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Found 535 hits of Enz. Inhib. data with enzyme = 'Aurora kinase B' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aurora kinase B


(Homo sapiens (Human))
BDBM387194
PNG
(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C20H29ClN8O3S/c1-12(30)8-28-11-17(6-23-28)25-20-22-7-18(21)19(26-20)24-16-4-13-9-29(10-14(13)5-16)33(31,32)27-15-2-3-15/h6-7,11-16,27,30H,2-5,8-10H2,1H3,(H2,22,24,25,26)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387182
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C17H25ClN8O2S/c1-3-21-29(27,28)26-8-11-4-13(5-12(11)9-26)22-16-15(18)7-19-17(24-16)23-14-6-20-25(2)10-14/h6-7,10-13,21H,3-5,8-9H2,1-2H3,(H2,19,22,23,24)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387192
PNG
(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Show SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(CC(C)O)c2)ncc1Cl
Show InChI InChI=1S/C19H29ClN8O3S/c1-3-23-32(30,31)28-9-13-4-15(5-14(13)10-28)24-18-17(20)7-21-19(26-18)25-16-6-22-27(11-16)8-12(2)29/h6-7,11-15,23,29H,3-5,8-10H2,1-2H3,(H2,21,24,25,26)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387184
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C18H25ClN8O2S/c1-26-10-15(6-21-26)23-18-20-7-16(19)17(24-18)22-14-4-11-8-27(9-12(11)5-14)30(28,29)25-13-2-3-13/h6-7,10-14,25H,2-5,8-9H2,1H3,(H2,20,22,23,24)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387187
PNG
(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C19H28ClN7O3S/c1-19(2,28)11-26-10-15(6-22-26)24-18-21-7-16(20)17(25-18)23-14-4-12-8-27(31(3,29)30)9-13(12)5-14/h6-7,10,12-14,28H,4-5,8-9,11H2,1-3H3,(H2,21,23,24,25)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387193
PNG
(1-(4-((5-chloro-4-((2-((cyclopropylmethyl)sulfonyl...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)CC3CC3)n2)cn1
Show InChI InChI=1S/C21H30ClN7O3S/c1-13(30)8-28-11-18(6-24-28)26-21-23-7-19(22)20(27-21)25-17-4-15-9-29(10-16(15)5-17)33(31,32)12-14-2-3-14/h6-7,11,13-17,30H,2-5,8-10,12H2,1H3,(H2,23,25,26,27)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387191
PNG
(1-(4-((5-chloro-4-((2-(cyclopropylsulfonyl)octahyd...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)C3CC3)n2)cn1
Show InChI InChI=1S/C20H28ClN7O3S/c1-12(29)8-27-11-16(6-23-27)25-20-22-7-18(21)19(26-20)24-15-4-13-9-28(10-14(13)5-15)32(30,31)17-2-3-17/h6-7,11-15,17,29H,2-5,8-10H2,1H3,(H2,22,24,25,26)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387186
PNG
(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C18H26ClN7O3S/c1-11(27)7-25-10-15(5-21-25)23-18-20-6-16(19)17(24-18)22-14-3-12-8-26(30(2,28)29)9-13(12)4-14/h5-6,10-14,27H,3-4,7-9H2,1-2H3,(H2,20,22,23,24)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387181
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C19H25ClN8O/c1-27-10-15(6-22-27)24-18-21-7-16(20)17(26-18)23-14-4-11-8-28(9-12(11)5-14)19(29)25-13-2-3-13/h6-7,10-14H,2-5,8-9H2,1H3,(H,25,29)(H2,21,23,24,26)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387180
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387177
PNG
(US9938257, Example 15 | ethyl 5-((5-chloro-2-((1-m...)
Show SMILES CCOC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H24ClN7O2/c1-3-28-18(27)26-8-11-4-13(5-12(11)9-26)22-16-15(19)7-20-17(24-16)23-14-6-21-25(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H2,20,22,23,24)
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Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM140390
PNG
(US8912173, 115 | US9914735, Example 115)
Show SMILES CC(C)n1cc(cn1)-c1cc(O[C@H](C)[C@H]2CNC(=O)C2)c2cccnc2c1
Show InChI InChI=1/C21H24N4O2/c1-13(2)25-12-17(11-24-25)15-7-19-18(5-4-6-22-19)20(8-15)27-14(3)16-9-21(26)23-10-16/h4-8,11-14,16H,9-10H2,1-3H3,(H,23,26)/t14-,16-/s2
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US Patent
n/an/a 21n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...


