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Compile Data Set for Download or QSAR

Found 29 hits of Enz. Inhib. data with enzyme = 'Bcl-2-like protein 1' and Substrate = 'Bak-BH3 peptide'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bcl-2-like protein 1


(Homo sapiens)
BDBM31809
PNG
(Apogossypol derivative, 8k)
Show SMILES CC(NC(=O)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(=O)NC(C)c3ccc(Cl)cc3)c(O)c(O)cc2c1O)c1ccc(Cl)cc1
Show InChI InChI=1S/C40H34Cl2N2O8/c1-17-13-25-27(15-29(45)37(49)33(25)39(51)43-19(3)21-5-9-23(41)10-6-21)35(47)31(17)32-18(2)14-26-28(36(32)48)16-30(46)38(50)34(26)40(52)44-20(4)22-7-11-24(42)12-8-22/h5-16,19-20,45-50H,1-4H3,(H,43,51)(H,44,52)
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n/an/a 270 110n/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31810
PNG
(Apogossypol derivative, 8r)
Show SMILES CC(CNC(=O)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(=O)NCC(C)c3ccccc3)c(O)c(O)cc2c1O)c1ccccc1
Show InChI InChI=1S/C42H40N2O8/c1-21-15-27-29(17-31(45)39(49)35(27)41(51)43-19-23(3)25-11-7-5-8-12-25)37(47)33(21)34-22(2)16-28-30(38(34)48)18-32(46)40(50)36(28)42(52)44-20-24(4)26-13-9-6-10-14-26/h5-18,23-24,45-50H,19-20H2,1-4H3,(H,43,51)(H,44,52)
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n/an/a 760 110n/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31808
PNG
(Apogossypol derivative, 8j)
Show SMILES Cc1cc(C)c(CNC(=O)c2c(O)c(O)cc3c(O)c(c(C)cc23)-c2c(C)cc3c(C(=O)NCc4c(C)cc(C)cc4C)c(O)c(O)cc3c2O)c(C)c1
Show InChI InChI=1S/C44H44N2O8/c1-19-9-21(3)31(22(4)10-19)17-45-43(53)37-27-13-25(7)35(39(49)29(27)15-33(47)41(37)51)36-26(8)14-28-30(40(36)50)16-34(48)42(52)38(28)44(54)46-18-32-23(5)11-20(2)12-24(32)6/h9-16,47-52H,17-18H2,1-8H3,(H,45,53)(H,46,54)
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n/an/a 800n/an/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31805
PNG
(Apogossypol derivative, 8n)
Show SMILES Cc1cc2c(C(=O)NCCc3ccccc3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)NCCc3ccccc3)c(O)c(O)cc2c1O
Show InChI InChI=1S/C40H36N2O8/c1-21-17-25-27(19-29(43)37(47)33(25)39(49)41-15-13-23-9-5-3-6-10-23)35(45)31(21)32-22(2)18-26-28(36(32)46)20-30(44)38(48)34(26)40(50)42-16-14-24-11-7-4-8-12-24/h3-12,17-20,43-48H,13-16H2,1-2H3,(H,41,49)(H,42,50)
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n/an/a 800n/an/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31811
PNG
(Apogossypol derivative, 8s)
Show SMILES Cc1cc2c(C(=O)NC3Cc4ccccc4C3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)NC3Cc4ccccc4C3)c(O)c(O)cc2c1O
Show InChI InChI=1S/C42H36N2O8/c1-19-11-27-29(17-31(45)39(49)35(27)41(51)43-25-13-21-7-3-4-8-22(21)14-25)37(47)33(19)34-20(2)12-28-30(38(34)48)18-32(46)40(50)36(28)42(52)44-26-15-23-9-5-6-10-24(23)16-26/h3-12,17-18,25-26,45-50H,13-16H2,1-2H3,(H,43,51)(H,44,52)
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n/an/a 850n/an/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31807
PNG
(Apogossypol derivative, 8q)
Show SMILES CCc1ccc(CCNC(=O)c2c(O)c(O)cc3c(O)c(c(C)cc23)-c2c(C)cc3c(C(=O)NCCc4ccc(CC)cc4)c(O)c(O)cc3c2O)cc1
