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Compile Data Set for Download or QSAR

Found 574 hits of Enz. Inhib. data with enzyme = 'Bromodomain containing 4' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318453
PNG
(US9624241, Example 1A | US9624241, Example 1B)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C20H17N3O3/c1-11-17(12(2)26-22-11)14-8-9-15-18-19(14)25-10-16(23(18)20(24)21-15)13-6-4-3-5-7-13/h3-9,16H,10H2,1-2H3,(H,21,24)
PDB

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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318453
PNG
(US9624241, Example 1A | US9624241, Example 1B)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C20H17N3O3/c1-11-17(12(2)26-22-11)14-8-9-15-18-19(14)25-10-16(23(18)20(24)21-15)13-6-4-3-5-7-13/h3-9,16H,10H2,1-2H3,(H,21,24)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318457
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-1-methyl-4-phenyl-4,...)
Show SMILES Cc1noc(C)c1-c1ccc2n(C)c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C21H19N3O3/c1-12-18(13(2)27-22-12)15-9-10-16-19-20(15)26-11-17(14-7-5-4-6-8-14)24(19)21(25)23(16)3/h4-10,17H,11H2,1-3H3
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318457
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-1-methyl-4-phenyl-4,...)
Show SMILES Cc1noc(C)c1-c1ccc2n(C)c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C21H19N3O3/c1-12-18(13(2)27-22-12)15-9-10-16-19-20(15)26-11-17(14-7-5-4-6-8-14)24(19)21(25)23(16)3/h4-10,17H,11H2,1-3H3
PDB

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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318458
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-5-methyl-4-phenyl-4,...)
Show SMILES CC1Oc2c(ccc3[nH]c(=O)n(C1c1ccccc1)c23)-c1c(C)noc1C
Show InChI InChI=1S/C21H19N3O3/c1-11-17(12(2)27-23-11)15-9-10-16-19-20(15)26-13(3)18(24(19)21(25)22-16)14-7-5-4-6-8-14/h4-10,13,18H,1-3H3,(H,22,25)
PDB

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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318458
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-5-methyl-4-phenyl-4,...)
Show SMILES CC1Oc2c(ccc3[nH]c(=O)n(C1c1ccccc1)c23)-c1c(C)noc1C
Show InChI InChI=1S/C21H19N3O3/c1-11-17(12(2)27-23-11)15-9-10-16-19-20(15)26-13(3)18(24(19)21(25)22-16)14-7-5-4-6-8-14/h4-10,13,18H,1-3H3,(H,22,25)
PDB

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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318459
PNG
(4-[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-tet...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(cc1)C#N
Show InChI InChI=1S/C21H16N4O3/c1-11-18(12(2)28-24-11)15-7-8-16-19-20(15)27-10-17(25(19)21(26)23-16)14-5-3-13(9-22)4-6-14/h3-8,17H,10H2,1-2H3,(H,23,26)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318459
PNG
(4-[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-tet...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(cc1)C#N
Show InChI InChI=1S/C21H16N4O3/c1-11-18(12(2)28-24-11)15-7-8-16-19-20(15)27-10-17(25(19)21(26)23-16)14-5-3-13(9-22)4-6-14/h3-8,17H,10H2,1-2H3,(H,23,26)
PDB

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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318460
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-yl-4,5-d...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1cccnc1
Show InChI InChI=1S/C19H16N4O3/c1-10-16(11(2)26-22-10)13-5-6-14-17-18(13)25-9-15(23(17)19(24)21-14)12-4-3-7-20-8-12/h3-8,15H,9H2,1-2H3,(H,21,24)
PDB

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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318460
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-3-yl-4,5-d...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1cccnc1
Show InChI InChI=1S/C19H16N4O3/c1-10-16(11(2)26-22-10)13-5-6-14-17-18(13)25-9-15(23(17)19(24)21-14)12-4-3-7-20-8-12/h3-8,15H,9H2,1-2H3,(H,21,24)
PDB

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US Patent
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318461
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(c1)C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C21H19N3O4/c1-11-18(12(2)28-23-11)15-7-8-16-19-20(15)27-10-17(24(19)21(25)22-16)13-5-4-6-14(9-13)26-3/h4-9,17H,10H2,1-3H3,(H,22,25)
PDB

