BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 473 hits of Enz. Inhib. data with enzyme = 'AP2-associated protein kinase 1' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311218
PNG
((S)-1-(2-cyclopropyl-4-(quinolin-4-yl)phenoxy)-2,4...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C1CC1)-c1ccnc2ccccc12
Show InChI InChI=1/C25H30N2O/c1-17(2)15-25(3,26)16-28-24-11-10-19(14-22(24)18-8-9-18)20-12-13-27-23-7-5-4-6-21(20)23/h4-7,10-14,17-18H,8-9,15-16,26H2,1-3H3/t25-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0700n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311218
PNG
((S)-1-(2-cyclopropyl-4-(quinolin-4-yl)phenoxy)-2,4...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C1CC1)-c1ccnc2ccccc12
Show InChI InChI=1/C25H30N2O/c1-17(2)15-25(3,26)16-28-24-11-10-19(14-22(24)18-8-9-18)20-12-13-27-23-7-5-4-6-21(20)23/h4-7,10-14,17-18H,8-9,15-16,26H2,1-3H3/t25-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.0700n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311290
PNG
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cc(c(OC[C@@](C)(N)CC(C)C)cn1)C(F)(F)F
Show InChI InChI=1/C20H25F3N4O3/c1-12(2)9-19(3,24)11-30-16-10-26-15(8-14(16)20(21,22)23)13-5-6-25-17(7-13)27-18(28)29-4/h5-8,10,12H,9,11,24H2,1-4H3,(H,25,27,28)/t19-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.190n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311290
PNG
((S)-methyl (5-((2-amino-2,4-dimethylpentyl)oxy)-4-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cc(c(OC[C@@](C)(N)CC(C)C)cn1)C(F)(F)F
Show InChI InChI=1/C20H25F3N4O3/c1-12(2)9-19(3,24)11-30-16-10-26-15(8-14(16)20(21,22)23)13-5-6-25-17(7-13)27-18(28)29-4/h5-8,10,12H,9,11,24H2,1-4H3,(H,25,27,28)/t19-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.190n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311339
PNG
((S)-methyl (6-((2-amino-2,4-dimethylpentyl)oxy)-5-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)F
Show InChI InChI=1/C20H26F2N4O3/c1-12(2)9-20(3,23)11-29-18-15(17(21)22)7-14(10-25-18)13-5-6-24-16(8-13)26-19(27)28-4/h5-8,10,12,17H,9,11,23H2,1-4H3,(H,24,26,27)/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311339
PNG
((S)-methyl (6-((2-amino-2,4-dimethylpentyl)oxy)-5-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)F
Show InChI InChI=1/C20H26F2N4O3/c1-12(2)9-20(3,23)11-29-18-15(17(21)22)7-14(10-25-18)13-5-6-24-16(8-13)26-19(27)28-4/h5-8,10,12,17H,9,11,23H2,1-4H3,(H,24,26,27)/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311347
PNG
((S)-1-((3-(difluoromethyl)-5-(quinolin-4-yl)pyridi...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2ccccc12
Show InChI InChI=1/C22H25F2N3O/c1-14(2)11-22(3,25)13-28-21-18(20(23)24)10-15(12-27-21)16-8-9-26-19-7-5-4-6-17(16)19/h4-10,12,14,20H,11,13,25H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.230n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311347
PNG
((S)-1-((3-(difluoromethyl)-5-(quinolin-4-yl)pyridi...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2ccccc12
Show InChI InChI=1/C22H25F2N3O/c1-14(2)11-22(3,25)13-28-21-18(20(23)24)10-15(12-27-21)16-8-9-26-19-7-5-4-6-17(16)19/h4-10,12,14,20H,11,13,25H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.230n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311289
PNG
((S)-2,4-dimethyl-1-((6-(quinolin-4-yl)-4-(trifluor...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)(F)F)-c1ccnc2ccccc12
Show InChI InChI=1/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-12-28-19(10-17(20)22(23,24)25)16-8-9-27-18-7-5-4-6-15(16)18/h4-10,12,14H,11,13,26H2,1-3H3/t21-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311289
PNG
((S)-2,4-dimethyl-1-((6-(quinolin-4-yl)-4-(trifluor...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)(F)F)-c1ccnc2ccccc12
Show InChI InChI=1/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-12-28-19(10-17(20)22(23,24)25)16-8-9-27-18-7-5-4-6-15(16)18/h4-10,12,14H,11,13,26H2,1-3H3/t21-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.240n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311338
PNG
((S)-1-((3-(difluoromethyl)-5-(7-fluoroquinolin-4-y...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2cc(F)ccc12
Show InChI InChI=1/C22H24F3N3O/c1-13(2)10-22(3,26)12-29-21-18(20(24)25)8-14(11-28-21)16-6-7-27-19-9-15(23)4-5-17(16)19/h4-9,11,13,20H,10,12,26H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.25n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311338
PNG
((S)-1-((3-(difluoromethyl)-5-(7-fluoroquinolin-4-y...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2cc(F)ccc12
Show InChI InChI=1/C22H24F3N3O/c1-13(2)10-22(3,26)12-29-21-18(20(24)25)8-14(11-28-21)16-6-7-27-19-9-15(23)4-5-17(16)19/h4-9,11,13,20H,10,12,26H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.25n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311155
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-cyanop...)
