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Found 258 hits of Enz. Inhib. data with enzyme = 'Amine oxidase [flavin-containing] A' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM261746
PNG
(US9708309, 13)
Show SMILES Nc1nnc(CN[C@H]2C[C@@H]2c2ccc(OCc3cc(F)cc(F)c3)cc2)o1
Show InChI InChI=1S/C19H18F2N4O2/c20-13-5-11(6-14(21)7-13)10-26-15-3-1-12(2-4-15)16-8-17(16)23-9-18-24-25-19(22)27-18/h1-7,16-17,23H,8-10H2,(H2,22,25)/t16-,17+/m1/s1
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2.10E+4n/an/an/an/an/an/an/an/a



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US9708309 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM261741
PNG
(US9708309, 1)
Show SMILES Nc1ncc(CN[C@H]2C[C@@H]2c2ccc(OCc3ccccc3)cc2)cn1
Show InChI InChI=1S/C21H22N4O/c22-21-24-12-16(13-25-21)11-23-20-10-19(20)17-6-8-18(9-7-17)26-14-15-4-2-1-3-5-15/h1-9,12-13,19-20,23H,10-11,14H2,(H2,22,24,25)/t19-,20+/m1/s1
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ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US9708309 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM261748
PNG
(US9708309, 15)
Show SMILES Nc1nnc(CN[C@H]2C[C@@H]2c2ccc(OCc3cccc(Cl)c3)cc2)o1
Show InChI InChI=1S/C19H19ClN4O2/c20-14-3-1-2-12(8-14)11-25-15-6-4-13(5-7-15)16-9-17(16)22-10-18-23-24-19(21)26-18/h1-8,16-17,22H,9-11H2,(H2,21,24)/t16-,17+/m1/s1
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ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US9708309 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM261747
PNG
(US9708309, 14)
Show SMILES Nc1nnc(CN[C@H]2C[C@@H]2c2ccc(OCc3ccc(Cl)cc3)cc2)o1
Show InChI InChI=1S/C19H19ClN4O2/c20-14-5-1-12(2-6-14)11-25-15-7-3-13(4-8-15)16-9-17(16)22-10-18-23-24-19(21)26-18/h1-8,16-17,22H,9-11H2,(H2,21,24)/t16-,17+/m1/s1
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ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US9708309 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM261742
PNG
(US9708309, 2)
Show SMILES Nc1ncc(CN[C@H]2C[C@@H]2c2ccc(OCc3ccccc3)cc2)s1
Show InChI InChI=1S/C20H21N3OS/c21-20-23-12-17(25-20)11-22-19-10-18(19)15-6-8-16(9-7-15)24-13-14-4-2-1-3-5-14/h1-9,12,18-19,22H,10-11,13H2,(H2,21,23)/t18-,19+/m1/s1
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ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US9708309 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM261745
PNG
(US9708309, 12)
Show SMILES Nc1nnc(CN[C@H]2C[C@@H]2c2ccc(OCc3cccc(F)c3)cc2)o1
Show InChI InChI=1S/C19H19FN4O2/c20-14-3-1-2-12(8-14)11-25-15-6-4-13(5-7-15)16-9-17(16)22-10-18-23-24-19(21)26-18/h1-8,16-17,22H,9-11H2,(H2,21,24)/t16-,17+/m1/s1
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ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US9708309 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM261744
PNG
(US9708309, 11)
Show SMILES Nc1nnc(CN[C@H]2C[C@@H]2c2ccc(OCc3ccc(F)cc3)cc2)o1
Show InChI InChI=1S/C19H19FN4O2/c20-14-5-1-12(2-6-14)11-25-15-7-3-13(4-8-15)16-9-17(16)22-10-18-23-24-19(21)26-18/h1-8,16-17,22H,9-11H2,(H2,21,24)/t16-,17+/m1/s1
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ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US9708309 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM261743
PNG
(US9708309, 10)
Show SMILES Nc1nnc(CN[C@H]2C[C@@H]2c2ccc(OCc3ccccc3)cc2)o1
Show InChI InChI=1S/C19H20N4O2/c20-19-23-22-18(25-19)11-21-17-10-16(17)14-6-8-15(9-7-14)24-12-13-4-2-1-3-5-13/h1-9,16-17,21H,10-12H2,(H2,20,23)/t16-,17+/m1/s1
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ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of MAO (0.25 μg for MAO-A and 0.5 μg for MAO-B) was incubated on ice for 15 minutes in the reaction buffer, in the ...


