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Found 39 hits of Enz. Inhib. data with enzyme = 'Amine oxidase, copper containing' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309489
PNG
(US9603833, Example 111)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2cccc(COC(=O)NN)c2)nc1
Show InChI InChI=1S/C21H27N5O3/c1-16(27)25-9-11-26(12-10-25)20-8-7-19(23-14-20)6-5-17-3-2-4-18(13-17)15-29-21(28)24-22/h2-4,7-8,13-14H,5-6,9-12,15,22H2,1H3,(H,24,28)
KEGG

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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309497
PNG
(US9603833, Example 120)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CC(=O)NN)s2)nc1
Show InChI InChI=1S/C19H25N5O2S/c1-14(25)23-8-10-24(11-9-23)16-4-2-15(21-13-16)3-5-17-6-7-18(27-17)12-19(26)22-20/h2,4,6-7,13H,3,5,8-12,20H2,1H3,(H,22,26)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309490
PNG
(US9603833, Example 112)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2cccc(CNC(=O)NN)c2)nc1
Show InChI InChI=1S/C21H28N6O2/c1-16(28)26-9-11-27(12-10-26)20-8-7-19(23-15-20)6-5-17-3-2-4-18(13-17)14-24-21(29)25-22/h2-4,7-8,13,15H,5-6,9-12,14,22H2,1H3,(H2,24,25,29)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309491
PNG
(US9603833, Example 113)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(COC(=O)NN)cc2F)nc1
Show InChI InChI=1S/C21H26FN5O3/c1-15(28)26-8-10-27(11-9-26)19-7-6-18(24-13-19)5-4-17-3-2-16(12-20(17)22)14-30-21(29)25-23/h2-3,6-7,12-13H,4-5,8-11,14,23H2,1H3,(H,25,29)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309486
PNG
(US9603833, Example 108)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(COC(=O)NN)cc2)nc1
Show InChI InChI=1S/C21H27N5O3/c1-16(27)25-10-12-26(13-11-25)20-9-8-19(23-14-20)7-6-17-2-4-18(5-3-17)15-29-21(28)24-22/h2-5,8-9,14H,6-7,10-13,15,22H2,1H3,(H,24,28)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309479
PNG
(US9603833, Example 92)
Show SMILES CCCN(CCC)c1ccc(CCc2ccc(CC(=O)NN)cc2)cn1
Show InChI InChI=1S/C21H30N4O/c1-3-13-25(14-4-2)20-12-11-19(16-23-20)10-7-17-5-8-18(9-6-17)15-21(26)24-22/h5-6,8-9,11-12,16H,3-4,7,10,13-15,22H2,1-2H3,(H,24,26)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309477
PNG
(US9603833, Example 89)
Show SMILES CCN(C)c1ccc(CCc2ccc(CC(=O)NN)cc2)cn1
Show InChI InChI=1S/C18H24N4O/c1-3-22(2)17-11-10-16(13-20-17)9-6-14-4-7-15(8-5-14)12-18(23)21-19/h4-5,7-8,10-11,13H,3,6,9,12,19H2,1-2H3,(H,21,23)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309476
PNG
(US9603833, Example 88)
Show SMILES CCN(CC)c1ccc(CCc2ccc(CC(=O)NN)cc2)nc1
Show InChI InChI=1S/C19H26N4O/c1-3-23(4-2)18-12-11-17(21-14-18)10-9-15-5-7-16(8-6-15)13-19(24)22-20/h5-8,11-12,14H,3-4,9-10,13,20H2,1-2H3,(H,22,24)
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US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309474
PNG
(US9603833, Example 86)
Show SMILES NNC(=O)Cc1ccc(CCc2ccc(cn2)N2CCNCC2)cc1
Show InChI InChI=1S/C19H25N5O/c20-23-19(25)13-16-3-1-15(2-4-16)5-6-17-7-8-18(14-22-17)24-11-9-21-10-12-24/h1-4,7-8,14,21H,5-6,9-13,20H2,(H,23,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309459
PNG
(US9603833, Example 12)