Show SMILES CC(C)C[C@H](N)COc1ccc(cc1C#N)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1/C20H24N4O2/c1-13(2)8-18(22)12-26-19-5-4-15(9-17(19)11-21)16-6-7-23-20(10-16)24-14(3)25/h4-7,9-10,13,18H,8,12,22H2,1-3H3,(H,23,24,25)/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311265
PNG
((S)-1-((4-(difluoromethyl)-6-(quinolin-4-yl)pyridi...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1ccnc2ccccc12
Show InChI InChI=1/C22H25F2N3O/c1-14(2)11-22(3,25)13-28-20-12-27-19(10-17(20)21(23)24)16-8-9-26-18-7-5-4-6-15(16)18/h4-10,12,14,21H,11,13,25H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311155
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-cyanop...)
Show SMILES CC(C)C[C@H](N)COc1ccc(cc1C#N)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1/C20H24N4O2/c1-13(2)8-18(22)12-26-19-5-4-15(9-17(19)11-21)16-6-7-23-20(10-16)24-14(3)25/h4-7,9-10,13,18H,8,12,22H2,1-3H3,(H,23,24,25)/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311265
PNG
((S)-1-((4-(difluoromethyl)-6-(quinolin-4-yl)pyridi...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1ccnc2ccccc12
Show InChI InChI=1/C22H25F2N3O/c1-14(2)11-22(3,25)13-28-20-12-27-19(10-17(20)21(23)24)16-8-9-26-18-7-5-4-6-15(16)18/h4-10,12,14,21H,11,13,25H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311340
PNG
((S)-1-((5-(7-chloroquinolin-4-yl)-3-(difluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2cc(Cl)ccc12
Show InChI InChI=1/C22H24ClF2N3O/c1-13(2)10-22(3,26)12-29-21-18(20(24)25)8-14(11-28-21)16-6-7-27-19-9-15(23)4-5-17(16)19/h4-9,11,13,20H,10,12,26H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.310n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311340
PNG
((S)-1-((5-(7-chloroquinolin-4-yl)-3-(difluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1C(F)F)-c1ccnc2cc(Cl)ccc12
Show InChI InChI=1/C22H24ClF2N3O/c1-13(2)10-22(3,26)12-29-21-18(20(24)25)8-14(11-28-21)16-6-7-27-19-9-15(23)4-5-17(16)19/h4-9,11,13,20H,10,12,26H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.310n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311189
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C1CC1
Show InChI InChI=1/C23H31N3O3/c1-15(2)13-23(3,24)14-29-20-8-7-17(11-19(20)16-5-6-16)18-9-10-25-21(12-18)26-22(27)28-4/h7-12,15-16H,5-6,13-14,24H2,1-4H3,(H,25,26,27)/t23-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311229
PNG
((S)-1-(4-(1,6-naphthyridin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2ccncc12
Show InChI InChI=1/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-5-4-15(10-18(20)22(23,24)25)16-6-9-28-19-7-8-27-12-17(16)19/h4-10,12,14H,11,13,26H2,1-3H3/t21-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311189
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C1CC1
Show InChI InChI=1/C23H31N3O3/c1-15(2)13-23(3,24)14-29-20-8-7-17(11-19(20)16-5-6-16)18-9-10-25-21(12-18)26-22(27)28-4/h7-12,15-16H,5-6,13-14,24H2,1-4H3,(H,25,26,27)/t23-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311229
PNG
((S)-1-(4-(1,6-naphthyridin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2ccncc12
Show InChI InChI=1/C22H24F3N3O/c1-14(2)11-21(3,26)13-29-20-5-4-15(10-18(20)22(23,24)25)16-6-9-28-19-7-8-27-12-17(16)19/h4-10,12,14H,11,13,26H2,1-3H3/t21-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.320n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311292
PNG
((S)-1-((4-(difluoromethyl)-5′-fluoro-2′...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1cc(C)ncc1F
Show InChI InChI=1/C19H24F3N3O/c1-11(2)7-19(4,23)10-26-17-9-25-16(6-14(17)18(21)22)13-5-12(3)24-8-15(13)20/h5-6,8-9,11,18H,7,10,23H2,1-4H3/t19-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.340n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311292
PNG
((S)-1-((4-(difluoromethyl)-5′-fluoro-2′...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1cc(C)ncc1F