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US Patent
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318461
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(3-methoxyphenyl)-...)
Show SMILES COc1cccc(c1)C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C21H19N3O4/c1-11-18(12(2)28-23-11)15-7-8-16-19-20(15)27-10-17(24(19)21(25)22-16)13-5-4-6-14(9-13)26-3/h4-9,17H,10H2,1-3H3,(H,22,25)
PDB

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US Patent
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318462
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(2-methoxyphenyl)-...)
Show SMILES COc1ccccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C21H19N3O4/c1-11-18(12(2)28-23-11)14-8-9-15-19-20(14)27-10-16(24(19)21(25)22-15)13-6-4-5-7-17(13)26-3/h4-9,16H,10H2,1-3H3,(H,22,25)
PDB

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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318462
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(2-methoxyphenyl)-...)
Show SMILES COc1ccccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C21H19N3O4/c1-11-18(12(2)28-23-11)14-8-9-15-19-20(14)27-10-16(24(19)21(25)22-15)13-6-4-5-7-17(13)26-3/h4-9,16H,10H2,1-3H3,(H,22,25)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318463
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(2,4-difluoropheny...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(F)cc1F
Show InChI InChI=1S/C20H15F2N3O3/c1-9-17(10(2)28-24-9)13-5-6-15-18-19(13)27-8-16(25(18)20(26)23-15)12-4-3-11(21)7-14(12)22/h3-7,16H,8H2,1-2H3,(H,23,26)
PDB

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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318463
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(2,4-difluoropheny...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccc(F)cc1F
Show InChI InChI=1S/C20H15F2N3O3/c1-9-17(10(2)28-24-9)13-5-6-15-18-19(13)27-8-16(25(18)20(26)23-15)12-4-3-11(21)7-14(12)22/h3-7,16H,8H2,1-2H3,(H,23,26)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318464
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-2-methyl-4-phenyl-4,...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C21H19N3O2/c1-12-19(13(2)26-23-12)16-9-10-17-20-21(16)25-11-18(24(20)14(3)22-17)15-7-5-4-6-8-15/h4-10,18H,11H2,1-3H3
PDB

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US Patent
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318464
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-2-methyl-4-phenyl-4,...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(C)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C21H19N3O2/c1-12-19(13(2)26-23-12)16-9-10-17-20-21(16)25-11-18(24(20)14(3)22-17)15-7-5-4-6-8-15/h4-10,18H,11H2,1-3H3
PDB

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US Patent
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318465
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-1-(2-morpholin-4-yle...)
Show SMILES Cc1noc(C)c1-c1ccc2n(CCN3CCOCC3)c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C26H28N4O4/c1-17-23(18(2)34-27-17)20-8-9-21-24-25(20)33-16-22(19-6-4-3-5-7-19)30(24)26(31)29(21)11-10-28-12-14-32-15-13-28/h3-9,22H,10-16H2,1-2H3
PDB

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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318467
PNG
(7-(3-Methyl-1H-pyrazol-4-yl)-4-phenyl-4,5-dihydroi...)
Show SMILES Cc1n[nH]cc1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C19H14N4O2/c1-11-14(9-20-22-11)13-7-8-15-17-18(13)25-10-16(23(17)19(24)21-15)12-5-3-2-4-6-12/h2-9,16H,10H2,1H3/b14-13-
PDB

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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318468
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-d...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccn1
Show InChI InChI=1S/C19H16N4O3/c1-10-16(11(2)26-22-10)12-6-7-14-17-18(12)25-9-15(23(17)19(24)21-14)13-5-3-4-8-20-13/h3-8,15H,9H2,1-2H3,(H,21,24)
PDB

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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318468
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-d...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1ccccn1
Show InChI InChI=1S/C19H16N4O3/c1-10-16(11(2)26-22-10)12-6-7-14-17-18(12)25-9-15(23(17)19(24)21-14)13-5-3-4-8-20-13/h3-8,15H,9H2,1-2H3,(H,21,24)
PDB

