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Found 110 hits of Enz. Inhib. data with enzyme = 'Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253625
PNG
(US9701672, 56)
Show SMILES FC(F)(F)CCCOc1ccc(c(Cl)c1)[C@@]1(CC(c2ccc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C24H20ClF6N5O2S/c25-16-10-13(38-9-1-8-23(26,27)28)4-5-15(16)22(24(29,30)31)11-14(18-7-6-17(39-18)12-2-3-12)19(21(37)32-22)20-33-35-36-34-20/h4-7,10,12H,1-3,8-9,11H2,(H,32,37)(H,33,34,35,36)/t22-/m0/s1
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n/an/a 0.200n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253635
PNG
(US9701672, 66)
Show SMILES CCc1cnc(s1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C24H23F7N6O2S/c1-2-14-12-32-21(40-14)15-11-22(24(29,30)31,33-20(38)18(15)19-34-36-37-35-19)16-7-6-13(10-17(16)25)39-9-5-3-4-8-23(26,27)28/h6-7,10,12H,2-5,8-9,11H2,1H3,(H,33,38)(H,34,35,36,37)/t22-/m0/s1
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n/an/a 0.5n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253632
PNG
(US9701672, 63)
Show SMILES FC(F)(F)CCCCCOc1ccc(c(Cl)c1)[C@@]1(CC(c2ncc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C25H23ClF6N6O2S/c26-17-10-14(40-9-3-1-2-8-24(27,28)29)6-7-16(17)23(25(30,31)32)11-15(22-33-12-18(41-22)13-4-5-13)19(21(39)34-23)20-35-37-38-36-20/h6-7,10,12-13H,1-5,8-9,11H2,(H,34,39)(H,35,36,37,38)/t23-/m0/s1
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n/an/a 0.700n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247150
PNG
((S,E)-2-Methyl-N-(2,2,2-trifluoro-1-(4-((5,5,5-tri...)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C24H20F7N5O2S/c25-16-10-13(38-9-1-8-23(26,27)28)4-5-15(16)22(24(29,30)31)11-14(18-7-6-17(39-18)12-2-3-12)19(21(37)32-22)20-33-35-36-34-20/h4-7,10,12H,1-3,8-9,11H2,(H,32,37)(H,33,34,35,36)/t22-/m0/s1
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n/an/a 0.900n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253633
PNG
(US9701672, 64)
Show SMILES FC(F)(F)CCCOc1ccc(c(Cl)c1)[C@@]1(CC(c2ncc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C23H19ClF6N6O2S/c24-15-8-12(38-7-1-6-22(25,26)27)4-5-14(15)21(23(28,29)30)9-13(20-31-10-16(39-20)11-2-3-11)17(19(37)32-21)18-33-35-36-34-18/h4-5,8,10-11H,1-3,6-7,9H2,(H,32,37)(H,33,34,35,36)/t21-/m0/s1
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n/an/a 1.10n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247150
PNG
((S,E)-2-Methyl-N-(2,2,2-trifluoro-1-(4-((5,5,5-tri...)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C24H20F7N5O2S/c25-16-10-13(38-9-1-8-23(26,27)28)4-5-15(16)22(24(29,30)31)11-14(18-7-6-17(39-18)12-2-3-12)19(21(37)32-22)20-33-35-36-34-20/h4-7,10,12H,1-3,8-9,11H2,(H,32,37)(H,33,34,35,36)/t22-/m0/s1
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n/an/a 1.10n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247168
PNG
(1-(5-Cyclopropylthiazol-2-yl)ethanone | US9701672,...)
