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Found 78 hits of Enz. Inhib. data with enzyme = 'Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)' and Substrate = 'BDBM8978'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8980
PNG
(N-[(1-benzylpiperidin-4-yl)methyl]-2-(1,2,3,4-tetr...)
Show SMILES O=C(CNc1c2CCCCc2nc2ccccc12)NCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C28H34N4O/c33-27(29-18-21-14-16-32(17-15-21)20-22-8-2-1-3-9-22)19-30-28-23-10-4-6-12-25(23)31-26-13-7-5-11-24(26)28/h1-4,6,8-10,12,21H,5,7,11,13-20H2,(H,29,33)(H,30,31)
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n/an/a 12.4n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us...


Bioorg Med Chem Lett 14: 4639-42 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.005
BindingDB Entry DOI: 10.7270/Q23X84VR
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/a 44n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Biol Chem 271: 23646-9 (1996)


Article DOI: 10.1038/sj.bjp.0706048
BindingDB Entry DOI: 10.7270/Q2XW4H0P
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8979
PNG
(CHEMBL486901 | N-[2-(1-benzylpiperidin-4-yl)ethyl]...)
Show SMILES O=C(CNc1c2CCCCc2nc2ccccc12)NCCC1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C29H36N4O/c34-28(30-17-14-22-15-18-33(19-16-22)21-23-8-2-1-3-9-23)20-31-29-24-10-4-6-12-26(24)32-27-13-7-5-11-25(27)29/h1-4,6,8-10,12,22H,5,7,11,13-21H2,(H,30,34)(H,31,32)
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n/an/a 76n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us...


Bioorg Med Chem Lett 14: 4639-42 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.005
BindingDB Entry DOI: 10.7270/Q23X84VR
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/a 92n/an/an/an/a8.025



Shanghai Institute of Materia Medica



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. The appearance of product was monitored at 412 nm for 5 min us...


Bioorg Med Chem Lett 14: 4639-42 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.005
BindingDB Entry DOI: 10.7270/Q23X84VR
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/a 92n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 351-7 (1999)


Article DOI: 10.1016/j.bmc.2007.08.013
BindingDB Entry DOI: 10.7270/Q2T43R9Q
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8961
PNG
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Show SMILES Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)
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n/an/a 92n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10478
PNG
(A2A.2HCl | Bis-THA inhibitor 1 | CHEMBL213377 | N-...)
Show SMILES C(CNc1c2CCCCc2nc2ccccc12)Nc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C28H30N4/c1-5-13-23-19(9-1)27(20-10-2-6-14-24(20)31-23)29-17-18-30-28-21-11-3-7-15-25(21)32-26-16-8-4-12-22(26)28/h1,3,5,7,9,11,13,15H,2,4,6,8,10,12,14,16-18H2,(H,29,31)(H,30,32)
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n/an/a 102n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 351-7 (1999)


Article DOI: 10.1016/j.bmc.2007.08.013
BindingDB Entry DOI: 10.7270/Q2T43R9Q
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8964
PNG
(CHEMBL75274 | Homodimeric Tacrine Analog 3c | N-[8...)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C34H42N4/c1(3-13-23-35-33-25-15-5-9-19-29(25)37-30-20-10-6-16-26(30)33)2-4-14-24-36-34-27-17-7-11-21-31(27)38-32-22-12-8-18-28(32)34/h5,7,9,11,15,17,19,21H,1-4,6,8,10,12-14,16,18,20,22-24H2,(H,35,37)(H,36,38)
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n/an/a 105n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9440
PNG
(CHEMBL1084775 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCNc1ccnc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C29H34N4/c1(2-10-19-30-26-18-21-31-25-15-7-4-12-22(25)26)3-11-20-32-29-23-13-5-8-16-27(23)33-28-17-9-6-14-24(28)29/h4-5,7-8,12-13,15-16,18,21H,1-3,6,9-11,14,17,19-20H2,(H,30,31)(H,32,33)
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n/an/a 110n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9047
PNG
(Bis-THA inhibitor 5 | CHEMBL73800 | Hexylene-Linke...)
Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C32H38N4/c1(11-21-33-31-23-13-3-7-17-27(23)35-28-18-8-4-14-24(28)31)2-12-22-34-32-25-15-5-9-19-29(25)36-30-20-10-6-16-26(30)32/h3,5,7,9,13,15,17,19H,1-2,4,6,8,10-12,14,16,18,20-22H2,(H,33,35)(H,34,36)
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n/an/a 119n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 351-7 (1999)


