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Compile Data Set for Download or QSAR

Found 80 hits of Enz. Inhib. data with enzyme = 'BDNF/NT-3 growth factors receptor (TRKB)' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164901
PNG
(US10166239, Ex. 3-15 | US9067914, Ex. 3-15)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C26H26N6O3/c1-31-15-20(13-29-31)19-11-22-25(28-12-19)32(26(27)30-22)14-18-6-9-23(24(10-18)34-3)35-16-17-4-7-21(33-2)8-5-17/h4-13,15H,14,16H2,1-3H3,(H2,27,30)
PDB
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n/an/a 0.100n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164945
PNG
(US10166239, Ex. 3-40-5 | US9067914, Ex. 3-40-5)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1csc(n1)C(F)(F)F
Show InChI InChI=1S/C23H20F3N7O2S/c1-32-10-15(8-29-32)14-6-17-20(28-7-14)33(22(27)31-17)9-13-3-4-18(19(5-13)34-2)35-11-16-12-36-21(30-16)23(24,25)26/h3-8,10,12H,9,11H2,1-2H3,(H2,27,31)
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US Patent
n/an/a 0.200n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164943
PNG
(US10166239, Ex. 3-40-3 | US9067914, Ex. 3-40-3)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C(C)C
Show InChI InChI=1S/C27H29N7O2/c1-17(2)22-7-5-19(11-29-22)16-36-24-8-6-18(9-25(24)35-4)14-34-26-23(32-27(34)28)10-20(12-30-26)21-13-31-33(3)15-21/h5-13,15,17H,14,16H2,1-4H3,(H2,28,32)
PDB
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US Patent
n/an/a 0.200n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164928
PNG
(US10166239, Ex. 3-35-2 | US9067914, Ex. 3-35-2)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N7O2/c1-34-13-18(11-32-34)17-8-19-23(31-10-17)35(24(29)33-19)12-15-3-5-20(21(7-15)36-2)37-14-16-4-6-22(30-9-16)25(26,27)28/h3-11,13H,12,14H2,1-2H3,(H2,29,33)
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n/an/a 0.200n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164930
PNG
(US10166239, Ex. 3-35-4 | US9067914, Ex. 3-35-4)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(nc1)C1CC1
Show InChI InChI=1S/C27H27N7O2/c1-33-15-21(13-31-33)20-10-23-26(30-12-20)34(27(28)32-23)14-17-4-8-24(25(9-17)35-2)36-16-18-3-7-22(29-11-18)19-5-6-19/h3-4,7-13,15,19H,5-6,14,16H2,1-2H3,(H2,28,32)
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n/an/a 0.200n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164902
PNG
(US10166239, Ex. 3-16 | US9067914, Ex. 3-16)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccc(nc3)P(C)(C)=O)cc2OC)cc1
Show InChI InChI=1S/C29H30N5O4P/c1-36-23-9-5-19(6-10-23)18-38-25-11-7-20(13-26(25)37-2)17-34-28-24(33-29(34)30)14-22(16-32-28)21-8-12-27(31-15-21)39(3,4)35/h5-16H,17-18H2,1-4H3,(H2,30,33)
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n/an/a 0.200n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164931
PNG
(US10166239, Ex. 3-35-5 | US9067914, Ex. 3-35-5)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1csc(C)n1
Show InChI InChI=1S/C23H23N7O2S/c1-14-27-18(13-33-14)12-32-20-5-4-15(6-21(20)31-3)10-30-22-19(28-23(30)24)7-16(8-25-22)17-9-26-29(2)11-17/h4-9,11,13H,10,12H2,1-3H3,(H2,24,28)
PDB
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n/an/a 0.200n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164941
