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Compile Data Set for Download or QSAR

Found 72 hits of Enz. Inhib. data with enzyme = 'BRD9 (aa 134-239)' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321411
PNG
(6-[(E)-but-2-enyl]-4-[3-methoxy-4-(morpholine-4-ca...)
Show SMILES COc1cc(ccc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12
Show InChI InChI=1S/C24H27N3O4/c1-4-5-8-27-15-20(19-13-16(2)25-22(19)24(27)29)17-6-7-18(21(14-17)30-3)23(28)26-9-11-31-12-10-26/h4-7,13-15,25H,8-12H2,1-3H3/b5-4+
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321429
PNG
((E)-1-(4-(6-(but-2-en-1-yl)-2-methyl-7-oxo-6,7-dih...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCC(CC3)C(N)=O)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H27ClN4O3/c1-3-4-9-30-14-20(19-12-15(2)28-22(19)25(30)33)17-5-6-18(21(26)13-17)24(32)29-10-7-16(8-11-29)23(27)31/h3-6,12-14,16,28H,7-11H2,1-2H3,(H2,27,31)/b4-3+
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321430
PNG
(6-[(E)-but-2-enyl]-4-[3-isopropoxy-4-(morpholine-4...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(OC(C)C)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C26H31N3O4/c1-5-6-9-29-16-22(21-14-18(4)27-24(21)26(29)31)19-7-8-20(23(15-19)33-17(2)3)25(30)28-10-12-32-13-11-28/h5-8,14-17,27H,9-13H2,1-4H3/b6-5+
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321438
PNG
(3-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)NCc1cncnc1
Show InChI InChI=1S/C25H25N5O3/c1-4-5-8-30-14-21(20-9-16(2)29-23(20)25(30)32)19-10-18(6-7-22(19)33-3)24(31)28-13-17-11-26-15-27-12-17/h4-7,9-12,14-15,29H,8,13H2,1-3H3,(H,28,31)/b5-4+
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n/an/a 3n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321424
PNG
(6-[(E)-but-2-enyl]-4-[2,5-dimethoxy-4-(morpholine-...)
Show SMILES COc1cc(c(OC)cc1C(=O)N1CCOCC1)-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12
Show InChI InChI=1S/C25H29N3O5/c1-5-6-7-28-15-20(18-12-16(2)26-23(18)25(28)30)17-13-22(32-4)19(14-21(17)31-3)24(29)27-8-10-33-11-9-27/h5-6,12-15,26H,7-11H2,1-4H3/b6-5+
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n/an/a 4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321432
PNG
((E)-6-(but-2-en-1-yl)-4-(3-chloro-4-(piperazine-1-...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCNCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H25ClN4O2/c1-3-4-9-28-14-19(18-12-15(2)26-21(18)23(28)30)16-5-6-17(20(24)13-16)22(29)27-10-7-25-8-11-27/h3-6,12-14,25-26H,7-11H2,1-2H3/b4-3+
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n/an/a 4n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321433
PNG
((E)-4-(4-(3-(3-amino-1H-pyrazol-1-yl)azetidine-1-c...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CC(C3)n3ccc(N)n3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H25ClN6O2/c1-3-4-8-30-14-20(19-10-15(2)28-23(19)25(30)34)16-5-6-18(21(26)11-16)24(33)31-12-17(13-31)32-9-7-22(27)29-32/h3-7,9-11,14,17,28H,8,12-13H2,1-2H3,(H2,27,29)/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321412
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H24ClN3O3/c1-3-4-7-27-14-19(18-12-15(2)25-21(18)23(27)29)16-5-6-17(20(24)13-16)22(28)26-8-10-30-11-9-26/h3-6,12-14,25H,7-11H2,1-2H3/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321431
PNG
(6-[(E)-but-2-enyl]-4-[3-(cyclopropylmethoxy)-4-(mo...)
