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Found 313 hits of Enz. Inhib. data with enzyme = 'Beta-secretase 1' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-secretase 1


(Homo sapiens (Human))
BDBM276786
PNG
(3-chloro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(Cl)cnc23)ccc1F
Show InChI InChI=1S/C19H18ClFN6O2S/c1-19(10-30(28,29)27(2)18(22)26-19)14-8-13(3-4-15(14)21)25-17-16-11(5-6-23-17)7-12(20)9-24-16/h3-9H,10H2,1-2H3,(H2,22,26)(H,23,25)/t19-/m0/s1
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1.20n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276791
PNG
(8-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(cnc23)[N+]#[C-])ccc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-20(11-31(29,30)28(3)19(22)27-20)15-9-13(4-5-16(15)21)26-18-17-12(6-7-24-18)8-14(23-2)10-25-17/h4-10H,11H2,1,3H3,(H2,22,27)(H,24,26)/t20-/m0/s1
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1.30n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276791
PNG
(8-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(cnc23)[N+]#[C-])ccc1F
Show InChI InChI=1S/C20H18FN7O2S/c1-20(11-31(29,30)28(3)19(22)27-20)15-9-13(4-5-16(15)21)26-18-17-12(6-7-24-18)8-14(23-2)10-25-17/h4-10H,11H2,1,3H3,(H2,22,27)(H,24,26)/t20-/m0/s1
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1.31n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276787
PNG
(3-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(Br)cnc23)ccc1F
Show InChI InChI=1S/C19H18BrFN6O2S/c1-19(10-30(28,29)27(2)18(22)26-19)14-8-13(3-4-15(14)21)25-17-16-11(5-6-23-17)7-12(20)9-24-16/h3-9H,10H2,1-2H3,(H2,22,26)(H,23,25)/t19-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276793
PNG
(3-fluoro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(F)cnc23)ccc1F
Show InChI InChI=1S/C19H18F2N6O2S/c1-19(10-30(28,29)27(2)18(22)26-19)14-8-13(3-4-15(14)21)25-17-16-11(5-6-23-17)7-12(20)9-24-16/h3-9H,10H2,1-2H3,(H2,22,26)(H,23,25)/t19-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276796
PNG
(8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)ccc(Nc2nccc3cc(cnc23)[N+]#[C-])c1F
Show InChI InChI=1S/C20H17F2N7O2S/c1-20(10-32(30,31)29(3)19(23)28-20)15-13(21)4-5-14(16(15)22)27-18-17-11(6-7-25-18)8-12(24-2)9-26-17/h4-9H,10H2,1,3H3,(H2,23,28)(H,25,27)/t20-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276796
PNG
(8-({2,4-difluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1c(F)ccc(Nc2nccc3cc(cnc23)[N+]#[C-])c1F
Show InChI InChI=1S/C20H17F2N7O2S/c1-20(10-32(30,31)29(3)19(23)28-20)15-13(21)4-5-14(16(15)22)27-18-17-11(6-7-25-18)8-12(24-2)9-26-17/h4-9H,10H2,1,3H3,(H2,23,28)(H,25,27)/t20-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276793
PNG
(3-fluoro-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3cc(F)cnc23)ccc1F
Show InChI InChI=1S/C19H18F2N6O2S/c1-19(10-30(28,29)27(2)18(22)26-19)14-8-13(3-4-15(14)21)25-17-16-11(5-6-23-17)7-12(20)9-24-16/h3-9H,10H2,1-2H3,(H2,22,26)(H,23,25)/t19-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276794
PNG
(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)nccc2n1
Show InChI InChI=1S/C19H20FN7O3S/c1-19(10-31(28,29)27(2)18(21)26-19)12-8-11(4-5-13(12)20)24-17-16-14(6-7-22-17)25-15(30-3)9-23-16/h4-9H,10H2,1-3H3,(H2,21,26)(H,22,24)/t19-/m0/s1
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2.60n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276794
PNG
(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)nccc2n1
Show InChI InChI=1S/C19H20FN7O3S/c1-19(10-31(28,29)27(2)18(21)26-19)12-8-11(4-5-13(12)20)24-17-16-14(6-7-22-17)25-15(30-3)9-23-16/h4-9H,10H2,1-3H3,(H2,21,26)(H,22,24)/t19-/m0/s1
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2.60n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276788