PNG
(US10166239, Ex. 3-40-1 | US9067914, Ex. 3-40-1)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C26H23F3N6O3/c1-34-14-19(12-32-34)18-10-21-24(31-11-18)35(25(30)33-21)13-17-5-8-22(23(9-17)36-2)37-15-16-3-6-20(7-4-16)38-26(27,28)29/h3-12,14H,13,15H2,1-2H3,(H2,30,33)
PDB
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n/an/a 0.200n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164927
PNG
(US10166239, Ex. 3-35-1 | US9067914, Ex. 3-35-1)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cn1
Show InChI InChI=1S/C25H25N7O3/c1-31-14-19(12-29-31)18-9-20-24(28-11-18)32(25(26)30-20)13-16-4-6-21(22(8-16)33-2)35-15-17-5-7-23(34-3)27-10-17/h4-12,14H,13,15H2,1-3H3,(H2,26,30)
PDB
MMDB

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US Patent
n/an/a 0.300n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164944
PNG
(US10166239, Ex. 3-40-4 | US9067914, Ex. 3-40-4)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(CC(F)(F)F)cc1
Show InChI InChI=1S/C27H25F3N6O2/c1-35-15-21(13-33-35)20-10-22-25(32-12-20)36(26(31)34-22)14-19-7-8-23(24(9-19)37-2)38-16-18-5-3-17(4-6-18)11-27(28,29)30/h3-10,12-13,15H,11,14,16H2,1-2H3,(H2,31,34)
PDB
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US Patent
n/an/a 0.300n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164929
PNG
(US10166239, Ex. 3-35-3 | US9067914, Ex. 3-35-3)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H23F3N6O2/c1-34-14-19(12-32-34)18-10-21-24(31-11-18)35(25(30)33-21)13-17-5-8-22(23(9-17)36-2)37-15-16-3-6-20(7-4-16)26(27,28)29/h3-12,14H,13,15H2,1-2H3,(H2,30,33)
PDB
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US Patent
n/an/a 0.300n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164885
PNG
(US10166239, Ex. 3-1 | US9067914, Ex. 3-1)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3cnn(C)c3)cc2OC)cc1
Show InChI InChI=1S/C27H27N5O3/c1-31-16-21(14-29-31)20-7-10-24-23(13-20)30-27(28)32(24)15-19-6-11-25(26(12-19)34-3)35-17-18-4-8-22(33-2)9-5-18/h4-14,16H,15,17H2,1-3H3,(H2,28,30)
PDB
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n/an/a 0.5n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM314760
PNG
(US9611265, Ex. 3-49)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)C(C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H25F3N6O2/c1-16(36-25-22(34-26(36)31)10-19(12-32-25)20-13-33-35(2)14-20)18-6-9-23(24(11-18)37-3)38-15-17-4-7-21(8-5-17)27(28,29)30/h4-14,16H,15H2,1-3H3,(H2,31,34)
PDB
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UniProtKB/SwissProt

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US Patent
n/an/a 0.600n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM314763
PNG
(US9611265, Ex. 3-50-1)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)C(C)n1c(N)nc2cc(cnc12)-c1cnn(CCO)c1
Show InChI InChI=1S/C28H27F3N6O3/c1-17(37-26-23(35-27(37)32)11-20(13-33-26)21-14-34-36(15-21)9-10-38)19-5-8-24(25(12-19)39-2)40-16-18-3-6-22(7-4-18)28(29,30)31/h3-8,11-15,17,38H,9-10,16H2,1-2H3,(H2,32,35)
PDB
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164940
PNG
