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Found 79 hits of Enz. Inhib. data with enzyme = 'Amine oxidase [flavin-containing] A' and Substrate = 'BDBM29135'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM15581
PNG
(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Show SMILES CN(CCCOc1ccc(Cl)cc1Cl)CC#C
Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
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PubMed
n/an/a 4.5n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29134
PNG
(substituted chalcone, 5m)
Show SMILES Oc1ccc(C(=O)\C=C\c2ccc(Cl)cc2)c(O)c1
Show InChI InChI=1S/C15H11ClO3/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,17,19H/b8-3+
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n/an/a 4.95E+3n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29136
PNG
(CHEMBL92401 | Euphozid | Iprazid | Iproniazid)
Show SMILES CC(C)NNC(=O)c1ccncc1
Show InChI InChI=1S/C9H13N3O/c1-7(2)11-12-9(13)8-3-5-10-6-4-8/h3-7,11H,1-2H3,(H,12,13)
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PubMed
n/an/a 6.56E+3n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29171
PNG
(3-carboxamido coumarin, 21)
Show SMILES CS(=O)(=O)c1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C17H13NO5S/c1-24(21,22)13-8-6-12(7-9-13)18-16(19)14-10-11-4-2-3-5-15(11)23-17(14)20/h2-10H,1H3,(H,18,19)
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n/an/a 9.33E+3n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29180
PNG
(3-carboxamido coumarin, 30)
Show SMILES COc1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1OC
Show InChI InChI=1S/C18H15NO5/c1-22-15-8-7-12(10-16(15)23-2)19-17(20)13-9-11-5-3-4-6-14(11)24-18(13)21/h3-10H,1-2H3,(H,19,20)
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n/an/a 9.45E+3n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29170
PNG
(3-carboxamido coumarin, 20)
Show SMILES ClC(=O)c1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C17H10ClNO4/c18-15(20)10-5-7-12(8-6-10)19-16(21)13-9-11-3-1-2-4-14(11)23-17(13)22/h1-9H,(H,19,21)
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n/an/a 9.67E+3n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29177
PNG
(3-carboxamido coumarin, 27)
Show SMILES Cc1cccc(C)c1NC(=O)c1cc2ccccc2oc1=O
Show InChI InChI=1S/C18H15NO3/c1-11-6-5-7-12(2)16(11)19-17(20)14-10-13-8-3-4-9-15(13)22-18(14)21/h3-10H,1-2H3,(H,19,20)
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n/an/a 9.79E+3n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29169
PNG
(3-carboxamido coumarin, 19)
Show SMILES OC(=O)c1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C17H11NO5/c19-15(18-12-7-5-10(6-8-12)16(20)21)13-9-11-3-1-2-4-14(11)23-17(13)22/h1-9H,(H,18,19)(H,20,21)
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n/an/a 9.97E+3n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29185
PNG
(3-carboxamido coumarin, 35)
Show SMILES Fc1nc(F)c(F)c(NC(=O)c2cc3ccccc3oc2=O)c1F
Show InChI InChI=1S/C15H6F4N2O3/c16-9-11(10(17)13(19)21-12(9)18)20-14(22)7-5-6-3-1-2-4-8(6)24-15(7)23/h1-5H,(H,20,21,22)
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n/an/a 1.14E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29175
PNG
(3-carboxamido coumarin, 25)
Show SMILES Cc1ccc(NC(=O)c2cc3ccccc3oc2=O)c(C)c1
Show InChI InChI=1S/C18H15NO3/c1-11-7-8-15(12(2)9-11)19-17(20)14-10-13-5-3-4-6-16(13)22-18(14)21/h3-10H,1-2H3,(H,19,20)
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n/an/a 1.23E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29178
PNG
(3-carboxamido coumarin, 28)
Show SMILES Fc1cccc(F)c1NC(=O)c1cc2ccccc2oc1=O
Show InChI InChI=1S/C16H9F2NO3/c17-11-5-3-6-12(18)14(11)19-15(20)10-8-9-4-1-2-7-13(9)22-16(10)21/h1-8H,(H,19,20)
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n/an/a 1.28E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29168
PNG
(3-carboxamido coumarin, 18)
Show SMILES Fc1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C16H10FNO3/c17-11-5-7-12(8-6-11)18-15(19)13-9-10-3-1-2-4-14(10)21-16(13)20/h1-9H,(H,18,19)
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n/an/a 1.31E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM23543
PNG
(2-oxo-N-phenyl-2H-chromene-3-carboxamide | 3-Carbo...)