Show SMILES FC(F)(F)CCCCc1ccc(cc1)[C@@]1(CC(c2ccn(CC3CC3)n2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C25H25F6N7O/c26-24(27,28)11-2-1-3-15-6-8-17(9-7-15)23(25(29,30)31)13-18(19-10-12-38(35-19)14-16-4-5-16)20(22(39)32-23)21-33-36-37-34-21/h6-10,12,16H,1-5,11,13-14H2,(H,32,39)(H,33,34,36,37)/t23-/m0/s1
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n/an/a 1.20n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253626
PNG
(US9701672, 57)
Show SMILES COc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C25H23F6N5O3S/c1-38-17-11-14(39-10-2-9-24(26,27)28)5-6-16(17)23(25(29,30)31)12-15(19-8-7-18(40-19)13-3-4-13)20(22(37)32-23)21-33-35-36-34-21/h5-8,11,13H,2-4,9-10,12H2,1H3,(H,32,37)(H,33,34,35,36)/t23-/m0/s1
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n/an/a 1.40n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253628
PNG
(US9701672, 59)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ncc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C23H19F7N6O2S/c24-15-8-12(38-7-1-6-22(25,26)27)4-5-14(15)21(23(28,29)30)9-13(20-31-10-16(39-20)11-2-3-11)17(19(37)32-21)18-33-35-36-34-18/h4-5,8,10-11H,1-3,6-7,9H2,(H,32,37)(H,33,34,35,36)/t21-/m0/s1
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US Patent
n/an/a 1.40n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247154
PNG
(1-(5-Methylthiazol-2-yl)ethanone | US9701672, 8)
Show SMILES FC(F)(F)CCCCCOc1ccc(cc1)[C@@]1(CC(c2ccc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C26H25F6N5O2S/c27-25(28,29)12-2-1-3-13-39-17-8-6-16(7-9-17)24(26(30,31)32)14-18(20-11-10-19(40-20)15-4-5-15)21(23(38)33-24)22-34-36-37-35-22/h6-11,15H,1-5,12-14H2,(H,33,38)(H,34,35,36,37)/t24-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253649
PNG
((S)—N-(4-(5-Ethylthiophen-2-yl)-2-oxo-6-(4-((...)
Show SMILES CCc1ccc(s1)C1=C(NC(=O)CS(C)(=O)=O)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C27H30F6N2O5S2/c1-3-19-11-12-21(41-19)20-15-25(27(31,32)33,35-24(37)23(20)34-22(36)16-42(2,38)39)17-7-9-18(10-8-17)40-14-6-4-5-13-26(28,29)30/h7-12H,3-6,13-16H2,1-2H3,(H,34,36)(H,35,37)/t25-/m0/s1
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n/an/a 1.5n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM272063
PNG
(US10065945, Example 57)
Show SMILES C[C@@H](N1CCc2ccc(cc2C1)S(=O)(=O)Nc1nc(no1)C(=O)N1CCCC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C24H25F2N5O4S/c1-15(17-10-19(25)13-20(26)11-17)31-9-6-16-4-5-21(12-18(16)14-31)36(33,34)29-24-27-22(28-35-24)23(32)30-7-2-3-8-30/h4-5,10-13,15H,2-3,6-9,14H2,1H3,(H,27,28,29)/t15-/m1/s1
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n/an/a 1.60n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A solution of 1 M LiHMDS in THF (51.7 ml, 51.7 mmol) was added dropwise to a mixture of Intermediate 3 (7.5 g, 17.2 mmol) and 5-(tert-butyl)-4-methyl...


US Patent US10065945 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM289045
PNG
(US10093650, Example 22)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ncc([nH]2)C2CC2)=C(C(=O)N1)n1nn[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C23H20F7N7O3/c24-15-8-12(40-7-1-6-22(25,26)27)4-5-14(15)21(23(28,29)30)9-13(18-31-10-16(32-18)11-2-3-11)17(19(38)33-21)37-20(39)34-35-36-37/h4-5,8,10-11H,1-3,6-7,9H2,(H,31,32)(H,33,38)(H,34,36,39)/t21-/m0/s1
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n/an/a 2n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253631
PNG
(US9701672, 62)
Show SMILES CCc1cnc(s1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C22H19F7N6O2S/c1-2-12-10-30-19(38-12)13-9-20(22(27,28)29,31-18(36)16(13)17-32-34-35-33-17)14-5-4-11(8-15(14)23)37-7-3-6-21(24,25)26/h4-5,8,10H,2-3,6-7,9H2,1H3,(H,31,36)(H,32,33,34,35)/t20-/m0/s1
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n/an/a 2.10n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247169
PNG
(1-(5-Ethylthiazol-2-yl)ethanone | US9701672, 23)
Show SMILES CC(C)n1ccc(n1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(CCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C24H25F6N7O/c1-14(2)37-12-10-18(34-37)17-13-22(24(28,29)30,31-21(38)19(17)20-32-35-36-33-20)16-8-6-15(7-9-16)5-3-4-11-23(25,26)27/h6-10,12,14H,3-5,11,13H2,1-2H3,(H,31,38)(H,32,33,35,36)/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253627
PNG
(US9701672, 58)
Show SMILES CCc1ccc(s1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C25H25F6N5O2S/c1-2-17-10-11-19(39-17)18-14-23(25(29,30)31,32-22(37)20(18)21-33-35-36-34-21)15-6-8-16(9-7-15)38-13-5-3-4-12-24(26,27)28/h6-11H,2-5,12-14H2,1H3,(H,32,37)(H,33,34,35,36)/t23-/m0/s1
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n/an/a 2.20n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247152
PNG
(1-(5-Cyclopropylthiophen-2-yl)ethanone | US9701672...)
