(47)26-11-5-2-6-12-26)43-37(50)30(21-24-9-3-1-4-10-24)42-33(46)23-40-31(44)18-19-32(45)41-28/h2,5-6,11-12,14-19,24,28-30H,1,3-4,7-10,13,20-23H2,(H2,38,48)(H,39,49)(H,40,44)(H,41,45)(H,42,46)(H,43,50)/b19-18+/t28?,29-,30+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 500n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...


US Patent US9243038 (2016)


BindingDB Entry DOI: 10.7270/Q2MW2FZV
More data for this
Ligand-Target Pair