PNG
(7-bromo-N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2ncnc3cc(Br)cnc23)ccc1F
Show InChI InChI=1S/C18H17BrFN7O2S/c1-18(8-30(28,29)27(2)17(21)26-18)12-6-11(3-4-13(12)20)25-16-15-14(23-9-24-16)5-10(19)7-22-15/h3-7,9H,8H2,1-2H3,(H2,21,26)(H,23,24,25)/t18-/m0/s1
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2.80n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276803
PNG
((S)-7-((4-fluoro-3-((R)-3-imino-2,5-dimethyl-1,1-d...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@H]2CCc3cc(cnc23)[N+]#[C-])ccc1F
Show InChI InChI=1S/C20H21FN6O2S/c1-20(11-30(28,29)27(3)19(22)26-20)15-9-13(5-6-16(15)21)25-17-7-4-12-8-14(23-2)10-24-18(12)17/h5-6,8-10,17,25H,4,7,11H2,1,3H3,(H2,22,26)/t17-,20-/m0/s1
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3.10n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276792
PNG
(4-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2ncnc3cc(cnc23)[N+]#[C-])ccc1F
Show InChI InChI=1S/C19H17FN8O2S/c1-19(9-31(29,30)28(3)18(21)27-19)13-6-11(4-5-14(13)20)26-17-16-15(24-10-25-17)7-12(22-2)8-23-16/h4-8,10H,9H2,1,3H3,(H2,21,27)(H,24,25,26)/t19-/m0/s1
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3.20n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276792
PNG
(4-({4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-diox...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2ncnc3cc(cnc23)[N+]#[C-])ccc1F
Show InChI InChI=1S/C19H17FN8O2S/c1-19(9-31(29,30)28(3)18(21)27-19)13-6-11(4-5-14(13)20)26-17-16-15(24-10-25-17)7-12(22-2)8-23-16/h4-8,10H,9H2,1,3H3,(H2,21,27)(H,24,25,26)/t19-/m0/s1
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3.20n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM270566
PNG
(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Show SMILES COc1ccc(nc1)C(=O)Nc1cc(F)c(F)c(c1)[C@@]1(C)N=C(N)[C@@](C)(F)C[C@@H]1F
Show InChI InChI=1S/C20H20F4N4O2/c1-19(24)8-15(22)20(2,28-18(19)25)12-6-10(7-13(21)16(12)23)27-17(29)14-5-4-11(30-3)9-26-14/h4-7,9,15H,8H2,1-3H3,(H2,25,28)(H,27,29)/t15-,19-,20+/m0/s1
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3.60n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10059669 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM270565
PNG
(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Show SMILES Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@](C)(F)C[C@@H]1F)C#N
Show InChI InChI=1S/C21H20F3N5O/c1-11-6-12(9-25)10-27-17(11)18(30)28-13-4-5-15(22)14(7-13)21(3)16(23)8-20(2,24)19(26)29-21/h4-7,10,16H,8H2,1-3H3,(H2,26,29)(H,28,30)/t16-,20-,21+/m0/s1
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H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10059669 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276799
PNG
(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)ncnc2c1
Show InChI InChI=1S/C19H20FN7O3S/c1-19(9-31(28,29)27(2)18(21)26-19)13-6-11(4-5-14(13)20)25-17-16-15(23-10-24-17)7-12(30-3)8-22-16/h4-8,10H,9H2,1-3H3,(H2,21,26)(H,23,24,25)/t19-/m0/s1
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4.30n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM270568
PNG
(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Show SMILES C[C@]1(F)C[C@H](F)[C@](C)(N=C1N)c1cc(NC(=O)c2ccc(Br)cn2)ccc1F
Show InChI InChI=1S/C19H18BrF3N4O/c1-18(23)8-15(22)19(2,27-17(18)24)12-7-11(4-5-13(12)21)26-16(28)14-6-3-10(20)9-25-14/h3-7,9,15H,8H2,1-2H3,(H2,24,27)(H,26,28)/t15-,18-,19+/m0/s1
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4.30n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10059669 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276799
PNG
(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)ncnc2c1