US Patent US9914735 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375949
PNG
(US9914735, Example 15 | US9914735, Example 76)
Show SMILES C[C@@H](Oc1nc(cc2nn(C)cc12)-c1cnn(CCC(F)(F)F)c1)[C@H]1CNC(=O)C1
Show InChI InChI=1/C19H21F3N6O2/c1-11(12-5-17(29)23-7-12)30-18-14-10-27(2)26-16(14)6-15(25-18)13-8-24-28(9-13)4-3-19(20,21)22/h6,8-12H,3-5,7H2,1-2H3,(H,23,29)/t11-,12-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...


US Patent US9914735 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375967
PNG
(US9914735, Example 45)
Show SMILES C[C@@H](Oc1cc(cc2nn(C)cc12)-c1cnn(c1)C1CCNCC1)[C@H]1CNC(=O)C1
Show InChI InChI=1/C22H28N6O2/c1-14(16-9-22(29)24-10-16)30-21-8-15(7-20-19(21)13-27(2)26-20)17-11-25-28(12-17)18-3-5-23-6-4-18/h7-8,11-14,16,18,23H,3-6,9-10H2,1-2H3,(H,24,29)/t14-,16-/s2
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Recombinant human Aurora B (amino acids 1-344, clone number DU1773, Molecular weight 40.2 kDa, University of Dundee) was expressed as a fusion protei...


US Patent US9914735 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375492
PNG
(US10358436, Example A201 | US9907800, Example A201)
Show SMILES C[C@H]1CCC[C@@H](C)N1Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1
Show InChI InChI=1/C33H34N4O/c1-21-6-5-7-22(2)37(21)20-24-12-10-23(11-13-24)14-17-29-26-16-15-25(18-31(26)36-35-29)28-19-33(28)27-8-3-4-9-30(27)34-32(33)38/h3-4,8-18,21-22,28H,5-7,19-20H2,1-2H3,(H,34,38)(H,35,36)/b17-14+/t21-,22+,28-,33-/s2
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US Patent


Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375493
PNG
(US10358436, Example A202 | US9907800, Example A202)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3csc(CN4CCOCC4)c3)n[nH]c2c1
Show InChI InChI=1/C28H26N4O2S/c33-27-28(22-3-1-2-4-25(22)29-27)15-23(28)19-6-7-21-24(30-31-26(21)14-19)8-5-18-13-20(35-17-18)16-32-9-11-34-12-10-32/h1-8,13-14,17,23H,9-12,15-16H2,(H,29,33)(H,30,31)/b8-5+/t23-,28-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375494
PNG
(US10358436, Example A203 | US9907800, Example A203)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6[C@@H](C)CCC[C@H]6C)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1/C34H36N4O2/c1-21-5-4-6-22(2)38(21)20-24-9-7-23(8-10-24)11-15-30-27-14-12-25(17-32(27)37-36-30)29-19-34(29)28-18-26(40-3)13-16-31(28)35-33(34)39/h7-18,21-22,29H,4-6,19-20H2,1-3H3,(H,35,39)(H,36,37)/b15-11+/t21-,22+,29-,34-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375495
PNG
(US10358436, Example A204 | US9907800, Example A204)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(OCCN4CCOCC4)cc3)n[nH]c2c1
Show InChI InChI=1/C31H30N4O3/c36-30-31(25-3-1-2-4-28(25)32-30)20-26(31)22-8-11-24-27(33-34-29(24)19-22)12-7-21-5-9-23(10-6-21)38-18-15-35-13-16-37-17-14-35/h1-12,19,26H,13-18,20H2,(H,32,36)(H,33,34)/b12-7+/t26-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM408800
PNG
(US10358436, Example A205)
Show SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CCN4CCCOC4)cc3)n[nH]c2c1
Show InChI InChI=1/C31H30N4O2/c36-30-31(25-4-1-2-5-28(25)32-30)19-26(31)23-11-12-24-27(33-34-29(24)18-23)13-10-21-6-8-22(9-7-21)14-16-35-15-3-17-37-20-35/h1-2,4-13,18,26H,3,14-17,19-20H2,(H,32,36)(H,33,34)/b13-10+/t26-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375497
PNG