Show SMILES NNC(=O)Cc1ccc(CCc2ccc(nc2)N2CCOCC2)cc1
Show InChI InChI=1S/C19H24N4O2/c20-22-19(24)13-16-4-1-15(2-5-16)3-6-17-7-8-18(21-14-17)23-9-11-25-12-10-23/h1-2,4-5,7-8,14H,3,6,9-13,20H2,(H,22,24)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309492
PNG
(US9603833, Example 114)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CNC(=O)NN)cc2F)nc1
Show InChI InChI=1S/C21H27FN6O2/c1-15(29)27-8-10-28(11-9-27)19-7-6-18(24-14-19)5-4-17-3-2-16(12-20(17)22)13-25-21(30)26-23/h2-3,6-7,12,14H,4-5,8-11,13,23H2,1H3,(H2,25,26,30)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309464
PNG
(US9603833, Example 45)
Show SMILES NNC(=O)Cc1ccc(CCc2ccc(nc2)N2CCCCC2)cc1
Show InChI InChI=1S/C20H26N4O/c21-23-20(25)14-17-7-4-16(5-8-17)6-9-18-10-11-19(22-15-18)24-12-2-1-3-13-24/h4-5,7-8,10-11,15H,1-3,6,9,12-14,21H2,(H,23,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309470
PNG
(US9603833, Example 70)
Show SMILES NNC(=O)Cc1ccc(CCc2ccc(CN3CCOCC3)cc2)cc1
Show InChI InChI=1S/C21H27N3O2/c22-23-21(25)15-19-7-3-17(4-8-19)1-2-18-5-9-20(10-6-18)16-24-11-13-26-14-12-24/h3-10H,1-2,11-16,22H2,(H,23,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309487
PNG
(US9603833, Example 109)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CNC(=O)NN)cc2)nc1
Show InChI InChI=1S/C21H28N6O2/c1-16(28)26-10-12-27(13-11-26)20-9-8-19(23-15-20)7-6-17-2-4-18(5-3-17)14-24-21(29)25-22/h2-5,8-9,15H,6-7,10-14,22H2,1H3,(H2,24,25,29)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309475
PNG
(US9603833, Example 87)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CC(=O)NN)cc2)nc1
Show InChI InChI=1S/C21H27N5O2/c1-16(27)25-10-12-26(13-11-25)20-9-8-19(23-15-20)7-6-17-2-4-18(5-3-17)14-21(28)24-22/h2-5,8-9,15H,6-7,10-14,22H2,1H3,(H,24,28)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309478
PNG
(US9603833, Example 90)
Show SMILES CCCN(C)c1ccc(CCc2ccc(CC(=O)NN)cc2)cn1
Show InChI InChI=1S/C19H26N4O/c1-3-12-23(2)18-11-10-17(14-21-18)9-6-15-4-7-16(8-5-15)13-19(24)22-20/h4-5,7-8,10-11,14H,3,6,9,12-13,20H2,1-2H3,(H,22,24)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309488
PNG
(US9603833, Example 110)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(OC(=O)NN)cc2)nc1
Show InChI InChI=1S/C20H25N5O3/c1-15(26)24-10-12-25(13-11-24)18-7-6-17(22-14-18)5-2-16-3-8-19(9-4-16)28-20(27)23-21/h3-4,6-9,14H,2,5,10-13,21H2,1H3,(H,23,27)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309498
PNG
(US9603833, Example 121)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2csc(CCC(=O)NN)c2)nc1
Show InChI InChI=1S/C20H27N5O2S/c1-15(26)24-8-10-25(11-9-24)18-5-4-17(22-13-18)3-2-16-12-19(28-14-16)6-7-20(27)23-21/h4-5,12-14H,2-3,6-11,21H2,1H3,(H,23,27)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309473
PNG
(US9603833, Example 85)
Show SMILES CCN(CC)c1ccc(CCc2ccc(CC(=O)NN)cc2)cn1
Show InChI InChI=1S/C19H26N4O/c1-3-23(4-2)18-12-11-17(14-21-18)10-7-15-5-8-16(9-6-15)13-19(24)22-20/h5-6,8-9,11-12,14H,3-4,7,10,13,20H2,1-2H3,(H,22,24)
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US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309482
PNG
(US9603833, Example 101)
Show SMILES CC(=O)N1CCN(CC1)c1cnc(CCc2ccc(CC(=O)NN)cc2)cn1