US Patent US9708309 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256691
PNG
(US10053456, 70 | US9487511, 70 | US9718814, 70)
Show SMILES Cc1nnc(NC(=O)c2cc(sc2C)C2CC2NCC2CCOCC2)s1
Show InChI InChI=1S/C18H24N4O2S2/c1-10-13(17(23)20-18-22-21-11(2)26-18)8-16(25-10)14-7-15(14)19-9-12-3-5-24-6-4-12/h8,12,14-15,19H,3-7,9H2,1-2H3,(H,20,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256691
PNG
(US10053456, 70 | US9487511, 70 | US9718814, 70)
Show SMILES Cc1nnc(NC(=O)c2cc(sc2C)C2CC2NCC2CCOCC2)s1
Show InChI InChI=1S/C18H24N4O2S2/c1-10-13(17(23)20-18-22-21-11(2)26-18)8-16(25-10)14-7-15(14)19-9-12-3-5-24-6-4-12/h8,12,14-15,19H,3-7,9H2,1-2H3,(H,20,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256657
PNG
(US10053456, 36 | US9487511, 36 | US9718814, 36)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1ccc(s1)C1CC1NCC1CC1
Show InChI InChI=1S/C18H24F2N2OS/c19-18(20)7-5-12(6-8-18)22-17(23)16-4-3-15(24-16)13-9-14(13)21-10-11-1-2-11/h3-4,11-14,21H,1-2,5-10H2,(H,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256657
PNG
(US10053456, 36 | US9487511, 36 | US9718814, 36)
Show SMILES FC1(F)CCC(CC1)NC(=O)c1ccc(s1)C1CC1NCC1CC1
Show InChI InChI=1S/C18H24F2N2OS/c19-18(20)7-5-12(6-8-18)22-17(23)16-4-3-15(24-16)13-9-14(13)21-10-11-1-2-11/h3-4,11-14,21H,1-2,5-10H2,(H,22,23)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM243404
PNG
(N-cyclopentyl-5- ((1R,2R)-2- (tetrahydro-2H- pyran...)
Show SMILES O=C(NC1CCCC1)c1csc(c1)C1CC1NC1CCOCC1
Show InChI InChI=1S/C18H26N2O2S/c21-18(20-13-3-1-2-4-13)12-9-17(23-11-12)15-10-16(15)19-14-5-7-22-8-6-14/h9,11,13-16,19H,1-8,10H2,(H,20,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM243404
PNG
(N-cyclopentyl-5- ((1R,2R)-2- (tetrahydro-2H- pyran...)
Show SMILES O=C(NC1CCCC1)c1csc(c1)C1CC1NC1CCOCC1
Show InChI InChI=1S/C18H26N2O2S/c21-18(20-13-3-1-2-4-13)12-9-17(23-11-12)15-10-16(15)19-14-5-7-22-8-6-14/h9,11,13-16,19H,1-8,10H2,(H,20,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256686
PNG
(US10053456, 65 | US9487511, 65 | US9718814, 65)
Show SMILES Cc1sc(cc1C(=O)NC1CCC(F)(F)CC1)C1CC1NCC1CC1
Show InChI InChI=1S/C19H26F2N2OS/c1-11-14(18(24)23-13-4-6-19(20,21)7-5-13)9-17(25-11)15-8-16(15)22-10-12-2-3-12/h9,12-13,15-16,22H,2-8,10H2,1H3,(H,23,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256686
PNG
(US10053456, 65 | US9487511, 65 | US9718814, 65)
Show SMILES Cc1sc(cc1C(=O)NC1CCC(F)(F)CC1)C1CC1NCC1CC1
Show InChI InChI=1S/C19H26F2N2OS/c1-11-14(18(24)23-13-4-6-19(20,21)7-5-13)9-17(25-11)15-8-16(15)22-10-12-2-3-12/h9,12-13,15-16,22H,2-8,10H2,1H3,(H,23,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM243414
PNG
(5-((1R,2R)-2-((1- cyclopropylpiperi- din-4-yl)amin...)