Show InChI InChI=1S/C19H20FN7O3S/c1-19(9-31(28,29)27(2)18(21)26-19)13-6-11(4-5-14(13)20)25-17-16-15(23-10-24-17)7-12(30-3)8-22-16/h4-8,10H,9H2,1-3H3,(H2,21,26)(H,23,24,25)/t19-/m0/s1
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4.30n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276797
PNG
(2-(difluoromethyl)-N-{4-fluoro-3-[(5R)-3-imino-2,5...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3nc(cnc23)C(F)F)ccc1F
Show InChI InChI=1S/C19H18F3N7O2S/c1-19(9-32(30,31)29(2)18(23)28-19)11-7-10(3-4-12(11)20)26-17-15-13(5-6-24-17)27-14(8-25-15)16(21)22/h3-8,16H,9H2,1-2H3,(H2,23,28)(H,24,26)/t19-/m0/s1
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5.20n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276797
PNG
(2-(difluoromethyl)-N-{4-fluoro-3-[(5R)-3-imino-2,5...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(Nc2nccc3nc(cnc23)C(F)F)ccc1F
Show InChI InChI=1S/C19H18F3N7O2S/c1-19(9-32(30,31)29(2)18(23)28-19)11-7-10(3-4-12(11)20)26-17-15-13(5-6-24-17)27-14(8-25-15)16(21)22/h3-8,16H,9H2,1-2H3,(H2,23,28)(H,24,26)/t19-/m0/s1
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5.20n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269485
PNG
( (S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2...)
Show SMILES NC1=N[C@](CF)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)C(F)(F)CC1
Show InChI InChI=1S/C18H15ClF4N4O/c19-10-1-4-14(25-8-10)16(28)26-11-2-3-13(21)12(7-11)17(9-20)18(22,23)6-5-15(24)27-17/h1-4,7-8H,5-6,9H2,(H2,24,27)(H,26,28)/t17-/m1/s1
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5.70n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230876
PNG
(US10045974, 12 | US9346797, 12)
Show SMILES NC1=N[C@](C(F)F)(c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)C(F)(F)CC1
Show InChI InChI=1S/C18H14BrF5N4O/c19-9-1-4-13(26-8-9)15(29)27-10-2-3-12(20)11(7-10)18(16(21)22)17(23,24)6-5-14(25)28-18/h1-4,7-8,16H,5-6H2,(H2,25,28)(H,27,29)/t18-/m0/s1
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6.10n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230869
PNG
(US10045974, 13 | US9346797, 13 | US9346797, 5)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F
Show InChI InChI=1S/C19H17F5N4O2/c1-30-11-3-5-14(26-9-11)16(29)27-10-2-4-13(20)12(8-10)19(17(21)22)18(23,24)7-6-15(25)28-19/h2-5,8-9,17H,6-7H2,1H3,(H2,25,28)(H,27,29)/t19-/m0/s1
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6.70n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM270562
PNG
(N-(3-((2R,3S,5R)-6-amino-3,5-difluoro-2,5-dimethyl...)
Show SMILES COc1ccc(nc1)C(=O)Nc1cc(F)c(F)c(c1)[C@@]1(C)N=C(N)[C@](C)(F)C[C@@H]1F
Show InChI InChI=1S/C20H20F4N4O2/c1-19(24)8-15(22)20(2,28-18(19)25)12-6-10(7-13(21)16(12)23)27-17(29)14-5-4-11(30-3)9-26-14/h4-7,9,15H,8H2,1-3H3,(H2,25,28)(H,27,29)/t15-,19+,20+/m0/s1
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6.80n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10059669 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM228168
PNG
((S)-N-(3-(6-amino-2-(difluoromethyl)-3,3-difluoro-...)
Show SMILES COc1cnc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F
Show InChI InChI=1S/C18H16F5N5O2/c1-30-10-7-25-14(26-8-10)15(29)27-9-2-3-12(19)11(6-9)18(16(20)21)17(22,23)5-4-13(24)28-18/h2-3,6-8,16H,4-5H2,1H3,(H2,24,28)(H,27,29)/t18-/m0/s1
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6.90n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230871
PNG
(US10045974, 7 | US9346797, 7)
Show SMILES NC1=N[C@](C(F)F)(c2cc(NC(=O)c3ccc(cn3)C#N)ccc2F)C(F)(F)CC1
Show InChI InChI=1S/C19H14F5N5O/c20-13-3-2-11(28-16(30)14-4-1-10(8-25)9-27-14)7-12(13)19(17(21)22)18(23,24)6-5-15(26)29-19/h1-4,7,9,17H,5-6H2,(H2,26,29)(H,28,30)/t19-/m0/s1
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7.40n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM228170
