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Found 78 hits of Enz. Inhib. data with enzyme = '11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)' and Substrate = 'BDBM13739'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Rattus norvegicus (rat))
BDBM22473
PNG
(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)
Show SMILES O=C1N=C(NC23CC4CC2CC(C3)C4)SC11CCCC1
Show InChI InChI=1S/C16H22N2OS/c19-13-16(3-1-2-4-16)20-14(17-13)18-15-8-10-5-11(9-15)7-12(15)6-10/h10-12H,1-9H2,(H,17,18,19)
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180 -9.10n/an/an/an/an/a7.222



Biovitrum AB



Assay Description
Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ...


J Med Chem 51: 2933-43 (2008)


Article DOI: 10.1021/jm701551j
BindingDB Entry DOI: 10.7270/Q2HM56Q8
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32522
PNG
(pyridine amide, 30)
Show SMILES Cc1ccc(cc1F)-c1cccc(n1)C(=O)N1CCCC(C)(C)C1
Show InChI InChI=1S/C20H23FN2O/c1-14-8-9-15(12-16(14)21)17-6-4-7-18(22-17)19(24)23-11-5-10-20(2,3)13-23/h4,6-9,12H,5,10-11,13H2,1-3H3
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n/an/a 0.100n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32520
PNG
(pyridine amide, 28)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O/c1-19(2)11-4-12-22(13-19)18(23)17-6-3-5-16(21-17)14-7-9-15(20)10-8-14/h3,5-10H,4,11-13H2,1-2H3
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n/an/a 1.10n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32521
PNG
(pyridine amide, 29)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H21F3N2O2/c1-19(2)11-4-12-25(13-19)18(26)17-6-3-5-16(24-17)14-7-9-15(10-8-14)27-20(21,22)23/h3,5-10H,4,11-13H2,1-2H3
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n/an/a 1.10n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32527
PNG
(pyridine amide, 35)
Show SMILES C[C@]12C[C@H](CC(C)(C)C1)N(C2)C(=O)c1cncc(COc2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C23H26Cl2N2O2/c1-22(2)8-17-9-23(3,13-22)14-27(17)21(28)16-7-15(10-26-11-16)12-29-20-18(24)5-4-6-19(20)25/h4-7,10-11,17H,8-9,12-14H2,1-3H3/t17-,23-/m0/s1
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n/an/a 1.70n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32526
PNG
(pyridine amide, 34)
Show SMILES Clc1cccc(Cl)c1OCc1cncc(c1)C(=O)N1CCCCC1c1cccnc1
Show InChI InChI=1S/C23H21Cl2N3O2/c24-19-6-3-7-20(25)22(19)30-15-16-11-18(14-27-12-16)23(29)28-10-2-1-8-21(28)17-5-4-9-26-13-17/h3-7,9,11-14,21H,1-2,8,10,15H2
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n/an/a 2n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32523
PNG
(pyridine amide, 31)
Show SMILES [O-][N+](=O)c1ccccc1-c1cccc(n1)C(=O)N1CCCC2CCCCC12
Show InChI InChI=1S/C21H23N3O3/c25-21(23-14-6-8-15-7-1-3-12-19(15)23)18-11-5-10-17(22-18)16-9-2-4-13-20(16)24(26)27/h2,4-5,9-11,13,15,19H,1,3,6-8,12,14H2
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n/an/a 2n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32508
PNG
(pyridine amide, 23)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCCCC1
Show InChI InChI=1S/C21H24Cl2N2O3S/c22-18-8-7-9-19(23)20(18)29(27,28)15-16-12-17(14-24-13-16)21(26)25-10-5-3-1-2-4-6-11-25/h7-9,12-14H,1-6,10-11,15H2
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n/an/a 2.5n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32519
PNG
(pyridine amide, 27)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C19H21ClN2O/c1-19(2)11-6-12-22(13-19)18(23)17-10-5-9-16(21-17)14-7-3-4-8-15(14)20/h3-5,7-10H,6,11-13H2,1-2H3
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n/an/a 2.90n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32573
PNG
(CHEMBL427896 | arylsulfonylpiperazine, 45)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C21H27N3O4S/c1-16-15-22(18-7-9-19(10-8-18)24(25)26)13-14-23(16)29(27,28)20-11-5-17(6-12-20)21(2,3)4/h5-12,16H,13-15H2,1-4H3/t16-/m1/s1
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n/an/a 3n/a 57n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32566
PNG
(arylsulfonylpiperazine, 38)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C21H26F3N3O2S/c1-20(2,3)16-7-9-17(10-8-16)30(28,29)27-13-5-12-26(14-15-27)19-18(21(22,23)24)6-4-11-25-19/h4,6-11H,5,12-15H2,1-3H3
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n/an/a 3n/a 315n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32524
PNG
(pyridine amide, 32)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cccc(n1)C(=O)N1CCCC2CCCCC12