(US10358436, Example A206 | US9907800, Example A206)
Show SMILES CCN(CC)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccc(OC)cc23)cc1
Show InChI InChI=1/C31H32N4O2/c1-4-35(5-2)19-21-8-6-20(7-9-21)10-14-27-24-13-11-22(16-29(24)34-33-27)26-18-31(26)25-17-23(37-3)12-15-28(25)32-30(31)36/h6-17,26H,4-5,18-19H2,1-3H3,(H,32,36)(H,33,34)/b14-10+/t26-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM408802
PNG
(US10358436, Example A207)
Show SMILES Fc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(\C=C\c5ccc(nc5)N5CCOCC5)n[nH]c4c3)c2c1
Show InChI InChI=1/C28H24FN5O2/c29-19-4-7-24-21(14-19)28(27(35)31-24)15-22(28)18-3-5-20-23(32-33-25(20)13-18)6-1-17-2-8-26(30-16-17)34-9-11-36-12-10-34/h1-8,13-14,16,22H,9-12,15H2,(H,31,35)(H,32,33)/b6-1+/t22?,28-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044652
PNG
(CHEMBL3353352 | US10358436, Example A208 | US99078...)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccc(F)cc23)cc1
Show InChI InChI=1/C28H25FN4O/c1-33(2)16-18-5-3-17(4-6-18)7-11-24-21-10-8-19(13-26(21)32-31-24)23-15-28(23)22-14-20(29)9-12-25(22)30-27(28)34/h3-14,23H,15-16H2,1-2H3,(H,30,34)(H,31,32)/b11-7+/t23-,28-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375500
PNG
(US10358436, Example A209 | US9907800, Example A209)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1n[nH]c2cc(ccc12)[C@@H]1C[C@@]11C(=O)Nc2ccc(OC(F)F)cc12
Show InChI InChI=1/C28H26F2N6O2/c1-35-8-10-36(11-9-35)24-7-3-17(15-31-24)25-19-5-2-16(12-23(19)33-34-25)21-14-28(21)20-13-18(38-27(29)30)4-6-22(20)32-26(28)37/h2-7,12-13,15,21,27H,8-11,14H2,1H3,(H,32,37)(H,33,34)/t21-,28-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375501
PNG
(US10358436, Example A210 | US9907800, Example A210)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1n[nH]c2cc(ccc12)[C@@H]1C[C@@]11C(=O)Nc2ccc(F)cc12
Show InChI InChI=1/C27H25FN6O/c1-33-8-10-34(11-9-33)24-7-3-17(15-29-24)25-19-5-2-16(12-23(19)31-32-25)21-14-27(21)20-13-18(28)4-6-22(20)30-26(27)35/h2-7,12-13,15,21H,8-11,14H2,1H3,(H,30,35)(H,31,32)/t21-,27-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044664
PNG
(CHEMBL3353360 | US10358436, Example A212 | US99078...)
Show SMILES CCN(CC)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1
Show InChI InChI=1/C30H30N4O/c1-3-34(4-2)19-21-11-9-20(10-12-21)13-16-26-23-15-14-22(17-28(23)33-32-26)25-18-30(25)24-7-5-6-8-27(24)31-29(30)35/h5-17,25H,3-4,18-19H2,1-2H3,(H,31,35)(H,32,33)/b16-13+/t25-,30-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044664
PNG
(CHEMBL3353360 | US10358436, Example A212 | US99078...)
Show SMILES CCN(CC)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1
Show InChI InChI=1/C30H30N4O/c1-3-34(4-2)19-21-11-9-20(10-12-21)13-16-26-23-15-14-22(17-28(23)33-32-26)25-18-30(25)24-7-5-6-8-27(24)31-29(30)35/h5-17,25H,3-4,18-19H2,1-2H3,(H,31,35)(H,32,33)/b16-13+/t25-,30-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM408808
PNG
(US10358436, Example A213)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(nc5)N5CCOCC5)n[nH]c4c3)c2c1
Show InChI InChI=1/C29H27N5O3/c1-36-20-5-8-25-22(15-20)29(28(35)31-25)16-23(29)19-4-6-21-24(32-33-26(21)14-19)7-2-18-3-9-27(30-17-18)34-10-12-37-13-11-34/h2-9,14-15,17,23H,10-13,16H2,1H3,(H,31,35)(H,32,33)/b7-2+/t23-,29-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044651
PNG
(CHEMBL3353349 | US10358436, Example A214 | US99078...)