(US10166239, Ex. 3-39 | US9067914, Ex. 3-39)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(cc1)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C27H23F5N6O2/c1-37-14-19(12-35-37)18-10-21-24(34-11-18)38(25(33)36-21)13-17-5-8-22(23(9-17)39-2)40-15-16-3-6-20(7-4-16)26(28,29)27(30,31)32/h3-12,14H,13,15H2,1-2H3,(H2,33,36)
PDB
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164912
PNG
(US10166239, Ex. 3-20 | US9067914, Ex. 3-20)
Show SMILES COc1cc(Cn2cnc3cc(cnc23)-c2cnn(c2)C2CCNCC2)ccc1OCc1ccc(C)nc1
Show InChI InChI=1S/C29H31N7O2/c1-20-3-4-22(13-31-20)18-38-27-6-5-21(11-28(27)37-2)16-35-19-33-26-12-23(14-32-29(26)35)24-15-34-36(17-24)25-7-9-30-10-8-25/h3-6,11-15,17,19,25,30H,7-10,16,18H2,1-2H3
PDB
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164942
PNG
(US10166239, Ex. 3-40-2 | US9067914, Ex. 3-40-2)
Show SMILES COc1cc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)ccc1OCc1ccc(SC(F)(F)F)cc1
Show InChI InChI=1S/C26H23F3N6O2S/c1-34-14-19(12-32-34)18-10-21-24(31-11-18)35(25(30)33-21)13-17-5-8-22(23(9-17)36-2)37-15-16-3-6-20(7-4-16)38-26(27,28)29/h3-12,14H,13,15H2,1-2H3,(H2,30,33)
PDB
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US Patent
n/an/a 0.600n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164937
PNG
(US10166239, Ex. 3-37-5 | US9067914, Ex. 3-37-5)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccncc3)cc2OC)cn1
Show InChI InChI=1S/C26H24N6O3/c1-33-23-11-17(3-5-22(23)35-16-18-4-6-24(34-2)29-13-18)15-32-25-21(31-26(32)27)12-20(14-30-25)19-7-9-28-10-8-19/h3-14H,15-16H2,1-2H3,(H2,27,31)
PDB
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UniProtKB/SwissProt

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US Patent
n/an/a 0.700n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164911
PNG
(US10166239, Ex. 3-19 | US9067914, Ex. 3-19)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-c3cnn(c3)C3CCNCC3)cc2OC)cn1
Show InChI InChI=1S/C29H31N7O3/c1-37-27-11-20(3-5-26(27)39-18-21-4-6-28(38-2)31-13-21)16-35-19-33-25-12-22(14-32-29(25)35)23-15-34-36(17-23)24-7-9-30-10-8-24/h3-6,11-15,17,19,24,30H,7-10,16,18H2,1-2H3
PDB
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US Patent
n/an/a 0.900n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164957
PNG
(US10166239, Ex. 3-49-6b | US9067914, Ex. 3-49-6b)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H25F3N6O2/c1-16(36-25-22(34-26(36)31)10-19(12-32-25)20-13-33-35(2)14-20)18-6-9-23(24(11-18)37-3)38-15-17-4-7-21(8-5-17)27(28,29)30/h4-14,16H,15H2,1-3H3,(H2,31,34)/t16-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM314764
PNG
(US9611265, Ex. 3-50-2)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)C(C)n1c(N)nc2cc(cnc12)-c1cn[nH]c1
Show InChI InChI=1S/C26H23F3N6O2/c1-15(35-24-21(34-25(35)30)9-18(11-31-24)19-12-32-33-13-19)17-5-8-22(23(10-17)36-2)37-14-16-3-6-20(7-4-16)26(27,28)29/h3-13,15H,14H2,1-2H3,(H2,30,34)(H,32,33)
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n/an/a 1n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164888
PNG
(US10166239, Ex. 3-2-3 | US9067914, Ex. 3-2-3)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3cnn(CCN4CCOCC4)c3)cc2OC)cc1