Show SMILES Cc1nnc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCN(CC2)C2CC2)s1
Show InChI InChI=1S/C19H25N5OS2/c1-11-22-23-19(27-11)21-18(25)12-8-17(26-10-12)15-9-16(15)20-13-4-6-24(7-5-13)14-2-3-14/h8,10,13-16,20H,2-7,9H2,1H3,(H,21,23,25)/t15-,16-/m1/s1
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n/an/a 3.10E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM243414
PNG
(5-((1R,2R)-2-((1- cyclopropylpiperi- din-4-yl)amin...)
Show SMILES Cc1nnc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NC2CCN(CC2)C2CC2)s1
Show InChI InChI=1S/C19H25N5OS2/c1-11-22-23-19(27-11)21-18(25)12-8-17(26-10-12)15-9-16(15)20-13-4-6-24(7-5-13)14-2-3-14/h8,10,13-16,20H,2-7,9H2,1H3,(H,21,23,25)/t15-,16-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256690
PNG
(US10053456, 69 | US9487511, 69 | US9718814, 69)
Show SMILES Cc1nnc(NC(=O)c2cc(sc2C)C2CC2NCC2CC2)s1
Show InChI InChI=1S/C16H20N4OS2/c1-8-11(15(21)18-16-20-19-9(2)23-16)6-14(22-8)12-5-13(12)17-7-10-3-4-10/h6,10,12-13,17H,3-5,7H2,1-2H3,(H,18,20,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256690
PNG
(US10053456, 69 | US9487511, 69 | US9718814, 69)
Show SMILES Cc1nnc(NC(=O)c2cc(sc2C)C2CC2NCC2CC2)s1
Show InChI InChI=1S/C16H20N4OS2/c1-8-11(15(21)18-16-20-19-9(2)23-16)6-14(22-8)12-5-13(12)17-7-10-3-4-10/h6,10,12-13,17H,3-5,7H2,1-2H3,(H,18,20,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM243996
PNG
(N-(5-methyl-1,2- oxazol-3-yl)-5- ((1R,2R)-2- ((tet...)
Show SMILES Cc1cc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NCC2CCOCC2)no1
Show InChI InChI=1S/C18H23N3O3S/c1-11-6-17(21-24-11)20-18(22)13-7-16(25-10-13)14-8-15(14)19-9-12-2-4-23-5-3-12/h6-7,10,12,14-15,19H,2-5,8-9H2,1H3,(H,20,21,22)/t14-,15-/m1/s1
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n/an/a 3.60E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM243996
PNG
(N-(5-methyl-1,2- oxazol-3-yl)-5- ((1R,2R)-2- ((tet...)
Show SMILES Cc1cc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NCC2CCOCC2)no1
Show InChI InChI=1S/C18H23N3O3S/c1-11-6-17(21-24-11)20-18(22)13-7-16(25-10-13)14-8-15(14)19-9-12-2-4-23-5-3-12/h6-7,10,12,14-15,19H,2-5,8-9H2,1H3,(H,20,21,22)/t14-,15-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256723
PNG
(US10053456, 110 | US9487511, 110 | US9718814, 110)
Show SMILES OC(=O)c1ccc(CN[C@@H]2C[C@H]2c2cc(cs2)C(=O)NC2CCC(F)(F)CC2)cc1
Show InChI InChI=1S/C22H24F2N2O3S/c23-22(24)7-5-16(6-8-22)26-20(27)15-9-19(30-12-15)17-10-18(17)25-11-13-1-3-14(4-2-13)21(28)29/h1-4,9,12,16-18,25H,5-8,10-11H2,(H,26,27)(H,28,29)/t17-,18-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256723
PNG
(US10053456, 110 | US9487511, 110 | US9718814, 110)
Show SMILES OC(=O)c1ccc(CN[C@@H]2C[C@H]2c2cc(cs2)C(=O)NC2CCC(F)(F)CC2)cc1
Show InChI InChI=1S/C22H24F2N2O3S/c23-22(24)7-5-16(6-8-22)26-20(27)15-9-19(30-12-15)17-10-18(17)25-11-13-1-3-14(4-2-13)21(28)29/h1-4,9,12,16-18,25H,5-8,10-11H2,(H,26,27)(H,28,29)/t17-,18-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256724
PNG
(US10053456, 111 | US9487511, 111 | US9718814, 111)
Show SMILES Nc1nnc(CN[C@@H]2C[C@H]2c2cc(cs2)C(=O)NC2CCC(F)(F)CC2)o1