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)17-12-10-15(11-13-17)18-7-3-8-19(26-18)21(28)27-14-4-6-16-5-1-2-9-20(16)27/h3,7-8,10-13,16,20H,1-2,4-6,9,14H2
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n/an/a 3.60n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32538
PNG
(arylsulfonylpiperazine, 10)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C20H24F3N3O2S/c1-19(2,3)15-6-8-16(9-7-15)29(27,28)26-13-11-25(12-14-26)18-17(20(21,22)23)5-4-10-24-18/h4-10H,11-14H2,1-3H3
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n/an/a 4n/a 201n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32529
PNG
(pyridine amide, 37)
Show SMILES Clc1cccc(Cl)c1OCc1cccc(n1)C(=O)N1CCCC2CCCCC12
Show InChI InChI=1S/C22H24Cl2N2O2/c23-17-9-4-10-18(24)21(17)28-14-16-8-3-11-19(25-16)22(27)26-13-5-7-15-6-1-2-12-20(15)26/h3-4,8-11,15,20H,1-2,5-7,12-14H2
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n/an/a 4.60n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32525
PNG
(pyridine amide, 33)
Show SMILES O=C(N1CCCC2CCCCC12)c1cccc(n1)-c1ccccc1-c1ccccc1
Show InChI InChI=1S/C27H28N2O/c30-27(29-19-9-13-21-12-4-7-18-26(21)29)25-17-8-16-24(28-25)23-15-6-5-14-22(23)20-10-2-1-3-11-20/h1-3,5-6,8,10-11,14-17,21,26H,4,7,9,12-13,18-19H2
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n/an/a 4.70n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32528
PNG
(pyridine amide, 36)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(COc2c(Cl)cc(Cl)cc2Cl)n1
Show InChI InChI=1S/C20H21Cl3N2O2/c1-20(2)7-4-8-25(12-20)19(26)17-6-3-5-14(24-17)11-27-18-15(22)9-13(21)10-16(18)23/h3,5-6,9-10H,4,7-8,11-12H2,1-2H3
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n/an/a 6.5n/an/an/an/an/a25



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32550
PNG
(arylsulfonylpiperazine, 22)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H14Cl2F3N3O2S/c17-11-3-4-14(13(18)10-11)27(25,26)24-8-6-23(7-9-24)15-12(16(19,20)21)2-1-5-22-15/h1-5,10H,6-9H2
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n/an/a 7n/a 241n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32512
PNG
(pyridine amide, 6)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(CSc2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C19H20Cl2N2OS/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-25-18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3
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n/an/a 7.20n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32572
PNG
(arylsulfonylpiperazine, 44)
Show SMILES C[C@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C21H26F3N3O2S/c1-15-14-26(19-18(21(22,23)24)6-5-11-25-19)12-13-27(15)30(28,29)17-9-7-16(8-10-17)20(2,3)4/h5-11,15H,12-14H2,1-4H3/t15-/m0/s1
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n/an/a 9n/a 569n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32567
PNG
(arylsulfonylpiperazine, 39)
Show SMILES CC1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C21H26F3N3O2S/c1-15-14-26(19-18(21(22,23)24)6-5-11-25-19)12-13-27(15)30(28,29)17-9-7-16(8-10-17)20(2,3)4/h5-11,15H,12-14H2,1-4H3
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n/an/a 9n/a 632n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32561
PNG
(arylsulfonylpiperazine, 33)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C20H25N3O4S/c1-20(2,3)16-4-10-19(11-5-16)28(26,27)22-14-12-21(13-15-22)17-6-8-18(9-7-17)23(24)25/h4-11H,12-15H2,1-3H3
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n/an/a 10n/a 247n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32507
PNG
(pyridine amide, 22)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCCC1
Show InChI InChI=1S/C20H22Cl2N2O3S/c21-17-7-6-8-18(22)19(17)28(26,27)14-15-11-16(13-23-12-15)20(25)24-9-4-2-1-3-5-10-24/h6-8,11-13H,1-5,9-10,14H2
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n/an/a 11n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32571
PNG
(arylsulfonylpiperazine, 43)
Show SMILES C[C@@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C21H26F3N3O2S/c1-15-14-26(19-18(21(22,23)24)6-5-11-25-19)12-13-27(15)30(28,29)17-9-7-16(8-10-17)20(2,3)4/h5-11,15H,12-14H2,1-4H3/t15-/m1/s1
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n/an/a 11n/a 762n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32547
PNG
(arylsulfonylpiperazine, 19)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)17-8-4-10-24-19(17)25-11-13-26(14-12-25)29(27,28)18-9-3-6-15-5-1-2-7-16(15)18/h1-10H,11-14H2