Show SMILES C\C=C\CN1C=C2NC(C)C=C2C(=C1)c1ccc(C(=O)N2CCOCC2)c(OCC2CC2)c1
Show InChI InChI=1S/C27H33N3O3/c1-3-4-9-29-16-24(23-14-19(2)28-25(23)17-29)21-7-8-22(26(15-21)33-18-20-5-6-20)27(31)30-10-12-32-13-11-30/h3-4,7-8,14-17,19-20,28H,5-6,9-13,18H2,1-2H3/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321425
PNG
(3-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)NCc1cnccn1
Show InChI InChI=1S/C25H25N5O3/c1-4-5-10-30-15-21(20-11-16(2)29-23(20)25(30)32)19-12-17(6-7-22(19)33-3)24(31)28-14-18-13-26-8-9-27-18/h4-9,11-13,15,29H,10,14H2,1-3H3,(H,28,31)/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321422
PNG
(5-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo[2,...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(c2)C#N)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C24H24N4O3/c1-3-4-7-28-15-21(20-12-16(2)26-22(20)24(28)30)17-5-6-19(18(13-17)14-25)23(29)27-8-10-31-11-9-27/h3-6,12-13,15,26H,7-11H2,1-2H3/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321437
PNG
((E)-6-(but-2-en-1-yl)-4-(4-(2-hydroxypropan-2-yl)-...)
Show SMILES COc1cc(c(OC)cc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(C)(C)O
Show InChI InChI=1S/C23H28N2O4/c1-7-8-9-25-13-17(16-10-14(2)24-21(16)22(25)26)15-11-20(29-6)18(23(3,4)27)12-19(15)28-5/h7-8,10-13,24,27H,9H2,1-6H3/b8-7+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321428
PNG
(1-[4-[6-[(E)-but-2-enyl]-2-methyl-7-oxo-1H-pyrrolo...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCC(CC3)C(O)=O)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H26ClN3O4/c1-3-4-9-29-14-20(19-12-15(2)27-22(19)24(29)31)17-5-6-18(21(26)13-17)23(30)28-10-7-16(8-11-28)25(32)33/h3-6,12-14,16,27H,7-11H2,1-2H3,(H,32,33)/b4-3+
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n/an/a 8n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321436
PNG
(4-[4-[3-(3-aminopyrazol-1-yl)azetidine-1-carbonyl]...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CC(C2)n2ccc(N)n2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H26N6O2/c1-3-4-10-29-15-21(20-12-16(2)27-23(20)25(29)33)17-5-7-18(8-6-17)24(32)30-13-19(14-30)31-11-9-22(26)28-31/h3-9,11-12,15,19,27H,10,13-14H2,1-2H3,(H2,26,28)/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321418
PNG
(6-allyl-4-[2,5-dimethoxy-4-(morpholine-4-carbonyl)...)
Show SMILES COc1cc(c(OC)cc1C(=O)N1CCOCC1)-c1cn(CC=C)c(=O)c2[nH]c(C)cc12
Show InChI InChI=1S/C24H27N3O5/c1-5-6-27-14-19(17-11-15(2)25-22(17)24(27)29)16-12-21(31-4)18(13-20(16)30-3)23(28)26-7-9-32-10-8-26/h5,11-14,25H,1,6-10H2,2-4H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321414
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(4-methylpiperazi...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCN(C)CC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C24H27ClN4O2/c1-4-5-8-29-15-20(19-13-16(2)26-22(19)24(29)31)17-6-7-18(21(25)14-17)23(30)28-11-9-27(3)10-12-28/h4-7,13-15,26H,8-12H2,1-3H3/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321409
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(pyrrolidine-1-ca...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H24ClN3O2/c1-3-4-9-27-14-19(18-12-15(2)25-21(18)23(27)29)16-7-8-17(20(24)13-16)22(28)26-10-5-6-11-26/h3-4,7-8,12-14,25H,5-6,9-11H2,1-2H3/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321415
PNG
(6-[(E)-but-2-enyl]-2-methyl-4-[3-methyl-4-(morphol...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(C)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C24H27N3O3/c1-4-5-8-27-15-21(20-14-17(3)25-22(20)24(27)29)18-6-7-19(16(2)13-18)23(28)26-9-11-30-12-10-26/h4-7,13-15,25H,8-12H2,1-3H3/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321417
PNG
(6-allyl-4-[3-chloro-4-(morpholine-4-carbonyl)pheny...)
