BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 67 hits of Enz. Inhib. data with enzyme = 'C-RAF (Y340D Y341D)' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210020
PNG
(US9273046, 2.26 | US9895376, Compound 2.26)
Show SMILES Clc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H17ClN4O3/c25-14-2-1-3-15-21(14)29-24(27-15)20-19-13-10-11(4-6-16(13)32-22(19)20)31-17-8-9-26-23-12(17)5-7-18(30)28-23/h1-4,6,8-10,19-20,22H,5,7H2,(H,27,29)(H,26,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.25n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210021
PNG
(US9273046, 2.27 | US9895376, Compound 2.27)
Show SMILES Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H18N4O4/c29-11-1-4-15-16(9-11)27-24(26-15)21-20-14-10-12(2-5-17(14)32-22(20)21)31-18-7-8-25-23-13(18)3-6-19(30)28-23/h1-2,4-5,7-10,20-22,29H,3,6H2,(H,26,27)(H,25,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.25n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210051
PNG
(US9273046, 2.29 | US9895376, Compound 2.29)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(no3)-c3ccccc3)ccnc2N1
Show InChI InChI=1/C25H18N4O4/c30-19-9-7-15-18(10-11-26-24(15)27-19)31-14-6-8-17-16(12-14)20-21(22(20)32-17)25-28-23(29-33-25)13-4-2-1-3-5-13/h1-6,8,10-12,20-22H,7,9H2,(H,26,27,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.25n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM373010
PNG
(US9895376, Compound 2.30)
Show SMILES O=C(COC(=O)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12)c1ccccc1
Show InChI InChI=1/C26H20N2O6/c29-18(14-4-2-1-3-5-14)13-32-26(31)23-22-17-12-15(6-8-19(17)34-24(22)23)33-20-10-11-27-25-16(20)7-9-21(30)28-25/h1-6,8,10-12,22-24H,7,9,13H2,(H,27,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.25n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210037
PNG
(US9273046, 2.1 | US9895376, Compound 2.1)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1
Show InChI InChI=1/C24H18N4O3/c29-19-8-6-13-18(9-10-25-23(13)28-19)30-12-5-7-17-14(11-12)20-21(22(20)31-17)24-26-15-3-1-2-4-16(15)27-24/h1-5,7,9-11,20-22H,6,8H2,(H,26,27)(H,25,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210022
PNG
(US9273046, 2.31 | US9895376, Compound 2.31)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc(c[nH]3)-c3ccncc3)ccnc2N1
Show InChI InChI=1/C25H19N5O3/c31-20-4-2-15-19(7-10-27-24(15)30-20)32-14-1-3-18-16(11-14)21-22(23(21)33-18)25-28-12-17(29-25)13-5-8-26-9-6-13/h1,3,5-12,21-23H,2,4H2,(H,28,29)(H,27,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.350n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210015
PNG
(US9273046, 2.21 | US9895376, Compound 2.21)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4cc5CCCc5cc4[nH]3)ccnc2N1
Show InChI InChI=1/C27H22N4O3/c32-22-7-5-16-21(8-9-28-26(16)31-22)33-15-4-6-20-17(12-15)23-24(25(23)34-20)27-29-18-10-13-2-1-3-14(13)11-19(18)30-27/h4,6,8-12,23-25H,1-3,5,7H2,(H,29,30)(H,28,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.400n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM372977
PNG
(US9895376, Compound 2.4a)
Show SMILES Cc1cc2[nH]c(nc2cc1F)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1/C25H19FN4O3/c1-11-8-16-17(10-15(11)26)29-25(28-16)22-21-14-9-12(2-4-18(14)33-23(21)22)32-19-6-7-27-24-13(19)3-5-20(31)30-24/h2,4,6-10,21-23H,3,5H2,1H3,(H,28,29)(H,27,30,31)/t21-,22-,23-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.540n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210044
PNG
(US9273046, 2.4 | US9895376, Compound 2.4)
Show SMILES Cc1cc2[nH]c(nc2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H19FN4O3/c1-11-8-16-17(10-15(11)26)29-25(28-16)22-21-14-9-12(2-4-18(14)33-23(21)22)32-19-6-7-27-24-13(19)3-5-20(31)30-24/h2,4,6-10,21-23H,3,5H2,1H3,(H,28,29)(H,27,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<0.560n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210024