Show InChI InChI=1S/C32H36N6O4/c1-39-27-7-3-23(4-8-27)22-42-30-10-5-24(17-31(30)40-2)20-38-29-9-6-25(18-28(29)35-32(38)33)26-19-34-37(21-26)12-11-36-13-15-41-16-14-36/h3-10,17-19,21H,11-16,20,22H2,1-2H3,(H2,33,35)
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n/an/a 1n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164950
PNG
(US10166239, Ex. 3-45 | US9067914, Ex. 3-45)
Show SMILES COc1ccc(COc2ccc(cc2OC)C(C)n2c(N)nc3cc(ccc23)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C27H28N6O3/c1-17(33-23-8-6-20(11-22(23)31-27(33)28)21-14-30-32(2)15-21)19-7-9-24(25(12-19)34-3)36-16-18-5-10-26(35-4)29-13-18/h5-15,17H,16H2,1-4H3,(H2,28,31)
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n/an/a 1n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164939
PNG
(US10166239, Ex. 3-38 | US9067914, Ex. 3-38)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccccn3)cc2OC)cn1
Show InChI InChI=1S/C26H24N6O3/c1-33-23-11-17(6-8-22(23)35-16-18-7-9-24(34-2)29-13-18)15-32-25-21(31-26(32)27)12-19(14-30-25)20-5-3-4-10-28-20/h3-14H,15-16H2,1-2H3,(H2,27,31)
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n/an/a 2n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164934
PNG
(US10166239, Ex. 3-37-2 | US9067914, Ex. 3-37-2)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccn(C)n3)cc2OC)cn1
Show InChI InChI=1S/C25H25N7O3/c1-31-9-8-19(30-31)18-11-20-24(28-13-18)32(25(26)29-20)14-16-4-6-21(22(10-16)33-2)35-15-17-5-7-23(34-3)27-12-17/h4-13H,14-15H2,1-3H3,(H2,26,29)
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n/an/a 2n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164938
PNG
(US10166239, Ex. 3-37-6 | US9067914, Ex. 3-37-6)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cccnc3)cc2OC)cn1
Show InChI InChI=1S/C26H24N6O3/c1-33-23-10-17(5-7-22(23)35-16-18-6-8-24(34-2)29-12-18)15-32-25-21(31-26(32)27)11-20(14-30-25)19-4-3-9-28-13-19/h3-14H,15-16H2,1-2H3,(H2,27,31)
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n/an/a 2n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164947
PNG
(US10166239, Ex. 3-42 | US9067914, Ex. 3-42)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)C#CCCO)cc2OC)cn1
Show InChI InChI=1S/C25H25N5O4/c1-32-22-12-18(6-8-21(22)34-16-19-7-9-23(33-2)27-14-19)15-30-24-20(29-25(30)26)11-17(13-28-24)5-3-4-10-31/h6-9,11-14,31H,4,10,15-16H2,1-2H3,(H2,26,29)
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n/an/a 3n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164956
PNG
(US10166239, Ex. 3-49-6a | US9067914, Ex. 3-49-6a)
Show SMILES COc1cc(ccc1OCc1ccc(cc1)C(F)(F)F)[C@H](C)n1c(N)nc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H25F3N6O2/c1-16(36-25-22(34-26(36)31)10-19(12-32-25)20-13-33-35(2)14-20)18-6-9-23(24(11-18)37-3)38-15-17-4-7-21(8-5-17)27(28,29)30/h4-14,16H,15H2,1-3H3,(H2,31,34)/t16-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164932
PNG
(US10166239, Ex. 3-36 | US9067914, Ex. 3-36)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccccc3)cc2OC)cn1
Show InChI InChI=1S/C27H25N5O3/c1-33-24-12-18(8-10-23(24)35-17-19-9-11-25(34-2)29-14-19)16-32-26-22(31-27(32)28)13-21(15-30-26)20-6-4-3-5-7-20/h3-15H,16-17H2,1-2H3,(H2,28,31)
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n/an/a 4n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164933