Show SMILES Cc1cc2c(cn(CC=C)c(=O)c2[nH]1)-c1ccc(C(=O)N2CCOCC2)c(Cl)c1
Show InChI InChI=1S/C22H22ClN3O3/c1-3-6-26-13-18(17-11-14(2)24-20(17)22(26)28)15-4-5-16(19(23)12-15)21(27)25-7-9-29-10-8-25/h3-5,11-13,24H,1,6-10H2,2H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321407
PNG
(6-[(E)-but-2-enyl]-2-methyl-4-[4-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H25N3O3/c1-3-4-9-26-15-20(19-14-16(2)24-21(19)23(26)28)17-5-7-18(8-6-17)22(27)25-10-12-29-13-11-25/h3-8,14-15,24H,9-13H2,1-2H3/b4-3+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321408
PNG
(6-[(E)-but-2-enyl]-2-methyl-4-[4-(pyrrolidine-1-ca...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(=O)N2CCCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H25N3O2/c1-3-4-11-26-15-20(19-14-16(2)24-21(19)23(26)28)17-7-9-18(10-8-17)22(27)25-12-5-6-13-25/h3-4,7-10,14-15,24H,5-6,11-13H2,1-2H3/b4-3+
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321389
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(Cl)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H22ClN3O3/c1-2-3-8-26-14-18(16-6-7-24-20(16)22(26)28)15-4-5-17(19(23)13-15)21(27)25-9-11-29-12-10-25/h2-7,13-14,24H,8-12H2,1H3/b3-2+
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321383
PNG
(6-but-2-enyl-4-[4-(morpholine-4-carbonyl)phenyl]-1...)
Show SMILES CC=CCn1cc(-c2ccc(cc2)C(=O)N2CCOCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H23N3O3/c1-2-3-10-25-15-19(18-8-9-23-20(18)22(25)27)16-4-6-17(7-5-16)21(26)24-11-13-28-14-12-24/h2-9,15,23H,10-14H2,1H3/b3-2+
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n/an/a 13n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321402
PNG
(6-[(E)-but-2-enyl]-4-[4-(1-hydroxy-1-methyl-ethyl)...)
Show SMILES C\C=C\Cn1cc(-c2ccc(cc2)C(C)(C)O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H22N2O2/c1-4-5-12-22-13-17(16-10-11-21-18(16)19(22)23)14-6-8-15(9-7-14)20(2,3)24/h4-11,13,21,24H,12H2,1-3H3/b5-4+
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n/an/a 17n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321439
PNG
(6-butyl-4-[2,5-dimethoxy-4-(morpholine-4-carbonyl)...)
Show SMILES CCCCn1cc(-c2cc(OC)c(cc2OC)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C25H31N3O5/c1-5-6-7-28-15-20(18-12-16(2)26-23(18)25(28)30)17-13-22(32-4)19(14-21(17)31-3)24(29)27-8-10-33-11-9-27/h12-15,26H,5-11H2,1-4H3
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n/an/a 17n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321400
PNG
(6-[(E)-but-2-enyl]-4-[4-(1-hydroxy-1-methyl-ethyl)...)
Show SMILES COc1cc(ccc1-n1cc(C\C=C\C)c(=O)c2[nH]ccc12)C(C)(C)O
Show InChI InChI=1S/C21H24N2O3/c1-5-6-7-14-13-23(17-10-11-22-19(17)20(14)24)16-9-8-15(21(2,3)25)12-18(16)26-4/h5-6,8-13,22,25H,7H2,1-4H3/b6-5+
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n/an/a 20n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310899
PNG
(4-[4-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-1H...)
