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Compile Data Set for Download or QSAR

Found 92 hits of Enz. Inhib. data with enzyme = 'C-C chemokine receptor type 4' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374631
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-6-((3...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCCC1
Show InChI InChI=1/C24H30Cl2N6/c1-15-14-31(11-8-21(15)30-9-4-5-10-30)22-13-27-23-16(2)29-32(24(23)28-22)17(3)19-7-6-18(25)12-20(19)26/h6-7,12-13,15,17,21H,4-5,8-11,14H2,1-3H3/t15-,17-,21?/s2
UniProtKB/SwissProt
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PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374709
PNG
(US10246462, Example 90)
Show SMILES C[C@H](c1ccc(Cl)cc1F)n1nc(C#N)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1CCC(O)=O
Show InChI InChI=1/C27H31ClFN7O2/c1-16-15-34(11-9-23(16)35-10-3-4-19(35)6-8-25(37)38)24-14-31-26-22(13-30)33-36(27(26)32-24)17(2)20-7-5-18(28)12-21(20)29/h5,7,12,14,16-17,19,23H,3-4,6,8-11,15H2,1-2H3,(H,37,38)/t16-,17-,19+,23+/s2
UniProtKB/SwissProt
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US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374633
PNG
(6-((3R,4S)-4-(Azepan-1-yl)-3-methylpiperidin-1-yl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCCCCC1
Show InChI InChI=1/C26H34Cl2N6/c1-17-16-33(13-10-23(17)32-11-6-4-5-7-12-32)24-15-29-25-18(2)31-34(26(25)30-24)19(3)21-9-8-20(27)14-22(21)28/h8-9,14-15,17,19,23H,4-7,10-13,16H2,1-3H3/t17-,19-,23+/s2
UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374635
PNG
(6-((3R,4S)-4-(Azocan-1-yl)-3-methylpiperidin-1-yl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCCCCCC1
Show InChI InChI=1/C27H36Cl2N6/c1-18-17-34(14-11-24(18)33-12-7-5-4-6-8-13-33)25-16-30-26-19(2)32-35(27(26)31-25)20(3)22-10-9-21(28)15-23(22)29/h9-10,15-16,18,20,24H,4-8,11-14,17H2,1-3H3/t18-,20-,24+/s2
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374639
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-6-((3...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1C
Show InChI InChI=1/C25H32Cl2N6/c1-15-14-31(11-9-22(15)32-10-5-6-16(32)2)23-13-28-24-17(3)30-33(25(24)29-23)18(4)20-8-7-19(26)12-21(20)27/h7-8,12-13,15-16,18,22H,5-6,9-11,14H2,1-4H3/t15-,16-,18-,22+/s2
UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374642
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3′R,...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCCCC1
Show InChI InChI=1/C25H29Cl2N7/c1-16-15-33(11-8-22(16)32-9-4-3-5-10-32)23-14-29-24-21(13-28)31-34(25(24)30-23)17(2)19-7-6-18(26)12-20(19)27/h6-7,12,14,16-17,22H,3-5,8-11,15H2,1-2H3/t16-,17-,22+/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374648
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3′R,...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC[C@@H]([C@H](CO)C1)N1CCCCC1
Show InChI InChI=1/C25H29Cl2N7O/c1-16(19-6-5-18(26)11-20(19)27)34-25-24(21(12-28)31-34)29-13-23(30-25)33-10-7-22(17(14-33)15-35)32-8-3-2-4-9-32/h5-6,11,13,16-17,22,35H,2-4,7-10,14-15H2,1H3/t16-,17+,22+/s2
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374650
