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Compile Data Set for Download or QSAR

Found 87 hits of Enz. Inhib. data with enzyme = 'Arachidonate 15-lipoxygenase' and Substrate = 'BDBM22231'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22266
PNG
(2,4,5-tri-substituted imidazole, 21n | {ethyl[(3R)...)
Show SMILES CCN([C@@H]1CCN(C1)C(C)c1ccc(F)cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1
Show InChI InChI=1S/C30H36FN5O3S2/c1-4-36(25-16-18-35(20-25)21(2)22-7-11-24(31)12-8-22)41(37,38)32-17-15-27-29(23-9-13-26(39-3)14-10-23)34-30(33-27)28-6-5-19-40-28/h5-14,19,21,25,32H,4,15-18,20H2,1-3H3,(H,33,34)/t21?,25-/m1/s1
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22302
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C29H30N2O3S/c1-2-3-4-9-21-14-16-23(17-15-21)35(32,33)30-19-18-25-24-11-6-7-12-26(24)31-29(25)28-20-22-10-5-8-13-27(22)34-28/h5-8,10-17,20,30-31H,2-4,9,18-19H2,1H3
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22249
PNG
(2,4,5-tri-substituted imidazole, 14n | N-{2-[5-(4-...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1
Show InChI InChI=1S/C27H31N3O3S2/c1-3-4-5-7-20-9-15-23(16-10-20)35(31,32)28-18-17-24-26(21-11-13-22(33-2)14-12-21)30-27(29-24)25-8-6-19-34-25/h6,8-16,19,28H,3-5,7,17-18H2,1-2H3,(H,29,30)
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22304
PNG
(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Show SMILES O=S(=O)(NCCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C31H26N2O3S/c34-37(35,25-18-16-23(17-19-25)22-9-2-1-3-10-22)32-20-8-13-27-26-12-5-6-14-28(26)33-31(27)30-21-24-11-4-7-15-29(24)36-30/h1-7,9-12,14-19,21,32-33H,8,13,20H2
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22305
PNG
(N-[2-(2-dibenzo[b,d]furan-2-yl-1H-indol-3-yl)ethyl...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1ccc2oc3ccccc3c2c1
Show InChI InChI=1S/C33H32N2O3S/c1-2-3-4-9-23-14-17-25(18-15-23)39(36,37)34-21-20-28-26-10-5-7-12-30(26)35-33(28)24-16-19-32-29(22-24)27-11-6-8-13-31(27)38-32/h5-8,10-19,22,34-35H,2-4,9,20-21H2,1H3
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22303
PNG
(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C30H32N2O3S/c1-2-3-4-10-22-16-18-24(19-17-22)36(33,34)31-20-9-13-26-25-12-6-7-14-27(25)32-30(26)29-21-23-11-5-8-15-28(23)35-29/h5-8,11-12,14-19,21,31-32H,2-4,9-10,13,20H2,1H3
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22265
PNG
(2,4,5-tri-substituted imidazole, 21m | {ethyl[(3R)...)