Show SMILES Cn1cc(-c2ccc(cc2)C(C)(C)O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C17H18N2O2/c1-17(2,21)12-6-4-11(5-7-12)14-10-19(3)16(20)15-13(14)8-9-18-15/h4-10,18,21H,1-3H3
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n/an/a 21n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321381
PNG
(N-[4-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-...)
Show SMILES CC=CCn1cc(-c2ccc(NS(C)(=O)=O)cc2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C18H19N3O3S/c1-3-4-11-21-12-16(15-9-10-19-17(15)18(21)22)13-5-7-14(8-6-13)20-25(2,23)24/h3-10,12,19-20H,11H2,1-2H3/b4-3+
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n/an/a 22n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321420
PNG
(6-[(E)-but-2-enyl]-4-[4-chloro-5-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2cc(Cl)c(cn2)C(=O)N2CCOCC2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C22H23ClN4O3/c1-3-4-5-27-13-17(15-10-14(2)25-20(15)22(27)29)19-11-18(23)16(12-24-19)21(28)26-6-8-30-9-7-26/h3-4,10-13,25H,5-9H2,1-2H3/b4-3+
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n/an/a 22n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321396
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NCCN(C)C
Show InChI InChI=1S/C23H28N4O3/c1-5-6-12-27-15-19(17-9-10-24-21(17)23(27)29)18-14-16(7-8-20(18)30-4)22(28)25-11-13-26(2)3/h5-10,14-15,24H,11-13H2,1-4H3,(H,25,28)/b6-5+
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n/an/a 23n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310892
PNG
(N-(2-methoxyethyl)-4-(6-methyl-7-oxo-1H-pyrrolo[2,...)
Show SMILES COCCNC(=O)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C18H19N3O3/c1-21-11-15(14-7-8-19-16(14)18(21)23)12-3-5-13(6-4-12)17(22)20-9-10-24-2/h3-8,11,19H,9-10H2,1-2H3,(H,20,22)
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n/an/a 24n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310896
PNG
(7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-1...)
Show SMILES Cn1cc(-c2ccc3NC(=O)CCNc3c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C17H16N4O2/c1-21-9-12(11-4-6-19-16(11)17(21)23)10-2-3-13-14(8-10)18-7-5-15(22)20-13/h2-4,6,8-9,18-19H,5,7H2,1H3,(H,20,22)
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n/an/a 25n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321398
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES CCCNC(=O)c1ccc(OC)c(c1)-c1cn(C\C=C\C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C22H25N3O3/c1-4-6-12-25-14-18(16-9-11-23-20(16)22(25)27)17-13-15(7-8-19(17)28-3)21(26)24-10-5-2/h4,6-9,11,13-14,23H,5,10,12H2,1-3H3,(H,24,26)/b6-4+
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n/an/a 27n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321392
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES CCNC(=O)c1ccc(OC)c(c1)-c1cn(C\C=C\C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C21H23N3O3/c1-4-6-11-24-13-17(15-9-10-23-19(15)21(24)26)16-12-14(20(25)22-5-2)7-8-18(16)27-3/h4,6-10,12-13,23H,5,11H2,1-3H3,(H,22,25)/b6-4+
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n/an/a 28n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321395
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NCC(C)C
Show InChI InChI=1S/C23H27N3O3/c1-5-6-11-26-14-19(17-9-10-24-21(17)23(26)28)18-12-16(7-8-20(18)29-4)22(27)25-13-15(2)3/h5-10,12,14-15,24H,11,13H2,1-4H3,(H,25,27)/b6-5+
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n/an/a 28n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321377
PNG
(4-(6-but-2-enyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-y...)