Show InChI InChI=1S/C17H21F2N5O2S/c18-17(19)3-1-10(2-4-17)22-15(25)9-5-13(27-8-9)11-6-12(11)21-7-14-23-24-16(20)26-14/h5,8,10-12,21H,1-4,6-7H2,(H2,20,24)(H,22,25)/t11-,12-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256724
PNG
(US10053456, 111 | US9487511, 111 | US9718814, 111)
Show SMILES Nc1nnc(CN[C@@H]2C[C@H]2c2cc(cs2)C(=O)NC2CCC(F)(F)CC2)o1
Show InChI InChI=1S/C17H21F2N5O2S/c18-17(19)3-1-10(2-4-17)22-15(25)9-5-13(27-8-9)11-6-12(11)21-7-14-23-24-16(20)26-14/h5,8,10-12,21H,1-4,6-7H2,(H2,20,24)(H,22,25)/t11-,12-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM243419
PNG
(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NCC2CCOCC2)s1
Show InChI InChI=1S/C18H23N3O2S2/c1-11-19-9-17(25-11)21-18(22)13-6-16(24-10-13)14-7-15(14)20-8-12-2-4-23-5-3-12/h6,9-10,12,14-15,20H,2-5,7-8H2,1H3,(H,21,22)/t14-,15-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM243419
PNG
(N-(2-methyl-1,3- thiazol-5-yl)-5- ((1R,2R)-2- ((te...)
Show SMILES Cc1ncc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NCC2CCOCC2)s1
Show InChI InChI=1S/C18H23N3O2S2/c1-11-19-9-17(25-11)21-18(22)13-6-16(24-10-13)14-7-15(14)20-8-12-2-4-23-5-3-12/h6,9-10,12,14-15,20H,2-5,7-8H2,1H3,(H,21,22)/t14-,15-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256661
PNG
(BDBM256662 | US10053456, 41 | US9487511, 40 | US97...)
Show SMILES Cc1nnc(NC(=O)c2csc(c2)C2CC2NCC2CCOCC2)s1
Show InChI InChI=1S/C17H22N4O2S2/c1-10-20-21-17(25-10)19-16(22)12-6-15(24-9-12)13-7-14(13)18-8-11-2-4-23-5-3-11/h6,9,11,13-14,18H,2-5,7-8H2,1H3,(H,19,21,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256661
PNG
(BDBM256662 | US10053456, 41 | US9487511, 40 | US97...)
Show SMILES Cc1nnc(NC(=O)c2csc(c2)C2CC2NCC2CCOCC2)s1
Show InChI InChI=1S/C17H22N4O2S2/c1-10-20-21-17(25-10)19-16(22)12-6-15(24-9-12)13-7-14(13)18-8-11-2-4-23-5-3-11/h6,9,11,13-14,18H,2-5,7-8H2,1H3,(H,19,21,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256688
PNG
(US10053456, 67 | US9487511, 67 | US9718814, 67)
Show SMILES Cc1sc(cc1C(=O)NC1CCC(F)(F)CC1)C1CC1NC1CCOCC1
Show InChI InChI=1S/C20H28F2N2O2S/c1-12-15(19(25)24-13-2-6-20(21,22)7-3-13)11-18(27-12)16-10-17(16)23-14-4-8-26-9-5-14/h11,13-14,16-17,23H,2-10H2,1H3,(H,24,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256688
PNG
(US10053456, 67 | US9487511, 67 | US9718814, 67)
Show SMILES Cc1sc(cc1C(=O)NC1CCC(F)(F)CC1)C1CC1NC1CCOCC1
Show InChI InChI=1S/C20H28F2N2O2S/c1-12-15(19(25)24-13-2-6-20(21,22)7-3-13)11-18(27-12)16-10-17(16)23-14-4-8-26-9-5-14/h11,13-14,16-17,23H,2-10H2,1H3,(H,24,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256628
PNG
(US10053456, 7 | US9487511, 7 | US9718814, 7)
Show SMILES Cc1nnc(NC(=O)c2cc(C3CC3NCC3CC3)c3ccccc3c2)s1
Show InChI InChI=1S/C21H22N4OS/c1-12-24-25-21(27-12)23-20(26)15-8-14-4-2-3-5-16(14)17(9-15)18-10-19(18)22-11-13-6-7-13/h2-5,8-9,13,18-19,22H,6-7,10-11H2,1H3,(H,23,25,26)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256628
PNG
(US10053456, 7 | US9487511, 7 | US9718814, 7)
Show SMILES Cc1nnc(NC(=O)c2cc(C3CC3NCC3CC3)c3ccccc3c2)s1
Show InChI InChI=1S/C21H22N4OS/c1-12-24-25-21(27-12)23-20(26)15-8-14-4-2-3-5-16(14)17(9-15)18-10-19(18)22-11-13-6-7-13/h2-5,8-9,13,18-19,22H,6-7,10-11H2,1H3,(H,23,25,26)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256658