Show SMILES CCN([C@@H]1CCN(C1)C(C)(C)c1ccccc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1
Show InChI InChI=1S/C31H39N5O3S2/c1-5-36(25-18-20-35(22-25)31(2,3)24-10-7-6-8-11-24)41(37,38)32-19-17-27-29(23-13-15-26(39-4)16-14-23)34-30(33-27)28-12-9-21-40-28/h6-16,21,25,32H,5,17-20,22H2,1-4H3,(H,33,34)/t25-/m1/s1
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22308
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C25H22N2O3S/c1-17-10-12-19(13-11-17)31(28,29)26-15-14-21-20-7-3-4-8-22(20)27-25(21)24-16-18-6-2-5-9-23(18)30-24/h2-13,16,26-27H,14-15H2,1H3
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22312
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)S(=O)(=O)NCCc2c([nH]c3ccccc23)-c2cc3ccccc3o2)cc1
Show InChI InChI=1S/C32H27N3O5S/c1-39-24-14-12-23(13-15-24)34-32(36)21-10-16-25(17-11-21)41(37,38)33-19-18-27-26-7-3-4-8-28(26)35-31(27)30-20-22-6-2-5-9-29(22)40-30/h2-17,20,33,35H,18-19H2,1H3,(H,34,36)
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22299
PNG
(4-pentyl-N-{2-[2-(4-propanoylphenyl)-1H-indol-3-yl...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1ccc(cc1)C(=O)CC
Show InChI InChI=1S/C30H34N2O3S/c1-3-5-6-9-22-12-18-25(19-13-22)36(34,35)31-21-20-27-26-10-7-8-11-28(26)32-30(27)24-16-14-23(15-17-24)29(33)4-2/h7-8,10-19,31-32H,3-6,9,20-21H2,1-2H3
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22300
PNG
(4-pentyl-N-(2-{2-[4-(trifluoromethyl)phenyl]-1H-in...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H29F3N2O2S/c1-2-3-4-7-20-10-16-23(17-11-20)36(34,35)32-19-18-25-24-8-5-6-9-26(24)33-27(25)21-12-14-22(15-13-21)28(29,30)31/h5-6,8-17,32-33H,2-4,7,18-19H2,1H3
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22264
PNG
(2,4,5-tri-substituted imidazole, 21l | {[(3R)-1-(3...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N(C)[C@@H]1CCN(C1)c1ccc(Cl)c(Cl)c1)-c1cccs1
Show InChI InChI=1S/C27H29Cl2N5O3S2/c1-33(20-12-14-34(17-20)19-7-10-22(28)23(29)16-19)39(35,36)30-13-11-24-26(18-5-8-21(37-2)9-6-18)32-27(31-24)25-4-3-15-38-25/h3-10,15-16,20,30H,11-14,17H2,1-2H3,(H,31,32)/t20-/m1/s1
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22314
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES O=C(NC1CCCCC1)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C31H31N3O4S/c35-31(33-23-9-2-1-3-10-23)21-14-16-24(17-15-21)39(36,37)32-19-18-26-25-11-5-6-12-27(25)34-30(26)29-20-22-8-4-7-13-28(22)38-29/h4-8,11-17,20,23,32,34H,1-3,9-10,18-19H2,(H,33,35)
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22306
PNG
(4-pentyl-N-{2-[2-(quinolin-3-yl)-1H-indol-3-yl]eth...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cnc2ccccc2c1
Show InChI InChI=1S/C30H31N3O2S/c1-2-3-4-9-22-14-16-25(17-15-22)36(34,35)32-19-18-27-26-11-6-8-13-29(26)33-30(27)24-20-23-10-5-7-12-28(23)31-21-24/h5-8,10-17,20-21,32-33H,2-4,9,18-19H2,1H3
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22253
PNG
(2,4,5-tri-substituted imidazole, 21a | 4-butyl-N-{...)
Show SMILES CCCCN1CCN(CC1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1
Show InChI InChI=1S/C24H33N5O3S2/c1-3-4-13-28-14-16-29(17-15-28)34(30,31)25-12-11-21-23(19-7-9-20(32-2)10-8-19)27-24(26-21)22-6-5-18-33-22/h5-10,18,25H,3-4,11-17H2,1-2H3,(H,26,27)
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22230
PNG
(2,4,5-tri-substituted imidazole, 2 | N-{2-[5-(4-me...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1ccccc1
Show InChI InChI=1S/C29H33N3O3S/c1-3-4-6-9-22-12-18-26(19-13-22)36(33,34)30-21-20-27-28(23-14-16-25(35-2)17-15-23)32-29(31-27)24-10-7-5-8-11-24/h5,7-8,10-19,30H,3-4,6,9,20-21H2,1-2H3,(H,31,32)
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22311
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES O=C(Nc1ccccc1)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C31H25N3O4S/c35-31(33-23-9-2-1-3-10-23)21-14-16-24(17-15-21)39(36,37)32-19-18-26-25-11-5-6-12-27(25)34-30(26)29-20-22-8-4-7-13-28(22)38-29/h1-17,20,32,34H,18-19H2,(H,33,35)
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22297
PNG
(N-{2-[2-(3-methylphenyl)-1H-indol-3-yl]ethyl}-4-pe...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cccc(C)c1
Show InChI InChI=1S/C28H32N2O2S/c1-3-4-5-10-22-14-16-24(17-15-22)33(31,32)29-19-18-26-25-12-6-7-13-27(25)30-28(26)23-11-8-9-21(2)20-23/h6-9,11-17,20,29-30H,3-5,10,18-19H2,1-2H3
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22295
PNG
(N-{2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl}-4-p...)