Article DOI: 10.1016/j.bmc.2007.08.013
BindingDB Entry DOI: 10.7270/Q2T43R9Q
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9441
PNG
(CHEMBL1082738 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1ccnc2ccccc12
Show InChI InChI=1S/C30H36N4/c1(3-11-20-31-27-19-22-32-26-16-8-5-13-23(26)27)2-4-12-21-33-30-24-14-6-9-17-28(24)34-29-18-10-7-15-25(29)30/h5-6,8-9,13-14,16-17,19,22H,1-4,7,10-12,15,18,20-21H2,(H,31,32)(H,33,34)
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n/an/a 126n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9430
PNG
(CHEMBL1083791 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES CN(C)CCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C22H33N3/c1-25(2)17-11-5-3-4-10-16-23-22-18-12-6-8-14-20(18)24-21-15-9-7-13-19(21)22/h6,8,12,14H,3-5,7,9-11,13,15-17H2,1-2H3,(H,23,24)
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n/an/a 143n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8963
PNG
(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C33H40N4/c1(2-12-22-34-32-24-14-4-8-18-28(24)36-29-19-9-5-15-25(29)32)3-13-23-35-33-26-16-6-10-20-30(26)37-31-21-11-7-17-27(31)33/h4,6,8,10,14,16,18,20H,1-3,5,7,9,11-13,15,17,19,21-23H2,(H,34,36)(H,35,37)
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n/an/a 149n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10479
PNG
(A3A.2HCl | Bis-THA inhibitor 2 | CHEMBL378006 | N-...)
Show SMILES C(CNc1c2CCCCc2nc2ccccc12)CNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C29H32N4/c1-5-14-24-20(10-1)28(21-11-2-6-15-25(21)32-24)30-18-9-19-31-29-22-12-3-7-16-26(22)33-27-17-8-4-13-23(27)29/h1,3,5,7,10,12,14,16H,2,4,6,8-9,11,13,15,17-19H2,(H,30,32)(H,31,33)
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n/an/a 152n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 351-7 (1999)


Article DOI: 10.1016/j.bmc.2007.08.013
BindingDB Entry DOI: 10.7270/Q2T43R9Q
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10469
PNG
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C35H44N4/c1(2-4-14-24-36-34-26-16-6-10-20-30(26)38-31-21-11-7-17-27(31)34)3-5-15-25-37-35-28-18-8-12-22-32(28)39-33-23-13-9-19-29(33)35/h6,8,10,12,16,18,20,22H,1-5,7,9,11,13-15,17,19,21,23-25H2,(H,36,38)(H,37,39)
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n/an/a 155n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 351-7 (1999)


Article DOI: 10.1016/j.bmc.2007.08.013
BindingDB Entry DOI: 10.7270/Q2T43R9Q
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9442
PNG
(CHEMBL1082739 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCCNc1ccnc2ccccc12)CCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C31H38N4/c1(2-4-12-21-32-28-20-23-33-27-17-9-6-14-24(27)28)3-5-13-22-34-31-25-15-7-10-18-29(25)35-30-19-11-8-16-26(30)31/h6-7,9-10,14-15,17-18,20,23H,1-5,8,11-13,16,19,21-22H2,(H,32,33)(H,34,35)
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n/an/a 156n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9436
PNG
(CHEMBL1084096 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCNc1ccncc1
Show InChI InChI=1S/C26H34N4/c1(3-9-17-28-21-15-19-27-20-16-21)2-4-10-18-29-26-22-11-5-7-13-24(22)30-25-14-8-6-12-23(25)26/h5,7,11,13,15-16,19-20H,1-4,6,8-10,12,14,17-18H2,(H,27,28)(H,29,30)
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n/an/a 157n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10470
PNG
(Bis-THA inhibitor 1d | Bis-THA inhibitor 9 | CHEMB...)
Show SMILES C(CCCCCNc1c2CCCCc2nc2ccccc12)CCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C36H46N4/c1(3-5-15-25-37-35-27-17-7-11-21-31(27)39-32-22-12-8-18-28(32)35)2-4-6-16-26-38-36-29-19-9-13-23-33(29)40-34-24-14-10-20-30(34)36/h7,9,11,13,17,19,21,23H,1-6,8,10,12,14-16,18,20,22,24-26H2,(H,37,39)(H,38,40)
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n/an/a 167n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 351-7 (1999)