PNG
(US10166239, Ex. 3-37-1 | US9067914, Ex. 3-37-1)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3ccc(F)cc3)cc2OC)cn1
Show InChI InChI=1S/C27H24FN5O3/c1-34-24-11-17(3-9-23(24)36-16-18-4-10-25(35-2)30-13-18)15-33-26-22(32-27(33)29)12-20(14-31-26)19-5-7-21(28)8-6-19/h3-14H,15-16H2,1-2H3,(H2,29,32)
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n/an/a 4n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM314765
PNG
(US9611265, Ex. 3-51)
Show SMILES CCC(c1ccc(OCc2ccc(nc2)C(F)(F)F)c(OC)c1)n1c(N)nc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H26F3N7O2/c1-4-21(37-25-20(35-26(37)31)9-18(12-33-25)19-13-34-36(2)14-19)17-6-7-22(23(10-17)38-3)39-15-16-5-8-24(32-11-16)27(28,29)30/h5-14,21H,4,15H2,1-3H3,(H2,31,35)
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n/an/a 4n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164887
PNG
(US10166239, Ex. 3-2-2 | US9067914, Ex. 3-2-2)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3ccncc3)cc2OC)cc1
Show InChI InChI=1S/C28H26N4O3/c1-33-23-7-3-19(4-8-23)18-35-26-10-5-20(15-27(26)34-2)17-32-25-9-6-22(16-24(25)31-28(32)29)21-11-13-30-14-12-21/h3-16H,17-18H2,1-2H3,(H2,29,31)
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n/an/a 4n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164891
PNG
(US10166239, Ex. 3-5 | US9067914, Ex. 3-5)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(ccc34)-c3cnn(c3)C3CCNCC3)cc2OC)cn1
Show InChI InChI=1S/C30H32N6O3/c1-37-29-13-21(3-7-28(29)39-19-22-4-8-30(38-2)32-15-22)17-35-20-33-26-14-23(5-6-27(26)35)24-16-34-36(18-24)25-9-11-31-12-10-25/h3-8,13-16,18,20,25,31H,9-12,17,19H2,1-2H3
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n/an/a 5n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164889
PNG
(US10166239, Ex. 3-3 | US9067914, Ex. 3-3)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3ccc(nc3)P(C)(C)=O)cc2OC)cc1
Show InChI InChI=1S/C30H31N4O4P/c1-36-24-10-5-20(6-11-24)19-38-27-13-7-21(15-28(27)37-2)18-34-26-12-8-22(16-25(26)33-30(34)31)23-9-14-29(32-17-23)39(3,4)35/h5-17H,18-19H2,1-4H3,(H2,31,33)
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n/an/a 6n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164936
PNG
(US10166239, Ex. 3-37-4 | US9067914, Ex. 3-37-4)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3c(C)nn(C)c3C)cc2OC)cn1
Show InChI InChI=1S/C27H29N7O3/c1-16-25(17(2)33(3)32-16)20-11-21-26(30-13-20)34(27(28)31-21)14-18-6-8-22(23(10-18)35-4)37-15-19-7-9-24(36-5)29-12-19/h6-13H,14-15H2,1-5H3,(H2,28,31)
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n/an/a 13n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164910
PNG
(US10166239, Ex. 3-18-7 | US9067914, Ex. 3-18-7)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCC[C@H]3C(O)=O)cc2OC)cn1
Show InChI InChI=1S/C26H27N5O5/c1-34-23-10-17(5-7-22(23)36-15-18-6-8-24(35-2)27-12-18)14-30-16-29-20-11-19(13-28-25(20)30)31-9-3-4-21(31)26(32)33/h5-8,10-13,16,21H,3-4,9,14-15H2,1-2H3,(H,32,33)/t21-/m0/s1
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n/an/a 13n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164961
PNG
(US10166239, Ex. 3-52 | US9067914, Ex. 3-52)