PNG
(US10053456, 37 | US9487511, 37 | US9718814, 37)
Show SMILES Cc1nnc(NC(=O)c2ccc(s2)C2CC2NCC2CC2)s1
Show InChI InChI=1S/C15H18N4OS2/c1-8-18-19-15(21-8)17-14(20)13-5-4-12(22-13)10-6-11(10)16-7-9-2-3-9/h4-5,9-11,16H,2-3,6-7H2,1H3,(H,17,19,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256658
PNG
(US10053456, 37 | US9487511, 37 | US9718814, 37)
Show SMILES Cc1nnc(NC(=O)c2ccc(s2)C2CC2NCC2CC2)s1
Show InChI InChI=1S/C15H18N4OS2/c1-8-18-19-15(21-8)17-14(20)13-5-4-12(22-13)10-6-11(10)16-7-9-2-3-9/h4-5,9-11,16H,2-3,6-7H2,1H3,(H,17,19,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM244001
PNG
(N-(1-ethyl-1H- pyrazol-4-yl)-5- ((1R,2R)-2- ((tetr...)
Show SMILES CCn1cc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NCC2CCOCC2)cn1
Show InChI InChI=1S/C19H26N4O2S/c1-2-23-11-15(10-21-23)22-19(24)14-7-18(26-12-14)16-8-17(16)20-9-13-3-5-25-6-4-13/h7,10-13,16-17,20H,2-6,8-9H2,1H3,(H,22,24)/t16-,17-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM244001
PNG
(N-(1-ethyl-1H- pyrazol-4-yl)-5- ((1R,2R)-2- ((tetr...)
Show SMILES CCn1cc(NC(=O)c2csc(c2)[C@@H]2C[C@H]2NCC2CCOCC2)cn1
Show InChI InChI=1S/C19H26N4O2S/c1-2-23-11-15(10-21-23)22-19(24)14-7-18(26-12-14)16-8-17(16)20-9-13-3-5-25-6-4-13/h7,10-13,16-17,20H,2-6,8-9H2,1H3,(H,22,24)/t16-,17-/m1/s1
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256636
PNG
(US10053456, 15 | US9487511, 15 | US9718814, 15)
Show SMILES Cc1nnc(NC(=O)c2cc(cc3ccccc23)C2CC2N)s1
Show InChI InChI=1S/C17H16N4OS/c1-9-20-21-17(23-9)19-16(22)14-7-11(13-8-15(13)18)6-10-4-2-3-5-12(10)14/h2-7,13,15H,8,18H2,1H3,(H,19,21,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256636
PNG
(US10053456, 15 | US9487511, 15 | US9718814, 15)
Show SMILES Cc1nnc(NC(=O)c2cc(cc3ccccc23)C2CC2N)s1
Show InChI InChI=1S/C17H16N4OS/c1-9-20-21-17(23-9)19-16(22)14-7-11(13-8-15(13)18)6-10-4-2-3-5-12(10)14/h2-7,13,15H,8,18H2,1H3,(H,19,21,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256687
PNG
(US10053456, 66 | US9487511, 66 | US9718814, 66)
Show SMILES Cc1sc(cc1C(=O)NC1CCC(F)(F)CC1)C1CC1NCC1CCOCC1
Show InChI InChI=1S/C21H30F2N2O2S/c1-13-16(20(26)25-15-2-6-21(22,23)7-3-15)11-19(28-13)17-10-18(17)24-12-14-4-8-27-9-5-14/h11,14-15,17-18,24H,2-10,12H2,1H3,(H,25,26)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256687
PNG
(US10053456, 66 | US9487511, 66 | US9718814, 66)
Show SMILES Cc1sc(cc1C(=O)NC1CCC(F)(F)CC1)C1CC1NCC1CCOCC1
Show InChI InChI=1S/C21H30F2N2O2S/c1-13-16(20(26)25-15-2-6-21(22,23)7-3-15)11-19(28-13)17-10-18(17)24-12-14-4-8-27-9-5-14/h11,14-15,17-18,24H,2-10,12H2,1H3,(H,25,26)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US10053456 (2018)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256622
PNG
(US10053456, 1 | US9487511, 1 | US9718814, 1)
Show SMILES Cc1nnc(NC(=O)c2cc(C3CC3N)c(C)s2)s1
Show InChI InChI=1S/C12H14N4OS2/c1-5-7(8-3-9(8)13)4-10(18-5)11(17)14-12-16-15-6(2)19-12/h4,8-9H,3,13H2,1-2H3,(H,14,16,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256623
PNG
(BDBM256647 | US10053456, 26 | US9487511, 2 | US971...)