Article DOI: 10.1016/j.bmc.2007.08.013
BindingDB Entry DOI: 10.7270/Q2T43R9Q
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9431
PNG
(CHEMBL1084094 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES CN(C)CCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C23H35N3/c1-26(2)18-12-6-4-3-5-11-17-24-23-19-13-7-9-15-21(19)25-22-16-10-8-14-20(22)23/h7,9,13,15H,3-6,8,10-12,14,16-18H2,1-2H3,(H,24,25)
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n/an/a 170n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10469
PNG
(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Show SMILES C(CCCCNc1c2CCCCc2nc2ccccc12)CCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C35H44N4/c1(2-4-14-24-36-34-26-16-6-10-20-30(26)38-31-21-11-7-17-27(31)34)3-5-15-25-37-35-28-18-8-12-22-32(28)39-33-23-13-9-19-29(33)35/h6,8,10,12,16,18,20,22H,1-5,7,9,11,13-15,17,19,21,23-25H2,(H,36,38)(H,37,39)
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n/an/a 190n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Biol Chem 271: 23646-9 (1996)


Article DOI: 10.1038/sj.bjp.0706048
BindingDB Entry DOI: 10.7270/Q2XW4H0P
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9437
PNG
(CHEMBL1084530 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCCNc1ccncc1)CCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C27H36N4/c1(2-4-10-18-29-22-16-20-28-21-17-22)3-5-11-19-30-27-23-12-6-8-14-25(23)31-26-15-9-7-13-24(26)27/h6,8,12,14,16-17,20-21H,1-5,7,9-11,13,15,18-19H2,(H,28,29)(H,30,31)
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n/an/a 200n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9426
PNG
(CHEMBL258928 | Heterodimeric Tacrine-Based Inhibit...)
Show SMILES NCCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C21H31N3/c22-15-9-3-1-2-4-10-16-23-21-17-11-5-7-13-19(17)24-20-14-8-6-12-18(20)21/h5,7,11,13H,1-4,6,8-10,12,14-16,22H2,(H,23,24)
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n/an/a 202n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9432
PNG
(CHEMBL1084095 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES CN(C)CCCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C24H37N3/c1-27(2)19-13-7-5-3-4-6-12-18-25-24-20-14-8-10-16-22(20)26-23-17-11-9-15-21(23)24/h8,10,14,16H,3-7,9,11-13,15,17-19H2,1-2H3,(H,25,26)
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n/an/a 237n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10480
PNG
(A4A.2HCl | Bis-THA inhibitor 3 | CHEMBL211313 | N-...)
Show SMILES C(CCNc1c2CCCCc2nc2ccccc12)CNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C30H34N4/c1-5-15-25-21(11-1)29(22-12-2-6-16-26(22)33-25)31-19-9-10-20-32-30-23-13-3-7-17-27(23)34-28-18-8-4-14-24(28)30/h1,3,5,7,11,13,15,17H,2,4,6,8-10,12,14,16,18-20H2,(H,31,33)(H,32,34)
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n/an/a 252n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 351-7 (1999)


Article DOI: 10.1016/j.bmc.2007.08.013
BindingDB Entry DOI: 10.7270/Q2T43R9Q
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9435
PNG
(CHEMBL1084369 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCNc1ccncc1)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C25H32N4/c1(2-8-16-27-20-14-18-26-19-15-20)3-9-17-28-25-21-10-4-6-12-23(21)29-24-13-7-5-11-22(24)25/h4,6,10,12,14-15,18-19H,1-3,5,7-9,11,13,16-17H2,(H,26,27)(H,28,29)
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n/an/a 302n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM8962
PNG
(Bis-THA inhibitor 4 | CHEMBL179732 | N-[5-(1,2,3,4...)
Show SMILES C(CCNc1c2CCCCc2nc2ccccc12)CCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C31H36N4/c1(10-20-32-30-22-12-2-6-16-26(22)34-27-17-7-3-13-23(27)30)11-21-33-31-24-14-4-8-18-28(24)35-29-19-9-5-15-25(29)31/h2,4,6,8,12,14,16,18H,1,3,5,7,9-11,13,15,17,19-21H2,(H,32,34)(H,33,35)
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n/an/a 329n/an/an/an/a7.437



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 351-7 (1999)