Show SMILES COc1cc(ccc1OCc1ccc(nc1)C(F)(F)F)C(C)n1cnc2cc(cnc12)-c1cnn(C)c1
Show InChI InChI=1S/C26H23F3N6O2/c1-16(35-15-32-21-8-19(11-31-25(21)35)20-12-33-34(2)13-20)18-5-6-22(23(9-18)36-3)37-14-17-4-7-24(30-10-17)26(27,28)29/h4-13,15-16H,14H2,1-3H3
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n/an/a 13n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164953
PNG
(US10166239, Ex. 3-48-1 | US9067914, Ex. 3-48-1)
Show SMILES COc1cc(ccc1OCc1ccc(nc1)C(F)(F)F)C(C)n1cnc2cc(ccc12)-c1cnn(C)c1
Show InChI InChI=1S/C27H24F3N5O2/c1-17(35-16-32-22-10-20(5-7-23(22)35)21-13-33-34(2)14-21)19-6-8-24(25(11-19)36-3)37-15-18-4-9-26(31-12-18)27(28,29)30/h4-14,16-17H,15H2,1-3H3
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n/an/a 14n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164935
PNG
(US10166239, Ex. 3-37-3 | US9067914, Ex. 3-37-3)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cncnc3)cc2OC)cn1
Show InChI InChI=1S/C25H23N7O3/c1-33-22-7-16(3-5-21(22)35-14-17-4-6-23(34-2)29-9-17)13-32-24-20(31-25(32)26)8-18(12-30-24)19-10-27-15-28-11-19/h3-12,15H,13-14H2,1-2H3,(H2,26,31)
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n/an/a 16n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164917
PNG
(US10166239, Ex. 3-25 | US9067914, Ex. 3-25)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-n3cc(nn3)C3CCCNC3)cc2OC)cn1
Show InChI InChI=1S/C28H30N8O3/c1-37-26-10-19(5-7-25(26)39-17-20-6-8-27(38-2)30-12-20)15-35-18-32-23-11-22(14-31-28(23)35)36-16-24(33-34-36)21-4-3-9-29-13-21/h5-8,10-12,14,16,18,21,29H,3-4,9,13,15,17H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164908
PNG
(US10166239, Ex. 3-18-5 | US9067914, Ex. 3-18-5)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CC4(C3)CCNCC4)cc2OC)cn1
Show InChI InChI=1S/C28H32N6O3/c1-35-25-11-20(3-5-24(25)37-16-21-4-6-26(36-2)30-13-21)15-33-19-32-23-12-22(14-31-27(23)33)34-17-28(18-34)7-9-29-10-8-28/h3-6,11-14,19,29H,7-10,15-18H2,1-2H3
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n/an/a 21n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164886
PNG
(US10166239, Ex. 3-2-1 | US9067914, Ex. 3-2-1)
Show SMILES COc1ccc(COc2ccc(Cn3c(N)nc4cc(ccc34)-c3cncnc3)cc2OC)cc1
Show InChI InChI=1S/C27H25N5O3/c1-33-22-7-3-18(4-8-22)16-35-25-10-5-19(11-26(25)34-2)15-32-24-9-6-20(12-23(24)31-27(32)28)21-13-29-17-30-14-21/h3-14,17H,15-16H2,1-2H3,(H2,28,31)
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n/an/a 23n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164913
PNG
(US10166239, Ex. 3-21 | US9067914, Ex. 3-21)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-c3noc(n3)C3CCNCC3)cc2OC)cn1
Show InChI InChI=1S/C28H29N7O4/c1-36-24-11-18(3-5-23(24)38-16-19-4-6-25(37-2)30-13-19)15-35-17-32-22-12-21(14-31-27(22)35)26-33-28(39-34-26)20-7-9-29-10-8-20/h3-6,11-14,17,20,29H,7-10,15-16H2,1-2H3
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n/an/a 24n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164926
PNG
(US10166239, Ex. 3-34 | US9067914, Ex.3-34)
Show SMILES CCC(Oc1ccc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)cc1OC)c1ccc(OC)nc1
Show InChI InChI=1S/C27H29N7O3/c1-5-22(18-7-9-25(36-4)29-12-18)37-23-8-6-17(10-24(23)35-3)15-34-26-21(32-27(34)28)11-19(13-30-26)20-14-31-33(2)16-20/h6-14,16,22H,5,15H2,1-4H3,(H2,28,32)