Show SMILES COc1ccc(cc1)-c1[nH]c2ccccc2c1CCNS(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C29H26N2O3S/c1-34-24-15-11-23(12-16-24)29-27(26-9-5-6-10-28(26)31-29)19-20-30-35(32,33)25-17-13-22(14-18-25)21-7-3-2-4-8-21/h2-18,30-31H,19-20H2,1H3
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22301
PNG
(N-{2-[2-(2,5-dimethoxyphenyl)-1H-indol-3-yl]ethyl}...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc(OC)ccc1OC
Show InChI InChI=1S/C29H34N2O4S/c1-4-5-6-9-21-12-15-23(16-13-21)36(32,33)30-19-18-25-24-10-7-8-11-27(24)31-29(25)26-20-22(34-2)14-17-28(26)35-3/h7-8,10-17,20,30-31H,4-6,9,18-19H2,1-3H3
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22309
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES Brc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C24H19BrN2O3S/c25-17-9-11-18(12-10-17)31(28,29)26-14-13-20-19-6-2-3-7-21(19)27-24(20)23-15-16-5-1-4-8-22(16)30-23/h1-12,15,26-27H,13-14H2
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22261
PNG
(2,4,5-tri-substituted imidazole, 21i | {[(3R)-1-be...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N(C)[C@@H]1CCN(Cc2ccccc2)C1)-c1ccccc1
Show InChI InChI=1S/C30H35N5O3S/c1-34(26-18-20-35(22-26)21-23-9-5-3-6-10-23)39(36,37)31-19-17-28-29(24-13-15-27(38-2)16-14-24)33-30(32-28)25-11-7-4-8-12-25/h3-16,26,31H,17-22H2,1-2H3,(H,32,33)/t26-/m1/s1
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22298
PNG
(N-{2-[2-(4-chlorophenyl)-1H-indol-3-yl]ethyl}-4-pe...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C27H29ClN2O2S/c1-2-3-4-7-20-10-16-23(17-11-20)33(31,32)29-19-18-25-24-8-5-6-9-26(24)30-27(25)21-12-14-22(28)15-13-21/h5-6,8-17,29-30H,2-4,7,18-19H2,1H3
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22232
PNG
(2,4,5-tri-substituted imidazole, 6a | N-[2-(2,5-di...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C28H31N3O2S/c1-2-3-6-11-22-16-18-25(19-17-22)34(32,33)29-21-20-26-27(23-12-7-4-8-13-23)31-28(30-26)24-14-9-5-10-15-24/h4-5,7-10,12-19,29H,2-3,6,11,20-21H2,1H3,(H,30,31)
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22256
PNG
(2,4,5-tri-substituted imidazole, 21d | 4-(3,4-dich...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N1CCN(CC1)c1ccc(Cl)c(Cl)c1)-c1cccs1
Show InChI InChI=1S/C26H27Cl2N5O3S2/c1-36-20-7-4-18(5-8-20)25-23(30-26(31-25)24-3-2-16-37-24)10-11-29-38(34,35)33-14-12-32(13-15-33)19-6-9-21(27)22(28)17-19/h2-9,16-17,29H,10-15H2,1H3,(H,30,31)
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Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22293
PNG
(N-{2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl}-4-p...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C28H32N2O3S/c1-3-4-5-8-21-11-17-24(18-12-21)34(31,32)29-20-19-26-25-9-6-7-10-27(25)30-28(26)22-13-15-23(33-2)16-14-22/h6-7,9-18,29-30H,3-5,8,19-20H2,1-2H3
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n/an/a 37n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22263
PNG
(2,4,5-tri-substituted imidazole, 21k | {[(3R)-1-be...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N(C)[C@@H]1CCN(Cc2ccccc2)C1)-c1cccs1
Show InChI InChI=1S/C28H33N5O3S2/c1-32(23-15-17-33(20-23)19-21-7-4-3-5-8-21)38(34,35)29-16-14-25-27(22-10-12-24(36-2)13-11-22)31-28(30-25)26-9-6-18-37-26/h3-13,18,23,29H,14-17,19-20H2,1-2H3,(H,30,31)/t23-/m1/s1
