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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'insulin-degrading enzyme isoform 1 precursor' and Ligand = 'BDBM209046'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
insulin-degrading enzyme isoform 1 precursor


(Homo sapiens (Human))
BDBM209046
PNG
(US9243038, 21)
Show SMILES NC(=O)C1CCCCNC(=O)[C@@H](Cc2ccc(cc2)C(=O)c2ccccc2)NC(=O)[C@H](CC2CCCCC2)NC(=O)C(CCC(O)=O)NC(=O)\C=C\C(=O)N1
Show InChI InChI=1S/C40H50N6O9/c41-37(52)29-13-7-8-22-42-38(53)31(24-26-14-16-28(17-15-26)36(51)27-11-5-2-6-12-27)45-40(55)32(23-25-9-3-1-4-10-25)46-39(54)30(18-21-35(49)50)44-34(48)20-19-33(47)43-29/h2,5-6,11-12,14-17,19-20,25,29-32H,1,3-4,7-10,13,18,21-24H2,(H2,41,52)(H,42,53)(H,43,47)(H,44,48)(H,45,55)(H,46,54)(H,49,50)/b20-19+/t29?,30?,31-,32+/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 85n/an/an/an/an/an/a



President and Fellows of Harvard College

US Patent


Assay Description
Macrocycles were assayed for IDE inhibition by monitoring cleavage of a substrate peptide containing a fluorophore-quencher pair such that cleavage o...


US Patent US9243038 (2016)


BindingDB Entry DOI: 10.7270/Q2MW2FZV
More data for this
Ligand-Target Pair