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US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318470
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-d...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3[C@@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C19H16N4O3/c1-10-16(11(2)26-22-10)12-6-7-14-17-18(12)25-9-15(23(17)19(24)21-14)13-5-3-4-8-20-13/h3-8,15H,9H2,1-2H3,(H,21,24)/t15-/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318470
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-d...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3[C@@H](COc1c23)c1ccccn1
Show InChI InChI=1S/C19H16N4O3/c1-10-16(11(2)26-22-10)12-6-7-14-17-18(12)25-9-15(23(17)19(24)21-14)13-5-3-4-8-20-13/h3-8,15H,9H2,1-2H3,(H,21,24)/t15-/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318471
PNG
(4-Cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)-4,5-dih...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)C1CCCCC1
Show InChI InChI=1S/C20H23N3O3/c1-11-17(12(2)26-22-11)14-8-9-15-18-19(14)25-10-16(23(18)20(24)21-15)13-6-4-3-5-7-13/h8-9,13,16H,3-7,10H2,1-2H3,(H,21,24)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318471
PNG
(4-Cyclohexyl-7-(3,5-dimethylisoxazol-4-yl)-4,5-dih...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)C1CCCCC1
Show InChI InChI=1S/C20H23N3O3/c1-11-17(12(2)26-22-11)14-8-9-15-18-19(14)25-10-16(23(18)20(24)21-15)13-6-4-3-5-7-13/h8-9,13,16H,3-7,10H2,1-2H3,(H,21,24)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318472
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(tetrahydrofuran-2...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3[C@H](COc1c23)C1CCCO1
Show InChI InChI=1S/C18H19N3O4/c1-9-15(10(2)25-20-9)11-5-6-12-16-17(11)24-8-13(14-4-3-7-23-14)21(16)18(22)19-12/h5-6,13-14H,3-4,7-8H2,1-2H3,(H,19,22)/t13-,14?/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318473
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(tetrahydrofuran-2...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3[C@@H](COc1c23)C1CCCO1
Show InChI InChI=1S/C18H19N3O4/c1-9-15(10(2)25-20-9)11-5-6-12-16-17(11)24-8-13(14-4-3-7-23-14)21(16)18(22)19-12/h5-6,13-14H,3-4,7-8H2,1-2H3,(H,19,22)/t13-,14?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318474
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(1,3-thiazol-2-yl)...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1nccs1
Show InChI InChI=1S/C17H14N4O3S/c1-8-13(9(2)24-20-8)10-3-4-11-14-15(10)23-7-12(16-18-5-6-25-16)21(14)17(22)19-11/h3-6,12H,7H2,1-2H3,(H,19,22)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318474
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-4-(1,3-thiazol-2-yl)...)
Show SMILES Cc1noc(C)c1-c1ccc2[nH]c(=O)n3C(COc1c23)c1nccs1
Show InChI InChI=1S/C17H14N4O3S/c1-8-13(9(2)24-20-8)10-3-4-11-14-15(10)23-7-12(16-18-5-6-25-16)21(14)17(22)19-11/h3-6,12H,7H2,1-2H3,(H,19,22)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318475
PNG
(2-{2-[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-...)
Show SMILES CCNC(=O)COc1ccccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C24H24N4O5/c1-4-25-20(29)12-31-19-8-6-5-7-15(19)18-11-32-23-16(21-13(2)27-33-14(21)3)9-10-17-22(23)28(18)24(30)26-17/h5-10,18H,4,11-12H2,1-3H3,(H,25,29)(H,26,30)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318475
PNG
(2-{2-[7-(3,5-Dimethylisoxazol-4-yl)-2-oxo-1,2,4,5-...)
Show SMILES CCNC(=O)COc1ccccc1C1COc2c(ccc3[nH]c(=O)n1c23)-c1c(C)noc1C
Show InChI InChI=1S/C24H24N4O5/c1-4-25-20(29)12-31-19-8-6-5-7-15(19)18-11-32-23-16(21-13(2)27-33-14(21)3)9-10-17-22(23)28(18)24(30)26-17/h5-10,18H,4,11-12H2,1-3H3,(H,25,29)(H,26,30)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318476
PNG
(Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl...)
Show SMILES CCOC(=O)C1Oc2c(ccc3[nH]c(=O)n(C1c1ccccc1)c23)-c1c(C)noc1C
Show InChI InChI=1S/C23H21N3O5/c1-4-29-22(27)21-18(14-8-6-5-7-9-14)26-19-16(24-23(26)28)11-10-15(20(19)30-21)17-12(2)25-31-13(17)3/h5-11,18,21H,4H2,1-3H3,(H,24,28)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318476
PNG
(Ethyl 7-(3,5-dimethylisoxazol-4-yl)-2-oxo-4-phenyl...)
Show SMILES CCOC(=O)C1Oc2c(ccc3[nH]c(=O)n(C1c1ccccc1)c23)-c1c(C)noc1C
Show InChI InChI=1S/C23H21N3O5/c1-4-29-22(27)21-18(14-8-6-5-7-9-14)26-19-16(24-23(26)28)11-10-15(20(19)30-21)17-12(2)25-31-13(17)3/h5-11,18,21H,4H2,1-3H3,(H,24,28)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318477
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-2-oxo-4-phen...)
Show SMILES CCNC(=O)C1Oc2c(ccc3[nH]c(=O)n([C@H]1c1ccccc1)c23)-c1c(C)noc1C
Show InChI InChI=1S/C23H22N4O4/c1-4-24-22(28)21-18(14-8-6-5-7-9-14)27-19-16(25-23(27)29)11-10-15(20(19)30-21)17-12(2)26-31-13(17)3/h5-11,18,21H,4H2,1-3H3,(H,24,28)(H,25,29)/t18-,21?/m0/s1
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318478
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-2-oxo-4-phen...)
Show SMILES CCNC(=O)C1Oc2c(ccc3[nH]c(=O)n([C@@H]1c1ccccc1)c23)-c1c(C)noc1C
Show InChI InChI=1S/C23H22N4O4/c1-4-24-22(28)21-18(14-8-6-5-7-9-14)27-19-16(25-23(27)29)11-10-15(20(19)30-21)17-12(2)26-31-13(17)3/h5-11,18,21H,4H2,1-3H3,(H,24,28)(H,25,29)/t18-,21?/m1/s1
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318479
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-isopropyl-4-phenyl...)
Show SMILES CC(C)Nc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1S/C23H24N4O2/c1-13(2)24-23-25-18-11-10-17(20-14(3)26-29-15(20)4)22-21(18)27(23)19(12-28-22)16-8-6-5-7-9-16/h5-11,13,19H,12H2,1-4H3,(H,24,25)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318479
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-isopropyl-4-phenyl...)
Show SMILES CC(C)Nc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1S/C23H24N4O2/c1-13(2)24-23-25-18-11-10-17(20-14(3)26-29-15(20)4)22-21(18)27(23)19(12-28-22)16-8-6-5-7-9-16/h5-11,13,19H,12H2,1-4H3,(H,24,25)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318480
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-methyl-4-phenyl-4,...)
Show SMILES CNc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1S/C21H20N4O2/c1-12-18(13(2)27-24-12)15-9-10-16-19-20(15)26-11-17(14-7-5-4-6-8-14)25(19)21(22-3)23-16/h4-10,17H,11H2,1-3H3,(H,22,23)
PDB