Show InChI InChI=1/C19H24F3N3O/c1-11(2)7-19(4,23)10-26-17-9-25-16(6-14(17)18(21)22)13-5-12(3)24-8-15(13)20/h5-6,8-9,11,18H,7,10,23H2,1-4H3/t19-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.340n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311176
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)(F)F
Show InChI InChI=1/C21H26F3N3O3/c1-13(2)11-20(3,25)12-30-17-6-5-14(9-16(17)21(22,23)24)15-7-8-26-18(10-15)27-19(28)29-4/h5-10,13H,11-12,25H2,1-4H3,(H,26,27,28)/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.340n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311176
PNG
((S)-methyl (4-(4-((2-amino-2,4-dimethylpentyl)oxy)...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1ccc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)(F)F
Show InChI InChI=1/C21H26F3N3O3/c1-13(2)11-20(3,25)12-30-17-6-5-14(9-16(17)21(22,23)24)15-7-8-26-18(10-15)27-19(28)29-4/h5-10,13H,11-12,25H2,1-4H3,(H,26,27,28)/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.340n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM406253
PNG
((S)-1-((4-chloro-6-(6-fluoroquinolin-4-yl)pyridin-...)
Show SMILES CC(C)C[C@@](C)(COc1cnc(cc1Cl)-c1ccnc2ccc(F)cc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C26H31ClFN3O3/c1-16(2)13-26(6,31-24(32)34-25(3,4)5)15-33-23-14-30-22(12-20(23)27)18-9-10-29-21-8-7-17(28)11-19(18)21/h7-12,14,16H,13,15H2,1-6H3,(H,31,32)/t26-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.360n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311170
PNG
((S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(t...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1/C21H26F3N3O2/c1-13(2)11-20(4,25)12-29-18-6-5-15(9-17(18)21(22,23)24)16-7-8-26-19(10-16)27-14(3)28/h5-10,13H,11-12,25H2,1-4H3,(H,26,27,28)/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.360n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311170
PNG
((S)-N-(4-(4-((2-amino-2,4-dimethylpentyl)oxy)-3-(t...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1/C21H26F3N3O2/c1-13(2)11-20(4,25)12-29-18-6-5-15(9-17(18)21(22,23)24)16-7-8-26-19(10-16)27-14(3)28/h5-10,13H,11-12,25H2,1-4H3,(H,26,27,28)/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.360n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311378
PNG
((S)-1-((4-chloro-6-(6-fluoroquinolin-4-yl)pyridin-...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1Cl)-c1ccnc2ccc(F)cc12
Show InChI InChI=1/C21H23ClFN3O/c1-13(2)10-21(3,24)12-27-20-11-26-19(9-17(20)22)15-6-7-25-18-5-4-14(23)8-16(15)18/h4-9,11,13H,10,12,24H2,1-3H3/t21-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.360n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311363
PNG
((S)-methyl (6-((2-amino-2,4-dimethylpentyl)oxy)-5-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)(F)F
Show InChI InChI=1/C20H25F3N4O3/c1-12(2)9-19(3,24)11-30-17-15(20(21,22)23)7-14(10-26-17)13-5-6-25-16(8-13)27-18(28)29-4/h5-8,10,12H,9,11,24H2,1-4H3,(H,25,27,28)/t19-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.380n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311206
PNG
((S)-1-(2-(difluoromethyl)-4-(2-methylpyridin-4-yl)...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)F)-c1ccnc(C)c1
Show InChI InChI=1/C20H26F2N2O/c1-13(2)11-20(4,23)12-25-18-6-5-15(10-17(18)19(21)22)16-7-8-24-14(3)9-16/h5-10,13,19H,11-12,23H2,1-4H3/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.380n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311206
PNG
((S)-1-(2-(difluoromethyl)-4-(2-methylpyridin-4-yl)...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)F)-c1ccnc(C)c1
Show InChI InChI=1/C20H26F2N2O/c1-13(2)11-20(4,23)12-25-18-6-5-15(10-17(18)19(21)22)16-7-8-24-14(3)9-16/h5-10,13,19H,11-12,23H2,1-4H3/t20-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.380n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311363
PNG
((S)-methyl (6-((2-amino-2,4-dimethylpentyl)oxy)-5-...)