PNG
(US9273046, 2.33 | US9895376, Compound 2.33)
Show SMILES FC(F)(F)c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C21H15F3N4O3/c22-21(23,24)14-8-26-20(27-14)17-16-11-7-9(1-3-12(11)31-18(16)17)30-13-5-6-25-19-10(13)2-4-15(29)28-19/h1,3,5-8,16-18H,2,4H2,(H,26,27)(H,25,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.600n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210002
PNG
(US9273046, 2.8 | US9895376, Compound 2.8)
Show SMILES Cc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H20N4O3/c1-12-2-5-16-17(10-12)28-25(27-16)22-21-15-11-13(3-6-18(15)32-23(21)22)31-19-8-9-26-24-14(19)4-7-20(30)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,28)(H,26,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.710n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210023
PNG
(US9273046, 2.32 | US9895376, Compound 2.32)
Show SMILES Clc1ccccc1-c1c[nH]c(n1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C26H19ClN4O3/c27-17-4-2-1-3-14(17)18-12-29-26(30-18)23-22-16-11-13(5-7-19(16)34-24(22)23)33-20-9-10-28-25-15(20)6-8-21(32)31-25/h1-5,7,9-12,22-24H,6,8H2,(H,29,30)(H,28,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 0.900n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210016
PNG
(US9273046, 2.22 | US9895376, Compound 2.22)
Show SMILES NC(=O)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H19N5O4/c26-23(32)11-1-4-15-16(9-11)29-25(28-15)21-20-14-10-12(2-5-17(14)34-22(20)21)33-18-7-8-27-24-13(18)3-6-19(31)30-24/h1-2,4-5,7-10,20-22H,3,6H2,(H2,26,32)(H,28,29)(H,27,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM372967
PNG
(US9895376, Compound 2.2a)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
Show InChI InChI=1/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.20n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210038
PNG
(US9273046, 2.2 | US9895376, Compound 2.2)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)
PDB

GoogleScholar
Purchase

PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210034
PNG
(US9273046, 1.1 | US9895376, Compound 1.1)
Show SMILES O=C1CCc2c(Oc3ccc4CC5C(C5c4c3)c3nc4ccccc4[nH]3)ccnc2N1
Show InChI InChI=1/C25H20N4O2/c30-21-8-7-15-20(9-10-26-24(15)29-21)31-14-6-5-13-11-17-22(16(13)12-14)23(17)25-27-18-3-1-2-4-19(18)28-25/h1-6,9-10,12,17,22-23H,7-8,11H2,(H,27,28)(H,26,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210013
PNG
(US9273046, 2.19 | US9895376, Compound 2.19)
Show SMILES Fc1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H17FN4O3/c25-14-2-1-3-15-21(14)29-24(27-15)20-19-13-10-11(4-6-16(13)32-22(19)20)31-17-8-9-26-23-12(17)5-7-18(30)28-23/h1-4,6,8-10,19-20,22H,5,7H2,(H,27,29)(H,26,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.60n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210007
PNG
(US9273046, 2.13 | US9895376, Compound 2.28)
Show SMILES Brc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H17BrN4O3/c25-11-1-4-15-16(9-11)28-24(27-15)21-20-14-10-12(2-5-17(14)32-22(20)21)31-18-7-8-26-23-13(18)3-6-19(30)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,28)(H,26,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.70n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210001
PNG
(US9273046, 2.7 | US9895376, Compound 2.7)
Show SMILES Fc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H17FN4O3/c25-11-1-4-15-16(9-11)28-24(27-15)21-20-14-10-12(2-5-17(14)32-22(20)21)31-18-7-8-26-23-13(18)3-6-19(30)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,28)(H,26,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.10n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM372978