Show SMILES CCCCCCC#C[C@@]1(CC(c2ccc(Br)s2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C19H19BrF3N5OS/c1-2-3-4-5-6-7-10-18(19(21,22)23)11-12(13-8-9-14(20)30-13)15(17(29)24-18)16-25-27-28-26-16/h8-9H,2-6,11H2,1H3,(H,24,29)(H,25,26,27,28)/t18-/m1/s1
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n/an/a 2.20n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247056
PNG
((S,E)-2-Methyl-N-(2,2,2-trifluoro-1-(4-(4,4,4-trif...)
Show SMILES CC(C)(C)[S@](=O)\N=C(/c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C16H19F6NO2S/c1-14(2,3)26(24)23-13(16(20,21)22)11-5-7-12(8-6-11)25-10-4-9-15(17,18)19/h5-8H,4,9-10H2,1-3H3/b23-13+/t26-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM252410
PNG
(US9701672, 47)
Show SMILES Fc1cc(CCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(n2)C2CCC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C25H24F7N7O/c26-18-12-14(4-1-2-10-24(27,28)29)7-8-17(18)23(25(30,31)32)13-16(19-9-11-39(36-19)15-5-3-6-15)20(22(40)33-23)21-34-37-38-35-21/h7-9,11-12,15H,1-6,10,13H2,(H,33,40)(H,34,35,37,38)/t23-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM249008
PNG
(US9701672, 30)
Show SMILES FC(F)(F)CCCCCOc1ccc(cc1)[C@@]1(CC(c2ccn(CC3CC3)n2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C26H27F6N7O2/c27-25(28,29)11-2-1-3-13-41-18-8-6-17(7-9-18)24(26(30,31)32)14-19(20-10-12-39(36-20)15-16-4-5-16)21(23(40)33-24)22-34-37-38-35-22/h6-10,12,16H,1-5,11,13-15H2,(H,33,40)(H,34,35,37,38)/t24-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM289043
PNG
(US10093650, Example 20)
Show SMILES FC(F)(F)CCCCc1ccc(cc1)[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)N1)n1nn[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C25H25F6N7O2/c26-24(27,28)11-2-1-3-15-6-8-17(9-7-15)23(25(29,30)31)13-18(19-10-12-37(34-19)14-16-4-5-16)20(21(39)32-23)38-22(40)33-35-36-38/h6-10,12,16H,1-5,11,13-14H2,(H,32,39)(H,33,36,40)/t23-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM249861
PNG
(US9701672, 42)
Show SMILES Fc1cc(CCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C25H24F7N7O/c26-18-11-14(3-1-2-9-24(27,28)29)6-7-17(18)23(25(30,31)32)12-16(19-8-10-39(36-19)13-15-4-5-15)20(22(40)33-23)21-34-37-38-35-21/h6-8,10-11,15H,1-5,9,12-13H2,(H,33,40)(H,34,35,37,38)/t23-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253621
PNG
(US9701672, 52)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C24H22F7N7O2/c25-17-10-14(40-9-1-7-23(26,27)28)4-5-16(17)22(24(29,30)31)11-15(18-6-8-38(35-18)12-13-2-3-13)19(21(39)32-22)20-33-36-37-34-20/h4-6,8,10,13H,1-3,7,9,11-12H2,(H,32,39)(H,33,34,36,37)/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM251745
PNG
(US9701672, 45)
Show SMILES CN(C)c1cnc(s1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C23H23F6N7O2S/c1-36(2)16-12-30-20(39-16)15-11-21(23(27,28)29,31-19(37)17(15)18-32-34-35-33-18)13-5-7-14(8-6-13)38-10-4-3-9-22(24,25)26/h5-8,12H,3-4,9-11H2,1-2H3,(H,31,37)(H,32,33,34,35)/t21-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM272061
PNG
(US10065945, Example 55)
Show SMILES C[C@@H](N1CCc2ccc(cc2C1)S(=O)(=O)Nc1nc(no1)C(=O)N1CCC1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C23H23F2N5O4S/c1-14(16-9-18(24)12-19(25)10-16)30-8-5-15-3-4-20(11-17(15)13-30)35(32,33)28-23-26-21(27-34-23)22(31)29-6-2-7-29/h3-4,9-12,14H,2,5-8,13H2,1H3,(H,26,27,28)/t14-/m1/s1
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n/an/a 3.70n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A solution of 1 M LiHMDS in THF (51.7 ml, 51.7 mmol) was added dropwise to a mixture of Intermediate 3 (7.5 g, 17.2 mmol) and 5-(tert-butyl)-4-methyl...