Show SMILES Cc1nnc(NC(=O)c2cc(C3CC3NCC3CC3)c(C)s2)s1
Show InChI InChI=1S/C16H20N4OS2/c1-8-11(12-5-13(12)17-7-10-3-4-10)6-14(22-8)15(21)18-16-20-19-9(2)23-16/h6,10,12-13,17H,3-5,7H2,1-2H3,(H,18,20,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256624
PNG
(US10053456, 3 | US9487511, 3 | US9718814, 3)
Show SMILES Cn1nc(cc1C1CC1NCC1CC1)C(=O)NC1CCC(F)(F)CC1
Show InChI InChI=1S/C18H26F2N4O/c1-24-16(13-8-14(13)21-10-11-2-3-11)9-15(23-24)17(25)22-12-4-6-18(19,20)7-5-12/h9,11-14,21H,2-8,10H2,1H3,(H,22,25)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256625
PNG
(US10053456, 4 | US9487511, 4 | US9718814, 4)
Show SMILES Cn1nc(cc1C1CC1N)C(=O)NC1CCC(F)(F)CC1
Show InChI InChI=1S/C14H20F2N4O/c1-20-12(9-6-10(9)17)7-11(19-20)13(21)18-8-2-4-14(15,16)5-3-8/h7-10H,2-6,17H2,1H3,(H,18,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256626
PNG
(US10053456, 5 | US9487511, 5 | US9718814, 5)
Show SMILES Cc1nnc(NC(=O)c2cc(C3CC3N)c3ccccc3c2)s1
Show InChI InChI=1S/C17H16N4OS/c1-9-20-21-17(23-9)19-16(22)11-6-10-4-2-3-5-12(10)13(7-11)14-8-15(14)18/h2-7,14-15H,8,18H2,1H3,(H,19,21,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256627
PNG
(US10053456, 6 | US9487511, 6 | US9718814, 6)
Show SMILES Cc1nnc(NC(=O)c2cc(C3CC3NCC3CCOCC3)c3ccccc3c2)s1
Show InChI InChI=1S/C23H26N4O2S/c1-14-26-27-23(30-14)25-22(28)17-10-16-4-2-3-5-18(16)19(11-17)20-12-21(20)24-13-15-6-8-29-9-7-15/h2-5,10-11,15,20-21,24H,6-9,12-13H2,1H3,(H,25,27,28)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256629
PNG
(US10053456, 8 | US9487511, 8 | US9718814, 8)
Show SMILES Cc1sc(cc1C1CC1NCC1CCOCC1)C(=O)NC1CCC(F)(F)CC1
Show InChI InChI=1S/C21H30F2N2O2S/c1-13-16(17-10-18(17)24-12-14-4-8-27-9-5-14)11-19(28-13)20(26)25-15-2-6-21(22,23)7-3-15/h11,14-15,17-18,24H,2-10,12H2,1H3,(H,25,26)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] A


(Homo sapiens (Human))
BDBM256630
PNG
(US10053456, 9 | US9487511, 9 | US9718814, 9)
Show SMILES Cc1nnc(NC(=O)c2cc3CCOc3c(c2)C2CC2N)s1
Show InChI InChI=1S/C15H16N4O2S/c1-7-18-19-15(22-7)17-14(20)9-4-8-2-3-21-13(8)11(5-9)10-6-12(10)16/h4-5,10,12H,2-3,6,16H2,1H3,(H,17,19,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The MAO-A inhibitory activity evaluation described below followed the protocol of MAO-Glo (registered trademark) Assay of Promega KK.A test compound ...


US Patent US9714241 (2017)

More data for this
Ligand-Target Pair
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