PNG
(((S)-1-((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)et...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1CO
Show InChI InChI=1/C25H32Cl2N6O/c1-15-13-31(10-8-22(15)32-9-4-5-19(32)14-34)23-12-28-24-16(2)30-33(25(24)29-23)17(3)20-7-6-18(26)11-21(20)27/h6-7,11-12,15,17,19,22,34H,4-5,8-10,13-14H2,1-3H3/t15-,17-,19+,22+/s2
UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374652
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3R,4S)-4-(...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1CO
Show InChI InChI=1/C25H29Cl2N7O/c1-15-13-32(9-7-22(15)33-8-3-4-18(33)14-35)23-12-29-24-21(11-28)31-34(25(24)30-23)16(2)19-6-5-17(26)10-20(19)27/h5-6,10,12,15-16,18,22,35H,3-4,7-9,13-14H2,1-2H3/t15-,16-,18+,22+/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374662
PNG
(3-((S)-1-((3R,4S)-1-(3-Cyano-1-((R)-1-(2,4-dichlor...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O
Show InChI InChI=1/C27H31Cl2N7O2/c1-16-15-34(11-9-23(16)35-10-3-4-19(35)6-8-25(37)38)24-14-31-26-22(13-30)33-36(27(26)32-24)17(2)20-7-5-18(28)12-21(20)29/h5,7,12,14,16-17,19,23H,3-4,6,8-11,15H2,1-2H3,(H,37,38)/t16-,17-,19+,23?/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374663
PNG
(3-((S)-1-((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@H]1CCC(N)=O
Show InChI InChI=1/C27H35Cl2N7O/c1-16-15-34(12-10-23(16)35-11-4-5-20(35)7-9-24(30)37)25-14-31-26-17(2)33-36(27(26)32-25)18(3)21-8-6-19(28)13-22(21)29/h6,8,13-14,16,18,20,23H,4-5,7,9-12,15H2,1-3H3,(H2,30,37)/t16-,18-,20+,23?/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374667
PNG
(3-((S)-1-((3R,4S)-1-(3-Cyano-1-((R)-1-(2,4-dichlor...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@H]1CCC(N)=O
Show InChI InChI=1/C27H32Cl2N8O/c1-16-15-35(11-9-23(16)36-10-3-4-19(36)6-8-24(31)38)25-14-32-26-22(13-30)34-37(27(26)33-25)17(2)20-7-5-18(28)12-21(20)29/h5,7,12,14,16-17,19,23H,3-4,6,8-11,15H2,1-2H3,(H2,31,38)/t16-,17-,19+,23?/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374671
PNG
(2-((S)-1-((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@H]1CCS(N)(=O)=O
Show InChI InChI=1/C26H35Cl2N7O2S/c1-16-15-33(11-8-23(16)34-10-4-5-20(34)9-12-38(29,36)37)24-14-30-25-17(2)32-35(26(25)31-24)18(3)21-7-6-19(27)13-22(21)28/h6-7,13-14,16,18,20,23H,4-5,8-12,15H2,1-3H3,(H2,29,36,37)/t16-,18-,20+,23?/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374690
PNG
(3-((S)-1-((1S,6R)-4-(1-((R)-1-(2,4-Dichlorophenyl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O
Show InChI InChI=1/C28H33Cl2N5O2/c1-16-13-19(6-10-25(16)34-12-4-5-21(34)8-11-26(36)37)24-15-31-27-17(2)33-35(28(27)32-24)18(3)22-9-7-20(29)14-23(22)30/h6-7,9,14-16,18,21,25H,4-5,8,10-13H2,1-3H3,(H,36,37)/t16-,18-,21+,25?/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374693
PNG
(3-((2S)-1-(4-(3-Cyano-1-((R)-1-(2,4-dichlorophenyl...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=CCC(C(C)C1)N1CCC[C@H]1CCC(O)=O
Show InChI InChI=1/C28H30Cl2N6O2/c1-16-12-18(5-9-25(16)35-11-3-4-20(35)7-10-26(37)38)24-15-32-27-23(14-31)34-36(28(27)33-24)17(2)21-8-6-19(29)13-22(21)30/h5-6,8,13,15-17,20,25H,3-4,7,9-12H2,1-2H3,(H,37,38)/t16?,17-,20+,25?/s2