PNG
((S)-N-(3-(6-amino-2-(difluoromethyl)-3,3-difluoro-...)
Show SMILES Cc1cc(cnc1C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F)C#N
Show InChI InChI=1S/C20H16F5N5O/c1-10-6-11(8-26)9-28-16(10)17(31)29-12-2-3-14(21)13(7-12)20(18(22)23)19(24,25)5-4-15(27)30-20/h2-3,6-7,9,18H,4-5H2,1H3,(H2,27,30)(H,29,31)/t20-/m0/s1
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7.80n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230867
PNG
(US10045974, 14 | US9346797, 14 | US9346797, 3)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F
Show InChI InChI=1S/C18H16F5N5O2/c1-30-14-8-25-12(7-26-14)15(29)27-9-2-3-11(19)10(6-9)18(16(20)21)17(22,23)5-4-13(24)28-18/h2-3,6-8,16H,4-5H2,1H3,(H2,24,28)(H,27,29)/t18-/m0/s1
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8.5n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269499
PNG
((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Show SMILES COc1ccc(nc1)C(=O)Nc1cc(F)c(F)c(c1)[C@@]1(CF)N=C(N)CCC1(F)F
Show InChI InChI=1S/C19H17F5N4O2/c1-30-11-2-3-14(26-8-11)17(29)27-10-6-12(16(22)13(21)7-10)18(9-20)19(23,24)5-4-15(25)28-18/h2-3,6-8H,4-5,9H2,1H3,(H2,25,28)(H,27,29)/t18-/m1/s1
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9n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276802
PNG
((R)-5-(5-(((S)-5-chloro-2,3-dihydro-1H-inden-1-yl)...)
Show SMILES CN1C(=N)N[C@@](C)(CS1(=O)=O)c1cc(N[C@H]2CCc3cc(Cl)ccc23)ccc1F
Show InChI InChI=1S/C20H22ClFN4O2S/c1-20(11-29(27,28)26(2)19(23)25-20)16-10-14(5-7-17(16)22)24-18-8-3-12-9-13(21)4-6-15(12)18/h4-7,9-10,18,24H,3,8,11H2,1-2H3,(H2,23,25)/t18-,20-/m0/s1
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10.2n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276798
PNG
(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)ncnc2n1
Show InChI InChI=1S/C18H19FN8O3S/c1-18(8-31(28,29)27(2)17(20)26-18)11-6-10(4-5-12(11)19)24-15-14-16(23-9-22-15)25-13(30-3)7-21-14/h4-7,9H,8H2,1-3H3,(H2,20,26)(H,22,23,24,25)/t18-/m0/s1
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10.6n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269503
PNG
((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Show SMILES NC1=N[C@](CF)(c2cc(NC(=O)c3ccc(Br)cn3)ccc2F)C(F)(F)CC1
Show InChI InChI=1S/C18H15BrF4N4O/c19-10-1-4-14(25-8-10)16(28)26-11-2-3-13(21)12(7-11)17(9-20)18(22,23)6-5-15(24)27-17/h1-4,7-8H,5-6,9H2,(H2,24,27)(H,26,28)/t17-/m1/s1
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11n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276789
PNG
(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)nccc2c1
Show InChI InChI=1S/C20H21FN6O3S/c1-20(11-31(28,29)27(2)19(22)26-20)15-9-13(4-5-16(15)21)25-18-17-12(6-7-23-18)8-14(30-3)10-24-17/h4-10H,11H2,1-3H3,(H2,22,26)(H,23,25)/t20-/m0/s1
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11.7n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276789
PNG
(N-{4-fluoro-3-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3ccc(F)c(c3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)nccc2c1
Show InChI InChI=1S/C20H21FN6O3S/c1-20(11-31(28,29)27(2)19(22)26-20)15-9-13(4-5-16(15)21)25-18-17-12(6-7-23-18)8-14(30-3)10-24-17/h4-10H,11H2,1-3H3,(H2,22,26)(H,23,25)/t20-/m0/s1
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12n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269487
PNG
((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@@]1(CF)N=C(N)CCC1(F)F
Show InChI InChI=1S/C18H17F4N5O2/c1-29-15-8-24-13(7-25-15)16(28)26-10-2-3-12(20)11(6-10)17(9-19)18(21,22)5-4-14(23)27-17/h2-3,6-8H,4-5,9H2,1H3,(H2,23,27)(H,26,28)/t17-/m1/s1
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13n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230869