Show SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccc(OC(F)F)cc23)cc1
Show InChI InChI=1/C29H26F2N4O2/c1-35(2)16-18-5-3-17(4-6-18)7-11-24-21-10-8-19(13-26(21)34-33-24)23-15-29(23)22-14-20(37-28(30)31)9-12-25(22)32-27(29)36/h3-14,23,28H,15-16H2,1-2H3,(H,32,36)(H,33,34)/b11-7+/t23-,29-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375507
PNG
(US10358436, Example A216 | US9907800, Example A216)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cc(F)c(CN(C)C)c(F)c5)n[nH]c4c3)c2c1
Show InChI InChI=1/C29H26F2N4O2/c1-35(2)15-20-23(30)10-16(11-24(20)31)4-8-25-19-7-5-17(12-27(19)34-33-25)22-14-29(22)21-13-18(37-3)6-9-26(21)32-28(29)36/h4-13,22H,14-15H2,1-3H3,(H,32,36)(H,33,34)/b8-4+/t22-,29-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375507
PNG
(US10358436, Example A216 | US9907800, Example A216)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cc(F)c(CN(C)C)c(F)c5)n[nH]c4c3)c2c1
Show InChI InChI=1/C29H26F2N4O2/c1-35(2)15-20-23(30)10-16(11-24(20)31)4-8-25-19-7-5-17(12-27(19)34-33-25)22-14-29(22)21-13-18(37-3)6-9-26(21)32-28(29)36/h4-13,22H,14-15H2,1-3H3,(H,32,36)(H,33,34)/b8-4+/t22-,29-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044672
PNG
(CHEMBL3353358 | US10358436, Example A217 | US99078...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cc(F)c(CN6CCOCC6)c(F)c5)n[nH]c4c3)c2c1
Show InChI InChI=1/C31H28F2N4O3/c1-39-20-4-7-28-23(15-20)31(30(38)34-28)16-24(31)19-3-5-21-27(35-36-29(21)14-19)6-2-18-12-25(32)22(26(33)13-18)17-37-8-10-40-11-9-37/h2-7,12-15,24H,8-11,16-17H2,1H3,(H,34,38)(H,35,36)/b6-2+/t24-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044672
PNG
(CHEMBL3353358 | US10358436, Example A217 | US99078...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cc(F)c(CN6CCOCC6)c(F)c5)n[nH]c4c3)c2c1
Show InChI InChI=1/C31H28F2N4O3/c1-39-20-4-7-28-23(15-20)31(30(38)34-28)16-24(31)19-3-5-21-27(35-36-29(21)14-19)6-2-18-12-25(32)22(26(33)13-18)17-37-8-10-40-11-9-37/h2-7,12-15,24H,8-11,16-17H2,1H3,(H,34,38)(H,35,36)/b6-2+/t24-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044669
PNG
(CHEMBL3353356 | US10358436, Example A220 | US99078...)
Show SMILES Fc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CCOCC6)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1/C30H27FN4O2/c31-22-7-10-27-24(16-22)30(29(36)32-27)17-25(30)21-6-8-23-26(33-34-28(23)15-21)9-5-19-1-3-20(4-2-19)18-35-11-13-37-14-12-35/h1-10,15-16,25H,11-14,17-18H2,(H,32,36)(H,33,34)/b9-5+/t25-,30-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM50044669
PNG
(CHEMBL3353356 | US10358436, Example A220 | US99078...)