US Patent US10065945 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253652
PNG
(US9701672, 76)
Show SMILES COc1ccc(NC(=O)C2=C(C[C@](NC2=O)(c2ccc(OCCCC(F)(F)F)cc2)C(F)(F)F)c2ccn(n2)C2CC2)cc1
Show InChI InChI=1S/C30H28F6N4O4/c1-43-21-11-5-19(6-12-21)37-26(41)25-23(24-13-15-40(39-24)20-7-8-20)17-28(30(34,35)36,38-27(25)42)18-3-9-22(10-4-18)44-16-2-14-29(31,32)33/h3-6,9-13,15,20H,2,7-8,14,16-17H2,1H3,(H,37,41)(H,38,42)/t28-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253618
PNG
(US9701672, 49)
Show SMILES CCn1ccc(n1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(CCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C23H22F7N7O/c1-2-37-10-8-17(34-37)14-12-21(23(28,29)30,31-20(38)18(14)19-32-35-36-33-19)15-7-6-13(11-16(15)24)5-3-4-9-22(25,26)27/h6-8,10-11H,2-5,9,12H2,1H3,(H,31,38)(H,32,33,35,36)/t21-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM289021
PNG
(US10093650, Example 17)
Show SMILES FC(F)(F)CCCCCCn1cc(cn1)[C@@]1(CC(=C(C(=O)N1)n1nn[nH]c1=O)c1ccc2CCCCc2c1)C(F)(F)F
Show InChI InChI=1S/C27H29F6N7O2/c28-26(29,30)11-5-1-2-6-12-39-16-20(15-34-39)25(27(31,32)33)14-21(19-10-9-17-7-3-4-8-18(17)13-19)22(23(41)35-25)40-24(42)36-37-38-40/h9-10,13,15-16H,1-8,11-12,14H2,(H,35,41)(H,36,38,42)/t25-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM38176
PNG
(US10093650, Example 2)
Show SMILES Cc1ccc(cc1)C1=C(C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F)n1nn[nH]c1=O
Show InChI InChI=1S/C15H10F2N2O3/c16-11-4-3-5-12(17)10(11)9-22-19-14-7-2-1-6-13(14)18(21)8-15(19)20/h1-8H,9H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM289003
PNG
(US10093650, Example 14 | US10093650, Example 16)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)N1)n1nn[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C24H22F7N7O3/c25-17-10-14(41-9-1-7-23(26,27)28)4-5-16(17)22(24(29,30)31)11-15(18-6-8-37(34-18)12-13-2-3-13)19(20(39)32-22)38-21(40)33-35-36-38/h4-6,8,10,13H,1-3,7,9,11-12H2,(H,32,39)(H,33,36,40)/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM289003
PNG
(US10093650, Example 14 | US10093650, Example 16)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)N1)n1nn[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C24H22F7N7O3/c25-17-10-14(41-9-1-7-23(26,27)28)4-5-16(17)22(24(29,30)31)11-15(18-6-8-37(34-18)12-13-2-3-13)19(20(39)32-22)38-21(40)33-35-36-38/h4-6,8,10,13H,1-3,7,9,11-12H2,(H,32,39)(H,33,36,40)/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM272062
PNG
(US10065945, Example 56)
Show SMILES C[C@@H](N1CCc2ccc(cc2C1)S(=O)(=O)Nc1nc(no1)C(=O)N(C)C)c1cc(F)cc(F)c1
Show InChI InChI=1S/C22H23F2N5O4S/c1-13(15-8-17(23)11-18(24)9-15)29-7-6-14-4-5-19(10-16(14)12-29)34(31,32)27-22-25-20(26-33-22)21(30)28(2)3/h4-5,8-11,13H,6-7,12H2,1-3H3,(H,25,26,27)/t13-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A solution of 1 M LiHMDS in THF (51.7 ml, 51.7 mmol) was added dropwise to a mixture of Intermediate 3 (7.5 g, 17.2 mmol) and 5-(tert-butyl)-4-methyl...