Article DOI: 10.1016/j.bmc.2007.08.013
BindingDB Entry DOI: 10.7270/Q2T43R9Q
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10442
PNG
(9-N-heptyl-amino-1,2,3,4-tetrahydroacridine hydroc...)
Show SMILES CCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C20H28N2/c1-2-3-4-5-10-15-21-20-16-11-6-8-13-18(16)22-19-14-9-7-12-17(19)20/h6,8,11,13H,2-5,7,9-10,12,14-15H2,1H3,(H,21,22)
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n/an/a 340n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9425
PNG
(CHEMBL1083789 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES NCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C20H29N3/c21-14-8-2-1-3-9-15-22-20-16-10-4-6-12-18(16)23-19-13-7-5-11-17(19)20/h4,6,10,12H,1-3,5,7-9,11,13-15,21H2,(H,22,23)
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n/an/a 357n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9439
PNG
(Heterodimeric Tacrine-Based Inhibitor 7k | N-4-Pyr...)
Show SMILES C(CCCCCCNc1c2CCCCc2nc2ccccc12)CCCCCNc1ccncc1
Show InChI InChI=1S/C30H42N4/c1(3-5-7-13-21-32-25-19-23-31-24-20-25)2-4-6-8-14-22-33-30-26-15-9-11-17-28(26)34-29-18-12-10-16-27(29)30/h9,11,15,17,19-20,23-24H,1-8,10,12-14,16,18,21-22H2,(H,31,32)(H,33,34)
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n/an/a 377n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9438
PNG
(CHEMBL1084531 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES C(CCCCCNc1c2CCCCc2nc2ccccc12)CCCCNc1ccncc1
Show InChI InChI=1S/C28H38N4/c1(3-5-11-19-30-23-17-21-29-22-18-23)2-4-6-12-20-31-28-24-13-7-9-15-26(24)32-27-16-10-8-14-25(27)28/h7,9,13,15,17-18,21-22H,1-6,8,10-12,14,16,19-20H2,(H,29,30)(H,31,32)
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n/an/a 427n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10470
PNG
(Bis-THA inhibitor 1d | Bis-THA inhibitor 9 | CHEMB...)
Show SMILES C(CCCCCNc1c2CCCCc2nc2ccccc12)CCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C36H46N4/c1(3-5-15-25-37-35-27-17-7-11-21-31(27)39-32-22-12-8-18-28(32)35)2-4-6-16-26-38-36-29-19-9-13-23-33(29)40-34-24-14-10-20-30(34)36/h7,9,11,13,17,19,21,23H,1-6,8,10,12,14-16,18,20,22,24-26H2,(H,37,39)(H,38,40)
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n/an/a 440n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Biol Chem 271: 23646-9 (1996)


Article DOI: 10.1038/sj.bjp.0706048
BindingDB Entry DOI: 10.7270/Q2XW4H0P
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10472
PNG
(N-(5-phenylpentyl)-1,2,3,4-tetrahydroacridin-9-ami...)
Show SMILES C(CCNc1c2CCCCc2nc2ccccc12)CCc1ccccc1
Show InChI InChI=1S/C24H28N2/c1-3-11-19(12-4-1)13-5-2-10-18-25-24-20-14-6-8-16-22(20)26-23-17-9-7-15-21(23)24/h1,3-4,6,8,11-12,14,16H,2,5,7,9-10,13,15,17-18H2,(H,25,26)
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n/an/a 520n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Biol Chem 271: 23646-9 (1996)


Article DOI: 10.1038/sj.bjp.0706048
BindingDB Entry DOI: 10.7270/Q2XW4H0P
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9433
PNG
(CHEMBL1084367 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES CN(C)CCCCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C25H39N3/c1-28(2)20-14-8-6-4-3-5-7-13-19-26-25-21-15-9-11-17-23(21)27-24-18-12-10-16-22(24)25/h9,11,15,17H,3-8,10,12-14,16,18-20H2,1-2H3,(H,26,27)
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n/an/a 581n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9428
PNG
(CHEMBL1084092 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES NCCCCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C23H35N3/c24-17-11-5-3-1-2-4-6-12-18-25-23-19-13-7-9-15-21(19)26-22-16-10-8-14-20(22)23/h7,9,13,15H,1-6,8,10-12,14,16-18,24H2,(H,25,26)
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n/an/a 682n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9427
PNG
(CHEMBL1083790 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES NCCCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C22H33N3/c23-16-10-4-2-1-3-5-11-17-24-22-18-12-6-8-14-20(18)25-21-15-9-7-13-19(21)22/h6,8,12,14H,1-5,7,9-11,13,15-17,23H2,(H,24,25)
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n/an/a 687n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9434
PNG
(CHEMBL1084368 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES CN(C)CCCCCCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C27H43N3/c1-30(2)22-16-10-8-6-4-3-5-7-9-15-21-28-27-23-17-11-13-19-25(23)29-26-20-14-12-18-24(26)27/h11,13,17,19H,3-10,12,14-16,18,20-22H2,1-2H3,(H,28,29)
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n/an/a 695n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM9429
PNG
(CHEMBL1084093 | Heterodimeric Tacrine-Based Inhibi...)
Show SMILES NCCCCCCCCCCCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C25H39N3/c26-19-13-7-5-3-1-2-4-6-8-14-20-27-25-21-15-9-11-17-23(21)28-24-18-12-10-16-22(24)25/h9,11,15,17H,1-8,10,12-14,16,18-20,26H2,(H,27,28)
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n/an/a 791n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Med Chem 42: 4225-31 (1999)