Show SMILES Fc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CCOCC6)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1/C30H27FN4O2/c31-22-7-10-27-24(16-22)30(29(36)32-27)17-25(30)21-6-8-23-26(33-34-28(23)15-21)9-5-19-1-3-20(4-2-19)18-35-11-13-37-14-12-35/h1-10,15-16,25H,11-14,17-18H2,(H,32,36)(H,33,34)/b9-5+/t25-,30-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375512
PNG
(US10358436, Example A221 | US9907800, Example A221)
Show SMILES CCN(CC)Cc1c(F)cc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1F
Show InChI InChI=1/C30H28F2N4O/c1-3-36(4-2)17-21-24(31)13-18(14-25(21)32)9-12-26-20-11-10-19(15-28(20)35-34-26)23-16-30(23)22-7-5-6-8-27(22)33-29(30)37/h5-15,23H,3-4,16-17H2,1-2H3,(H,33,37)(H,34,35)/b12-9+/t23-,30-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375395
PNG
(US10358436, Example A112 | US9907800, Example A112)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6CC[C@@H](F)C6)cc5)n[nH]c4c3)c2c1
Show InChI InChI=1/C31H29FN4O2/c1-38-23-8-11-28-25(15-23)31(30(37)33-28)16-26(31)21-7-9-24-27(34-35-29(24)14-21)10-6-19-2-4-20(5-3-19)17-36-13-12-22(32)18-36/h2-11,14-15,22,26H,12-13,16-18H2,1H3,(H,33,37)(H,34,35)/b10-6+/t22-,26+,31+/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375400
PNG
(US10358436, Example A116 | US9907800, Example A116)
Show SMILES Fc1cc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc(F)c1CN1CCOCC1
Show InChI InChI=1/C30H26F2N4O2/c31-24-13-18(14-25(32)21(24)17-36-9-11-38-12-10-36)5-8-26-20-7-6-19(15-28(20)35-34-26)23-16-30(23)22-3-1-2-4-27(22)33-29(30)37/h1-8,13-15,23H,9-12,16-17H2,(H,33,37)(H,34,35)/b8-5+/t23-,30-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM408703
PNG
(US10358436, Example A119)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCC(CC3)N(C)C)c2c1
Show InChI InChI=1/C31H33N5O2/c1-35(2)21-12-14-36(15-13-21)22-7-4-19(5-8-22)29-24-10-6-20(16-28(24)33-34-29)26-18-31(26)25-17-23(38-3)9-11-27(25)32-30(31)37/h4-11,16-17,21,26H,12-15,18H2,1-3H3,(H,32,37)(H,33,34)/t26?,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375403
PNG
(US10358436, Example A120 | US9907800, Example A119...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCC(CC3)N(C)C)c2c1
Show InChI InChI=1/C31H33N5O2/c1-35(2)21-12-14-36(15-13-21)22-7-4-19(5-8-22)29-24-10-6-20(16-28(24)33-34-29)26-18-31(26)25-17-23(38-3)9-11-27(25)32-30(31)37/h4-11,16-17,21,26H,12-15,18H2,1-3H3,(H,32,37)(H,33,34)/t26-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375409
PNG
(US10358436, Example A121 | US9907800, Example A121)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CCC(CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C33H35N5O3/c1-40-25-7-9-29-27(19-25)33(32(39)34-29)20-28(33)22-4-8-26-30(18-22)35-36-31(26)21-2-5-23(6-3-21)37-12-10-24(11-13-37)38-14-16-41-17-15-38/h2-9,18-19,24,28H,10-17,20H2,1H3,(H,34,39)(H,35,36)/t28-,33-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM408706
PNG
(US10358436, Example A122)
Show SMILES COc1ccc2NC(=O)[C@@]3(CC3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)C3CCNCC3)c2c1
Show InChI InChI=1/C29H28N4O2/c1-35-21-7-9-25-23(15-21)29(28(34)31-25)16-24(29)20-6-8-22-26(14-20)32-33-27(22)19-4-2-17(3-5-19)18-10-12-30-13-11-18/h2-9,14-15,18,24,30H,10-13,16H2,1H3,(H,31,34)(H,32,33)/t24?,29-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375411
PNG
(US10358436, Example A123 | US9907800, Example A123)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)C3CCN(C)CC3)c2c1
Show InChI InChI=1/C30H30N4O2/c1-34-13-11-19(12-14-34)18-3-5-20(6-4-18)28-23-9-7-21(15-27(23)32-33-28)25-17-30(25)24-16-22(36-2)8-10-26(24)31-29(30)35/h3-10,15-16,19,25H,11-14,17H2,1-2H3,(H,31,35)(H,32,33)/t25-,30-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375414