US Patent US10065945 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM249850
PNG
(US9701672, 40)
Show SMILES Fc1cc(OCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(n2)C2CCC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C24H22F7N7O2/c25-17-11-14(40-10-2-8-23(26,27)28)5-6-16(17)22(24(29,30)31)12-15(18-7-9-38(35-18)13-3-1-4-13)19(21(39)32-22)20-33-36-37-34-20/h5-7,9,11,13H,1-4,8,10,12H2,(H,32,39)(H,33,34,36,37)/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM272059
PNG
(US10065945, Example 53)
Show SMILES CCNC(=O)c1noc(NS(=O)(=O)c2ccc3CCN(Cc3c2)[C@H](C)c2cc(F)cc(F)c2)n1
Show InChI InChI=1S/C22H23F2N5O4S/c1-3-25-21(30)20-26-22(33-27-20)28-34(31,32)19-5-4-14-6-7-29(12-16(14)10-19)13(2)15-8-17(23)11-18(24)9-15/h4-5,8-11,13H,3,6-7,12H2,1-2H3,(H,25,30)(H,26,27,28)/t13-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
A solution of 1 M LiHMDS in THF (51.7 ml, 51.7 mmol) was added dropwise to a mixture of Intermediate 3 (7.5 g, 17.2 mmol) and 5-(tert-butyl)-4-methyl...


US Patent US10065945 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253624
PNG
(US9701672, 55)
Show SMILES CCCCCCn1cc(cn1)[C@@]1(CC(c2ccc(s2)C2CC2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C23H26F3N7OS/c1-2-3-4-5-10-33-13-15(12-27-33)22(23(24,25)26)11-16(18-9-8-17(35-18)14-6-7-14)19(21(34)28-22)20-29-31-32-30-20/h8-9,12-14H,2-7,10-11H2,1H3,(H,28,34)(H,29,30,31,32)/t22-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247151
PNG
((S,E)-2-Methyl-N-(1,1,1-trifluorodec-3-yn-2-yliden...)
Show SMILES CCCCCCC#C[C@@]1(CC(c2ccc(Cl)s2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C19H19ClF3N5OS/c1-2-3-4-5-6-7-10-18(19(21,22)23)11-12(13-8-9-14(20)30-13)15(17(29)24-18)16-25-27-28-26-16/h8-9H,2-6,11H2,1H3,(H,24,29)(H,25,26,27,28)/t18-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM289026
PNG
(US10093650, Example 18)
Show SMILES CC(=O)c1ccc(s1)C1=C(C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F)n1nn[nH]c1=O
Show InChI InChI=1S/C23H19F6N5O4S/c1-12(35)16-7-8-17(39-16)15-11-21(23(27,28)29,30-19(36)18(15)34-20(37)31-32-33-34)13-3-5-14(6-4-13)38-10-2-9-22(24,25)26/h3-8H,2,9-11H2,1H3,(H,30,36)(H,31,33,37)/t21-/m0/s1
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n/an/a 8n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM271895
PNG
(US10065945, Example 7)
Show SMILES CCc1noc(NS(=O)(=O)c2ccc3CCN(Cc3c2)[C@H](C)c2ccc(OCC(F)(F)F)nc2)n1
Show InChI InChI=1S/C22H24F3N5O4S/c1-3-19-27-21(34-28-19)29-35(31,32)18-6-4-15-8-9-30(12-17(15)10-18)14(2)16-5-7-20(26-11-16)33-13-22(23,24)25/h4-7,10-11,14H,3,8-9,12-13H2,1-2H3,(H,27,28,29)/t14-/m1/s1
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US Patent
n/an/a 8.10n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A solution of 1 M LiHMDS in THF (51.7 ml, 51.7 mmol) was added dropwise to a mixture of Intermediate 3 (7.5 g, 17.2 mmol) and 5-(tert-butyl)-4-methyl...