Article DOI: 10.1021/jm990224w
BindingDB Entry DOI: 10.7270/Q2W957CH
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10473
PNG
(N-(6-phenylhexyl)-1,2,3,4-tetrahydroacridin-9-amin...)
Show SMILES C(CCCc1ccccc1)CCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C25H30N2/c1(4-12-20-13-5-3-6-14-20)2-11-19-26-25-21-15-7-9-17-23(21)27-24-18-10-8-16-22(24)25/h3,5-7,9,13-15,17H,1-2,4,8,10-12,16,18-19H2,(H,26,27)
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n/an/a 810n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Biol Chem 271: 23646-9 (1996)


Article DOI: 10.1038/sj.bjp.0706048
BindingDB Entry DOI: 10.7270/Q2XW4H0P
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10474
PNG
(N-(7-phenylheptyl)-1,2,3,4-tetrahydroacridin-9-ami...)
Show SMILES C(CCCNc1c2CCCCc2nc2ccccc12)CCCc1ccccc1
Show InChI InChI=1S/C26H32N2/c1(2-5-13-21-14-6-4-7-15-21)3-12-20-27-26-22-16-8-10-18-24(22)28-25-19-11-9-17-23(25)26/h4,6-8,10,14-16,18H,1-3,5,9,11-13,17,19-20H2,(H,27,28)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Biol Chem 271: 23646-9 (1996)


Article DOI: 10.1038/sj.bjp.0706048
BindingDB Entry DOI: 10.7270/Q2XW4H0P
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10453
PNG
(Bivalent 4-Aminoquinoline 9g | N-[8-(quinolin-4-yl...)
Show SMILES C(CCCCNc1ccnc2ccccc12)CCCNc1ccnc2ccccc12
Show InChI InChI=1S/C26H30N4/c1(3-9-17-27-25-15-19-29-23-13-7-5-11-21(23)25)2-4-10-18-28-26-16-20-30-24-14-8-6-12-22(24)26/h5-8,11-16,19-20H,1-4,9-10,17-18H2,(H,27,29)(H,28,30)
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n/an/a 1.06E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10454
PNG
(Bivalent 4-Aminoquinoline 9h | N-[9-(quinolin-4-yl...)
Show SMILES C(CCCCNc1ccnc2ccccc12)CCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C27H32N4/c1(2-4-10-18-28-26-16-20-30-24-14-8-6-12-22(24)26)3-5-11-19-29-27-17-21-31-25-15-9-7-13-23(25)27/h6-9,12-17,20-21H,1-5,10-11,18-19H2,(H,28,30)(H,29,31)
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n/an/a 1.57E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10445
PNG
(2-methyl-N-{8-[(2-methylquinolin-4-yl)amino]octyl}...)
Show SMILES Cc1cc(NCCCCCCCCNc2cc(C)nc3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C28H34N4/c1-21-19-27(23-13-7-9-15-25(23)31-21)29-17-11-5-3-4-6-12-18-30-28-20-22(2)32-26-16-10-8-14-24(26)28/h7-10,13-16,19-20H,3-6,11-12,17-18H2,1-2H3,(H,29,31)(H,30,32)
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n/an/a 1.78E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10452
PNG
(Bivalent 4-Aminoquinoline 9f | N,N-di-4-Quinolyl-1...)
Show SMILES C(CCCNc1ccnc2ccccc12)CCCNc1ccnc2ccccc12
Show InChI InChI=1S/C25H28N4/c1(2-8-16-26-24-14-18-28-22-12-6-4-10-20(22)24)3-9-17-27-25-15-19-29-23-13-7-5-11-21(23)25/h4-7,10-15,18-19H,1-3,8-9,16-17H2,(H,26,28)(H,27,29)
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n/an/a 1.80E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10446
PNG
(2-methyl-N-{9-[(2-methylquinolin-4-yl)amino]nonyl}...)
Show SMILES Cc1cc(NCCCCCCCCCNc2cc(C)nc3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C29H36N4/c1-22-20-28(24-14-8-10-16-26(24)32-22)30-18-12-6-4-3-5-7-13-19-31-29-21-23(2)33-27-17-11-9-15-25(27)29/h8-11,14-17,20-21H,3-7,12-13,18-19H2,1-2H3,(H,30,32)(H,31,33)
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n/an/a 2.13E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10455
PNG
(Bivalent 4-Aminoquinoline 9i | N-[10-(quinolin-4-y...)
Show SMILES C(CCCCCNc1ccnc2ccccc12)CCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C28H34N4/c1(3-5-11-19-29-27-17-21-31-25-15-9-7-13-23(25)27)2-4-6-12-20-30-28-18-22-32-26-16-10-8-14-24(26)28/h7-10,13-18,21-22H,1-6,11-12,19-20H2,(H,29,31)(H,30,32)
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n/an/a 2.15E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10475
PNG
(N-(8-phenyloctyl)-1,2,3,4-tetrahydroacridin-9-amin...)
Show SMILES C(CCCCc1ccccc1)CCCNc1c2CCCCc2nc2ccccc12
Show InChI InChI=1S/C27H34N2/c1(3-6-14-22-15-7-5-8-16-22)2-4-13-21-28-27-23-17-9-11-19-25(23)29-26-20-12-10-18-24(26)27/h5,7-9,11,15-17,19H,1-4,6,10,12-14,18,20-21H2,(H,28,29)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


