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Compile Data Set for Download or QSAR

Found 75 hits of Enz. Inhib. data with enzyme = 'Aminopeptidase' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aminopeptidase


(Homo sapiens (Human))
BDBM401355
PNG
(US10005762, Example 35)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3S/c1-13-11-21-16(9-15(13)6-4-3-5-14-7-8-14)10-19(24,18(22)23)17(20)12-25-2/h9,11,14,17,24H,3-8,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401368
PNG
(US10005762, Example 48)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(\C=C\c2ccccc2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C22H28N2O3/c1-15(2)11-20(23)22(27,21(25)26)13-19-12-18(16(3)14-24-19)10-9-17-7-5-4-6-8-17/h4-10,12,14-15,20,27H,11,13,23H2,1-3H3,(H,25,26)/b10-9+/t20-,22+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401389
PNG
(US10005762, Example 69)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CC3(C)CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)8-18(22)21(26,19(24)25)12-17-16-10-14(11-20(3)5-6-20)9-15(16)4-7-23-17/h4,7,13-14,18,26H,5-6,8-12,22H2,1-3H3,(H,24,25)/t14?,18-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401393
PNG
(US10005762, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)10-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)7-5-4-6-16-8-9-16/h11,13-14,16,19,26H,4-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401320
PNG
(US10005762, Example 4(1))
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)9-18(21)20(25,19(23)24)11-17-10-16(14(3)12-22-17)6-4-5-15-7-8-15/h10,12-13,15,18,25H,4-9,11,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401319
PNG
(US10005762, Example 3)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O3/c1-14-13-23-18(11-17(14)4-2-3-15-5-6-15)12-21(26,20(24)25)19(22)10-9-16-7-8-16/h11,13,15-16,19,26H,2-10,12,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401322
PNG
(US10005762, Example 4(3))
Show SMILES CCC(O)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H34N2O4/c1-5-17(23)8-6-7-15-10-16(22-12-14(15)4)11-20(26,19(24)25)18(21)9-13(2)3/h10,12-13,17-18,23,26H,5-9,11,21H2,1-4H3,(H,24,25)/t17?,18-,20+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401394
PNG
(US10005762, Example 74)
Show SMILES CCCCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C19H32N2O3/c1-5-6-7-8-15-10-16(21-12-14(15)4)11-19(24,18(22)23)17(20)9-13(2)3/h10,12-13,17,24H,5-9,11,20H2,1-4H3,(H,22,23)/t17-,19+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401395
PNG
(US10005762, Example 75)
Show SMILES CCCCCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H34N2O3/c1-5-6-7-8-9-16-11-17(22-13-15(16)4)12-20(25,19(23)24)18(21)10-14(2)3/h11,13-14,18,25H,5-10,12,21H2,1-4H3,(H,23,24)/t18-,20+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401350
PNG
(US10005762, Example 30)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C20H31FN2O3/c1-13-12-23-16(9-15(13)6-4-5-14-7-8-14)10-20(26,18(24)25)17(22)11-19(2,3)21/h9,12,14,17,26H,4-8,10-11,22H2,1-3H3,(H,24,25)/t17-,20+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401392
PNG
(US10005762, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(COC2CCCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O4/c1-14(2)9-19(22)21(26,20(24)25)11-17-10-16(15(3)12-23-17)13-27-18-7-5-4-6-8-18/h10,12,14,18-19,26H,4-9,11,13,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401317
PNG
(US10005762, Example 1)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C18H28N2O3S/c1-12-10-20-15(8-14(12)5-3-4-13-6-7-13)9-18(23,17(21)22)16(19)11-24-2/h8,10,13,16,23H,3-7,9,11,19H2,1-2H3,(H,21,22)/t16-,18+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401351
PNG
(US10005762, Example 31)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)CC2(C)CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O3/c1-14-13-23-17(10-16(14)5-3-4-15-6-7-15)11-21(26,19(24)25)18(22)12-20(2)8-9-20/h10,13,15,18,26H,3-9,11-12,22H2,1-2H3,(H,24,25)/t18-,21+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401367