PNG
(US10045974, 13 | US9346797, 13 | US9346797, 5)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F
Show InChI InChI=1S/C19H17F5N4O2/c1-30-11-3-5-14(26-9-11)16(29)27-10-2-4-13(20)12(8-10)19(17(21)22)18(23,24)7-6-15(25)28-19/h2-5,8-9,17H,6-7H2,1H3,(H2,25,28)(H,27,29)/t19-/m0/s1
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14n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269495
PNG
((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Show SMILES COc1cnc(cn1)C(=O)Nc1cc(F)c(F)c(c1)[C@@]1(CF)N=C(N)CCC1(F)F
Show InChI InChI=1S/C18H16F5N5O2/c1-30-14-7-25-12(6-26-14)16(29)27-9-4-10(15(21)11(20)5-9)17(8-19)18(22,23)3-2-13(24)28-17/h4-7H,2-3,8H2,1H3,(H2,24,28)(H,27,29)/t17-/m1/s1
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14n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269489
PNG
((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Show SMILES NC1=N[C@](CF)(c2cc(NC(=O)c3coc(n3)C(F)F)ccc2F)C(F)(F)CC1
Show InChI InChI=1S/C17H14F6N4O2/c18-7-16(17(22,23)4-3-12(24)27-16)9-5-8(1-2-10(9)19)25-14(28)11-6-29-15(26-11)13(20)21/h1-2,5-6,13H,3-4,7H2,(H2,24,27)(H,25,28)/t16-/m1/s1
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15n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230874
PNG
(US10045974, 10 | US9346797, 10)
Show SMILES COc1cnc(C(=O)Nc2ccc(F)c(c2)[C@]2(N=C(N)CCC2(F)F)C(F)F)c(C)n1
Show InChI InChI=1S/C19H18F5N5O2/c1-9-15(26-8-14(27-9)31-2)16(30)28-10-3-4-12(20)11(7-10)19(17(21)22)18(23,24)6-5-13(25)29-19/h3-4,7-8,17H,5-6H2,1-2H3,(H2,25,29)(H,28,30)/t19-/m0/s1
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16n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269501
PNG
((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Show SMILES Cc1cc(cnc1C(=O)Nc1cc(F)c(F)c(c1)[C@@]1(CF)N=C(N)CCC1(F)F)C#N
Show InChI InChI=1S/C20H16F5N5O/c1-10-4-11(7-26)8-28-17(10)18(31)29-12-5-13(16(23)14(22)6-12)19(9-21)20(24,25)3-2-15(27)30-19/h4-6,8H,2-3,9H2,1H3,(H2,27,30)(H,29,31)/t19-/m1/s1
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16n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276790
PNG
(N-{5-fluoro-4-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)nccc2c1
Show InChI InChI=1S/C19H20FN7O3S/c1-19(10-31(28,29)27(2)18(21)26-19)13-7-15(23-9-14(13)20)25-17-16-11(4-5-22-17)6-12(30-3)8-24-16/h4-9H,10H2,1-3H3,(H2,21,26)(H,22,23,25)/t19-/m0/s1
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16.2n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230867
PNG
(US10045974, 14 | US9346797, 14 | US9346797, 3)
Show SMILES COc1cnc(cn1)C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F
Show InChI InChI=1S/C18H16F5N5O2/c1-30-14-8-25-12(7-26-14)15(29)27-9-2-3-11(19)10(6-9)18(16(20)21)17(22,23)5-4-13(24)28-18/h2-3,6-8,16H,4-5H2,1H3,(H2,24,28)(H,27,29)/t18-/m0/s1
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18n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230865
PNG
(US10045974, 1 | US9346797, 1)
Show SMILES NC1=N[C@](C(F)F)(c2cc(NC(=O)c3ccc(Cl)cn3)ccc2F)C(F)(F)CC1
Show InChI InChI=1S/C18H14ClF5N4O/c19-9-1-4-13(26-8-9)15(29)27-10-2-3-12(20)11(7-10)18(16(21)22)17(23,24)6-5-14(25)28-18/h1-4,7-8,16H,5-6H2,(H2,25,28)(H,27,29)/t18-/m0/s1
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18n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM276795
PNG
(N-{5-fluoro-4-[(5R)-3-imino-2,5-dimethyl-1,1-dioxi...)
Show SMILES COc1cnc2c(Nc3cc(c(F)cn3)[C@]3(C)CS(=O)(=O)N(C)C(=N)N3)ncnc2c1
Show InChI InChI=1S/C18H19FN8O3S/c1-18(8-31(28,29)27(2)17(20)26-18)11-5-14(21-7-12(11)19)25-16-15-13(23-9-24-16)4-10(30-3)6-22-15/h4-7,9H,8H2,1-3H3,(H2,20,26)(H,21,23,24,25)/t18-/m0/s1
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19.3n/an/an/an/an/an/an/an/a



