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Compile Data Set for Download or QSAR

Found 133 hits of Enz. Inhib. data with enzyme = 'B-Raf (V600E) ' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
B-Raf (V600E)


(Homo sapiens (human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C26H22N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-11,13-14,18H,7,9,12,15H2,(H,28,29)(H,27,30,31)
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n/an/a 0.800n/an/an/an/an/an/a



Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322528
PNG
(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccsc3)ccnc2N1
Show InChI InChI=1S/C24H20N4O3S/c29-22-4-2-18-21(5-7-25-24(18)28-22)31-17-1-3-20-15(10-17)9-16(12-30-20)23-26-11-19(27-23)14-6-8-32-13-14/h1,3,5-8,10-11,13,16H,2,4,9,12H2,(H,26,27)(H,25,28,29)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322529
PNG
(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3cccs3)ccnc2N1
Show InChI InChI=1S/C24H20N4O3S/c29-22-6-4-17-20(7-8-25-24(17)28-22)31-16-3-5-19-14(11-16)10-15(13-30-19)23-26-12-18(27-23)21-2-1-9-32-21/h1-3,5,7-9,11-12,15H,4,6,10,13H2,(H,26,27)(H,25,28,29)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C26H22N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-11,13-14,18H,7,9,12,15H2,(H,28,29)(H,27,30,31)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C26H22N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-11,13-14,18H,7,9,12,15H2,(H,28,29)(H,27,30,31)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322528
PNG
(5-[3-[4-(3-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccsc3)ccnc2N1
Show InChI InChI=1S/C24H20N4O3S/c29-22-4-2-18-21(5-7-25-24(18)28-22)31-17-1-3-20-15(10-17)9-16(12-30-20)23-26-11-19(27-23)14-6-8-32-13-14/h1,3,5-8,10-11,13,16H,2,4,9,12H2,(H,26,27)(H,25,28,29)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322529
PNG
(5-[3-[4-(2-thienyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3cccs3)ccnc2N1
Show InChI InChI=1S/C24H20N4O3S/c29-22-6-4-17-20(7-8-25-24(17)28-22)31-16-3-5-19-14(11-16)10-15(13-30-19)23-26-12-18(27-23)21-2-1-9-32-21/h1-3,5,7-9,11-12,15H,4,6,10,13H2,(H,26,27)(H,25,28,29)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322530
PNG
(5-[3-[5-(2-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
Show SMILES Clc1ccccc1-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
Show InChI InChI=1S/C26H21ClN4O3/c27-20-4-2-1-3-18(20)21-13-29-25(30-21)16-11-15-12-17(5-7-22(15)33-14-16)34-23-9-10-28-26-19(23)6-8-24(32)31-26/h1-5,7,9-10,12-13,16H,6,8,11,14H2,(H,29,30)(H,28,31,32)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322541
PNG
(5-[[(3S)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
Show SMILES O=C1CCc2c(Oc3ccc4OC[C@@H](Oc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C25H20N4O4/c30-23-9-7-17-19(10-11-26-24(17)29-23)32-16-6-8-20-21(12-16)33-22(14-31-20)25-27-13-18(28-25)15-4-2-1-3-5-15/h1-6,8,10-13,22H,7,9,14H2,(H,27,28)(H,26,29,30)/t22-/m1/s1
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322532
PNG
(5-[3-[4-(benzofuran-3-yl)-1H-imidazol-2-yl]chroman...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3coc4ccccc34)ccnc2N1
Show InChI InChI=1S/C28H22N4O4/c33-26-8-6-20-25(9-10-29-28(20)32-26)36-18-5-7-23-16(12-18)11-17(14-34-23)27-30-13-22(31-27)21-15-35-24-4-2-1-3-19(21)24/h1-5,7,9-10,12-13,15,17H,6,8,11,14H2,(H,30,31)(H,29,32,33)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322533
PNG
(5-[3-[5-(3-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3ncc([nH]3)-c3cccnc3)ccnc2N1
Show InChI InChI=1S/C25H21N5O3/c31-23-6-4-19-22(7-9-27-25(19)30-23)33-18-3-5-21-16(11-18)10-17(14-32-21)24-28-13-20(29-24)15-2-1-8-26-12-15/h1-3,5,7-9,11-13,17H,4,6,10,14H2,(H,28,29)(H,27,30,31)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322535