PNG
(US10005762, Example 47)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)7-10-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)6-4-5-16-8-9-16/h11,13-14,16,19,26H,4-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401369
PNG
(US10005762, Example 49)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2(C)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H34N2O3/c1-14(2)10-18(22)21(26,19(24)25)12-17-11-16(15(3)13-23-17)6-5-7-20(4)8-9-20/h11,13-14,18,26H,5-10,12,22H2,1-4H3,(H,24,25)/t18-,21+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401388
PNG
(US10005762, Example 68)
Show SMILES CC(C)CCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C19H32N2O3/c1-12(2)6-7-15-9-16(21-11-14(15)5)10-19(24,18(22)23)17(20)8-13(3)4/h9,11-13,17,24H,6-8,10,20H2,1-5H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401391
PNG
(US10005762, Example 71)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CC2CCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-13(2)8-18(21)20(25,19(23)24)11-17-10-16(14(3)12-22-17)9-15-6-4-5-7-15/h10,12-13,15,18,25H,4-9,11,21H2,1-3H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401371
PNG
(US10005762, Example 51)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2CC(CC(C)C)Cc12)C(O)=O
Show InChI InChI=1S/C20H32N2O3/c1-12(2)7-14-9-15-5-6-22-17(16(15)10-14)11-20(25,19(23)24)18(21)8-13(3)4/h5-6,12-14,18,25H,7-11,21H2,1-4H3,(H,23,24)/t14?,18-,20+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401375
PNG
(US10005762, Example 55)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@H](CC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-17-16-10-14(8-13-3-4-13)9-15(16)5-6-22-17/h5-6,12-14,18,25H,3-4,7-11,21H2,1-2H3,(H,23,24)/t14-,18-,20+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401361
PNG
(US10005762, Example 41)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C19H28N2O3S/c1-25-11-17(20)19(24,18(22)23)10-16-15-9-13(5-4-12-2-3-12)8-14(15)6-7-21-16/h6-7,12-13,17,24H,2-5,8-11,20H2,1H3,(H,22,23)/t13-,17+,19-/m1/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401372
PNG
(US10005762, Example 52)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401324
PNG
(US10005762, Example 6(1) | US10005762, Example 6(2...)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1CC1CC1CC1)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-16-9-14(5-6-22-16)17-10-15(17)8-13-3-4-13/h5-6,9,12-13,15,17-18,25H,3-4,7-8,10-11,21H2,1-2H3,(H,23,24)/t15?,17?,18-,20+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401323
PNG
(US10005762, Example 5)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401370
PNG
(US10005762, Example 50)
Show SMILES CCC(C)(O)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C21H36N2O4/c1-6-20(5,26)9-7-8-16-11-17(23-13-15(16)4)12-21(27,19(24)25)18(22)10-14(2)3/h11,13-14,18,26-27H,6-10,12,22H2,1-5H3,(H,24,25)/t18-,20?,21+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401390
PNG
(US10005762, Example 70)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(C2CCCC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-12(2)8-17(20)19(24,18(22)23)10-15-9-16(13(3)11-21-15)14-6-4-5-7-14/h9,11-12,14,17,24H,4-8,10,20H2,1-3H3,(H,22,23)/t17-,19+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401321
PNG
(US10005762, Example 4(2))
Show SMILES CCC(Cl)CCCc1cc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)ncc1C
Show InChI InChI=1S/C20H33ClN2O3/c1-5-16(21)8-6-7-15-10-17(23-12-14(15)4)11-20(26,19(24)25)18(22)9-13(2)3/h10,12-13,16,18,26H,5-9,11,22H2,1-4H3,(H,24,25)/t16?,18-,20+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401364
PNG
(US10005762, Example 44)