Show InChI InChI=1S/C44H44N2O8/c1-5-25-7-11-27(12-8-25)15-17-45-43(53)37-29-19-23(3)35(39(49)31(29)21-33(47)41(37)51)36-24(4)20-30-32(40(36)50)22-34(48)42(52)38(30)44(54)46-18-16-28-13-9-26(6-2)10-14-28/h7-14,19-22,47-52H,5-6,15-18H2,1-4H3,(H,45,53)(H,46,54)
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n/an/a 930 120n/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31804
PNG
(Apogossypol derivative, 8m)
Show SMILES Cc1cc2c(C(=O)NCC3CCCCC3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)NCC3CCCCC3)c(O)c(O)cc2c1O
Show InChI InChI=1S/C38H44N2O8/c1-19-13-23-25(15-27(41)35(45)31(23)37(47)39-17-21-9-5-3-6-10-21)33(43)29(19)30-20(2)14-24-26(34(30)44)16-28(42)36(46)32(24)38(48)40-18-22-11-7-4-8-12-22/h13-16,21-22,41-46H,3-12,17-18H2,1-2H3,(H,39,47)(H,40,48)
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n/an/a 1.10E+3 850n/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25537
PNG
(4-(2-hydroxyethyl)-8-methyl-12,14-dioxa-8-azatetra...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2cc(CCO)ccc12
Show InChI InChI=1S/C17H16NO3/c1-18-9-14-12(3-5-16-17(14)21-10-20-16)13-8-11(6-7-19)2-4-15(13)18/h2-5,8-9,19H,6-7,10H2,1H3/q+1
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n/an/a 3.00E+3n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31803
PNG
(Apogossypol derivative, 12e)
Show SMILES Cc1cc2c(CCc3ccccc3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(CCc3ccccc3)c(O)c(O)cc2c1O
Show InChI InChI=1S/C38H34O6/c1-21-17-27-25(15-13-23-9-5-3-6-10-23)35(41)31(39)19-29(27)37(43)33(21)34-22(2)18-28-26(16-14-24-11-7-4-8-12-24)36(42)32(40)20-30(28)38(34)44/h3-12,17-20,39-44H,13-16H2,1-2H3
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n/an/a 3.50E+3 410n/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31802
PNG
(Apogossypol | US9115061, Apogossypol)
Show SMILES CC(C)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)cc2c1O
Show InChI InChI=1S/C28H30O6/c1-11(2)21-15-7-13(5)23(25(31)17(15)9-19(29)27(21)33)24-14(6)8-16-18(26(24)32)10-20(30)28(34)22(16)12(3)4/h7-12,29-34H,1-6H3
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n/an/a 3.70E+3 1.70E+3n/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25539
PNG
(4-(2-methoxyethyl)-8-methyl-12,14-dioxa-8-azatetra...)
Show SMILES COCCc1ccc2[n+](C)cc3c4OCOc4ccc3c2c1
Show InChI InChI=1S/C18H18NO3/c1-19-10-15-13(4-6-17-18(15)22-11-21-17)14-9-12(7-8-20-2)3-5-16(14)19/h3-6,9-10H,7-8,11H2,1-2H3/q+1
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n/an/a 6.00E+3n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM31806
PNG
(Apogossypol derivative, 8p)
Show SMILES Cc1cc2c(C(=O)NCCc3cccc(Cl)c3)c(O)c(O)cc2c(O)c1-c1c(C)cc2c(C(=O)NCCc3cccc(Cl)c3)c(O)c(O)cc2c1O
Show InChI InChI=1S/C40H34Cl2N2O8/c1-19-13-25-27(17-29(45)37(49)33(25)39(51)43-11-9-21-5-3-7-23(41)15-21)35(47)31(19)32-20(2)14-26-28(36(32)48)18-30(46)38(50)34(26)40(52)44-12-10-22-6-4-8-24(42)16-22/h3-8,13-18,45-50H,9-12H2,1-2H3,(H,43,51)(H,44,52)
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n/an/a 6.30E+3n/an/an/an/a7.423



Burnham Institute for Medical Research



Assay Description
FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...