J Biol Chem 271: 23646-9 (1996)


Article DOI: 10.1038/sj.bjp.0706048
BindingDB Entry DOI: 10.7270/Q2XW4H0P
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10451
PNG
(Bivalent 4-Aminoquinoline 9e | N-[6-(quinolin-4-yl...)
Show SMILES C(CCCNc1ccnc2ccccc12)CCNc1ccnc2ccccc12
Show InChI InChI=1S/C24H26N4/c1(7-15-25-23-13-17-27-21-11-5-3-9-19(21)23)2-8-16-26-24-14-18-28-22-12-6-4-10-20(22)24/h3-6,9-14,17-18H,1-2,7-8,15-16H2,(H,25,27)(H,26,28)
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n/an/a 2.73E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10456
PNG
(Bivalent 4-Aminoquinoline 9k | N-[12-(quinolin-4-y...)
Show SMILES C(CCCCCCNc1ccnc2ccccc12)CCCCCNc1ccnc2ccccc12
Show InChI InChI=1S/C30H38N4/c1(3-5-7-13-21-31-29-19-23-33-27-17-11-9-15-25(27)29)2-4-6-8-14-22-32-30-20-24-34-28-18-12-10-16-26(28)30/h9-12,15-20,23-24H,1-8,13-14,21-22H2,(H,31,33)(H,32,34)
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n/an/a 2.92E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10444
PNG
(2-methyl-N-{7-[(2-methylquinolin-4-yl)amino]heptyl...)
Show SMILES Cc1cc(NCCCCCCCNc2cc(C)nc3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C27H32N4/c1-20-18-26(22-12-6-8-14-24(22)30-20)28-16-10-4-3-5-11-17-29-27-19-21(2)31-25-15-9-7-13-23(25)27/h6-9,12-15,18-19H,3-5,10-11,16-17H2,1-2H3,(H,28,30)(H,29,31)
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n/an/a 2.94E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
Acetylcholinesterase and butyrylcholinesterase (AChE and BChE)


(Rattus norvegicus (rat))
BDBM10447
PNG
(2-methyl-N-{10-[(2-methylquinolin-4-yl)amino]decyl...)
Show SMILES Cc1cc(NCCCCCCCCCCNc2cc(C)nc3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C30H38N4/c1-23-21-29(25-15-9-11-17-27(25)33-23)31-19-13-7-5-3-4-6-8-14-20-32-30-22-24(2)34-28-18-12-10-16-26(28)30/h9-12,15-18,21-22H,3-8,13-14,19-20H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 2.98E+3n/an/an/an/an/an/a



Hong Kong University of Science and Technology



Assay Description
The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...


Bioorg Med Chem 7: 2569-75 (1999)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q22N50GZ
More data for this
Ligand-Target Pair
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