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374695
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((4S,5R)-4-(...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1CO
Show InChI InChI=1/C26H28Cl2N6O/c1-15-10-17(5-8-24(15)33-9-3-4-19(33)14-35)23-13-30-25-22(12-29)32-34(26(25)31-23)16(2)20-7-6-18(27)11-21(20)28/h5-7,11,13,15-16,19,24,35H,3-4,8-10,14H2,1-2H3/t15-,16-,19+,24?/s2
UniProtKB/SwissProt
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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374690
PNG
(3-((S)-1-((1S,6R)-4-(1-((R)-1-(2,4-Dichlorophenyl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O
Show InChI InChI=1/C28H33Cl2N5O2/c1-16-13-19(6-10-25(16)34-12-4-5-21(34)8-11-26(36)37)24-15-31-27-17(2)33-35(28(27)32-24)18(3)22-9-7-20(29)14-23(22)30/h6-7,9,14-16,18,21,25H,4-5,8,10-13H2,1-3H3,(H,36,37)/t16-,18-,21+,25?/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374697
PNG
(((2S)-1-(4-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)C1=CCC(C(C)C1)N1CCC[C@H]1CO
Show InChI InChI=1/C26H31Cl2N5O/c1-15-11-18(6-9-24(15)32-10-4-5-20(32)14-34)23-13-29-25-16(2)31-33(26(25)30-23)17(3)21-8-7-19(27)12-22(21)28/h6-8,12-13,15,17,20,24,34H,4-5,9-11,14H2,1-3H3/t15?,17-,20+,24?/s2
UniProtKB/SwissProt
UniProtKB/TrEMBL

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PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374698
PNG
(Step 1: (2S)-1-(4-(3-Cyano-1-((R)-1-(2,4-dichlorop...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=CCC(C(C)C1)N1CCC[C@H]1C(N)=O
Show InChI InChI=1/C26H27Cl2N7O/c1-14-10-16(5-8-22(14)34-9-3-4-23(34)25(30)36)21-13-31-24-20(12-29)33-35(26(24)32-21)15(2)18-7-6-17(27)11-19(18)28/h5-7,11,13-15,22-23H,3-4,8-10H2,1-2H3,(H2,30,36)/t14?,15-,22?,23+/s2
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n/an/a<100n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374702
PNG
(US10246462, Example 83)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1C
Show InChI InChI=1/C26H28Cl2N6/c1-15-11-18(6-9-24(15)33-10-4-5-16(33)2)23-14-30-25-22(13-29)32-34(26(25)31-23)17(3)20-8-7-19(27)12-21(20)28/h6-8,12,14-17,24H,4-5,9-11H2,1-3H3/t15-,16-,17-,24?/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374706
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((4S,5R)-4-(...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)C1=CCC([C@H](C)C1)N1CCC[C@H]1C(O)CS(C)(=O)=O
Show InChI InChI=1/C28H32Cl2N6O3S/c1-16-11-18(6-9-24(16)35-10-4-5-25(35)26(37)15-40(3,38)39)23-14-32-27-22(13-31)34-36(28(27)33-23)17(2)20-8-7-19(29)12-21(20)30/h6-8,12,14,16-17,24-26,37H,4-5,9-11,15H2,1-3H3/t16-,17-,24?,25+,26?/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374632
PNG
(6-((3R,4S)-4-(Azetidin-1-yl)-3-methylpiperidin-1-y...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC1
Show InChI InChI=1/C23H28Cl2N6/c1-14-13-30(10-7-20(14)29-8-4-9-29)21-12-26-22-15(2)28-31(23(22)27-21)16(3)18-6-5-17(24)11-19(18)25/h5-6,11-12,14,16,20H,4,7-10,13H2,1-3H3/t14-,16-,20+/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374621
PNG
(Ethyl 1-(1-(2,4-dichlorophenyl)ethyl)-6-(3′-...)