J Med Chem 52: 4511-23 (2009)


Article DOI: 10.1021/jm900472s
BindingDB Entry DOI: 10.7270/Q247486S
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25536
PNG
(4-(hydroxymethyl)-8-methyl-12,14-dioxa-8-azatetrac...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2cc(CO)ccc12
Show InChI InChI=1S/C16H14NO3/c1-17-7-13-11(3-5-15-16(13)20-9-19-15)12-6-10(8-18)2-4-14(12)17/h2-7,18H,8-9H2,1H3/q+1
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n/an/a 1.10E+4n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25538
PNG
(4-(methoxymethyl)-8-methyl-12,14-dioxa-8-azatetrac...)
Show SMILES COCc1ccc2[n+](C)cc3c4OCOc4ccc3c2c1
Show InChI InChI=1S/C17H16NO3/c1-18-8-14-12(4-6-16-17(14)21-10-20-16)13-7-11(9-19-2)3-5-15(13)18/h3-8H,9-10H2,1-2H3/q+1
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n/an/a 1.10E+4n/an/an/an/a8.022



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Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25530
PNG
(8-methyl-12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccccc12
Show InChI InChI=1S/C15H12NO2/c1-16-8-12-10(11-4-2-3-5-13(11)16)6-7-14-15(12)18-9-17-14/h2-8H,9H2,1H3/q+1
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n/an/a 1.20E+4n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25540
PNG
(7,8-dihydroxy-5-methylphenanthridin-5-ium chloride...)
Show SMILES Cn1cc2c(ccc(O)c2=[OH+])c2ccccc12
Show InChI InChI=1S/C14H11NO2/c1-15-8-11-9(6-7-13(16)14(11)17)10-4-2-3-5-12(10)15/h2-8,16H,1H3/p+1
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n/an/a 1.80E+4n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25525
PNG
(24-methyl-5,7,18,20-tetraoxa-24-azahexacyclo[11.11...)
Show SMILES C[n+]1cc2c3OCOc3ccc2c2ccc3cc4OCOc4cc3c12
Show InChI InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
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n/an/a 1.90E+4n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25541
PNG
(7,8-dihydroxy-2-(hydroxymethyl)-5-methylphenanthri...)
Show SMILES Cn1cc2c(ccc(O)c2=[OH+])c2cc(CO)ccc12
Show InChI InChI=1S/C15H13NO3/c1-16-7-12-10(3-5-14(18)15(12)19)11-6-9(8-17)2-4-13(11)16/h2-7,17-18H,8H2,1H3/p+1
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n/an/a 2.00E+4n/an/an/an/a8.022