Show SMILES CSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C19H28N2O3S/c1-25-11-17(20)19(24,18(22)23)10-16-15-9-13(5-4-12-2-3-12)8-14(15)6-7-21-16/h6-7,12-13,17,24H,2-5,8-11,20H2,1H3,(H,22,23)/t13-,17-,19+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401356
PNG
(US10005762, Example 36)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(CCCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C20H32N2O3S/c1-3-26-13-18(21)20(25,19(23)24)11-17-10-16(14(2)12-22-17)7-5-4-6-15-8-9-15/h10,12,15,18,25H,3-9,11,13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401373
PNG
(US10005762, Example 53)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-13(2)10-17(20)19(24,18(22)23)12-16-11-15(8-9-21-16)5-3-4-14-6-7-14/h8-9,11,13-14,17,24H,3-7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401332
PNG
(US10005762, Example 12)
Show SMILES COc1ccccc1CCc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C22H30N2O4/c1-15(2)12-20(23)22(27,21(25)26)14-18-13-16(10-11-24-18)8-9-17-6-4-5-7-19(17)28-3/h4-7,10-11,13,15,20,27H,8-9,12,14,23H2,1-3H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401354
PNG
(US10005762, Example 34)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(CCCC2CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C19H30N2O3S/c1-3-25-12-17(20)19(24,18(22)23)10-16-9-15(13(2)11-21-16)6-4-5-14-7-8-14/h9,11,14,17,24H,3-8,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401381
PNG
(US10005762, Example 61)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCc2cccc(C)c2)ccn1)C(O)=O
Show InChI InChI=1S/C22H30N2O3/c1-15(2)11-20(23)22(27,21(25)26)14-19-13-18(9-10-24-19)8-7-17-6-4-5-16(3)12-17/h4-6,9-10,12-13,15,20,27H,7-8,11,14,23H2,1-3H3,(H,25,26)/t20-,22+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401374
PNG
(US10005762, Example 54)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3/c1-12(2)7-18(21)20(25,19(23)24)11-17-16-10-14(8-13-3-4-13)9-15(16)5-6-22-17/h5-6,12-14,18,25H,3-4,7-11,21H2,1-2H3,(H,23,24)/t14-,18+,20-/m1/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401383
PNG
(US10005762, Example 63)
Show SMILES CCC1CCc2c(C1)ccnc2C[C@@](O)([C@@H](N)CC(C)C)C(O)=O
Show InChI InChI=1S/C19H30N2O3/c1-4-13-5-6-15-14(10-13)7-8-21-16(15)11-19(24,18(22)23)17(20)9-12(2)3/h7-8,12-13,17,24H,4-6,9-11,20H2,1-3H3,(H,22,23)/t13?,17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401331
PNG
(US10005762, Example 11)
Show SMILES CCCC1CC1c1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C19H30N2O3/c1-4-5-13-10-16(13)14-6-7-21-15(9-14)11-19(24,18(22)23)17(20)8-12(2)3/h6-7,9,12-13,16-17,24H,4-5,8,10-11,20H2,1-3H3,(H,22,23)/t13?,16?,17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401365
PNG
(US10005762, Example 45)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C20H30N2O3S/c1-2-26-12-18(21)20(25,19(23)24)11-17-16-10-14(6-5-13-3-4-13)9-15(16)7-8-22-17/h7-8,13-14,18,25H,2-6,9-12,21H2,1H3,(H,23,24)/t14-,18-,20+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401357
PNG
(US10005762, Example 37)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1=CCN(CC1)C(=O)OCc1ccccc1)C(O)=O
Show InChI InChI=1S/C26H33N3O5/c1-18(2)14-23(27)26(33,24(30)31)16-22-15-21(8-11-28-22)20-9-12-29(13-10-20)25(32)34-17-19-6-4-3-5-7-19/h3-9,11,15,18,23,33H,10,12-14,16-17,27H2,1-2H3,(H,30,31)/t23-,26+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401378
PNG
(US10005762, Example 58)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)C1=CCCCC1)C(O)=O
Show InChI InChI=1S/C19H28N2O3/c1-13(2)10-17(20)19(24,18(22)23)12-16-11-15(8-9-21-16)14-6-4-3-5-7-14/h6,8-9,11,13,17,24H,3-5,7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401384
PNG
(US10005762, Example 64)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(Cc2ccccc2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C21H28N2O3/c1-14(2)9-19(22)21(26,20(24)25)12-18-11-17(15(3)13-23-18)10-16-7-5-4-6-8-16/h4-8,11,13-14,19,26H,9-10,12,22H2,1-3H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401327