Show SMILES CCOC(=O)c1nn(C(C)c2ccc(Cl)cc2Cl)c2nc(cnc12)N1CCC(C(C)C1)N1CCCCC1
Show InChI InChI=1/C27H34Cl2N6O2/c1-4-37-27(36)25-24-26(35(32-25)18(3)20-9-8-19(28)14-21(20)29)31-23(15-30-24)34-13-10-22(17(2)16-34)33-11-6-5-7-12-33/h8-9,14-15,17-18,22H,4-7,10-13,16H2,1-3H3
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374623
PNG
(1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-methyl...)
Show SMILES CC(c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(nc12)N1CCC(C(C)C1)N1CCCCC1
Show InChI InChI=1/C25H31Cl2N7O/c1-15-14-33(11-8-20(15)32-9-4-3-5-10-32)21-13-29-23-22(24(28)35)31-34(25(23)30-21)16(2)18-7-6-17(26)12-19(18)27/h6-7,12-13,15-16,20H,3-5,8-11,14H2,1-2H3,(H2,28,35)
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374624
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-(3′-me...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(nc12)N1CCC(C(C)C1)N1CCCCC1
Show InChI InChI=1/C25H31Cl2N7O/c1-15-14-33(11-8-20(15)32-9-4-3-5-10-32)21-13-29-23-22(24(28)35)31-34(25(23)30-21)16(2)18-7-6-17(26)12-19(18)27/h6-7,12-13,15-16,20H,3-5,8-11,14H2,1-2H3,(H2,28,35)/t15?,16-,20?/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374625
PNG
(1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-ethyl-...)
Show SMILES CCC1CN(CCC1N1CCCCC1)c1cnc2c(nn(C(C)c3ccc(Cl)cc3Cl)c2n1)C(N)=O
Show InChI InChI=1/C26H33Cl2N7O/c1-3-17-15-34(12-9-21(17)33-10-5-4-6-11-33)22-14-30-24-23(25(29)36)32-35(26(24)31-22)16(2)19-8-7-18(27)13-20(19)28/h7-8,13-14,16-17,21H,3-6,9-12,15H2,1-2H3,(H2,29,36)
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374626
PNG
(1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-ethyl-...)
Show SMILES CCC1CN(CCC1N1CCCCC1)c1cnc2c(nn(C(C)c3ccc(Cl)cc3Cl)c2n1)C#N
Show InChI InChI=1/C26H31Cl2N7/c1-3-18-16-34(12-9-23(18)33-10-5-4-6-11-33)24-15-30-25-22(14-29)32-35(26(25)31-24)17(2)20-8-7-19(27)13-21(20)28/h7-8,13,15,17-18,23H,3-6,9-12,16H2,1-2H3
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374627
PNG
(1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-methyl...)
Show SMILES CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(nc12)N1CCC(C(C)C1)N1CCCCC1
Show InChI InChI=1/C24H30Cl2N6/c1-16-15-31(11-8-22(16)30-9-4-3-5-10-30)23-14-27-21-13-28-32(24(21)29-23)17(2)19-7-6-18(25)12-20(19)26/h6-7,12-14,16-17,22H,3-5,8-11,15H2,1-2H3
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374628
PNG
(1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-ethyl-...)
Show SMILES CCC1CN(CCC1N1CCCCC1)c1cnc2cnn(C(C)c3ccc(Cl)cc3Cl)c2n1
Show InChI InChI=1/C25H32Cl2N6/c1-3-18-16-32(12-9-23(18)31-10-5-4-6-11-31)24-15-28-22-14-29-33(25(22)30-24)17(2)20-8-7-19(26)13-21(20)27/h7-8,13-15,17-18,23H,3-6,9-12,16H2,1-2H3
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374630
PNG
(Ethyl 1-(2,4-dichlorobenzyl)-6-(3′-methyl-[1...)