US Patent US10065945 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM251746
PNG
(US9701672, 46 | US9701672, 48)
Show SMILES CC(C)n1ccc(n1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(CCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C24H24F7N7O/c1-13(2)38-10-8-18(35-38)15-12-22(24(29,30)31,32-21(39)19(15)20-33-36-37-34-20)16-7-6-14(11-17(16)25)5-3-4-9-23(26,27)28/h6-8,10-11,13H,3-5,9,12H2,1-2H3,(H,32,39)(H,33,34,36,37)/t22-/m0/s1
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n/an/a 8.80n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253634
PNG
(US9701672, 65)
Show SMILES CCc1ccc(s1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(Br)cc1)C(F)(F)F
Show InChI InChI=1S/C19H15BrF3N5OS/c1-2-12-7-8-14(30-12)13-9-18(19(21,22)23,10-3-5-11(20)6-4-10)24-17(29)15(13)16-25-27-28-26-16/h3-8H,2,9H2,1H3,(H,24,29)(H,25,26,27,28)/t18-/m0/s1
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n/an/a 8.80n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM211296
PNG
(US10093650, Example 11)
Show SMILES Fc1cc(CCCCC(F)(F)F)ccc1[C@@]1(CC(c2ccn(CC3CC3)n2)=C(C(=O)N1)n1nn[nH]c1=O)C(F)(F)F
Show InChI InChI=1S/C14H15N5O5/c1-7-10(8(2)24-17-7)6-18-5-9(4-15-18)19-13(22)11(3-12(20)21)16-14(19)23/h4-5,11H,3,6H2,1-2H3,(H,16,23)(H,20,21)
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n/an/a 9n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM247153
PNG
(1-(5-((Dimethylamino)methyl)thiophen-2-yl)ethanone...)
Show SMILES FC(F)(F)CCCOc1ccc(cc1)[C@@]1(CC(c2cc3ccccc3s2)=C(c2nnn[nH]2)C(=O)N1)C(F)(F)F
Show InChI InChI=1S/C25H19F6N5O2S/c26-24(27,28)10-3-11-38-16-8-6-15(7-9-16)23(25(29,30)31)13-17(19-12-14-4-1-2-5-18(14)39-19)20(22(37)32-23)21-33-35-36-34-21/h1-2,4-9,12H,3,10-11,13H2,(H,32,37)(H,33,34,35,36)/t23-/m0/s1
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n/an/a 9n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM271894
PNG
(US10065945, Example 6)
Show SMILES C[C@@H](N1CCc2ccc(cc2C1)S(=O)(=O)Nc1noc(n1)-c1ccccc1)c1ccc(OCC(F)(F)F)nc1
Show InChI InChI=1S/C26H24F3N5O4S/c1-17(20-8-10-23(30-14-20)37-16-26(27,28)29)34-12-11-18-7-9-22(13-21(18)15-34)39(35,36)33-25-31-24(38-32-25)19-5-3-2-4-6-19/h2-10,13-14,17H,11-12,15-16H2,1H3,(H,32,33)/t17-/m1/s1
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n/an/a 9.20n/an/an/an/an/a25



Merck Sharp & Dohme Corp.

US Patent


Assay Description
A solution of 1 M LiHMDS in THF (51.7 ml, 51.7 mmol) was added dropwise to a mixture of Intermediate 3 (7.5 g, 17.2 mmol) and 5-(tert-butyl)-4-methyl...