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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318480
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-methyl-4-phenyl-4,...)
Show SMILES CNc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1S/C21H20N4O2/c1-12-18(13(2)27-24-12)15-9-10-16-19-20(15)26-11-17(14-7-5-4-6-8-14)25(19)21(22-3)23-16/h4-10,17H,11H2,1-3H3,(H,22,23)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318481
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-4-phenyl-4,5...)
Show SMILES CCNc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1S/C22H22N4O2/c1-4-23-22-24-17-11-10-16(19-13(2)25-28-14(19)3)21-20(17)26(22)18(12-27-21)15-8-6-5-7-9-15/h5-11,18H,4,12H2,1-3H3,(H,23,24)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318481
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N-ethyl-4-phenyl-4,5...)
Show SMILES CCNc1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1S/C22H22N4O2/c1-4-23-22-24-17-11-10-16(19-13(2)25-28-14(19)3)21-20(17)26(22)18(12-27-21)15-8-6-5-7-9-15/h5-11,18H,4,12H2,1-3H3,(H,23,24)
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318482
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N,N-dimethyl-4-pheny...)
Show SMILES CN(C)c1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1S/C22H22N4O2/c1-13-19(14(2)28-24-13)16-10-11-17-20-21(16)27-12-18(15-8-6-5-7-9-15)26(20)22(23-17)25(3)4/h5-11,18H,12H2,1-4H3
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Incyte Corporation; Incyte Holdings Corporation