Show InChI InChI=1S/C20H26N6O2/c1-15(27)25-8-10-26(11-9-25)19-14-22-18(13-23-19)7-6-16-2-4-17(5-3-16)12-20(28)24-21/h2-5,13-14H,6-12,21H2,1H3,(H,24,28)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309461
PNG
(US9603833, Example 30)
Show SMILES CCN(CC)c1ccc(CCc2ccc(CC(=O)NN)cc2)cc1
Show InChI InChI=1S/C20H27N3O/c1-3-23(4-2)19-13-11-17(12-14-19)6-5-16-7-9-18(10-8-16)15-20(24)22-21/h7-14H,3-6,15,21H2,1-2H3,(H,22,24)
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US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309481
PNG
(US9603833, Example 99)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CC(=O)NN)cc2)nn1
Show InChI InChI=1S/C20H26N6O2/c1-15(27)25-10-12-26(13-11-25)19-9-8-18(23-24-19)7-6-16-2-4-17(5-3-16)14-20(28)22-21/h2-5,8-9H,6-7,10-14,21H2,1H3,(H,22,28)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309495
PNG
(US9603833, Example 117)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CCNC(=O)NN)s2)nc1
Show InChI InChI=1S/C20H28N6O2S/c1-15(27)25-10-12-26(13-11-25)17-4-2-16(23-14-17)3-5-18-6-7-19(29-18)8-9-22-20(28)24-21/h2,4,6-7,14H,3,5,8-13,21H2,1H3,(H2,22,24,28)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309480
PNG
(US9603833, Example 95)
Show SMILES NNC(=O)Cc1ccc(CCc2csc(n2)N2CCNCC2)cc1
Show InChI InChI=1S/C17H23N5OS/c18-21-16(23)11-14-3-1-13(2-4-14)5-6-15-12-24-17(20-15)22-9-7-19-8-10-22/h1-4,12,19H,5-11,18H2,(H,21,23)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309465
PNG
(US9603833, Example 47)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CC(=O)NN)cc2)cn1
Show InChI InChI=1S/C21H27N5O2/c1-16(27)25-10-12-26(13-11-25)20-9-8-19(15-23-20)7-4-17-2-5-18(6-3-17)14-21(28)24-22/h2-3,5-6,8-9,15H,4,7,10-14,22H2,1H3,(H,24,28)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309471
PNG
(US9603833, Example 74)
Show SMILES NNC(=O)Cc1ccc(CCc2ccc(s2)N2CCNCC2)cc1
Show InChI InChI=1S/C18H24N4OS/c19-21-17(23)13-15-3-1-14(2-4-15)5-6-16-7-8-18(24-16)22-11-9-20-10-12-22/h1-4,7-8,20H,5-6,9-13,19H2,(H,21,23)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309460
PNG
(US9603833, Example 20)
Show SMILES NNC(=O)Cc1ccc(CCc2csc(n2)C2CCNCC2)cc1
Show InChI InChI=1S/C18H24N4OS/c19-22-17(23)11-14-3-1-13(2-4-14)5-6-16-12-24-18(21-16)15-7-9-20-10-8-15/h1-4,12,15,20H,5-11,19H2,(H,22,23)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309462
PNG
(US9603833, Example 44)
Show SMILES NNC(=O)Cc1ccc(CCc2ccc(nc2)N2CCCC2)cc1
Show InChI InChI=1S/C19H24N4O/c20-22-19(24)13-16-6-3-15(4-7-16)5-8-17-9-10-18(21-14-17)23-11-1-2-12-23/h3-4,6-7,9-10,14H,1-2,5,8,11-13,20H2,(H,22,24)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309500
PNG
(US9603833, Example 124)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2csc(CCCOC(=O)NN)c2)nc1
Show InChI InChI=1S/C21H29N5O3S/c1-16(27)25-8-10-26(11-9-25)19-7-6-18(23-14-19)5-4-17-13-20(30-15-17)3-2-12-29-21(28)24-22/h6-7,13-15H,2-5,8-12,22H2,1H3,(H,24,28)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309472
PNG
(US9603833, Example 83)
Show SMILES CCN(CCN)c1ccc(CCc2ccc(CC(=O)NN)cc2)cc1
Show InChI InChI=1S/C20H28N4O/c1-2-24(14-13-21)19-11-9-17(10-12-19)4-3-16-5-7-18(8-6-16)15-20(25)23-22/h5-12H,2-4,13-15,21-22H2,1H3,(H,23,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309467