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n/an/a 26n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164905
PNG
(US10166239, Ex. 3-18-2 | US9067914, Ex. 3-18-2)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCOCC3)cc2OC)cn1
Show InChI InChI=1S/C25H27N5O4/c1-31-23-11-18(3-5-22(23)34-16-19-4-6-24(32-2)26-13-19)15-30-17-28-21-12-20(14-27-25(21)30)29-7-9-33-10-8-29/h3-6,11-14,17H,7-10,15-16H2,1-2H3
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n/an/a 31n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164951
PNG
(US10166239, Ex. 3-46 | US9067914, Ex. 3-46)
Show SMILES COc1ccc(COc2ccc(cc2OC)C(C)n2c(N)nc3cc(ccc23)-c2ccc(F)cc2)cn1
Show InChI InChI=1S/C29H27FN4O3/c1-18(21-8-12-26(27(15-21)35-2)37-17-19-4-13-28(36-3)32-16-19)34-25-11-7-22(14-24(25)33-29(34)31)20-5-9-23(30)10-6-20/h4-16,18H,17H2,1-3H3,(H2,31,33)
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n/an/a 37n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164949
PNG
(US10166239, Ex. 3-44 | US9067914, Ex. 344)
Show SMILES COc1cc2CCCC(Oc3ccc(Cn4c(N)nc5cc(cnc45)-c4cnn(C)c4)cc3OC)c2cn1
Show InChI InChI=1S/C28H29N7O3/c1-34-16-20(13-32-34)19-10-22-27(31-12-19)35(28(29)33-22)15-17-7-8-24(25(9-17)36-2)38-23-6-4-5-18-11-26(37-3)30-14-21(18)23/h7-14,16,23H,4-6,15H2,1-3H3,(H2,29,33)
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n/an/a 41n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164916
PNG
(US10166239, Ex. 3-24 | US9067914, Ex. 3-24)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)-n3cc(nn3)C(C)(C)N)cc2OC)cn1
Show InChI InChI=1S/C26H28N8O3/c1-26(2,27)23-14-34(32-31-23)19-10-20-25(29-12-19)33(16-30-20)13-17-5-7-21(22(9-17)35-3)37-15-18-6-8-24(36-4)28-11-18/h5-12,14,16H,13,15,27H2,1-4H3
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n/an/a 43n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164948
PNG
(US10166239, Ex. 3-43 | US9067914, Ex. 3-43)
Show SMILES COc1ccc(cn1)C(Oc1ccc(Cn2c(N)nc3cc(cnc23)-c2cnn(C)c2)cc1OC)C1CC1
Show InChI InChI=1S/C28H29N7O3/c1-34-16-21(14-32-34)20-11-22-27(31-13-20)35(28(29)33-22)15-17-4-8-23(24(10-17)36-2)38-26(18-5-6-18)19-7-9-25(37-3)30-12-19/h4,7-14,16,18,26H,5-6,15H2,1-3H3,(H2,29,33)
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n/an/a 51n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
BDNF/NT-3 growth factors receptor (TRKB)


(Homo sapiens (Human))
BDBM164906
PNG
(US10166239, Ex. 3-18-3 | US9067914, Ex. 3-18-3)
Show SMILES COc1ccc(COc2ccc(Cn3cnc4cc(cnc34)N3CCN(CC3)C3CC3)cc2OC)cn1
Show InChI InChI=1S/C28H32N6O3/c1-35-26-13-20(3-7-25(26)37-18-21-4-8-27(36-2)29-15-21)17-34-19-31-24-14-23(16-30-28(24)34)33-11-9-32(10-12-33)22-5-6-22/h3-4,7-8,13-16,19,22H,5-6,9-12,17-18H2,1-2H3
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n/an/a 52n/an/an/an/an/an/a



GENZYME CORPORATION

US Patent


Assay Description
Reagents and consumables were purchased from Sigma Aldrich, Carna Biosciences, or Caliper Life Sciences. All assay reaction conditions for IC50 deter...


US Patent US9611265 (2017)

More data for this
Ligand-Target Pair
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