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Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318482
PNG
(7-(3,5-Dimethylisoxazol-4-yl)-N,N-dimethyl-4-pheny...)
Show SMILES CN(C)c1nc2ccc(-c3c(C)noc3C)c3OCC(c4ccccc4)n1c23
Show InChI InChI=1S/C22H22N4O2/c1-13-19(14(2)28-24-13)16-10-11-17-20-21(16)27-12-18(15-8-6-5-7-9-15)26(20)22(23-17)25(3)4/h5-11,18H,12H2,1-4H3
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318483
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(NCCO)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C22H22N4O3/c1-13-19(14(2)29-25-13)16-8-9-17-20-21(16)28-12-18(15-6-4-3-5-7-15)26(20)22(24-17)23-10-11-27/h3-9,18,27H,10-12H2,1-2H3,(H,23,24)
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318483
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES Cc1noc(C)c1-c1ccc2nc(NCCO)n3C(COc1c23)c1ccccc1
Show InChI InChI=1S/C22H22N4O3/c1-13-19(14(2)29-25-13)16-8-9-17-20-21(16)28-12-18(15-6-4-3-5-7-15)26(20)22(24-17)23-10-11-27/h3-9,18,27H,10-12H2,1-2H3,(H,23,24)
PDB

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US Patent
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318484
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES CC(CO)Nc1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccc4)n1c23
Show InChI InChI=1S/C23H24N4O3/c1-13(11-28)24-23-25-18-10-9-17(20-14(2)26-30-15(20)3)22-21(18)27(23)19(12-29-22)16-7-5-4-6-8-16/h4-10,13,19,28H,11-12H2,1-3H3,(H,24,25)/t13?,19-/m1/s1
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318484
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES CC(CO)Nc1nc2ccc(-c3c(C)noc3C)c3OC[C@H](c4ccccc4)n1c23
Show InChI InChI=1S/C23H24N4O3/c1-13(11-28)24-23-25-18-10-9-17(20-14(2)26-30-15(20)3)22-21(18)27(23)19(12-29-22)16-7-5-4-6-8-16/h4-10,13,19,28H,11-12H2,1-3H3,(H,24,25)/t13?,19-/m1/s1
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318485
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES CC(CO)Nc1nc2ccc(-c3c(C)noc3C)c3OC[C@@H](c4ccccc4)n1c23
Show InChI InChI=1S/C23H24N4O3/c1-13(11-28)24-23-25-18-10-9-17(20-14(2)26-30-15(20)3)22-21(18)27(23)19(12-29-22)16-7-5-4-6-8-16/h4-10,13,19,28H,11-12H2,1-3H3,(H,24,25)/t13?,19-/m0/s1
PDB

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UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
Bromodomain containing 4


(Homo sapiens (Human))
BDBM318485
PNG
(2-{[7-(3,5-Dimethylisoxazol-4-yl)-4-phenyl-4,5-dih...)
Show SMILES CC(CO)Nc1nc2ccc(-c3c(C)noc3C)c3OC[C@@H](c4ccccc4)n1c23
Show InChI InChI=1S/C23H24N4O3/c1-13(11-28)24-23-25-18-10-9-17(20-14(2)26-30-15(20)3)22-21(18)27(23)19(12-29-22)16-7-5-4-6-8-16/h4-10,13,19,28H,11-12H2,1-3H3,(H,24,25)/t13?,19-/m0/s1
PDB

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AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
BRD4-BD1 and BRD4-BD2 assays were conducted in white 384-well polystyrene plate in a final volume of 20 μL for BD1 and 40 μL for BD2. Inhib...


US Patent US9624241 (2017)

More data for this
Ligand-Target Pair
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