PNG
(5-[3-[5-(4-fluorophenyl)-1H-imidazol-2-yl]chroman-...)
Show SMILES Fc1ccc(cc1)-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
Show InChI InChI=1S/C26H21FN4O3/c27-18-3-1-15(2-4-18)21-13-29-25(30-21)17-11-16-12-19(5-7-22(16)33-14-17)34-23-9-10-28-26-20(23)6-8-24(32)31-26/h1-5,7,9-10,12-13,17H,6,8,11,14H2,(H,29,30)(H,28,31,32)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322536
PNG
(5-[3-[5-(1,3-benzodioxol-5-yl)-1H-imidazol-2-yl]ch...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3ncc([nH]3)-c3ccc4OCOc4c3)ccnc2N1
Show InChI InChI=1S/C27H22N4O5/c32-25-6-3-19-22(7-8-28-27(19)31-25)36-18-2-5-21-16(10-18)9-17(13-33-21)26-29-12-20(30-26)15-1-4-23-24(11-15)35-14-34-23/h1-2,4-5,7-8,10-12,17H,3,6,9,13-14H2,(H,29,30)(H,28,31,32)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322542
PNG
(5-[[(3R)-3-(4-phenyl-1H-imidazol-2-yl)-2,3-dihydro...)
Show SMILES O=C1CCc2c(Oc3ccc4OC[C@H](Oc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C25H20N4O4/c30-23-9-7-17-19(10-11-26-24(17)29-23)32-16-6-8-20-21(12-16)33-22(14-31-20)25-27-13-18(28-25)15-4-2-1-3-5-15/h1-6,8,10-13,22H,7,9,14H2,(H,27,28)(H,26,29,30)/t22-/m0/s1
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US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322540
PNG
(5-[3-(5-phenyl-1H-pyrazol-3-yl)chroman-6-yl]oxy-3,...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3cc([nH]n3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C26H22N4O3/c31-25-9-7-20-24(10-11-27-26(20)28-25)33-19-6-8-23-17(13-19)12-18(15-32-23)22-14-21(29-30-22)16-4-2-1-3-5-16/h1-6,8,10-11,13-14,18H,7,9,12,15H2,(H,29,30)(H,27,28,31)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322525
PNG
(5-[3[4-(4-pyridyl)-1H-imidazol-2-yl]chroman-6-yl]o...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccncc3)ccnc2N1
Show InChI InChI=1S/C25H21N5O3/c31-23-4-2-19-22(7-10-27-25(19)30-23)33-18-1-3-21-16(12-18)11-17(14-32-21)24-28-13-20(29-24)15-5-8-26-9-6-15/h1,3,5-10,12-13,17H,2,4,11,14H2,(H,28,29)(H,27,30,31)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C26H22N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-11,13-14,18H,7,9,12,15H2,(H,28,29)(H,27,30,31)
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Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C26H22N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-11,13-14,18H,7,9,12,15H2,(H,28,29)(H,27,30,31)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322521
PNG
(5-[3-(4-phenyl-1H-imidazol-2-yl)chroman-6-yl]oxy-3...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C26H22N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-11,13-14,18H,7,9,12,15H2,(H,28,29)(H,27,30,31)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322518
PNG
(5-[3-(1H-benzimidazol-2-yl)chroman-6-yl]oxy-3,4-di...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc4ccccc4[nH]3)ccnc2N1
Show InChI InChI=1S/C24H20N4O3/c29-22-8-6-17-21(9-10-25-24(17)28-22)31-16-5-7-20-14(12-16)11-15(13-30-20)23-26-18-3-1-2-4-19(18)27-23/h1-5,7,9-10,12,15H,6,8,11,13H2,(H,26,27)(H,25,28,29)
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Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322531
PNG
(5-[3-[5-(3-chlorophenyl)-1H-imidazol-2-yl]chroman-...)
Show SMILES Clc1cccc(c1)-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
Show InChI InChI=1S/C26H21ClN4O3/c27-18-3-1-2-15(11-18)21-13-29-25(30-21)17-10-16-12-19(4-6-22(16)33-14-17)34-23-8-9-28-26-20(23)5-7-24(32)31-26/h1-4,6,8-9,11-13,17H,5,7,10,14H2,(H,29,30)(H,28,31,32)
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n/an/a<4n/an/an/an/an/an/a



Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313753
PNG
(US10167282, Compound TBAP-04)
Show SMILES COc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)C(C)(C)C
Show InChI InChI=1S/C28H26FN7O4/c1-28(2,3)22-14-23(36(35-22)16-6-5-7-17(12-16)39-4)33-27(38)32-20-9-8-18(13-19(20)29)40-21-10-11-30-26-25(21)31-15-24(37)34-26/h5-15H,1-4H3,(H,30,34,37)(H2,32,33,38)
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n/an/a 8n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
Mutant BRAF WM266.4 Cells.


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313751
PNG
(US10167282, Compound TBAP-02)
Show SMILES Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)C(C)(C)C
Show InChI InChI=1S/C28H26FN7O3/c1-16-6-5-7-17(12-16)36-23(14-22(35-36)28(2,3)4)33-27(38)32-20-9-8-18(13-19(20)29)39-21-10-11-30-26-25(21)31-15-24(37)34-26/h5-15H,1-4H3,(H,30,34,37)(H2,32,33,38)
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n/an/a 12n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
Mutant BRAF WM266.4 Cells.


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313750
PNG
(US10167282, Compound TBAP-01)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1cccc(F)c1
Show InChI InChI=1S/C27H23F2N7O3/c1-27(2,3)21-13-22(36(35-21)16-6-4-5-15(28)11-16)33-26(38)32-19-8-7-17(12-18(19)29)39-20-9-10-30-25-24(20)31-14-23(37)34-25/h4-14H,1-3H3,(H,30,34,37)(H2,32,33,38)
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n/an/a 18n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
Mutant BRAF WM266.4 Cells.


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313752
PNG
(US10167282, Compound TBAP-03)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H23F4N7O3/c1-27(2,3)21-13-22(39(38-21)16-6-4-5-15(11-16)28(30,31)32)36-26(41)35-19-8-7-17(12-18(19)29)42-20-9-10-33-25-24(20)34-14-23(40)37-25/h4-14H,1-3H3,(H,33,37,40)(H2,35,36,41)
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n/an/a 19n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
Mutant BRAF WM266.4 Cells.


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313753
PNG
(US10167282, Compound TBAP-04)
Show SMILES COc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)C(C)(C)C
Show InChI InChI=1S/C28H26FN7O4/c1-28(2,3)22-14-23(36(35-22)16-6-5-7-17(12-16)39-4)33-27(38)32-20-9-8-18(13-19(20)29)40-21-10-11-30-26-25(21)31-15-24(37)34-26/h5-15H,1-4H3,(H,30,34,37)(H2,32,33,38)
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n/an/a 47n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322539
PNG
(5-[3-(3-phenyl-1,2,4-oxadiazol-5-yl)chroman-6-yl]o...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3nc(no3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C25H20N4O4/c30-22-9-7-19-21(10-11-26-24(19)27-22)32-18-6-8-20-16(13-18)12-17(14-31-20)25-28-23(29-33-25)15-4-2-1-3-5-15/h1-6,8,10-11,13,17H,7,9,12,14H2,(H,26,27,30)
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n/an/a 52n/an/an/an/an/an/a



Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322527
PNG
(5-[3-(4-tert-butyl-1H-imidazol-2-yl)chroman-6-yl]o...)
Show SMILES CC(C)(C)c1c[nH]c(n1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
Show InChI InChI=1S/C24H26N4O3/c1-24(2,3)20-12-26-22(27-20)15-10-14-11-16(4-6-18(14)30-13-15)31-19-8-9-25-23-17(19)5-7-21(29)28-23/h4,6,8-9,11-12,15H,5,7,10,13H2,1-3H3,(H,26,27)(H,25,28,29)
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n/an/a 52n/an/an/an/an/an/a



Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322537
PNG
(5-[3-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-imid...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(Cc4c3)c3ncc([nH]3)-c3ccc4OCCOc4c3)ccnc2N1
Show InChI InChI=1S/C28H24N4O5/c33-26-6-3-20-23(7-8-29-28(20)32-26)37-19-2-5-22-17(12-19)11-18(15-36-22)27-30-14-21(31-27)16-1-4-24-25(13-16)35-10-9-34-24/h1-2,4-5,7-8,12-14,18H,3,6,9-11,15H2,(H,30,31)(H,29,32,33)
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n/an/a 52n/an/an/an/an/an/a



Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322538
PNG
(5-[[3-(4-phenyl-1H-imidazol-2-yl)-2H-chromen-6-yl]...)
Show SMILES O=C1CCc2c(Oc3ccc4OCC(=Cc4c3)c3nc(c[nH]3)-c3ccccc3)ccnc2N1
Show InChI InChI=1S/C26H20N4O3/c31-24-9-7-20-23(10-11-27-26(20)30-24)33-19-6-8-22-17(13-19)12-18(15-32-22)25-28-14-21(29-25)16-4-2-1-3-5-16/h1-6,8,10-14H,7,9,15H2,(H,28,29)(H,27,30,31)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322547
PNG
(2-Methyl-4-[3-(5-phenyl-1H-imidazol-2-yl)chroman-6...)
Show SMILES Cc1cc(Oc2ccc3OCC(Cc3c2)c2ncc([nH]2)-c2ccccc2)ccn1
Show InChI InChI=1S/C24H21N3O2/c1-16-11-21(9-10-25-16)29-20-7-8-23-18(13-20)12-19(15-28-23)24-26-14-22(27-24)17-5-3-2-4-6-17/h2-11,13-14,19H,12,15H2,1H3,(H,26,27)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322519
PNG
(5-[3-(7-chloro-1H-benzimidazol-2-yl]chroman-6-yl]o...)
Show SMILES Clc1cccc2nc([nH]c12)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
Show InChI InChI=1S/C24H19ClN4O3/c25-17-2-1-3-18-22(17)29-23(27-18)14-10-13-11-15(4-6-19(13)31-12-14)32-20-8-9-26-24-16(20)5-7-21(30)28-24/h1-4,6,8-9,11,14H,5,7,10,12H2,(H,27,29)(H,26,28,30)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313464
PNG
(N-(5'-(3-fluorooxetan-3- yl)-6'-methoxy-2- methyl-...)
Show SMILES COc1ncc(cc1C1(F)COC1)-c1cc(NC(=O)c2cc(ccn2)C(F)(F)F)cnc1C
Show InChI InChI=1S/C22H18F4N4O3/c1-12-16(13-5-17(20(32-2)29-8-13)21(23)10-33-11-21)7-15(9-28-12)30-19(31)18-6-14(3-4-27-18)22(24,25)26/h3-9H,10-11H2,1-2H3,(H,30,31)
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n/an/a 59.3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313750
PNG
(US10167282, Compound TBAP-01)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1cccc(F)c1
Show InChI InChI=1S/C27H23F2N7O3/c1-27(2,3)21-13-22(36(35-21)16-6-4-5-15(28)11-16)33-26(38)32-19-8-7-17(12-18(19)29)39-20-9-10-30-25-24(20)31-14-23(37)34-25/h4-14H,1-3H3,(H,30,34,37)(H2,32,33,38)
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n/an/a 62n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313751
PNG
(US10167282, Compound TBAP-02)
Show SMILES Cc1cccc(c1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)cnc23)cc1F)C(C)(C)C
Show InChI InChI=1S/C28H26FN7O3/c1-16-6-5-7-17(12-16)36-23(14-22(35-36)28(2,3)4)33-27(38)32-20-9-8-18(13-19(20)29)39-21-10-11-30-26-25(21)31-15-24(37)34-26/h5-15H,1-4H3,(H,30,34,37)(H2,32,33,38)
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n/an/a 99n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM322534
PNG
(5-[3-[5-(4-methylsulfonylphenyl)-1H-imidazol-2-yl]...)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc([nH]1)C1COc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1
Show InChI InChI=1S/C27H24N4O5S/c1-37(33,34)20-5-2-16(3-6-20)22-14-29-26(30-22)18-12-17-13-19(4-8-23(17)35-15-18)36-24-10-11-28-27-21(24)7-9-25(32)31-27/h2-6,8,10-11,13-14,18H,7,9,12,15H2,1H3,(H,29,30)(H,28,31,32)
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Redx Pharma PLC

US Patent


Assay Description
To determine whether compounds bind to RAF kinases, they are tested in a competition binding assay. The Invitrogen LanthaScreen Eu binding assay invo...