PNG
(US9895376, Compound 2.4b)
Show SMILES Cc1cc2[nH]c(nc2cc1F)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
Show InChI InChI=1/C25H19FN4O3/c1-11-8-16-17(10-15(11)26)29-25(28-16)22-21-14-9-12(2-4-18(14)33-23(21)22)32-19-6-7-27-24-13(19)3-5-20(31)30-24/h2,4,6-10,21-23H,3,5H2,1H3,(H,28,29)(H,27,30,31)/t21-,22-,23-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM372985
PNG
(US9895376, Compound 2.5b)
Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
Show InChI InChI=1/C25H16ClF3N4O3/c26-14-9-16-15(8-13(14)25(27,28)29)31-24(32-16)21-20-12-7-10(1-3-17(12)36-22(20)21)35-18-5-6-30-23-11(18)2-4-19(34)33-23/h1,3,5-9,20-22H,2,4H2,(H,31,32)(H,30,33,34)/t20-,21-,22-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.5n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM372973
PNG
(US9895376, Compound 2.3a)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)[C@H]1[C@@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@H]12
Show InChI InChI=1/C24H16Cl2N4O3/c25-13-8-15-16(9-14(13)26)29-24(28-15)21-20-12-7-10(1-3-17(12)33-22(20)21)32-18-5-6-27-23-11(18)2-4-19(31)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,29)(H,27,30,31)/t20-,21-,22-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210032
PNG
(US9273046, 3.7 | US9895376, Compound 3.7)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)OCc45)cc3C12
Show InChI InChI=1/C24H15F3N4O4/c25-24(26,27)10-1-3-14-15(7-10)30-22(29-14)19-18-12-8-11(2-4-16(12)35-20(18)19)34-17-5-6-28-21-13(17)9-33-23(32)31-21/h1-8,18-20H,9H2,(H,29,30)(H,28,31,32)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.20n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210005
PNG
(US9273046, 2.11 | US9895376, Compound 2.11)
Show SMILES Fc1cc2nc([nH]c2cc1F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H16F2N4O3/c25-13-8-15-16(9-14(13)26)29-24(28-15)21-20-12-7-10(1-3-17(12)33-22(20)21)32-18-5-6-27-23-11(18)2-4-19(31)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,29)(H,27,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.30n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210009
PNG
(US9273046, 2.15 | US9895376, Compound 2.15)
Show SMILES Cn1c(nc2ccccc12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H20N4O3/c1-29-17-5-3-2-4-16(17)27-25(29)22-21-15-12-13(6-8-18(15)32-23(21)22)31-19-10-11-26-24-14(19)7-9-20(30)28-24/h2-6,8,10-12,21-23H,7,9H2,1H3,(H,26,28,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.60n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210010
PNG
(US9273046, 2.16 | US9895376, Compound 2.16)
Show SMILES COc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H20N4O4/c1-31-12-2-5-16-17(11-12)28-25(27-16)22-21-15-10-13(3-6-18(15)33-23(21)22)32-19-8-9-26-24-14(19)4-7-20(30)29-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,27,28)(H,26,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM372974
PNG
(US9895376, Compound 2.3b)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1/C24H16Cl2N4O3/c25-13-8-15-16(9-14(13)26)29-24(28-15)21-20-12-7-10(1-3-17(12)33-22(20)21)32-18-5-6-27-23-11(18)2-4-19(31)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,29)(H,27,30,31)/t20-,21-,22-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210006
PNG
(US9273046, 2.12 | US9895376, Compound 2.12)
Show SMILES Clc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H17ClN4O3/c25-11-1-4-15-16(9-11)28-24(27-15)21-20-14-10-12(2-5-17(14)32-22(20)21)31-18-7-8-26-23-13(18)3-6-19(30)29-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,27,28)(H,26,29,30)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.10n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210025