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n/an/a 13n/a 329n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32546
PNG
(arylsulfonylpiperazine, 18)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)18-6-3-9-24-19(18)25-10-12-26(13-11-25)29(27,28)17-8-7-15-4-1-2-5-16(15)14-17/h1-9,14H,10-13H2
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n/an/a 13n/a 547n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32541
PNG
(arylsulfonylpiperazine, 13)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C17H15F6N3O2S/c18-16(19,20)12-3-5-13(6-4-12)29(27,28)26-10-8-25(9-11-26)15-14(17(21,22)23)2-1-7-24-15/h1-7H,8-11H2
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n/an/a 14n/a 727n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32540
PNG
(arylsulfonylpiperazine, 12)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClF3N3O2S/c17-12-3-5-13(6-4-12)26(24,25)23-10-8-22(9-11-23)15-14(16(18,19)20)2-1-7-21-15/h1-7H,8-11H2
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n/an/a 14n/a 518n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32537
PNG
(arylsulfonylpiperazine, 9)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C19H22F3N3O2S/c1-14(2)15-5-7-16(8-6-15)28(26,27)25-12-10-24(11-13-25)18-17(19(20,21)22)4-3-9-23-18/h3-9,14H,10-13H2,1-2H3
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n/an/a 15n/a 556n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32556
PNG
(arylsulfonylpiperazine, 28)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H25F3N2O2S/c1-20(2,3)16-8-10-17(11-9-16)29(27,28)26-14-12-25(13-15-26)19-7-5-4-6-18(19)21(22,23)24/h4-11H,12-15H2,1-3H3
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n/an/a 15n/a 971n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32575
PNG
(arylsulfonylpiperazine, 1)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O2S/c1-13-4-6-14(7-5-13)26(24,25)23-11-9-22(10-12-23)16-15(17(18,19)20)3-2-8-21-16/h2-8H,9-12H2,1H3
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n/an/a 16n/a 461n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32536
PNG
(arylsulfonylpiperazine, 8)
Show SMILES CCCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C19H22F3N3O2S/c1-2-4-15-6-8-16(9-7-15)28(26,27)25-13-11-24(12-14-25)18-17(19(20,21)22)5-3-10-23-18/h3,5-10H,2,4,11-14H2,1H3
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n/an/a 16n/a 613n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32568
PNG
(arylsulfonylpiperazine, 40)
Show SMILES CCC1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C22H28F3N3O2S/c1-5-17-15-27(20-19(22(23,24)25)7-6-12-26-20)13-14-28(17)31(29,30)18-10-8-16(9-11-18)21(2,3)4/h6-12,17H,5,13-15H2,1-4H3
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n/an/a 17n/a>1.00E+3n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32518
PNG
(pyridine amide, 9)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C18H19ClN2O/c1-13-9-11-21(12-10-13)18(22)17-8-4-7-16(20-17)14-5-2-3-6-15(14)19/h2-8,13H,9-12H2,1H3
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n/an/a 17n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32535
PNG
(arylsulfonylpiperazine, 7)
Show SMILES CCc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C18H20F3N3O2S/c1-2-14-5-7-15(8-6-14)27(25,26)24-12-10-23(11-13-24)17-16(18(19,20)21)4-3-9-22-17/h3-9H,2,10-13H2,1H3
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n/an/a 18n/a 510n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32542
PNG
(arylsulfonylpiperazine, 14)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O3S/c1-26-13-4-6-14(7-5-13)27(24,25)23-11-9-22(10-12-23)16-15(17(18,19)20)3-2-8-21-16/h2-8H,9-12H2,1H3
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Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32534
PNG
(arylsulfonylpiperazine, 6)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C17H18F3N3O2S/c18-17(19,20)15-7-4-8-21-16(15)22-9-11-23(12-10-22)26(24,25)13-14-5-2-1-3-6-14/h1-8H,9-13H2
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n/an/a 20n/a 574n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32506
PNG
(pyridine amide, 21)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C19H20Cl2N2O3S/c20-16-6-5-7-17(21)18(16)27(25,26)13-14-10-15(12-22-11-14)19(24)23-8-3-1-2-4-9-23/h5-7,10-12H,1-4,8-9,13H2
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n/an/a 21n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32500
PNG
(pyridine amide, 15)