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22313
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES CCCCNC(=O)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C29H29N3O4S/c1-2-3-17-30-29(33)20-12-14-22(15-13-20)37(34,35)31-18-16-24-23-9-5-6-10-25(23)32-28(24)27-19-21-8-4-7-11-26(21)36-27/h4-15,19,31-32H,2-3,16-18H2,1H3,(H,30,33)
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22255
PNG
(2,4,5-tri-substituted imidazole, 21c | 4-(2-chloro...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N1CCN(CC1)c1ccccc1Cl)-c1cccs1
Show InChI InChI=1S/C26H28ClN5O3S2/c1-35-20-10-8-19(9-11-20)25-22(29-26(30-25)24-7-4-18-36-24)12-13-28-37(33,34)32-16-14-31(15-17-32)23-6-3-2-5-21(23)27/h2-11,18,28H,12-17H2,1H3,(H,29,30)
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n/an/a 45n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22310
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES O=S(=O)(NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1)c1ccc(cc1)-c1ccncc1
Show InChI InChI=1S/C29H23N3O3S/c33-36(34,23-11-9-20(10-12-23)21-13-16-30-17-14-21)31-18-15-25-24-6-2-3-7-26(24)32-29(25)28-19-22-5-1-4-8-27(22)35-28/h1-14,16-17,19,31-32H,15,18H2
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n/an/a 47n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22286
PNG
(N-[3-(1H-indol-3-yl)propyl]-4-pentylbenzene-1-sulf...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C22H28N2O2S/c1-2-3-4-8-18-12-14-20(15-13-18)27(25,26)24-16-7-9-19-17-23-22-11-6-5-10-21(19)22/h5-6,10-15,17,23-24H,2-4,7-9,16H2,1H3
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22251
PNG
(2,4,5-tri-substituted imidazole, 14p | N-{3-[5-(4-...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1
Show InChI InChI=1S/C28H33N3O3S2/c1-3-4-5-8-21-11-17-24(18-12-21)36(32,33)29-19-6-9-25-27(22-13-15-23(34-2)16-14-22)31-28(30-25)26-10-7-20-35-26/h7,10-18,20,29H,3-6,8-9,19H2,1-2H3,(H,30,31)
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n/an/a 53n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22257
PNG
(2,4,5-tri-substituted imidazole, 21e | 4-(3,4-dich...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N1CCN(CC1)c1ccc(Cl)c(Cl)c1)-c1ccccc1
Show InChI InChI=1S/C28H29Cl2N5O3S/c1-38-23-10-7-20(8-11-23)27-26(32-28(33-27)21-5-3-2-4-6-21)13-14-31-39(36,37)35-17-15-34(16-18-35)22-9-12-24(29)25(30)19-22/h2-12,19,31H,13-18H2,1H3,(H,32,33)
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22234
PNG
(2,4,5-tri-substituted imidazole, 6c | N-{2-[5-(4-f...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(F)cc1)-c1ccccc1
Show InChI InChI=1S/C28H30FN3O2S/c1-2-3-5-8-21-11-17-25(18-12-21)35(33,34)30-20-19-26-27(22-13-15-24(29)16-14-22)32-28(31-26)23-9-6-4-7-10-23/h4,6-7,9-18,30H,2-3,5,8,19-20H2,1H3,(H,31,32)
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22296
PNG
(4-pentyl-N-[2-(2-phenyl-1H-indol-3-yl)ethyl]benzen...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C27H30N2O2S/c1-2-3-5-10-21-15-17-23(18-16-21)32(30,31)28-20-19-25-24-13-8-9-14-26(24)29-27(25)22-11-6-4-7-12-22/h4,6-9,11-18,28-29H,2-3,5,10,19-20H2,1H3
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Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22233