PNG
(US9273046, 2.34 | US9895376, Compound 2.34)
Show SMILES OCCn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C27H21F3N4O4/c28-27(29,30)13-1-4-18-17(11-13)32-26(34(18)9-10-35)23-22-16-12-14(2-5-19(16)38-24(22)23)37-20-7-8-31-25-15(20)3-6-21(36)33-25/h1-2,4-5,7-8,11-12,22-24,35H,3,6,9-10H2,(H,31,33,36)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.20n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210018
PNG
(US9273046, 2.24 | US9895376, Compound 2.24)
Show SMILES Cn1c(nc2cc(ccc12)C(F)(F)F)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C26H19F3N4O3/c1-33-17-5-2-12(26(27,28)29)10-16(17)31-25(33)22-21-15-11-13(3-6-18(15)36-23(21)22)35-19-8-9-30-24-14(19)4-7-20(34)32-24/h2-3,5-6,8-11,21-23H,4,7H2,1H3,(H,30,32,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.30n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210014
PNG
(US9273046, 2.20 | US9895376, Compound 2.20)
Show SMILES CC(C)(C)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C28H26N4O3/c1-28(2,3)14-4-7-18-19(12-14)31-27(30-18)24-23-17-13-15(5-8-20(17)35-25(23)24)34-21-10-11-29-26-16(21)6-9-22(33)32-26/h4-5,7-8,10-13,23-25H,6,9H2,1-3H3,(H,30,31)(H,29,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.40n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210003
PNG
(US9273046, 2.9 | US9895376, Compound 2.9)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccncc4[nH]3)ccnc2N1
Show InChI InChI=1/C23H17N5O3/c29-18-4-2-12-17(6-8-25-22(12)28-18)30-11-1-3-16-13(9-11)19-20(21(19)31-16)23-26-14-5-7-24-10-15(14)27-23/h1,3,5-10,19-21H,2,4H2,(H,26,27)(H,25,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210000
PNG
(US9273046, 2.6 | US9895376, Compound 2.6)
Show SMILES O=C1CCc2c(Oc3ccc4OC5C(C5c4c3)c3nc4ccc(cc4[nH]3)C#N)ccnc2N1
Show InChI InChI=1/C25H17N5O3/c26-11-12-1-4-16-17(9-12)29-25(28-16)22-21-15-10-13(2-5-18(15)33-23(21)22)32-19-7-8-27-24-14(19)3-6-20(31)30-24/h1-2,4-5,7-10,21-23H,3,6H2,(H,28,29)(H,27,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.5n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210041
PNG
(US9273046, 2.3 | US9895376, Compound 2.3)
Show SMILES Clc1cc2nc([nH]c2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H16Cl2N4O3/c25-13-8-15-16(9-14(13)26)29-24(28-15)21-20-12-7-10(1-3-17(12)33-22(20)21)32-18-5-6-27-23-11(18)2-4-19(31)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,29)(H,27,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.90n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210047
PNG
(US9273046, 2.5 | US9895376, Compound 2.5)
Show SMILES FC(F)(F)c1cc2[nH]c(nc2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H16ClF3N4O3/c26-14-9-16-15(8-13(14)25(27,28)29)31-24(32-16)21-20-12-7-10(1-3-17(12)36-22(20)21)35-18-5-6-30-23-11(18)2-4-19(34)33-23/h1,3,5-9,20-22H,2,4H2,(H,31,32)(H,30,33,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM185585
PNG
(US9156852, 16 | USRE47451, Example 16)
Show SMILES COc1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C24H20N6O2S/c1-13-3-8-17-16(9-10-26-23(17)29-14-4-6-15(32-2)7-5-14)19(13)30-24(31)18-11-33-21-20(18)27-12-28-22(21)25/h3-12H,1-2H3,(H,26,29)(H,30,31)(H2,25,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent USRE47451 (2019)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM185586
PNG
(US9156852, 38 | USRE47451, Example 38)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H17ClN6OS/c1-12-5-6-16-15(7-8-26-22(16)29-14-4-2-3-13(24)9-14)18(12)30-23(31)17-10-32-20-19(17)27-11-28-21(20)25/h2-11H,1H3,(H,26,29)(H,30,31)(H2,25,27,28)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent USRE47451 (2019)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM185591