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Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25542
PNG
(7,8-dihydroxy-2-(2-hydroxyethyl)-5-methylphenanthr...)
Show SMILES Cn1cc2c(ccc(O)c2=[OH+])c2cc(CCO)ccc12
Show InChI InChI=1S/C16H15NO3/c1-17-9-13-11(3-5-15(19)16(13)20)12-8-10(6-7-18)2-4-14(12)17/h2-5,8-9,18-19H,6-7H2,1H3/p+1
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n/an/a 2.20E+4n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25528
PNG
(13,13-dimethyl-12,14-dioxa-8-azatetracyclo[8.7.0.0...)
Show SMILES CC1(C)Oc2ccc3c(cnc4ccccc34)c2O1
Show InChI InChI=1S/C16H13NO2/c1-16(2)18-14-8-7-10-11-5-3-4-6-13(11)17-9-12(10)15(14)19-16/h3-9H,1-2H3
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n/an/a>1.00E+5n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25527
PNG
(12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}.0^{11,15...)
Show SMILES C1Oc2ccc3c(cnc4ccccc34)c2O1
Show InChI InChI=1S/C14H9NO2/c1-2-4-12-10(3-1)9-5-6-13-14(17-8-16-13)11(9)7-15-12/h1-7H,8H2
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n/an/a>1.00E+5n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25526
PNG
(7,8-dimethoxyphenanthridine | chelerythrine analog...)
Show SMILES COc1ccc2c(cnc3ccccc23)c1OC
Show InChI InChI=1S/C15H13NO2/c1-17-14-8-7-10-11-5-3-4-6-13(11)16-9-12(10)15(14)18-2/h3-9H,1-2H3
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n/an/a>1.00E+5n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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n/an/a 1.00E+5n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25529
PNG
(7,8-dimethoxy-5-methylphenanthridin-5-ium iodide |...)
Show SMILES COc1ccc2c(c[n+](C)c3ccccc23)c1OC
Show InChI InChI=1S/C16H16NO2/c1-17-10-13-11(12-6-4-5-7-14(12)17)8-9-15(18-2)16(13)19-3/h4-10H,1-3H3/q+1
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n/an/a>1.00E+5n/an/an/an/a8.022



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Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25531
PNG
(8,13,13-trimethyl-12,14-dioxa-8-azatetracyclo[8.7....)
Show SMILES C[n+]1cc2c3OC(C)(C)Oc3ccc2c2ccccc12
Show InChI InChI=1S/C17H16NO2/c1-17(2)19-15-9-8-11-12-6-4-5-7-14(12)18(3)10-13(11)16(15)20-17/h4-10H,1-3H3/q+1
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n/an/a>1.00E+5n/an/an/an/a8.022



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Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25532
PNG
(7,8-dimethoxy-5-oxidophenanthridin-5-ium | chelery...)
Show SMILES COc1ccc2c(c[n+]([O-])c3ccccc23)c1OC
Show InChI InChI=1S/C15H13NO3/c1-18-14-8-7-10-11-5-3-4-6-13(11)16(17)9-12(10)15(14)19-2/h3-9H,1-2H3
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n/an/a>1.00E+5n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25535
PNG
(2-(hydroxymethyl)-7,8-dimethoxy-5-methylphenanthri...)
Show SMILES COc1ccc2c(c[n+](C)c3ccc(CO)cc23)c1OC
Show InChI InChI=1S/C17H18NO3/c1-18-9-14-12(5-7-16(20-2)17(14)21-3)13-8-11(10-19)4-6-15(13)18/h4-9,19H,10H2,1-3H3/q+1
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n/an/a>1.00E+5n/an/an/an/a8.022



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Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25534
PNG
(13,13-dimethyl-8-oxido-12,14-dioxa-8-azatetracyclo...)
Show SMILES CC1(C)Oc2ccc3c(c[n+]([O-])c4ccccc34)c2O1
Show InChI InChI=1S/C16H13NO3/c1-16(2)19-14-8-7-10-11-5-3-4-6-13(11)17(18)9-12(10)15(14)20-16/h3-9H,1-2H3
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n/an/a>1.00E+5n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair
Bcl-2-like protein 1


(Homo sapiens)
BDBM25533
PNG
(8-oxido-12,14-dioxa-8-azatetracyclo[8.7.0.0^{2,7}....)
Show SMILES [O-][n+]1cc2c3OCOc3ccc2c2ccccc12
Show InChI InChI=1S/C14H9NO3/c16-15-7-11-9(10-3-1-2-4-12(10)15)5-6-13-14(11)18-8-17-13/h1-7H,8H2
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n/an/a>1.00E+5n/an/an/an/a8.022



A*STAR



Assay Description
In the fluorescence polarization assay, the Bcl-XL protein is incubated with a fluorescein-tagged Bak-BH3 peptide. The Bcl-XL:Bak-BH3 peptide complex...


J Med Chem 51: 6699-710 (2008)


Article DOI: 10.1021/jm8005433
BindingDB Entry DOI: 10.7270/Q25M641R
More data for this
Ligand-Target Pair