PNG
(2,4,5-tri-substituted imidazole, 6b | 4-pentyl-N-(...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(cc1)C(F)(F)F)-c1ccccc1
Show InChI InChI=1S/C29H30F3N3O2S/c1-2-3-5-8-21-11-17-25(18-12-21)38(36,37)33-20-19-26-27(22-13-15-24(16-14-22)29(30,31)32)35-28(34-26)23-9-6-4-7-10-23/h4,6-7,9-18,33H,2-3,5,8,19-20H2,1H3,(H,34,35)
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n/an/a 72n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22317
PNG
(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Show SMILES CN(C)CCN(C)C(=O)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C30H32N4O4S/c1-33(2)18-19-34(3)30(35)21-12-14-23(15-13-21)39(36,37)31-17-16-25-24-9-5-6-10-26(24)32-29(25)28-20-22-8-4-7-11-27(22)38-28/h4-15,20,31-32H,16-19H2,1-3H3
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n/an/a 76n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22262
PNG
(2,4,5-tri-substituted imidazole, 21j | {[(3S)-1-be...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N(C)[C@H]1CCN(Cc2ccccc2)C1)-c1ccccc1
Show InChI InChI=1S/C30H35N5O3S/c1-34(26-18-20-35(22-26)21-23-9-5-3-6-10-23)39(36,37)31-19-17-28-29(24-13-15-27(38-2)16-14-24)33-30(32-28)25-11-7-4-8-12-25/h3-16,26,31H,17-22H2,1-2H3,(H,32,33)/t26-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22235
PNG
(2,4,5-tri-substituted imidazole, 6d | N-{2-[5-(3-m...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1cccc(OC)c1)-c1ccccc1
Show InChI InChI=1S/C29H33N3O3S/c1-3-4-6-10-22-15-17-26(18-16-22)36(33,34)30-20-19-27-28(24-13-9-14-25(21-24)35-2)32-29(31-27)23-11-7-5-8-12-23/h5,7-9,11-18,21,30H,3-4,6,10,19-20H2,1-2H3,(H,31,32)
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n/an/a 82n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22259
PNG
(2,4,5-tri-substituted imidazole, 21g | {[(3R)-1-be...)
Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N[C@@H]1CCN(Cc2ccccc2)C1)-c1ccccc1
Show InChI InChI=1S/C29H33N5O3S/c1-37-26-14-12-23(13-15-26)28-27(31-29(32-28)24-10-6-3-7-11-24)16-18-30-38(35,36)33-25-17-19-34(21-25)20-22-8-4-2-5-9-22/h2-15,25,30,33H,16-21H2,1H3,(H,31,32)/t25-/m1/s1
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n/an/a 83n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22244
PNG
(2,4,5-tri-substituted imidazole, 14i | N-{2-[5-(4-...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1ccncc1
Show InChI InChI=1S/C28H32N4O3S/c1-3-4-5-6-21-7-13-25(14-8-21)36(33,34)30-20-17-26-27(22-9-11-24(35-2)12-10-22)32-28(31-26)23-15-18-29-19-16-23/h7-16,18-19,30H,3-6,17,20H2,1-2H3,(H,31,32)
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n/an/a 87n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22315
PNG
(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Show SMILES NNC(=O)c1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1cc2ccccc2o1
Show InChI InChI=1S/C25H22N4O4S/c26-29-25(30)16-9-11-18(12-10-16)34(31,32)27-14-13-20-19-6-2-3-7-21(19)28-24(20)23-15-17-5-1-4-8-22(17)33-23/h1-12,15,27-28H,13-14,26H2,(H,29,30)
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n/an/a 89n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22254
PNG
(2,4,5-tri-substituted imidazole, 21b | N-{2-[5-(4-...)
Show SMILES CCCCCN1CCN(CC1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1
Show InChI InChI=1S/C25H35N5O3S2/c1-3-4-5-14-29-15-17-30(18-16-29)35(31,32)26-13-12-22-24(20-8-10-21(33-2)11-9-20)28-25(27-22)23-7-6-19-34-23/h6-11,19,26H,3-5,12-18H2,1-2H3,(H,27,28)
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n/an/a 91n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22239
PNG
(2,4,5-tri-substituted imidazole, 14d | N-{2-[5-(4-...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C29H32N4O5S/c1-3-4-5-7-21-10-16-26(17-11-21)39(36,37)30-19-18-27-28(22-12-14-25(38-2)15-13-22)32-29(31-27)23-8-6-9-24(20-23)33(34)35/h6,8-17,20,30H,3-5,7,18-19H2,1-2H3,(H,31,32)
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n/an/a 99n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22291
PNG
(N-{2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl}-4-m...)
Show SMILES COc1ccc(cc1)-c1[nH]c2ccccc2c1CCNS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C24H24N2O3S/c1-17-7-13-20(14-8-17)30(27,28)25-16-15-22-21-5-3-4-6-23(21)26-24(22)18-9-11-19(29-2)12-10-18/h3-14,25-26H,15-16H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22287
PNG
(N-[4-(1H-indol-3-yl)butyl]-4-pentylbenzene-1-sulfo...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCCCc1c[nH]c2ccccc12
Show InChI InChI=1S/C23H30N2O2S/c1-2-3-4-9-19-13-15-21(16-14-19)28(26,27)25-17-8-7-10-20-18-24-23-12-6-5-11-22(20)23/h5-6,11-16,18,24-25H,2-4,7-10,17H2,1H3
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22292
PNG
(4-butyl-N-{2-[2-(4-methoxyphenyl)-1H-indol-3-yl]et...)
Show SMILES CCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1ccc(OC)cc1
Show InChI InChI=1S/C27H30N2O3S/c1-3-4-7-20-10-16-23(17-11-20)33(30,31)28-19-18-25-24-8-5-6-9-26(24)29-27(25)21-12-14-22(32-2)15-13-21/h5-6,8-17,28-29H,3-4,7,18-19H2,1-2H3
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n/an/a 110n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22250
PNG
(2,4,5-tri-substituted imidazole, 14o | N-{3-[5-(4-...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1ccccc1
Show InChI InChI=1S/C30H35N3O3S/c1-3-4-6-10-23-14-20-27(21-15-23)37(34,35)31-22-9-13-28-29(24-16-18-26(36-2)19-17-24)33-30(32-28)25-11-7-5-8-12-25/h5,7-8,11-12,14-21,31H,3-4,6,9-10,13,22H2,1-2H3,(H,32,33)
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n/an/a 140n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22307
PNG
(N-methyl indole sulfonamide, 39 | N-{2-[2-(1-benzo...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c(-c2cc3ccccc3o2)n(C)c2ccccc12
Show InChI InChI=1S/C30H32N2O3S/c1-3-4-5-10-22-15-17-24(18-16-22)36(33,34)31-20-19-26-25-12-7-8-13-27(25)32(2)30(26)29-21-23-11-6-9-14-28(23)35-29/h6-9,11-18,21,31H,3-5,10,19-20H2,1-2H3
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n/an/a 143n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 15: 1435-40 (2005)


Article DOI: 10.1016/j.bmcl.2004.12.081
BindingDB Entry DOI: 10.7270/Q2T43RD2
More data for this
Ligand-Target Pair
Arachidonate 15-lipoxygenase


(Oryctolagus cuniculus (rabbit))
BDBM22238
PNG
(2,4,5-tri-substituted imidazole, 14c | N-{2-[2-(4-...)
Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C29H32ClN3O3S/c1-3-4-5-6-21-7-17-26(18-8-21)37(34,35)31-20-19-27-28(22-11-15-25(36-2)16-12-22)33-29(32-27)23-9-13-24(30)14-10-23/h7-18,31H,3-6,19-20H2,1-2H3,(H,32,33)
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n/an/a 210n/an/an/an/an/an/a



Bristol-Myers Squibb Company



Assay Description
The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...


Bioorg Med Chem Lett 17: 5115-20 (2007)


Article DOI: 10.1016/j.bmcl.2007.07.011
BindingDB Entry DOI: 10.7270/Q2XW4H31
More data for this
Ligand-Target Pair
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