Show SMILES CNC(=O)c1ccc(cc1)-c1cn(CC=CC)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C19H19N3O2/c1-3-4-11-22-12-16(15-9-10-21-17(15)19(22)24)13-5-7-14(8-6-13)18(23)20-2/h3-10,12,21H,11H2,1-2H3,(H,20,23)/b4-3+
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n/an/a 29n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310895
PNG
(3-methyl-7-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridi...)
Show SMILES CC1CNc2cc(ccc2NC1=O)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C18H18N4O2/c1-10-8-20-15-7-11(3-4-14(15)21-17(10)23)13-9-22(2)18(24)16-12(13)5-6-19-16/h3-7,9-10,19-20H,8H2,1-2H3,(H,21,23)
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n/an/a 31n/an/an/an/an/an/a



Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321413
PNG
(6-[(E)-but-2-enyl]-4-[5-chloro-6-(morpholine-4-car...)
Show SMILES C\C=C\Cn1cc(-c2cnc(C(=O)N3CCOCC3)c(Cl)c2)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C22H23ClN4O3/c1-3-4-5-27-13-17(16-10-14(2)25-19(16)21(27)28)15-11-18(23)20(24-12-15)22(29)26-6-8-30-9-7-26/h3-4,10-13,25H,5-9H2,1-2H3/b4-3+
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n/an/a 32n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321410
PNG
(6-[(E)-but-2-enyl]-4-[2,3-difluoro-4-(morpholine-4...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCOCC3)c(F)c2F)c2cc(C)[nH]c2c1=O
Show InChI InChI=1S/C23H23F2N3O3/c1-3-4-7-28-13-18(17-12-14(2)26-21(17)23(28)30)15-5-6-16(20(25)19(15)24)22(29)27-8-10-31-11-9-27/h3-6,12-13,26H,7-11H2,1-2H3/b4-3+
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n/an/a 34n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321397
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)NCCO
Show InChI InChI=1S/C21H23N3O4/c1-3-4-10-24-13-17(15-7-8-22-19(15)21(24)27)16-12-14(5-6-18(16)28-2)20(26)23-9-11-25/h3-8,12-13,22,25H,9-11H2,1-2H3,(H,23,26)/b4-3+
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n/an/a 35n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321393
PNG
(3-[6-[(E)-but-2-enyl]-7-oxo-1H-pyrrolo[2,3-c]pyrid...)
Show SMILES CNC(=O)c1ccc(OC)c(c1)-c1cn(C\C=C\C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H21N3O3/c1-4-5-10-23-12-16(14-8-9-22-18(14)20(23)25)15-11-13(19(24)21-2)6-7-17(15)26-3/h4-9,11-12,22H,10H2,1-3H3,(H,21,24)/b5-4+
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n/an/a 35n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321394
PNG
(6-[(E)-but-2-enyl]-4-[2-methoxy-5-(pyrrolidine-1-c...)
Show SMILES COc1ccc(cc1-c1cn(C\C=C\C)c(=O)c2[nH]ccc12)C(=O)N1CCCC1
Show InChI InChI=1S/C23H25N3O3/c1-3-4-11-26-15-19(17-9-10-24-21(17)23(26)28)18-14-16(7-8-20(18)29-2)22(27)25-12-5-6-13-25/h3-4,7-10,14-15,24H,5-6,11-13H2,1-2H3/b4-3+
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n/an/a 39n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321378
PNG
(6-but-2-enyl-4-[3-(pyrrolidine-1-carbonyl)phenyl]-...)
Show SMILES CC=CCn1cc(-c2cccc(c2)C(=O)N2CCCC2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H23N3O2/c1-2-3-11-25-15-19(18-9-10-23-20(18)22(25)27)16-7-6-8-17(14-16)21(26)24-12-4-5-13-24/h2-3,6-10,14-15,23H,4-5,11-13H2,1H3/b3-2+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321426
PNG
(6-but-2-enyl-4-[3-methoxy-5-(4-methylpiperazine-1-...)