PNG
(US9603833, Example 59)
Show SMILES NNC(=O)Cc1ccc(CCc2ccc(cc2C(F)(F)F)N2CCNCC2)cc1
Show InChI InChI=1S/C21H25F3N4O/c22-21(23,24)19-14-18(28-11-9-26-10-12-28)8-7-17(19)6-5-15-1-3-16(4-2-15)13-20(29)27-25/h1-4,7-8,14,26H,5-6,9-13,25H2,(H,27,29)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309484
PNG
(US9603833, Example 105)
Show SMILES NNC(=O)Cc1ccc(CCc2ccnc(c2)N2CCNCC2)cc1
Show InChI InChI=1S/C19H25N5O/c20-23-19(25)14-16-4-1-15(2-5-16)3-6-17-7-8-22-18(13-17)24-11-9-21-10-12-24/h1-2,4-5,7-8,13,21H,3,6,9-12,14,20H2,(H,23,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309485
PNG
(US9603833, Example 106)
Show SMILES NNC(=O)Cc1ccc(CCc2cc(ncn2)N2CCNCC2)cc1
Show InChI InChI=1S/C18H24N6O/c19-23-18(25)11-15-3-1-14(2-4-15)5-6-16-12-17(22-13-21-16)24-9-7-20-8-10-24/h1-4,12-13,20H,5-11,19H2,(H,23,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309499
PNG
(US9603833, Example 122)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CCOC(=O)NN)cc2)nc1
Show InChI InChI=1S/C22H29N5O3/c1-17(28)26-11-13-27(14-12-26)21-9-8-20(24-16-21)7-6-18-2-4-19(5-3-18)10-15-30-22(29)25-23/h2-5,8-9,16H,6-7,10-15,23H2,1H3,(H,25,29)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309496
PNG
(US9603833, Example 119)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CCC(=O)NN)cc2)nc1
Show InChI InChI=1S/C22H29N5O2/c1-17(28)26-12-14-27(15-13-26)21-10-9-20(24-16-21)8-6-18-2-4-19(5-3-18)7-11-22(29)25-23/h2-5,9-10,16H,6-8,11-15,23H2,1H3,(H,25,29)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309483
PNG
(US9603833, Example 102)
Show SMILES NNC(=O)Cc1ccc(CCc2cncc(c2)N2CCNCC2)cc1
Show InChI InChI=1S/C19H25N5O/c20-23-19(25)12-16-4-1-15(2-5-16)3-6-17-11-18(14-22-13-17)24-9-7-21-8-10-24/h1-2,4-5,11,13-14,21H,3,6-10,12,20H2,(H,23,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309494
PNG
(US9603833, Example 116)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(s2)C(=O)NN)nc1
Show InChI InChI=1S/C18H23N5O2S/c1-13(24)22-8-10-23(11-9-22)15-4-2-14(20-12-15)3-5-16-6-7-17(26-16)18(25)21-19/h2,4,6-7,12H,3,5,8-11,19H2,1H3,(H,21,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309493
PNG
(US9603833, Example 115)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CCc2ccc(CCOC(=O)NN)s2)nc1
Show InChI InChI=1S/C20H27N5O3S/c1-15(26)24-9-11-25(12-10-24)17-4-2-16(22-14-17)3-5-18-6-7-19(29-18)8-13-28-20(27)23-21/h2,4,6-7,14H,3,5,8-13,21H2,1H3,(H,23,27)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair
Amine oxidase, copper containing


(Rattus norvegicus (Rat))
BDBM309466
PNG
(US9603833, Example 51)
Show SMILES NNC(=O)Cc1ccc(CCc2cccc(n2)N2CCNCC2)cc1
Show InChI InChI=1S/C19H25N5O/c20-23-19(25)14-16-6-4-15(5-7-16)8-9-17-2-1-3-18(22-17)24-12-10-21-11-13-24/h1-7,21H,8-14,20H2,(H,23,25)
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R-Tech Ueno, Ltd.

US Patent


Assay Description
The compounds of the present invention obtained in Production Examples were examined for the inhibitory effect on human and rat VAP-1 enzyme (SSAO) b...


US Patent US9603833 (2017)

More data for this
Ligand-Target Pair