US Patent US10065945 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253619
PNG
(US9701672, 50)
Show SMILES CC(C)Cn1ccc(n1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(CCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C25H26F7N7O/c1-14(2)13-39-10-8-19(36-39)16-12-23(25(30,31)32,33-22(40)20(16)21-34-37-38-35-21)17-7-6-15(11-18(17)26)5-3-4-9-24(27,28)29/h6-8,10-11,14H,3-5,9,12-13H2,1-2H3,(H,33,40)(H,34,35,37,38)/t23-/m0/s1
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n/an/a 9.40n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM289042
PNG
(US10093650, Example 19)
Show SMILES CC(O)c1ccc(s1)C1=C(C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F)n1nn[nH]c1=O
Show InChI InChI=1S/C23H21F6N5O4S/c1-12(35)16-7-8-17(39-16)15-11-21(23(27,28)29,30-19(36)18(15)34-20(37)31-32-33-34)13-3-5-14(6-4-13)38-10-2-9-22(24,25)26/h3-8,12,35H,2,9-11H2,1H3,(H,30,36)(H,31,33,37)/t12?,21-/m0/s1
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n/an/a 10n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM289044
PNG
(US10093650, Example 21)
Show SMILES FC(F)c1ccc(cc1)C1=C(C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1F)C(F)(F)F)n1nn[nH]c1=O
Show InChI InChI=1S/C24H18F9N5O3/c25-17-10-14(41-9-1-8-23(28,29)30)6-7-16(17)22(24(31,32)33)11-15(12-2-4-13(5-3-12)19(26)27)18(20(39)34-22)38-21(40)35-36-37-38/h2-7,10,19H,1,8-9,11H2,(H,34,39)(H,35,37,40)/t22-/m0/s1
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n/an/a 10n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US10093650 (2018)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM253643
PNG
(US9701672, 72)
Show SMILES COc1ccc(cn1)C1=C(C#N)C(=O)N[C@@](C1)(c1ccc(OCCCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C25H23F6N3O3/c1-36-21-10-5-16(15-33-21)19-13-23(25(29,30)31,34-22(35)20(19)14-32)17-6-8-18(9-7-17)37-12-4-2-3-11-24(26,27)28/h5-10,15H,2-4,11-13H2,1H3,(H,34,35)/t23-/m0/s1
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n/an/a 10.3n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM251746
PNG
(US9701672, 46 | US9701672, 48)
Show SMILES CC(C)n1ccc(n1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(CCCCC(F)(F)F)cc1F)C(F)(F)F
Show InChI InChI=1S/C24H24F7N7O/c1-13(2)38-10-8-18(35-38)15-12-22(24(29,30)31,32-21(39)19(15)20-33-36-37-34-20)16-7-6-14(11-17(16)25)5-3-4-9-23(26,27)28/h6-8,10-11,13H,3-5,9,12H2,1-2H3,(H,32,39)(H,33,34,36,37)/t22-/m0/s1
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n/an/a 11.4n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM249130
PNG
(US9701672, 35)
Show SMILES CN(C)c1cnc(s1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C22H21F6N7O2S/c1-35(2)15-11-29-19(38-15)14-10-20(22(26,27)28,30-18(36)16(14)17-31-33-34-32-17)12-4-6-13(7-5-12)37-9-3-8-21(23,24)25/h4-7,11H,3,8-10H2,1-2H3,(H,30,36)(H,31,32,33,34)/t20-/m0/s1
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n/an/a 11.5n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase


(Homo sapiens (Human))
BDBM249535
PNG
(US9701672, 36 | US9701672, 37)
Show SMILES Cc1ccc(nc1)C1=C(c2nnn[nH]2)C(=O)N[C@@](C1)(c1ccc(OCCCC(F)(F)F)cc1)C(F)(F)F
Show InChI InChI=1S/C23H20F6N6O2/c1-13-3-8-17(30-12-13)16-11-21(23(27,28)29,31-20(36)18(16)19-32-34-35-33-19)14-4-6-15(7-5-14)37-10-2-9-22(24,25)26/h3-8,12H,2,9-11H2,1H3,(H,31,36)(H,32,33,34,35)/t21-/m0/s1
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n/an/a 12.5n/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The MGAT enzyme reactions were performed in Corning FALCONŽ 96-well polypropylene plates, in a total volume of 60 μL of 50 mM potassium phosphat...


US Patent US9701672 (2017)

More data for this
Ligand-Target Pair
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