Show SMILES O=C(Nc1ccccc1)c1cc2ccccc2oc1=O
Show InChI InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18)
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n/an/a 1.31E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29158
PNG
(3-carboxamido coumarin, 8)
Show SMILES Cc1cccc(NC(=O)c2cc3ccccc3oc2=O)c1
Show InChI InChI=1S/C17H13NO3/c1-11-5-4-7-13(9-11)18-16(19)14-10-12-6-2-3-8-15(12)21-17(14)20/h2-10H,1H3,(H,18,19)
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n/an/a 1.45E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29167
PNG
(3-carboxamido coumarin, 17)
Show SMILES CSc1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C17H13NO3S/c1-22-13-8-6-12(7-9-13)18-16(19)14-10-11-4-2-3-5-15(11)21-17(14)20/h2-10H,1H3,(H,18,19)
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n/an/a 1.48E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29164
PNG
(3-carboxamido coumarin, 14)
Show SMILES CC(C)c1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C19H17NO3/c1-12(2)13-7-9-15(10-8-13)20-18(21)16-11-14-5-3-4-6-17(14)23-19(16)22/h3-12H,1-2H3,(H,20,21)
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n/an/a 1.51E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29163
PNG
(3-carboxamido coumarin, 13)
Show SMILES CCc1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C18H15NO3/c1-2-12-7-9-14(10-8-12)19-17(20)15-11-13-5-3-4-6-16(13)22-18(15)21/h3-11H,2H2,1H3,(H,19,20)
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n/an/a 1.57E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29174
PNG
(3-carboxamido coumarin, 24)
Show SMILES Cc1ccc(C)c(NC(=O)c2cc3ccccc3oc2=O)c1
Show InChI InChI=1S/C18H15NO3/c1-11-7-8-12(2)15(9-11)19-17(20)14-10-13-5-3-4-6-16(13)22-18(14)21/h3-10H,1-2H3,(H,19,20)
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n/an/a 1.60E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29165
PNG
(3-carboxamido coumarin, 15)
Show SMILES CCOC(=O)c1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C19H15NO5/c1-2-24-18(22)12-7-9-14(10-8-12)20-17(21)15-11-13-5-3-4-6-16(13)25-19(15)23/h3-11H,2H2,1H3,(H,20,21)
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n/an/a 1.60E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29184
PNG
(3-carboxamido coumarin, 34)
Show SMILES Fc1c(F)c(C#N)c(F)c(F)c1NC(=O)c1cc2ccccc2oc1=O
Show InChI InChI=1S/C17H6F4N2O3/c18-11-9(6-22)12(19)14(21)15(13(11)20)23-16(24)8-5-7-3-1-2-4-10(7)26-17(8)25/h1-5H,(H,23,24)
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n/an/a 1.60E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29181
PNG
(3-carboxamido coumarin, 31)
Show SMILES Cc1cc(C)cc(NC(=O)c2cc3ccccc3oc2=O)c1
Show InChI InChI=1S/C18H15NO3/c1-11-7-12(2)9-14(8-11)19-17(20)15-10-13-5-3-4-6-16(13)22-18(15)21/h3-10H,1-2H3,(H,19,20)
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n/an/a 1.76E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29179
PNG
(3-carboxamido coumarin, 29)
Show SMILES Cc1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1C
Show InChI InChI=1S/C18H15NO3/c1-11-7-8-14(9-12(11)2)19-17(20)15-10-13-5-3-4-6-16(13)22-18(15)21/h3-10H,1-2H3,(H,19,20)
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n/an/a 1.88E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29162
PNG
(3-carboxamido coumarin, 12)
Show SMILES Cc1ccc(NC(=O)c2cc3ccccc3oc2=O)cc1