PNG
(US10358436, Example A126 | US9907800, Example A126)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3C[C@H](C)N[C@H](C)C3)c2c1
Show InChI InChI=1/C30H31N5O2/c1-17-15-35(16-18(2)31-17)21-7-4-19(5-8-21)28-23-10-6-20(12-27(23)33-34-28)25-14-30(25)24-13-22(37-3)9-11-26(24)32-29(30)36/h4-13,17-18,25,31H,14-16H2,1-3H3,(H,32,36)(H,33,34)/t17-,18+,25-,30-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375415
PNG
(US10358436, Example A127 | US9907800, Example A127)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N3CC[C@H](C3)N(C)C)c2c1
Show InChI InChI=1/C30H31N5O2/c1-34(2)21-12-13-35(17-21)20-7-4-18(5-8-20)28-23-10-6-19(14-27(23)32-33-28)25-16-30(25)24-15-22(37-3)9-11-26(24)31-29(30)36/h4-11,14-15,21,25H,12-13,16-17H2,1-3H3,(H,31,36)(H,32,33)/t21-,25+,30+/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375417
PNG
(US10358436, Example A129 | US9907800, Example A129)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)N(C)CCN(C)C)c2c1
Show InChI InChI=1/C29H31N5O2/c1-33(2)13-14-34(3)20-8-5-18(6-9-20)27-22-11-7-19(15-26(22)31-32-27)24-17-29(24)23-16-21(36-4)10-12-25(23)30-28(29)35/h5-12,15-16,24H,13-14,17H2,1-4H3,(H,30,35)(H,31,32)/t24-,29-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375419
PNG
(US10358436, Example A131 | US9907800, Example A131)
Show SMILES COCCN1C(=O)[C@@]2(C[C@H]2c2ccc3c(\C=C\c4ccc(CN(C)C)cc4)n[nH]c3c2)c2ccccc12
Show InChI InChI=1/C31H32N4O2/c1-34(2)20-22-10-8-21(9-11-22)12-15-27-24-14-13-23(18-28(24)33-32-27)26-19-31(26)25-6-4-5-7-29(25)35(30(31)36)16-17-37-3/h4-15,18,26H,16-17,19-20H2,1-3H3,(H,32,33)/b15-12+/t26-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375420
PNG
(US10358436, Example A133 | US9907800, Example A132...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccc(CN6CCOCC6)c5)n[nH]c4c3)c2c1
Show InChI InChI=1/C31H30N4O3/c1-37-23-7-10-28-25(17-23)31(30(36)32-28)18-26(31)22-6-8-24-27(33-34-29(24)16-22)9-5-20-3-2-4-21(15-20)19-35-11-13-38-14-12-35/h2-10,15-17,26H,11-14,18-19H2,1H3,(H,32,36)(H,33,34)/b9-5+/t26-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375420
PNG
(US10358436, Example A133 | US9907800, Example A132...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccc(CN6CCOCC6)c5)n[nH]c4c3)c2c1
Show InChI InChI=1/C31H30N4O3/c1-37-23-7-10-28-25(17-23)31(30(36)32-28)18-26(31)22-6-8-24-27(33-34-29(24)16-22)9-5-20-3-2-4-21(15-20)19-35-11-13-38-14-12-35/h2-10,15-17,26H,11-14,18-19H2,1H3,(H,32,36)(H,33,34)/b9-5+/t26-,31-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375422
PNG
(US10358436, Example A135 | US9907800, Example A134...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccc(CN(C)C)c5)n[nH]c4c3)c2c1
Show InChI InChI=1/C29H28N4O2/c1-33(2)17-19-6-4-5-18(13-19)7-11-25-22-10-8-20(14-27(22)32-31-25)24-16-29(24)23-15-21(35-3)9-12-26(23)30-28(29)34/h4-15,24H,16-17H2,1-3H3,(H,30,34)(H,31,32)/b11-7+/t24-,29-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM375422
PNG
(US10358436, Example A135 | US9907800, Example A134...)
Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5cccc(CN(C)C)c5)n[nH]c4c3)c2c1
Show InChI InChI=1/C29H28N4O2/c1-33(2)17-19-6-4-5-18(13-19)7-11-25-22-10-8-20(14-27(22)32-31-25)24-16-29(24)23-15-21(35-3)9-12-26(23)30-28(29)34/h4-15,24H,16-17H2,1-3H3,(H,30,34)(H,31,32)/b11-7+/t24-,29-/s2
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Assay Description
Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...


US Patent US10358436 (2019)

More data for this
Ligand-Target Pair
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