Show SMILES CCOC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2nc(cnc12)N1CCC(C(C)C1)N1CCCCC1
Show InChI InChI=1/C26H32Cl2N6O2/c1-3-36-26(35)24-23-25(34(31-24)16-18-7-8-19(27)13-20(18)28)30-22(14-29-23)33-12-9-21(17(2)15-33)32-10-5-4-6-11-32/h7-8,13-14,17,21H,3-6,9-12,15-16H2,1-2H3
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374636
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3R,4S)-4-(...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CC=CC1
Show InChI InChI=1/C24H28Cl2N6/c1-15-14-31(11-8-21(15)30-9-4-5-10-30)22-13-27-23-16(2)29-32(24(23)28-22)17(3)19-7-6-18(25)12-20(19)26/h4-7,12-13,15,17,21H,8-11,14H2,1-3H3/t15-,17-,21+/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374637
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((2S)-2,5-di...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC(C)C(C[C@@H]1C)N1CCCC1
Show InChI InChI=1/C25H32Cl2N6/c1-15-14-32(16(2)11-22(15)31-9-5-6-10-31)23-13-28-24-17(3)30-33(25(24)29-23)18(4)20-8-7-19(26)12-21(20)27/h7-8,12-13,15-16,18,22H,5-6,9-11,14H2,1-4H3/t15?,16-,18+,22?/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374638
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((2S,4S,5R)-...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1C[C@@H](C)[C@H](C[C@@H]1C)N1CCCC1
Show InChI InChI=1/C25H32Cl2N6/c1-15-14-32(16(2)11-22(15)31-9-5-6-10-31)23-13-28-24-17(3)30-33(25(24)29-23)18(4)20-8-7-19(26)12-21(20)27/h7-8,12-13,15-16,18,22H,5-6,9-11,14H2,1-4H3/t15-,16+,18-,22+/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374641
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-methyl-6-((3...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@@H]1C
Show InChI InChI=1/C25H32Cl2N6/c1-15-14-31(11-9-22(15)32-10-5-6-16(32)2)23-13-28-24-17(3)30-33(25(24)29-23)18(4)20-8-7-19(26)12-21(20)27/h7-8,12-13,15-16,18,22H,5-6,9-11,14H2,1-4H3/t15-,16+,18-,22+/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374644
PNG
(1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-fluoro...)
Show SMILES CC(c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(nc12)N1CCC(C(F)C1)N1CCCCC1
Show InChI InChI=1/C24H28Cl2FN7O/c1-14(16-6-5-15(25)11-17(16)26)34-24-22(21(31-34)23(28)35)29-12-20(30-24)33-10-7-19(18(27)13-33)32-8-3-2-4-9-32/h5-6,11-12,14,18-19H,2-4,7-10,13H2,1H3,(H2,28,35)
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374646
PNG
(1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-(hydro...)