TBA

US Patent


Assay Description
The following reagents were used in this assay. Na+-Acetate pH 5.0; 1% Brij-35; Glycerol; Dimethyl Sulfoxide (DMSO); Recombinant human soluble BACE-1...


US Patent US10071998 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230868
PNG
(US10045974, 4 | US9346797, 4)
Show SMILES Cc1nc(co1)C(=O)Nc1ccc(F)c(c1)[C@]1(N=C(N)CCC1(F)F)C(F)F
Show InChI InChI=1S/C17H15F5N4O2/c1-8-24-12(7-28-8)14(27)25-9-2-3-11(18)10(6-9)17(15(19)20)16(21,22)5-4-13(23)26-17/h2-3,6-7,15H,4-5H2,1H3,(H2,23,26)(H,25,27)/t17-/m0/s1
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20n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM230870
PNG
(US10045974, 6 | US9346797, 6)
Show SMILES NC1=N[C@](C(F)F)(c2cc(NC(=O)c3cnc(cn3)C(F)F)ccc2F)C(F)(F)CC1
Show InChI InChI=1S/C18H14F7N5O/c19-10-2-1-8(29-15(31)12-7-27-11(6-28-12)14(20)21)5-9(10)18(16(22)23)17(24,25)4-3-13(26)30-18/h1-2,5-7,14,16H,3-4H2,(H2,26,30)(H,29,31)/t18-/m0/s1
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20n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10045974 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269490
PNG
((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Show SMILES NC1=N[C@](CF)(c2cc(NC(=O)c3ccc(cn3)C#N)ccc2F)C(F)(F)CC1
Show InChI InChI=1S/C19H15F4N5O/c20-10-18(19(22,23)6-5-16(25)28-18)13-7-12(2-3-14(13)21)27-17(29)15-4-1-11(8-24)9-26-15/h1-4,7,9H,5-6,10H2,(H2,25,28)(H,27,29)/t18-/m1/s1
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20n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM270547
PNG
(N-(3-((2R,3S,5S)-6-amino-3,5-difluoro-2,5-dimethyl...)
Show SMILES COc1ccc(nc1)C(=O)Nc1ccc(F)c(c1)[C@@]1(C)N=C(N)[C@@](C)(F)C[C@@H]1F
Show InChI InChI=1S/C20H21F3N4O2/c1-19(23)9-16(22)20(2,27-18(19)24)13-8-11(4-6-14(13)21)26-17(28)15-7-5-12(29-3)10-25-15/h4-8,10,16H,9H2,1-3H3,(H2,24,27)(H,26,28)/t16-,19-,20+/m0/s1
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20n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10059669 (2018)

More data for this
Ligand-Target Pair
Beta-secretase 1


(Homo sapiens (Human))
BDBM269499
PNG
((S)-N-(3-(6-amino-3,3-difluoro-2-(fluoromethyl)-2,...)
Show SMILES COc1ccc(nc1)C(=O)Nc1cc(F)c(F)c(c1)[C@@]1(CF)N=C(N)CCC1(F)F
Show InChI InChI=1S/C19H17F5N4O2/c1-30-11-2-3-14(26-8-11)17(29)27-10-6-12(16(22)13(21)7-10)18(9-20)19(23,24)5-4-15(25)28-18/h2-3,6-8H,4-5,9H2,1H3,(H2,25,28)(H,27,29)/t18-/m1/s1
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21n/an/an/an/an/an/an/an/a



H. Lundbeck A/S

US Patent


Assay Description
The binding assay was performed as SPA-based assay using a biotinylated form of human BACE1 recombinantly expressed and subsequently purified from Fr...


US Patent US10058540 (2018)

More data for this
Ligand-Target Pair
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