PNG
(US10005762, Example 8)
Show SMILES CCCCCc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1
Show InChI InChI=1S/C18H30N2O3/c1-4-5-6-7-14-8-9-20-15(11-14)12-18(23,17(21)22)16(19)10-13(2)3/h8-9,11,13,16,23H,4-7,10,12,19H2,1-3H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401342
PNG
(US10005762, Example 22)
Show SMILES N[C@@H](CSCCC1CC1)[C@](O)(Cc1cc(CCCC2CC2)ccn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c22-19(14-27-11-9-16-6-7-16)21(26,20(24)25)13-18-12-17(8-10-23-18)3-1-2-15-4-5-15/h8,10,12,15-16,19,26H,1-7,9,11,13-14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401336
PNG
(US10005762, Example 16)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc2[C@H](CCC3CC3)CCc2cn1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)11-17-10-18-15(6-5-14-3-4-14)7-8-16(18)12-23-17/h10,12-15,19,26H,3-9,11,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401362
PNG
(US10005762, Example 42)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-2-9-27-13-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,14-15,19,26H,2-6,9-13,22H2,1H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401338
PNG
(US10005762, Example 18)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(CCC2CC2)c(cn1)C1CC1)C(O)=O
Show InChI InChI=1S/C21H32N2O3/c1-13(2)9-19(22)21(26,20(24)25)11-17-10-16(6-5-14-3-4-14)18(12-23-17)15-7-8-15/h10,12-15,19,26H,3-9,11,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401347
PNG
(US10005762, Example 27)
Show SMILES Cc1cnc(C[C@@](O)([C@@H](N)COCC2CC2)C(O)=O)cc1CCCC1CC1
Show InChI InChI=1S/C21H32N2O4/c1-14-11-23-18(9-17(14)4-2-3-15-5-6-15)10-21(26,20(24)25)19(22)13-27-12-16-7-8-16/h9,11,15-16,19,26H,2-8,10,12-13,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401333
PNG
(US10005762, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(C2CCC3(CC3)CC2)c(C)cn1)C(O)=O
Show InChI InChI=1S/C22H34N2O3/c1-14(2)10-19(23)22(27,20(25)26)12-17-11-18(15(3)13-24-17)16-4-6-21(7-5-16)8-9-21/h11,13-14,16,19,27H,4-10,12,23H2,1-3H3,(H,25,26)/t19-,22+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401363
PNG
(US10005762, Example 43)
Show SMILES CC(C)SC[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-13(2)27-12-19(22)21(26,20(24)25)11-18-17-10-15(6-5-14-3-4-14)9-16(17)7-8-23-18/h7-8,13-15,19,26H,3-6,9-12,22H2,1-2H3,(H,24,25)/t15-,19+,21-/m1/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401386
PNG
(US10005762, Example 66 | US10005762, Example 67)
Show SMILES CCC1Cc2ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c2C1
Show InChI InChI=1S/C18H28N2O3/c1-4-12-8-13-5-6-20-15(14(13)9-12)10-18(23,17(21)22)16(19)7-11(2)3/h5-6,11-12,16,23H,4,7-10,19H2,1-3H3,(H,21,22)/t12?,16-,18+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401349
PNG
(US10005762, Example 29)
Show SMILES CC(C)(F)C[C@H](N)[C@](O)(Cc1nccc2C[C@@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H31FN2O3/c1-20(2,22)12-18(23)21(27,19(25)26)11-17-16-10-14(6-5-13-3-4-13)9-15(16)7-8-24-17/h7-8,13-14,18,27H,3-6,9-12,23H2,1-2H3,(H,25,26)/t14-,18+,21-/m1/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
Aminopeptidase


(Homo sapiens (Human))
BDBM401366
PNG
(US10005762, Example 46)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1nccc2C[C@H](CCC3CC3)Cc12)C(O)=O
Show InChI InChI=1S/C21H32N2O3S/c1-2-9-27-13-19(22)21(26,20(24)25)12-18-17-11-15(6-5-14-3-4-14)10-16(17)7-8-23-18/h7-8,14-15,19,26H,2-6,9-13,22H2,1H3,(H,24,25)/t15-,19-,21+/m0/s1
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Astellas Pharma Inc

US Patent


Assay Description
The inventors have assumed that inhibition of nocturnal activity of placental leucine aminopeptidase (P-LAP), i.e. aminopeptidase that cleaves AVP, w...


US Patent US10005762 (2018)

More data for this
Ligand-Target Pair
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