Show SMILES COc1cc(cnc1-c1cn(CC=CC)c(=O)c2[nH]c(C)cc12)C(=O)N1CCN(C)CC1
Show InChI InChI=1S/C24H29N5O3/c1-5-6-7-29-15-19(18-12-16(2)26-22(18)24(29)31)21-20(32-4)13-17(14-25-21)23(30)28-10-8-27(3)9-11-28/h5-6,12-15,26H,7-11H2,1-4H3/b6-5+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321403
PNG
(6-butyl-4-(4-(2-hydroxypropan-2-yl)phenyl)-1H-pyrr...)
Show SMILES CCCCn1cc(-c2ccc(cc2)C(C)(C)O)c2cc[nH]c2c1=O
Show InChI InChI=1S/C20H24N2O2/c1-4-5-12-22-13-17(16-10-11-21-18(16)19(22)23)14-6-8-15(9-7-14)20(2,3)24/h6-11,13,21,24H,4-5,12H2,1-3H3
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321388
PNG
(3-(6-butyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-...)
Show SMILES CCCCn1cc(-c2cc(ccc2OC)C#N)c2cc[nH]c2c1=O
Show InChI InChI=1S/C19H19N3O2/c1-3-4-9-22-12-16(14-7-8-21-18(14)19(22)23)15-10-13(11-20)5-6-17(15)24-2/h5-8,10,12,21H,3-4,9H2,1-2H3
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n/an/a 46n/an/an/an/an/an/a



GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321390
PNG
(6-[(E)-but-2-enyl]-4-[3-chloro-4-(pyrrolidine-1-ca...)
Show SMILES C\C=C\Cn1cc(-c2ccc(C(=O)N3CCCC3)c(Cl)c2)c2cc[nH]c2c1=O
Show InChI InChI=1S/C22H22ClN3O2/c1-2-3-10-26-14-18(16-8-9-24-20(16)22(26)28)15-6-7-17(19(23)13-15)21(27)25-11-4-5-12-25/h2-3,6-9,13-14,24H,4-5,10-12H2,1H3/b3-2+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM321419
PNG
(6-[(E)-but-2-enyl]-4-[3-methoxy-5-(morpholine-4-ca...)
Show SMILES COc1cc(cnc1-c1cn(C\C=C\C)c(=O)c2[nH]c(C)cc12)C(=O)N1CCOCC1
Show InChI InChI=1S/C23H26N4O4/c1-4-5-6-27-14-18(17-11-15(2)25-21(17)23(27)29)20-19(30-3)12-16(13-24-20)22(28)26-7-9-31-10-8-26/h4-5,11-14,25H,6-10H2,1-3H3/b5-4+
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GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10183009 (2019)

More data for this
Ligand-Target Pair
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310898
PNG
(N,N-dimethyl-3-(6-methyl-7-oxo-1H-pyrrolo[2,3-c]py...)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C17H17N3O2/c1-19(2)16(21)12-6-4-5-11(9-12)14-10-20(3)17(22)15-13(14)7-8-18-15/h4-10,18H,1-3H3
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Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
BRD9 (aa 134-239)


(Homo sapiens (human))
BDBM310902
PNG
(6-methyl-4-[4-(1-methyl-4-piperidyl)phenyl]-1H-pyr...)
Show SMILES CN1CCC(CC1)c1ccc(cc1)-c1cn(C)c(=O)c2[nH]ccc12
Show InChI InChI=1S/C20H23N3O/c1-22-11-8-15(9-12-22)14-3-5-16(6-4-14)18-13-23(2)20(24)19-17(18)7-10-21-19/h3-7,10,13,15,21H,8-9,11-12H2,1-2H3
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Genentech, Inc.; Constellation Pharmaceuticals Inc.

US Patent


Assay Description
His/Flag epitope tagged BRD9134-239 was cloned, expressed, and purified to homogeneity. BRD9 binding and inhibition was assessed by monitoring the en...


US Patent US10150767 (2018)

More data for this
Ligand-Target Pair
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