US Patent US10183939 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313752
PNG
(US10167282, Compound TBAP-03)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C28H23F4N7O3/c1-27(2,3)21-13-22(39(38-21)16-6-4-5-15(11-16)28(30,31)32)36-26(41)35-19-8-7-17(12-18(19)29)42-20-9-10-33-25-24(20)34-14-23(40)37-25/h4-14H,1-3H3,(H,33,37,40)(H2,35,36,41)
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n/an/a 130n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313484
PNG
(2-(1,1-difluoroethyl)-N- (3-(5-(3- (fluoromethyl)o...)
Show SMILES COc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(F)F)ccc1C
Show InChI InChI=1S/C25H24F3N3O3/c1-15-4-5-18(31-22(32)16-6-7-29-21(9-16)24(2,27)28)10-19(15)17-8-20(23(33-3)30-11-17)25(12-26)13-34-14-25/h4-11H,12-14H2,1-3H3,(H,31,32)
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Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313400
PNG
(N-(3-(6-ethoxy-5-(3- methyloxetan-3- yl)pyridin-3-...)
Show SMILES CCOc1ncc(cc1C1(C)COC1)-c1cc(NC(=O)c2cnnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H23F3N4O3/c1-4-34-22-19(23(3)12-33-13-23)7-15(10-28-22)18-9-17(6-5-14(18)2)30-21(32)16-8-20(24(25,26)27)31-29-11-16/h5-11H,4,12-13H2,1-3H3,(H,30,32)
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Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313486
PNG
(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Show SMILES COc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C24H21F4N3O3/c1-14-3-4-17(31-21(32)15-5-6-29-20(8-15)24(26,27)28)9-18(14)16-7-19(22(33-2)30-10-16)23(11-25)12-34-13-23/h3-10H,11-13H2,1-2H3,(H,31,32)
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Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313754
PNG
(US10167282, Compound TBAP-05)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1ccnc(O)c1
Show InChI InChI=1S/C26H23FN8O4/c1-26(2,3)19-12-20(35(34-19)14-6-8-28-21(36)10-14)32-25(38)31-17-5-4-15(11-16(17)27)39-18-7-9-29-24-23(18)30-13-22(37)33-24/h4-13H,1-3H3,(H,28,36)(H,29,33,37)(H2,31,32,38)
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n/an/a 390n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
V600EBRAF was generated by infection of SF9 insect cells cultured in SF-900 II medium (Invitrogen, Paisley, Scotland) with a baculovirus containing f...


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313485
PNG
(N-(3-(5-(3- (fluoromethyl)oxetan-3- yl)-6-methoxyp...)
Show SMILES COc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)F)ccc1C
Show InChI InChI=1S/C26H27F2N3O3/c1-16-5-6-19(31-23(32)17-7-8-29-22(10-17)25(2,3)28)11-20(16)18-9-21(24(33-4)30-12-18)26(13-27)14-34-15-26/h5-12H,13-15H2,1-4H3,(H,31,32)
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n/an/a 417n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313307
PNG
(2-(2-cyanopropan-2-yl)- N-(3-(6-ethoxy-5-(3- (fluo...)
Show SMILES CCOc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C
Show InChI InChI=1S/C28H29FN4O3/c1-5-36-26-23(28(14-29)16-35-17-28)10-20(13-32-26)22-12-21(7-6-18(22)2)33-25(34)19-8-9-31-24(11-19)27(3,4)15-30/h6-13H,5,14,16-17H2,1-4H3,(H,33,34)
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n/an/a 446n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313754
PNG
(US10167282, Compound TBAP-05)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc4[nH]c(=O)cnc34)cc2F)n(n1)-c1ccnc(O)c1
Show InChI InChI=1S/C26H23FN8O4/c1-26(2,3)19-12-20(35(34-19)14-6-8-28-21(36)10-14)32-25(38)31-17-5-4-15(11-16(17)27)39-18-7-9-29-24-23(18)30-13-22(37)33-24/h4-13H,1-3H3,(H,28,36)(H,29,33,37)(H2,31,32,38)
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n/an/a 450n/an/an/an/an/an/a



CANCER RESEARCH TECHNOLOGY LIMITED; INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL (THE)

US Patent


Assay Description
Mutant BRAF WM266.4 Cells.