Show SMILES COC(=O)Nc1cc(ccn1)-c1cnc(OC[C@@](C)(N)CC(C)C)c(c1)C(F)(F)F
Show InChI InChI=1/C20H25F3N4O3/c1-12(2)9-19(3,24)11-30-17-15(20(21,22)23)7-14(10-26-17)13-5-6-25-16(8-13)27-18(28)29-4/h5-8,10,12H,9,11,24H2,1-4H3,(H,25,27,28)/t19-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.380n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311382
PNG
((S)-1-((4-chloro-6-(6-chloroquinolin-4-yl)pyridin-...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1Cl)-c1ccnc2ccc(Cl)cc12
Show InChI InChI=1/C21H23Cl2N3O/c1-13(2)10-21(3,24)12-27-20-11-26-19(9-17(20)23)15-6-7-25-18-5-4-14(22)8-16(15)18/h4-9,11,13H,10,12,24H2,1-3H3/t21-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.390n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311382
PNG
((S)-1-((4-chloro-6-(6-chloroquinolin-4-yl)pyridin-...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1Cl)-c1ccnc2ccc(Cl)cc12
Show InChI InChI=1/C21H23Cl2N3O/c1-13(2)10-21(3,24)12-27-20-11-26-19(9-17(20)23)15-6-7-25-18-5-4-14(22)8-16(15)18/h4-9,11,13H,10,12,24H2,1-3H3/t21-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.390n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311375
PNG
((S)-1-((6-(7-fluoroquinolin-4-yl)-4-methylpyridin-...)
Show SMILES CC(C)C[C@@](C)(COc1cnc(cc1C)-c1ccnc2cc(F)ccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1/C27H34FN3O3/c1-17(2)14-27(7,31-25(32)34-26(4,5)6)16-33-24-15-30-22(12-18(24)3)21-10-11-29-23-13-19(28)8-9-20(21)23/h8-13,15,17H,14,16H2,1-7H3,(H,31,32)/t27-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.410n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311375
PNG
((S)-1-((6-(7-fluoroquinolin-4-yl)-4-methylpyridin-...)
Show SMILES CC(C)C[C@@](C)(COc1cnc(cc1C)-c1ccnc2cc(F)ccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1/C27H34FN3O3/c1-17(2)14-27(7,31-25(32)34-26(4,5)6)16-33-24-15-30-22(12-18(24)3)21-10-11-29-23-13-19(28)8-9-20(21)23/h8-13,15,17H,14,16H2,1-7H3,(H,31,32)/t27-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.410n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311159
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-methyl...)
Show SMILES CC(C)C[C@H](N)COc1ccc(cc1C)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1/C20H27N3O2/c1-13(2)9-18(21)12-25-19-6-5-16(10-14(19)3)17-7-8-22-20(11-17)23-15(4)24/h5-8,10-11,13,18H,9,12,21H2,1-4H3,(H,22,23,24)/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.420n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM405999
PNG
((S)—N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-m...)
Show SMILES CC(C)C[C@@H](COc1ccc(Br)cc1C)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C18H28BrNO3/c1-12(2)9-15(20-17(21)23-18(4,5)6)11-22-16-8-7-14(19)10-13(16)3/h7-8,10,12,15H,9,11H2,1-6H3,(H,20,21)/t15-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.420n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311287
PNG
((S)-1-((2′-chloro-4-(difluoromethyl)-5′...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1cc(Cl)ncc1F
Show InChI InChI=1/C18H21ClF3N3O/c1-10(2)6-18(3,23)9-26-15-8-24-14(4-12(15)17(21)22)11-5-16(19)25-7-13(11)20/h4-5,7-8,10,17H,6,9,23H2,1-3H3/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.450n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311287
PNG
((S)-1-((2′-chloro-4-(difluoromethyl)-5′...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C(F)F)-c1cc(Cl)ncc1F
Show InChI InChI=1/C18H21ClF3N3O/c1-10(2)6-18(3,23)9-26-15-8-24-14(4-12(15)17(21)22)11-5-16(19)25-7-13(11)20/h4-5,7-8,10,17H,6,9,23H2,1-3H3/t18-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.450n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311232
PNG
((S)-1-(4-(7-chloroquinolin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2cc(Cl)ccc12
Show InChI InChI=1/C23H24ClF3N2O/c1-14(2)12-22(3,28)13-30-21-7-4-15(10-19(21)23(25,26)27)17-8-9-29-20-11-16(24)5-6-18(17)20/h4-11,14H,12-13,28H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.460n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311232
PNG
((S)-1-(4-(7-chloroquinolin-4-yl)-2-(trifluoromethy...)