Show SMILES CC1CCN(CC1)C(=O)c1cncc(CS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-5-7-23(8-6-13)19(24)15-9-14(10-22-11-15)12-27(25,26)18-16(20)3-2-4-17(18)21/h2-4,9-11,13H,5-8,12H2,1H3
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n/an/a 22n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32574
PNG
(arylsulfonylpiperazine, 46)
Show SMILES C[C@H]1CN(CCN1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C21H27N3O4S/c1-16-15-22(18-7-9-19(10-8-18)24(25)26)13-14-23(16)29(27,28)20-11-5-17(6-12-20)21(2,3)4/h5-12,16H,13-15H2,1-4H3/t16-/m0/s1
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n/an/a 29n/a 527n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32557
PNG
(arylsulfonylpiperazine, 29)
Show SMILES Cc1ccccc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H28N2O2S/c1-17-7-5-6-8-20(17)22-13-15-23(16-14-22)26(24,25)19-11-9-18(10-12-19)21(2,3)4/h5-12H,13-16H2,1-4H3
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Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32499
PNG
(pyridine amide, 8)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(CS(=O)(=O)c2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-27(25,26)18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3
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n/an/a 35n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32560
PNG
(arylsulfonylpiperazine, 32)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C20H25N3O4S/c1-20(2,3)16-8-10-17(11-9-16)28(26,27)22-14-12-21(13-15-22)18-6-4-5-7-19(18)23(24)25/h4-11H,12-15H2,1-3H3
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n/an/a 37n/a 839n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32543
PNG
(arylsulfonylpiperazine, 15)
Show SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C16H15F3N4O4S/c17-16(18,19)14-2-1-7-20-15(14)21-8-10-22(11-9-21)28(26,27)13-5-3-12(4-6-13)23(24)25/h1-7H,8-11H2
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n/an/a 37n/a 922n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32564
PNG
(arylsulfonylpiperazine, 36)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C20H25FN2O2S/c1-20(2,3)16-4-10-19(11-5-16)26(24,25)23-14-12-22(13-15-23)18-8-6-17(21)7-9-18/h4-11H,12-15H2,1-3H3
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n/an/a 42n/a>1.00E+3n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32530
PNG
(arylsulfonylpiperazine, 2)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16F3N3O2S/c17-16(18,19)14-7-4-8-20-15(14)21-9-11-22(12-10-21)25(23,24)13-5-2-1-3-6-13/h1-8H,9-12H2
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n/an/a 45n/a 724n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32539
PNG
(arylsulfonylpiperazine, 11)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C16H15F4N3O2S/c17-12-3-5-13(6-4-12)26(24,25)23-10-8-22(9-11-23)15-14(16(18,19)20)2-1-7-21-15/h1-7H,8-11H2
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n/an/a 46n/a 667n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32544
PNG
(arylsulfonylpiperazine, 16)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C17H15F3N4O2S/c18-17(19,20)15-2-1-7-22-16(15)23-8-10-24(11-9-23)27(25,26)14-5-3-13(12-21)4-6-14/h1-7H,8-11H2
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n/an/a 50n/a 978n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32548
PNG
(arylsulfonylpiperazine, 20)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClF3N3O2S/c17-12-3-1-4-13(11-12)26(24,25)23-9-7-22(8-10-23)15-14(16(18,19)20)5-2-6-21-15/h1-6,11H,7-10H2
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n/an/a 55n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32569
PNG
(arylsulfonylpiperazine, 41)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1(C)C)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C22H28F3N3O2S/c1-20(2,3)16-8-10-17(11-9-16)31(29,30)28-14-13-27(15-21(28,4)5)19-18(22(23,24)25)7-6-12-26-19/h6-12H,13-15H2,1-5H3
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n/an/a 58n/a>1.00E+3n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32570
PNG
(arylsulfonylpiperazine, 42)
Show SMILES CC1CN(CC(C)N1S(=O)(=O)c1ccc(cc1)C(C)(C)C)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C22H28F3N3O2S/c1-15-13-27(20-19(22(23,24)25)7-6-12-26-20)14-16(2)28(15)31(29,30)18-10-8-17(9-11-18)21(3,4)5/h6-12,15-16H,13-14H2,1-5H3
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n/an/a 62n/a 638n/an/an/an/a



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
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