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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'insulin-degrading enzyme isoform 1 precursor' and Ligand = 'BDBM209044'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens (Human))
BDBM209044
PNG
(US9243038, 19)
Show SMILES NC(=O)C1CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC(=O)C(Cc2ccccc2)NC(=O)\C=C\C(=O)N1
Show InChI InChI=1S/C44H52N6O7/c45-41(54)34-18-10-11-25-46-42(55)35(28-31-19-21-33(22-20-31)40(53)32-16-8-3-9-17-32)49-44(57)37(27-30-14-6-2-7-15-30)50-43(56)36(26-29-12-4-1-5-13-29)48-39(52)24-23-38(51)47-34/h1,3-5,8-9,12-13,16-17,19-24,30,34-37H,2,6-7,10-11,14-15,18,25-28H2,(H2,45,54)(H,46,55)(H,47,51)(H,48,52)(H,49,57)(H,50,56)/b24-23+/t34?,35-,36?,37+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20E+3n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...


US Patent US9243038 (2016)


BindingDB Entry DOI: 10.7270/Q2MW2FZV
More data for this
Ligand-Target Pair