Show InChI InChI=1S/C17H13NO3/c1-11-6-8-13(9-7-11)18-16(19)14-10-12-4-2-3-5-15(12)21-17(14)20/h2-10H,1H3,(H,18,19)
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n/an/a 1.95E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29176
PNG
(3-carboxamido coumarin, 26)
Show SMILES Cc1cccc(NC(=O)c2cc3ccccc3oc2=O)c1C
Show InChI InChI=1S/C18H15NO3/c1-11-6-5-8-15(12(11)2)19-17(20)14-10-13-7-3-4-9-16(13)22-18(14)21/h3-10H,1-2H3,(H,19,20)
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n/an/a 2.06E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29201
PNG
(3-carboxamido coumarin, 51)
Show SMILES O=C(NNc1ccccc1)c1cc2ccc(OCc3ccccc3)cc2oc1=O
Show InChI InChI=1S/C23H18N2O4/c26-22(25-24-18-9-5-2-6-10-18)20-13-17-11-12-19(14-21(17)29-23(20)27)28-15-16-7-3-1-4-8-16/h1-14,24H,15H2,(H,25,26)
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n/an/a 4.14E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29209
PNG
(3-carboxamido coumarin, 59)
Show SMILES COc1ccc(NC(=O)c2cc3ccc(OCc4ccccc4)c(C)c3oc2=O)cc1OC
Show InChI InChI=1S/C26H23NO6/c1-16-21(32-15-17-7-5-4-6-8-17)11-9-18-13-20(26(29)33-24(16)18)25(28)27-19-10-12-22(30-2)23(14-19)31-3/h4-14H,15H2,1-3H3,(H,27,28)
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n/an/a 4.90E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29205
PNG
(3-carboxamido coumarin, 55)
Show SMILES COc1ccc(NC(=O)c2cc3ccc(OCc4ccc(F)cc4)cc3oc2=O)cc1OC
Show InChI InChI=1S/C25H20FNO6/c1-30-21-10-8-18(12-23(21)31-2)27-24(28)20-11-16-5-9-19(13-22(16)33-25(20)29)32-14-15-3-6-17(26)7-4-15/h3-13H,14H2,1-2H3,(H,27,28)
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n/an/a 4.92E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29197
PNG
(3-carboxamido coumarin, 47)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cc2ccc(OCc3ccccc3)cc2oc1=O
Show InChI InChI=1S/C24H18ClNO4/c1-15-6-5-9-20(25)22(15)26-23(27)19-12-17-10-11-18(13-21(17)30-24(19)28)29-14-16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,26,27)
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n/an/a 4.98E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29196
PNG
(3-carboxamido coumarin, 46)
Show SMILES O=C(Nc1ccccc1Cc1ccccc1)c1cc2ccc(OCc3ccccc3)cc2oc1=O
Show InChI InChI=1S/C30H23NO4/c32-29(31-27-14-8-7-13-23(27)17-21-9-3-1-4-10-21)26-18-24-15-16-25(19-28(24)35-30(26)33)34-20-22-11-5-2-6-12-22/h1-16,18-19H,17,20H2,(H,31,32)
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n/an/a 5.19E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29206
PNG
(3-carboxamido coumarin, 56)
Show SMILES COc1cc(NC(=O)c2cc3ccc(OCc4ccc(F)cc4)cc3oc2=O)cc(OC)c1
Show InChI InChI=1S/C25H20FNO6/c1-30-20-10-18(11-21(12-20)31-2)27-24(28)22-9-16-5-8-19(13-23(16)33-25(22)29)32-14-15-3-6-17(26)7-4-15/h3-13H,14H2,1-2H3,(H,27,28)
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n/an/a 5.26E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29199
PNG
(3-carboxamido coumarin, 49)
Show SMILES COc1cc(NC(=O)c2cc3ccc(OCc4ccccc4)cc3oc2=O)cc(OC)c1
Show InChI InChI=1S/C25H21NO6/c1-29-20-11-18(12-21(13-20)30-2)26-24(27)22-10-17-8-9-19(14-23(17)32-25(22)28)31-15-16-6-4-3-5-7-16/h3-14H,15H2,1-2H3,(H,26,27)
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n/an/a 5.29E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29203
PNG
(3-carboxamido coumarin, 53)
Show SMILES Fc1ccc(COc2ccc3cc(C(=O)Nc4ccccc4Cc4ccccc4)c(=O)oc3c2)cc1