Show SMILES CC(C)C[C@](C)(N)COc1ccc(cc1C(F)(F)F)-c1ccnc2cc(Cl)ccc12
Show InChI InChI=1/C23H24ClF3N2O/c1-14(2)12-22(3,28)13-30-21-7-4-15(10-19(21)23(25,26)27)17-8-9-29-20-11-16(24)5-6-18(17)20/h4-11,14H,12-13,28H2,1-3H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.460n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM406249
PNG
((S)-1-((6-(7-chloroquinolin-4-yl)-4-methylpyridin-...)
Show SMILES CC(C)C[C@@](C)(COc1cnc(cc1C)-c1ccnc2cc(Cl)ccc12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C27H34ClN3O3/c1-17(2)14-27(7,31-25(32)34-26(4,5)6)16-33-24-15-30-22(12-18(24)3)21-10-11-29-23-13-19(28)8-9-20(21)23/h8-13,15,17H,14,16H2,1-7H3,(H,31,32)/t27-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.470n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311158
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifl...)
Show SMILES CC(C)C[C@H](N)COc1ccc(cc1OC(F)(F)F)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1/C20H24F3N3O3/c1-12(2)8-16(24)11-28-17-5-4-14(9-18(17)29-20(21,22)23)15-6-7-25-19(10-15)26-13(3)27/h4-7,9-10,12,16H,8,11,24H2,1-3H3,(H,25,26,27)/t16-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.470n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311158
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-(trifl...)
Show SMILES CC(C)C[C@H](N)COc1ccc(cc1OC(F)(F)F)-c1ccnc(NC(C)=O)c1
Show InChI InChI=1/C20H24F3N3O3/c1-12(2)8-16(24)11-28-17-5-4-14(9-18(17)29-20(21,22)23)15-6-7-25-19(10-15)26-13(3)27/h4-7,9-10,12,16H,8,11,24H2,1-3H3,(H,25,26,27)/t16-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.470n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311374
PNG
((S)-1-((6-(7-chloroquinolin-4-yl)-4-methylpyridin-...)
Show SMILES CC(C)C[C@](C)(N)COc1cnc(cc1C)-c1ccnc2cc(Cl)ccc12
Show InChI InChI=1/C22H26ClN3O/c1-14(2)11-22(4,24)13-27-21-12-26-19(9-15(21)3)18-7-8-25-20-10-16(23)5-6-17(18)20/h5-10,12,14H,11,13,24H2,1-4H3/t22-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.470n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM406207
PNG
((S)—N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-f...)
Show SMILES CC(C)C[C@@](C)(COc1ncc(cc1Cl)-c1ccnc2cc(F)cc(F)c12)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C26H30ClF2N3O3/c1-15(2)12-26(6,32-24(33)35-25(3,4)5)14-34-23-19(27)9-16(13-31-23)18-7-8-30-21-11-17(28)10-20(29)22(18)21/h7-11,13,15H,12,14H2,1-6H3,(H,32,33)/t26-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.490n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US10351563 (2019)

More data for this
Ligand-Target Pair
AP2-associated protein kinase 1


(Homo sapiens (Human))
BDBM311332
PNG
((S)-N-(4-(4-((2-amino-4-methylpentyl)oxy)-3-fluoro...)
Show SMILES CC(C)C[C@](C)(N)COc1ncc(cc1Cl)-c1ccnc2cc(F)cc(F)c12
Show InChI InChI=1/C21H22ClF2N3O/c1-12(2)9-21(3,25)11-28-20-16(22)6-13(10-27-20)15-4-5-26-18-8-14(23)7-17(24)19(15)18/h4-8,10,12H,9,11,25H2,1-3H3/t21-/s2
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.490n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

US Patent


Assay Description
The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...


US Patent US9902722 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 473 total )  |  Next  |  Last  >>
Jump to: