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Compile Data Set for Download or QSAR

Found 131 hits of Enz. Inhib. data with enzyme = 'Aurora kinase A' and Substrate = 'CHOCKtide'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase A


(Homo sapiens (human))
BDBM12103
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 11 | 4-te...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1cccs1
Show InChI InChI=1S/C22H24N4O2S/c1-22(2,3)15-8-6-14(7-9-15)21(28)23-20-17-12-26(13-18(17)24-25-20)19(27)11-16-5-4-10-29-16/h4-10H,11-13H2,1-3H3,(H2,23,24,25,28)
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n/an/a 5n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 48: 3080-4 (2005)


Article DOI: 10.1021/jm049076m
BindingDB Entry DOI: 10.7270/Q2FF3QKK
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12983
PNG
(5-Amido-pyrrolopyrazole 9b | CHEMBL385872 | N-{5-[...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)[C@H](O)c1ccccc1
Show InChI InChI=1S/C25H28N6O3/c1-29-11-13-30(14-12-29)19-9-7-18(8-10-19)24(33)26-23-20-15-31(16-21(20)27-28-23)25(34)22(32)17-5-3-2-4-6-17/h2-10,22,32H,11-16H2,1H3,(H2,26,27,28,33)/t22-/m1/s1
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n/an/a 6n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12982
PNG
(5-Amido-pyrrolopyrazole 9a | CHEMBL385266 | N-{5-[...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)[C@H](F)c1ccccc1
Show InChI InChI=1S/C25H27FN6O2/c1-30-11-13-31(14-12-30)19-9-7-18(8-10-19)24(33)27-23-20-15-32(16-21(20)28-29-23)25(34)22(26)17-5-3-2-4-6-17/h2-10,22H,11-16H2,1H3,(H2,27,28,29,33)/t22-/m1/s1
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n/an/a 9n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12985
PNG
(5-Amido-pyrrolopyrazole 9d | CHEMBL402548 | N-{5-[...)
Show SMILES CO[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1
Show InChI InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m1/s1
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n/an/a 13n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12984
PNG
(4-(4-methylpiperazin-1-yl)-N-{5-[(2R)-2-phenylprop...)
Show SMILES C[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1
Show InChI InChI=1S/C26H30N6O2/c1-18(19-6-4-3-5-7-19)26(34)32-16-22-23(17-32)28-29-24(22)27-25(33)20-8-10-21(11-9-20)31-14-12-30(2)13-15-31/h3-11,18H,12-17H2,1-2H3,(H2,27,28,29,33)/t18-/m1/s1
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n/an/a 24n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12110
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 18 | 5-N-...)
Show SMILES CCc1cccc(CC)c1NC(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1
Show InChI InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H,4-5,13-18H2,1-3H3,(H,29,37)(H2,30,31,32,36)
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n/an/a 27n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12110
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 18 | 5-N-...)
Show SMILES CCc1cccc(CC)c1NC(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1
Show InChI InChI=1S/C28H35N7O2/c1-4-19-7-6-8-20(5-2)25(19)29-28(37)35-17-23-24(18-35)31-32-26(23)30-27(36)21-9-11-22(12-10-21)34-15-13-33(3)14-16-34/h6-12H,4-5,13-18H2,1-3H3,(H,29,37)(H2,30,31,32,36)
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n/an/a 27n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 48: 3080-4 (2005)


Article DOI: 10.1021/jm049076m
BindingDB Entry DOI: 10.7270/Q2FF3QKK
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31541
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 24)
Show SMILES CN1CCN(CC1)c1cccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)c1
Show InChI InChI=1S/C22H26N8O/c1-28-8-10-30(11-9-28)16-5-3-4-15(12-16)25-22-24-13-14-6-7-17-19(21(23)31)27-29(2)20(17)18(14)26-22/h3-5,12-13H,6-11H2,1-2H3,(H2,23,31)(H,24,25,26)
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n/an/a 30n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12104
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 12 | 4-te...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)c1ccco1
Show InChI InChI=1S/C21H22N4O3/c1-21(2,3)14-8-6-13(7-9-14)19(26)22-18-15-11-25(12-16(15)23-24-18)20(27)17-5-4-10-28-17/h4-10H,11-12H2,1-3H3,(H2,22,23,24,26)
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n/an/a 41n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 48: 3080-4 (2005)


Article DOI: 10.1021/jm049076m
BindingDB Entry DOI: 10.7270/Q2FF3QKK
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31532
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 1)
Show SMILES Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccccc4)nc3-c12
Show InChI InChI=1S/C17H16N6O/c1-23-15-12(14(22-23)16(18)24)8-7-10-9-19-17(21-13(10)15)20-11-5-3-2-4-6-11/h2-6,9H,7-8H2,1H3,(H2,18,24)(H,19,20,21)
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n/an/a 50n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31542
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 25)
Show SMILES Cn1nc(C(N)=O)c2CCc3cnc(Nc4ccc(cc4)N4CCOCC4)nc3-c12
Show InChI InChI=1S/C21H23N7O2/c1-27-19-16(18(26-27)20(22)29)7-2-13-12-23-21(25-17(13)19)24-14-3-5-15(6-4-14)28-8-10-30-11-9-28/h3-6,12H,2,7-11H2,1H3,(H2,22,29)(H,23,24,25)
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n/an/a 51n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31539
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 22)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CCc4c(nn(C)c4-c3n2)C(N)=O)cc1
Show InChI InChI=1S/C22H26N8O/c1-28-9-11-30(12-10-28)16-6-4-15(5-7-16)25-22-24-13-14-3-8-17-19(21(23)31)27-29(2)20(17)18(14)26-22/h4-7,13H,3,8-12H2,1-2H3,(H2,23,31)(H,24,25,26)
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n/an/a 53n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12107
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 15 | 4-(4...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1cccs1
Show InChI InChI=1S/C23H26N6O2S/c1-27-8-10-28(11-9-27)17-6-4-16(5-7-17)23(31)24-22-19-14-29(15-20(19)25-26-22)21(30)13-18-3-2-12-32-18/h2-7,12H,8-11,13-15H2,1H3,(H2,24,25,26,31)
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n/an/a 65n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12107
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 15 | 4-(4...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1cccs1
Show InChI InChI=1S/C23H26N6O2S/c1-27-8-10-28(11-9-27)17-6-4-16(5-7-17)23(31)24-22-19-14-29(15-20(19)25-26-22)21(30)13-18-3-2-12-32-18/h2-7,12H,8-11,13-15H2,1H3,(H2,24,25,26,31)
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n/an/a 65n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 48: 3080-4 (2005)


Article DOI: 10.1021/jm049076m
BindingDB Entry DOI: 10.7270/Q2FF3QKK
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25680
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Show SMILES OC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-6(2-4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)
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n/an/a 79n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25683
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(2-methoxyet...)
Show SMILES COCCNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C13H14BrN3O2S/c1-19-7-6-15-12(18)9-2-4-10(5-3-9)17-13-16-8-11(14)20-13/h2-5,8H,6-7H2,1H3,(H,15,18)(H,16,17)
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n/an/a 97n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12106
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 14 | 3-(4...)
Show SMILES CCc1cccc(CC)c1NC(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)C(C)(C)C)c2C1
Show InChI InChI=1S/C27H33N5O2/c1-6-17-9-8-10-18(7-2)23(17)28-26(34)32-15-21-22(16-32)30-31-24(21)29-25(33)19-11-13-20(14-12-19)27(3,4)5/h8-14H,6-7,15-16H2,1-5H3,(H,28,34)(H2,29,30,31,33)
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PubMed
n/an/a 100n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 48: 3080-4 (2005)


Article DOI: 10.1021/jm049076m
BindingDB Entry DOI: 10.7270/Q2FF3QKK
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12105
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 13 | 4-te...)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1ccccc1
Show InChI InChI=1S/C24H26N4O2/c1-24(2,3)18-11-9-17(10-12-18)23(30)25-22-19-14-28(15-20(19)26-27-22)21(29)13-16-7-5-4-6-8-16/h4-12H,13-15H2,1-3H3,(H2,25,26,27,30)
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PubMed
n/an/a 130n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 48: 3080-4 (2005)


Article DOI: 10.1021/jm049076m
BindingDB Entry DOI: 10.7270/Q2FF3QKK
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25681
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Show SMILES CNC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-13-10(16)7-2-4-8(5-3-7)15-11-14-6-9(12)17-11/h2-6H,1H3,(H,13,16)(H,14,15)
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n/an/a 140n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12109
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 17 | 4-(4...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1ccccc1
Show InChI InChI=1S/C25H28N6O2/c1-29-11-13-30(14-12-29)20-9-7-19(8-10-20)25(33)26-24-21-16-31(17-22(21)27-28-24)23(32)15-18-5-3-2-4-6-18/h2-10H,11-17H2,1H3,(H2,26,27,28,33)
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n/an/a 140n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 48: 3080-4 (2005)


Article DOI: 10.1021/jm049076m
BindingDB Entry DOI: 10.7270/Q2FF3QKK
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12109
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 17 | 4-(4...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)Cc1ccccc1
Show InChI InChI=1S/C25H28N6O2/c1-29-11-13-30(14-12-29)20-9-7-19(8-10-20)25(33)26-24-21-16-31(17-22(21)27-28-24)23(32)15-18-5-3-2-4-6-18/h2-10H,11-17H2,1H3,(H2,26,27,28,33)
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n/an/a 140n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12108
PNG
(1,4,5,6-Tetrahydropyrrolo[3,4-c]pyrazole 16 | CHEM...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)c1ccco1
Show InChI InChI=1S/C22H24N6O3/c1-26-8-10-27(11-9-26)16-6-4-15(5-7-16)21(29)23-20-17-13-28(14-18(17)24-25-20)22(30)19-3-2-12-31-19/h2-7,12H,8-11,13-14H2,1H3,(H2,23,24,25,29)
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n/an/a 160n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 48: 3080-4 (2005)


Article DOI: 10.1021/jm049076m
BindingDB Entry DOI: 10.7270/Q2FF3QKK
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12091
PNG
(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 9...)
Show SMILES CC(C)C(=O)N1Cc2n[nH]c(NC(=O)c3ccc4OCOc4c3)c2C1
Show InChI InChI=1S/C17H18N4O4/c1-9(2)17(23)21-6-11-12(7-21)19-20-15(11)18-16(22)10-3-4-13-14(5-10)25-8-24-13/h3-5,9H,6-8H2,1-2H3,(H2,18,19,20,22)
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n/an/a 160n/an/an/an/an/an/a



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


Bioorg Med Chem Lett 16: 1084-90 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.071
BindingDB Entry DOI: 10.7270/Q2PZ5725
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31540
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 23)
Show SMILES CNC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21
Show InChI InChI=1S/C23H28N8O/c1-24-22(32)20-18-9-4-15-14-25-23(27-19(15)21(18)30(3)28-20)26-16-5-7-17(8-6-16)31-12-10-29(2)11-13-31/h5-8,14H,4,9-13H2,1-3H3,(H,24,32)(H,25,26,27)
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n/an/a 175n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31534
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 17)
Show SMILES Cn1nc(C(=O)NC2CC2)c2CCc3cnc(Nc4ccccc4)nc3-c12
Show InChI InChI=1S/C20H20N6O/c1-26-18-15(17(25-26)19(27)22-14-8-9-14)10-7-12-11-21-20(24-16(12)18)23-13-5-3-2-4-6-13/h2-6,11,14H,7-10H2,1H3,(H,22,27)(H,21,23,24)
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n/an/a 213n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31533
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 16)
Show SMILES CNC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccccc3)nc-21
Show InChI InChI=1S/C18H18N6O/c1-19-17(25)15-13-9-8-11-10-20-18(21-12-6-4-3-5-7-12)22-14(11)16(13)24(2)23-15/h3-7,10H,8-9H2,1-2H3,(H,19,25)(H,20,21,22)
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n/an/a 312n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25684
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-(1-methoxypr...)
Show SMILES COCC(C)NC(=O)c1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C14H16BrN3O2S/c1-9(8-20-2)17-13(19)10-3-5-11(6-4-10)18-14-16-7-12(15)21-14/h3-7,9H,8H2,1-2H3,(H,16,18)(H,17,19)
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n/an/a 330n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12987
PNG
(5-Amido-pyrrolopyrazole 9f | CHEMBL384575 | N-{5-[...)
Show SMILES CO[C@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1
Show InChI InChI=1S/C26H30N6O3/c1-30-12-14-31(15-13-30)20-10-8-19(9-11-20)25(33)27-24-21-16-32(17-22(21)28-29-24)26(34)23(35-2)18-6-4-3-5-7-18/h3-11,23H,12-17H2,1-2H3,(H2,27,28,29,33)/t23-/m0/s1
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n/an/a 354n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25678
PNG
(N-{4-[(5-bromo-1,3-thiazol-2-yl)amino]phenyl}aceta...)
Show SMILES CC(=O)Nc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C11H10BrN3OS/c1-7(16)14-8-2-4-9(5-3-8)15-11-13-6-10(12)17-11/h2-6H,1H3,(H,13,15)(H,14,16)
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n/an/a 360n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31535
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 18)
Show SMILES Cn1nc(C(=O)NCCO)c2CCc3cnc(Nc4ccccc4)nc3-c12
Show InChI InChI=1S/C19H20N6O2/c1-25-17-14(16(24-25)18(27)20-9-10-26)8-7-12-11-21-19(23-15(12)17)22-13-5-3-2-4-6-13/h2-6,11,26H,7-10H2,1H3,(H,20,27)(H,21,22,23)
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n/an/a 364n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31538
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 21)
Show SMILES Cn1nc(C(=O)NCc2ccccc2)c2CCc3cnc(Nc4ccccc4)nc3-c12
Show InChI InChI=1S/C24H22N6O/c1-30-22-19(21(29-30)23(31)25-14-16-8-4-2-5-9-16)13-12-17-15-26-24(28-20(17)22)27-18-10-6-3-7-11-18/h2-11,15H,12-14H2,1H3,(H,25,31)(H,26,27,28)
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n/an/a 374n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12092
PNG
(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Show SMILES CC(C)NC(=O)N1Cc2n[nH]c(NC(=O)c3ccc4OCOc4c3)c2C1
Show InChI InChI=1S/C17H19N5O4/c1-9(2)18-17(24)22-6-11-12(7-22)20-21-15(11)19-16(23)10-3-4-13-14(5-10)26-8-25-13/h3-5,9H,6-8H2,1-2H3,(H,18,24)(H2,19,20,21,23)
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n/an/a 390n/an/an/an/an/an/a



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


Bioorg Med Chem Lett 16: 1084-90 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.071
BindingDB Entry DOI: 10.7270/Q2PZ5725
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25658
PNG
(5-bromo-N-(4-fluorophenyl)-1,3-thiazol-2-amine | a...)
Show SMILES Fc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H6BrFN2S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,(H,12,13)
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n/an/a 400n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12090
PNG
(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 8...)
Show SMILES Cc1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(=O)c1cccc2cccnc12
Show InChI InChI=1S/C23H19N5O2/c1-14-7-9-16(10-8-14)22(29)25-21-18-12-28(13-19(18)26-27-21)23(30)17-6-2-4-15-5-3-11-24-20(15)17/h2-11H,12-13H2,1H3,(H2,25,26,27,29)
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n/an/a 440n/an/an/an/an/an/a



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


Bioorg Med Chem Lett 16: 1084-90 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.071
BindingDB Entry DOI: 10.7270/Q2PZ5725
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25697
PNG
(3-[(5-bromo-1,3-thiazol-2-yl)amino]benzoic acid | ...)
Show SMILES OC(=O)c1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C10H7BrN2O2S/c11-8-5-12-10(16-8)13-7-3-1-2-6(4-7)9(14)15/h1-5H,(H,12,13)(H,14,15)
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n/an/a 440n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12986
PNG
(4-(4-methylpiperazin-1-yl)-N-{5-[(2S)-2-phenylprop...)
Show SMILES C[C@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCN(C)CC3)c2C1)c1ccccc1
Show InChI InChI=1S/C26H30N6O2/c1-18(19-6-4-3-5-7-19)26(34)32-16-22-23(17-32)28-29-24(22)27-25(33)20-8-10-21(11-9-20)31-14-12-30(2)13-15-31/h3-11,18H,12-17H2,1-2H3,(H2,27,28,29,33)/t18-/m0/s1
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n/an/a 452n/an/an/an/a7.522



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


J Med Chem 49: 7247-51 (2006)


Article DOI: 10.1021/jm060897w
BindingDB Entry DOI: 10.7270/Q2NS0S4R
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25660
PNG
(N-(4-fluorophenyl)-5-iodo-1,3-thiazol-2-amine | am...)
Show SMILES Fc1ccc(Nc2ncc(I)s2)cc1
Show InChI InChI=1S/C9H6FIN2S/c10-6-1-3-7(4-2-6)13-9-12-5-8(11)14-9/h1-5H,(H,12,13)
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n/an/a 500n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25694
PNG
(5-bromo-N-[3-(methylsulfanyl)phenyl]-1,3-thiazol-2...)
Show SMILES CSc1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C10H9BrN2S2/c1-14-8-4-2-3-7(5-8)13-10-12-6-9(11)15-10/h2-6H,1H3,(H,12,13)
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n/an/a 500n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25669
PNG
(4-[(5-bromo-1,3-thiazol-2-yl)amino]phenol | aminot...)
Show SMILES Oc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H7BrN2OS/c10-8-5-11-9(14-8)12-6-1-3-7(13)4-2-6/h1-5,13H,(H,11,12)
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n/an/a 510n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31553
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 36)
Show SMILES CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(CN4CCOCC4)cc3)nc-21
Show InChI InChI=1S/C25H31N7O2/c1-25(2)13-17-14-27-24(29-20(17)22-19(25)21(23(33)26-3)30-31(22)4)28-18-7-5-16(6-8-18)15-32-9-11-34-12-10-32/h5-8,14H,9-13,15H2,1-4H3,(H,26,33)(H,27,28,29)
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n/an/a 535n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31544
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 27)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CC(C)(C)c4c(nn(C)c4-c3n2)C(N)=O)cc1
Show InChI InChI=1S/C24H30N8O/c1-24(2)13-15-14-26-23(28-19(15)21-18(24)20(22(25)33)29-31(21)4)27-16-5-7-17(8-6-16)32-11-9-30(3)10-12-32/h5-8,14H,9-13H2,1-4H3,(H2,25,33)(H,26,27,28)
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n/an/a 582n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25676
PNG
(1-N-(5-bromo-1,3-thiazol-2-yl)benzene-1,4-diamine ...)
Show SMILES Nc1ccc(Nc2ncc(Br)s2)cc1
Show InChI InChI=1S/C9H8BrN3S/c10-8-5-12-9(14-8)13-7-3-1-6(11)2-4-7/h1-5H,11H2,(H,12,13)
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n/an/a 600n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31548
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 31)
Show SMILES CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3cccc(c3)N3CCOCC3)nc-21
Show InChI InChI=1S/C24H29N7O2/c1-24(2)13-15-14-26-23(27-16-6-5-7-17(12-16)31-8-10-33-11-9-31)28-19(15)21-18(24)20(22(32)25-3)29-30(21)4/h5-7,12,14H,8-11,13H2,1-4H3,(H,25,32)(H,26,27,28)
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n/an/a 625n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31554
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 37)
Show SMILES CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3cccc(CN4CCOCC4)c3)nc-21
Show InChI InChI=1S/C25H31N7O2/c1-25(2)13-17-14-27-24(29-20(17)22-19(25)21(23(33)26-3)30-31(22)4)28-18-7-5-6-16(12-18)15-32-8-10-34-11-9-32/h5-7,12,14H,8-11,13,15H2,1-4H3,(H,26,33)(H,27,28,29)
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n/an/a 638n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31547
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 30)
Show SMILES CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCOCC3)nc-21
Show InChI InChI=1S/C24H29N7O2/c1-24(2)13-15-14-26-23(27-16-5-7-17(8-6-16)31-9-11-33-12-10-31)28-19(15)21-18(24)20(22(32)25-3)29-30(21)4/h5-8,14H,9-13H2,1-4H3,(H,25,32)(H,26,27,28)
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n/an/a 649n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM12086
PNG
(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 4...)
Show SMILES COc1ccc(cc1)C(=O)Nc1[nH]nc2CN(Cc12)C(C)=O
Show InChI InChI=1S/C15H16N4O3/c1-9(20)19-7-12-13(8-19)17-18-14(12)16-15(21)10-3-5-11(22-2)6-4-10/h3-6H,7-8H2,1-2H3,(H2,16,17,18,21)
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n/an/a 660n/an/an/an/an/an/a



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


Bioorg Med Chem Lett 16: 1084-90 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.071
BindingDB Entry DOI: 10.7270/Q2PZ5725
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25699
PNG
(3-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzam...)
Show SMILES CNC(=O)c1cccc(Nc2ncc(Br)s2)c1
Show InChI InChI=1S/C11H10BrN3OS/c1-13-10(16)7-3-2-4-8(5-7)15-11-14-6-9(12)17-11/h2-6H,1H3,(H,13,16)(H,14,15)
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n/an/a 740n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM31555
PNG
(pyrazolo[4,3-h]quinazoline-3-carboxamide, 38)
Show SMILES CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N(C)C)nc-21
Show InChI InChI=1S/C22H27N7O/c1-22(2)11-13-12-24-21(25-14-7-9-15(10-8-14)28(4)5)26-17(13)19-16(22)18(20(30)23-3)27-29(19)6/h7-10,12H,11H2,1-6H3,(H,23,30)(H,24,25,26)
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n/an/a 855n/an/an/an/an/a25



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25721
PNG
(4-({6-[(5-cyano-1,3-thiazol-2-yl)amino]pyridin-3-y...)
Show SMILES CNC(=O)N1CCN(Cc2ccc(Nc3ncc(s3)C#N)nc2)CC1
Show InChI InChI=1S/C16H19N7OS/c1-18-16(24)23-6-4-22(5-7-23)11-12-2-3-14(19-9-12)21-15-20-10-13(8-17)25-15/h2-3,9-10H,4-7,11H2,1H3,(H,18,24)(H,19,20,21)
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n/an/a 880n/an/an/an/an/an/a



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (human))
BDBM25673
PNG
(5-bromo-N-[4-(pyridin-4-yloxy)phenyl]-1,3-thiazol-...)
Show SMILES Brc1cnc(Nc2ccc(Oc3ccncc3)cc2)s1
Show InChI InChI=1S/C14H10BrN3OS/c15-13-9-17-14(20-13)18-10-1-3-11(4-2-10)19-12-5-7-16-8-6-12/h1-9H,(H,17,18)
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PubMed
n/an/a 900n/an/an/an/a7.022



Novartis



Assay Description
The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...


ACS Chem Biol 3: 180-92 (2008)


Article DOI: 10.1021/cb700200w
BindingDB Entry DOI: 10.7270/Q2HX1B03
More data for this
Ligand-Target Pair
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