Show InChI InChI=1S/C30H22FNO4/c31-24-13-10-21(11-14-24)19-35-25-15-12-23-17-26(30(34)36-28(23)18-25)29(33)32-27-9-5-4-8-22(27)16-20-6-2-1-3-7-20/h1-15,17-18H,16,19H2,(H,32,33)
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n/an/a 5.58E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29202
PNG
(3-carboxamido coumarin, 52)
Show SMILES Fc1ccc(COc2ccc3cc(C(=O)Nc4c(F)c(F)c(C#N)c(F)c4F)c(=O)oc3c2)cc1
Show InChI InChI=1S/C24H11F5N2O4/c25-13-4-1-11(2-5-13)10-34-14-6-3-12-7-15(24(33)35-17(12)8-14)23(32)31-22-20(28)18(26)16(9-30)19(27)21(22)29/h1-8H,10H2,(H,31,32)
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n/an/a 5.85E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29193
PNG
(3-carboxamido coumarin, 43)
Show SMILES CC(C)CNC(=O)c1cc2ccc(OCc3ccccc3)cc2oc1=O
Show InChI InChI=1S/C21H21NO4/c1-14(2)12-22-20(23)18-10-16-8-9-17(11-19(16)26-21(18)24)25-13-15-6-4-3-5-7-15/h3-11,14H,12-13H2,1-2H3,(H,22,23)
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n/an/a 5.86E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29204
PNG
(3-carboxamido coumarin, 54)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cc2ccc(OCc3ccc(F)cc3)cc2oc1=O
Show InChI InChI=1S/C24H17ClFNO4/c1-14-3-2-4-20(25)22(14)27-23(28)19-11-16-7-10-18(12-21(16)31-24(19)29)30-13-15-5-8-17(26)9-6-15/h2-12H,13H2,1H3,(H,27,28)
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n/an/a 5.96E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29194
PNG
(3-carboxamido coumarin, 44)
Show SMILES CC(C)c1ccc(NC(=O)c2cc3ccc(OCc4ccccc4)cc3oc2=O)cc1
Show InChI InChI=1S/C26H23NO4/c1-17(2)19-8-11-21(12-9-19)27-25(28)23-14-20-10-13-22(15-24(20)31-26(23)29)30-16-18-6-4-3-5-7-18/h3-15,17H,16H2,1-2H3,(H,27,28)
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n/an/a 6.09E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29195
PNG
(3-carboxamido coumarin, 45)
Show SMILES Fc1c(F)c(C#N)c(F)c(F)c1NC(=O)c1cc2ccc(OCc3ccccc3)cc2oc1=O
Show InChI InChI=1S/C24H12F4N2O4/c25-18-16(10-29)19(26)21(28)22(20(18)27)30-23(31)15-8-13-6-7-14(9-17(13)34-24(15)32)33-11-12-4-2-1-3-5-12/h1-9H,11H2,(H,30,31)
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n/an/a 6.14E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29182
PNG
(3-carboxamido coumarin, 32)
Show SMILES COc1cc(NC(=O)c2cc3ccccc3oc2=O)cc(OC)c1
Show InChI InChI=1S/C18H15NO5/c1-22-13-8-12(9-14(10-13)23-2)19-17(20)15-7-11-5-3-4-6-16(11)24-18(15)21/h3-10H,1-2H3,(H,19,20)
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n/an/a 6.15E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29192
PNG
(3-carboxamido coumarin, 42)
Show SMILES CC(C)NC(=O)c1cc2ccc(OCc3ccccc3)cc2oc1=O
Show InChI InChI=1S/C20H19NO4/c1-13(2)21-19(22)17-10-15-8-9-16(11-18(15)25-20(17)23)24-12-14-6-4-3-5-7-14/h3-11,13H,12H2,1-2H3,(H,21,22)
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n/an/a 6.35E+4n/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 1935-42 (2009)


Article DOI: 10.1021/jm801496u
BindingDB Entry DOI: 10.7270/Q2SF2THN
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM15579
PNG
(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Show SMILES C[C@H](Cc1ccccc1)N(C)CC#C
Show InChI InChI=1/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/s2
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n/an/a 6.73E+4n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM15613
PNG
(4-chloro-N-(2-morpholin-4-ylethyl)benzamide | 4-ch...)
Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCOCC1
Show InChI InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
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n/an/a 3.61E+5n/an/an/an/a7.437



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29137
PNG
(substituted chalcone, 5a)
Show SMILES CC(C)=CCOc1ccc(C(=O)\C=C\c2ccccc2)c(O)c1
Show InChI InChI=1S/C20H20O3/c1-15(2)12-13-23-17-9-10-18(20(22)14-17)19(21)11-8-16-6-4-3-5-7-16/h3-12,14,22H,13H2,1-2H3/b11-8+
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n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29138
PNG
(substituted chalcone, 5b)
Show SMILES CC(C)=CCOc1ccc(C(=O)\C=C\c2ccc(C)cc2)c(O)c1
Show InChI InChI=1S/C21H22O3/c1-15(2)12-13-24-18-9-10-19(21(23)14-18)20(22)11-8-17-6-4-16(3)5-7-17/h4-12,14,23H,13H2,1-3H3/b11-8+
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n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29149
PNG
(substituted chalcone, 5c)
Show SMILES COc1ccc(\C=C\C(=O)c2ccc(OCC=C(C)C)cc2O)cc1
Show InChI InChI=1S/C21H22O4/c1-15(2)12-13-25-18-9-10-19(21(23)14-18)20(22)11-6-16-4-7-17(24-3)8-5-16/h4-12,14,23H,13H2,1-3H3/b11-6+
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n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29150
PNG
(substituted chalcone, 5d)
Show SMILES CC(C)=CCOc1ccc(C(=O)\C=C\c2ccc(OCc3ccccc3)cc2)c(O)c1
Show InChI InChI=1S/C27H26O4/c1-20(2)16-17-30-24-13-14-25(27(29)18-24)26(28)15-10-21-8-11-23(12-9-21)31-19-22-6-4-3-5-7-22/h3-16,18,29H,17,19H2,1-2H3/b15-10+
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n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29139
PNG
(substituted chalcone, 5e)
Show SMILES CC(C)=CCOc1ccc(C(=O)\C=C\c2ccc(Cl)cc2)c(O)c1
Show InChI InChI=1S/C20H19ClO3/c1-14(2)11-12-24-17-8-9-18(20(23)13-17)19(22)10-5-15-3-6-16(21)7-4-15/h3-11,13,23H,12H2,1-2H3/b10-5+
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n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29151
PNG
(substituted chalcone, 5f)
Show SMILES Clc1ccc(\C=C\C(=O)c2ccc(OCc3ccccc3)cc2)cc1
Show InChI InChI=1S/C22H17ClO2/c23-20-11-6-17(7-12-20)8-15-22(24)19-9-13-21(14-10-19)25-16-18-4-2-1-3-5-18/h1-15H,16H2/b15-8+
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n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29140
PNG
(substituted chalcone, 5g)
Show SMILES COc1ccc(cc1)C(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClO2/c1-19-15-9-5-13(6-10-15)16(18)11-4-12-2-7-14(17)8-3-12/h2-11H,1H3/b11-4+
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n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29141
PNG
(substituted chalcone, 5h)
Show SMILES COc1ccc(cc1)C(=O)\C=C\c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H20O3/c1-25-21-14-10-20(11-15-21)23(24)16-9-18-7-12-22(13-8-18)26-17-19-5-3-2-4-6-19/h2-16H,17H2,1H3/b16-9+
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n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM29142
PNG
(substituted chalcone, 5i)
Show SMILES COc1ccc(C(=O)\C=C\c2ccc(Cl)cc2)c(O)c1
Show InChI InChI=1S/C16H13ClO3/c1-20-13-7-8-14(16(19)10-13)15(18)9-4-11-2-5-12(17)6-3-11/h2-10,19H,1H3/b9-4+
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PubMed
n/an/an/an/an/an/an/an/an/a



Sapienza University of Rome



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
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