US Patent US10167282 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313333
PNG
(N-(5'-(3- (fluoromethyl)oxetan-3- yl)-6'-methoxy-2...)
Show SMILES COc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)cnc1C
Show InChI InChI=1S/C24H21F4N3O3/c1-14-19(16-7-20(22(33-2)30-9-16)23(11-25)12-34-13-23)8-18(10-29-14)31-21(32)15-4-3-5-17(6-15)24(26,27)28/h3-10H,11-13H2,1-2H3,(H,31,32)
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n/an/a 469n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313487
PNG
(2-(2-cyanopropan-2-yl)- N-(3-(5-(3- (fluoromethyl)...)
Show SMILES COc1ncc(cc1C1(CF)COC1)-c1cc(NC(=O)c2ccnc(c2)C(C)(C)C#N)ccc1C
Show InChI InChI=1S/C27H27FN4O3/c1-17-5-6-20(32-24(33)18-7-8-30-23(10-18)26(2,3)14-29)11-21(17)19-9-22(25(34-4)31-12-19)27(13-28)15-35-16-27/h5-12H,13,15-16H2,1-4H3,(H,32,33)
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n/an/a 580n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313396
PNG
(N-(6'-ethoxy-2-methyl- 5'-(3-methyloxetan-3- yl)-[...)
Show SMILES CCOc1ncc(cc1C1(C)COC1)-c1cc(NC(=O)c2ccnc(c2)C(F)(F)F)cnc1C
Show InChI InChI=1S/C24H23F3N4O3/c1-4-34-22-19(23(3)12-33-13-23)7-16(10-30-22)18-9-17(11-29-14(18)2)31-21(32)15-5-6-28-20(8-15)24(25,26)27/h5-11H,4,12-13H2,1-3H3,(H,31,32)
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n/an/a 613n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313500
PNG
(N-(3-(5-(3- hydroxyoxetan-3-yl)-6- ((tetrahydro-2H...)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cnc(OC2CCOCC2)c(c1)C1(O)COC1
Show InChI InChI=1S/C28H27F3N2O5/c1-17-5-6-21(33-25(34)18-3-2-4-20(11-18)28(29,30)31)13-23(17)19-12-24(27(35)15-37-16-27)26(32-14-19)38-22-7-9-36-10-8-22/h2-6,11-14,22,35H,7-10,15-16H2,1H3,(H,33,34)
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n/an/a 808n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313297
PNG
(N-(6-methyl-3'-(3- methyloxetan-3-yl)- [1,1'-biphe...)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cccc(c1)C1(C)COC1
Show InChI InChI=1S/C25H22F3NO2/c1-16-9-10-21(29-23(30)18-6-4-8-20(12-18)25(26,27)28)13-22(16)17-5-3-7-19(11-17)24(2)14-31-15-24/h3-13H,14-15H2,1-2H3,(H,29,30)
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n/an/a 870n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
B-Raf (V600E)


(Homo sapiens (human))
BDBM313469
PNG
(N-(3-(5-(3-fluorooxetan- 3-yl)-6-methoxypyridin- 3...)
Show SMILES COc1ncc(cc1C1(F)COC1)-c1cc(NC(=O)c2cc(ccn2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C23H19F4N3O3/c1-13-3-4-16(30-20(31)19-8-15(5-6-28-19)23(25,26)27)9-17(13)14-7-18(21(32-2)29-10-14)22(24)11-33-12-22/h3-10H,11-12H2,1-2H3,(H,30,31)
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n/an/a 934n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Assay Materials: Assay buffer is 50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% Bovine Serum Albumin (BSA) and 1 mM dithiothreitol (DTT); Stop buffer is 60 m...


US Patent US10167279 (2019)

More data for this
Ligand-Target Pair
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