Show SMILES CC(c1ccc(Cl)cc1Cl)n1nc(C(N)=O)c2ncc(nc12)N1CCC(C(CO)C1)N1CCCCC1
Show InChI InChI=1/C25H31Cl2N7O2/c1-15(18-6-5-17(26)11-19(18)27)34-25-23(22(31-34)24(28)36)29-12-21(30-25)33-10-7-20(16(13-33)14-35)32-8-3-2-4-9-32/h5-6,11-12,15-16,20,35H,2-4,7-10,13-14H2,1H3,(H2,28,36)
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374647
PNG
(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-6-((3′S,...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC[C@H]([C@@H](CO)C1)N1CCCCC1
Show InChI InChI=1/C25H29Cl2N7O/c1-16(19-6-5-18(26)11-20(19)27)34-25-24(21(12-28)31-34)29-13-23(30-25)33-10-7-22(17(14-33)15-35)32-8-3-2-4-9-32/h5-6,11,13,16-17,22,35H,2-4,7-10,14-15H2,1H3/t16-,17-,22-/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374649
PNG
((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3-m...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(CC1)N1CCC[C@H]1C
Show InChI InChI=1/C24H30Cl2N6/c1-15-5-4-10-31(15)19-8-11-30(12-9-19)22-14-27-23-16(2)29-32(24(23)28-22)17(3)20-7-6-18(25)13-21(20)26/h6-7,13-15,17,19H,4-5,8-12H2,1-3H3/t15-,17-/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374654
PNG
(((3R,4S)-1-(3-Cyano-1-((R)-1-(2,4-dichlorophenyl)e...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1C(O)=O
Show InChI InChI=1/C25H27Cl2N7O2/c1-14-13-32(9-7-20(14)33-8-3-4-21(33)25(35)36)22-12-29-23-19(11-28)31-34(24(23)30-22)15(2)17-6-5-16(26)10-18(17)27/h5-6,10,12,14-15,20-21H,3-4,7-9,13H2,1-2H3,(H,35,36)/t14-,15-,20+,21+/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374655
PNG
(2-((S)-1-((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@H]1C(C)(C)O
Show InChI InChI=1/C27H36Cl2N6O/c1-16-15-33(12-10-22(16)34-11-6-7-23(34)27(4,5)36)24-14-30-25-17(2)32-35(26(25)31-24)18(3)20-9-8-19(28)13-21(20)29/h8-9,13-14,16,18,22-23,36H,6-7,10-12,15H2,1-5H3/t16-,18-,22+,23+/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374657
PNG
(2-((3S,3′R,4′S)-1′-(1-((R)-1-(2,...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CC[C@@H]([C@H](C)C1)N1CCC[C@@H](C)C1
Show InChI InChI=1/C26H34Cl2N6/c1-16-6-5-10-32(14-16)23-9-11-33(15-17(23)2)24-13-29-25-18(3)31-34(26(25)30-24)19(4)21-8-7-20(27)12-22(21)28/h7-8,12-13,16-17,19,23H,5-6,9-11,14-15H2,1-4H3/t16-,17-,19-,23+/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374658
PNG
(2-((3S,3′R,4′S)-1′-(3-Cyano-1-((...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C#N)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@@H](C)C1
Show InChI InChI=1/C26H31Cl2N7/c1-16-5-4-9-33(14-16)23-8-10-34(15-17(23)2)24-13-30-25-22(12-29)32-35(26(25)31-24)18(3)20-7-6-19(27)11-21(20)28/h6-7,11,13,16-18,23H,4-5,8-10,14-15H2,1-3H3/t16-,17-,18-,23?/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374661
PNG
(3-((S)-1-((3R,4S)-1-(1-((R)-1-(2,4-dichlorophenyl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O
Show InChI InChI=1/C27H34Cl2N6O2/c1-16-15-33(12-10-23(16)34-11-4-5-20(34)7-9-25(36)37)24-14-30-26-17(2)32-35(27(26)31-24)18(3)21-8-6-19(28)13-22(21)29/h6,8,13-14,16,18,20,23H,4-5,7,9-12,15H2,1-3H3,(H,36,37)/t16-,18-,20+,23?/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374664
PNG
(3-((R)-1-((3R,4S)-1-(1-((R)-1-(2,4-Dichlorophenyl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@H]1CCN
Show InChI InChI=1/C26H35Cl2N7/c1-16-15-33(12-9-23(16)34-11-4-5-20(34)8-10-29)24-14-30-25-17(2)32-35(26(25)31-24)18(3)21-7-6-19(27)13-22(21)28/h6-7,13-14,16,18,20,23H,4-5,8-12,15,29H2,1-3H3/t16-,18-,20+,23?/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374665
PNG
(4-((2S)-1-(1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(C(C)C1)N1CCC[C@H]1CCC(O)C(F)(F)F
Show InChI InChI=1/C28H35Cl2F3N6O/c1-16-15-37(12-10-23(16)38-11-4-5-20(38)7-9-24(40)28(31,32)33)25-14-34-26-17(2)36-39(27(26)35-25)18(3)21-8-6-19(29)13-22(21)30/h6,8,13-14,16,18,20,23-24,40H,4-5,7,9-12,15H2,1-3H3/t16?,18-,20+,23?,24?/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374665
PNG
(4-((2S)-1-(1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(C(C)C1)N1CCC[C@H]1CCC(O)C(F)(F)F
Show InChI InChI=1/C28H35Cl2F3N6O/c1-16-15-37(12-10-23(16)38-11-4-5-20(38)7-9-24(40)28(31,32)33)25-14-34-26-17(2)36-39(27(26)35-25)18(3)21-8-6-19(29)13-22(21)30/h6,8,13-14,16,18,20,23-24,40H,4-5,7,9-12,15H2,1-3H3/t16?,18-,20+,23?,24?/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374668
PNG
(3-((S)-1-((3R,4S)-1-(1-((R)-1-(4-Chloro-2-fluoroph...)
Show SMILES C[C@H](c1ccc(Cl)cc1F)n1nc(C)c2ncc(nc12)N1CCC([C@H](C)C1)N1CCC[C@H]1CCC(O)=O
Show InChI InChI=1/C27H34ClFN6O2/c1-16-15-33(12-10-23(16)34-11-4-5-20(34)7-9-25(36)37)24-14-30-26-17(2)32-35(27(26)31-24)18(3)21-8-6-19(28)13-22(21)29/h6,8,13-14,16,18,20,23H,4-5,7,9-12,15H2,1-3H3,(H,36,37)/t16-,18-,20+,23?/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374670
PNG
(3-((S)-1-(1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-3...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(CC1)N1CCC[C@H]1CCC(O)=O
Show InChI InChI=1/C26H32Cl2N6O2/c1-16-25-26(34(31-16)17(2)21-7-5-18(27)14-22(21)28)30-23(15-29-25)32-12-9-20(10-13-32)33-11-3-4-19(33)6-8-24(35)36/h5,7,14-15,17,19-20H,3-4,6,8-13H2,1-2H3,(H,35,36)/t17-,19+/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374672
PNG
(2-((S)-1-((3S,4R)-1-(1-((R)-1-(2,4-Dichlorophenyl)...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC([C@@H](C)C1)N1CCC[C@H]1CCS(N)(=O)=O
Show InChI InChI=1/C26H35Cl2N7O2S/c1-16-15-33(11-8-23(16)34-10-4-5-20(34)9-12-38(29,36)37)24-14-30-25-17(2)32-35(26(25)31-24)18(3)21-7-6-19(27)13-22(21)28/h6-7,13-14,16,18,20,23H,4-5,8-12,15H2,1-3H3,(H2,29,36,37)/t16-,18+,20-,23?/s2
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n/an/a 300n/an/an/an/an/an/a



FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 4


(Homo sapiens (Human))
BDBM374675
PNG
(3-((2S)-1-(1-(1-((R)-1-(2,4-Dichlorophenyl)ethyl)-...)
Show SMILES C[C@H](c1ccc(Cl)cc1Cl)n1nc(C)c2ncc(nc12)N1CCC(C(C)C1)N1CCC[C@H]1CC(F)C(O)=O
Show InChI InChI=1/C27H33Cl2FN6O2/c1-15-14-34(10-8-23(15)35-9-4-5-19(35)12-22(30)27(37)38)24-13-31-25-16(2)33-36(26(25)32-24)17(3)20-7-6-18(28)11-21(20)29/h6-7,11,13,15,17,19,22-23H,4-5,8-10,12,14H2,1-3H3,(H,37,38)/t15?,17-,19+,22?,23?/s2
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FLX BIO, INC.

US Patent


Assay Description
To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...


US Patent US10246462 (2019)

More data for this
Ligand-Target Pair
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