PNG
(US9156852, 116 | USRE47451, Example 116)
Show SMILES Cc1ccc2c(Nc3cccc(Cl)c3F)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-5-6-13-12(7-8-27-22(13)30-16-4-2-3-15(24)17(16)25)18(11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent USRE47451 (2019)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM372962
PNG
(US9895376, Compound 1.3)
Show SMILES Sc1ccccc1NC(=O)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H21N3O3S/c29-21-8-7-15-19(9-10-26-24(15)28-21)31-14-6-5-13-11-17-22(16(13)12-14)23(17)25(30)27-18-3-1-2-4-20(18)32/h1-6,9-10,12,17,22-23,32H,7-8,11H2,(H,27,30)(H,26,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210011
PNG
(US9273046, 2.17 | US9895376, Compound 2.17)
Show SMILES Fc1cc2[nH]c(nc2cc1Cl)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C24H16ClFN4O3/c25-13-8-15-16(9-14(13)26)29-24(28-15)21-20-12-7-10(1-3-17(12)33-22(20)21)32-18-5-6-27-23-11(18)2-4-19(31)30-23/h1,3,5-9,20-22H,2,4H2,(H,28,29)(H,27,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.90n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM185588
PNG
(US9156852, 59 | USRE47451, Example 59)
Show SMILES CN(C)Cc1cc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)ccc1Cl
Show InChI InChI=1S/C26H24ClN7OS/c1-14-4-6-18-17(21(14)33-26(35)19-12-36-23-22(19)30-13-31-24(23)28)8-9-29-25(18)32-16-5-7-20(27)15(10-16)11-34(2)3/h4-10,12-13H,11H2,1-3H3,(H,29,32)(H,33,35)(H2,28,30,31)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent USRE47451 (2019)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210012
PNG
(US9273046, 2.18 | US9895376, Compound 2.18)
Show SMILES FC(F)(F)c1cccc2nc([nH]c12)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H17F3N4O3/c26-25(27,28)14-2-1-3-15-21(14)32-24(30-15)20-19-13-10-11(4-6-16(13)35-22(19)20)34-17-8-9-29-23-12(17)5-7-18(33)31-23/h1-4,6,8-10,19-20,22H,5,7H2,(H,30,32)(H,29,31,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.20n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM373018
PNG
(US9895376, Compound 3.1)
Show SMILES CNC(=O)Nc1cc(Oc2ccc3OC4C(C4c3c2)c2nc3ccc(cc3[nH]2)C(F)(F)F)ccn1
Show InChI InChI=1/C24H18F3N5O3/c1-28-23(33)32-18-10-13(6-7-29-18)34-12-3-5-17-14(9-12)19-20(21(19)35-17)22-30-15-4-2-11(24(25,26)27)8-16(15)31-22/h2-10,19-21H,1H3,(H,30,31)(H2,28,29,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.5n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM185589
PNG
(US9156852, 83 | USRE47451, Example 83)
Show SMILES CC(=O)c1ccc(Nc2nccc3c(NC(=O)c4csc5c(N)ncnc45)c(C)ccc23)cc1
Show InChI InChI=1S/C25H20N6O2S/c1-13-3-8-18-17(9-10-27-24(18)30-16-6-4-15(5-7-16)14(2)32)20(13)31-25(33)19-11-34-22-21(19)28-12-29-23(22)26/h3-12H,1-2H3,(H,27,30)(H,31,33)(H2,26,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent USRE47451 (2019)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM372968
PNG
(US9895376, Compound 2.2b)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)[C@@H]1[C@H]2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3[C@@H]12
Show InChI InChI=1/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22-/s2
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.80n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210008
PNG
(US9273046, 2.14 | US9895376, Compound 2.14)
Show SMILES FC(F)(F)Oc1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C25H17F3N4O4/c26-25(27,28)36-12-1-4-15-16(10-12)31-24(30-15)21-20-14-9-11(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.70n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210035
PNG
(US9273046, 1.2 | US9895376, Compound 1.2)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Cc3ccc(Oc4ccnc5NC(=O)CCc45)cc3C12
Show InChI InChI=1/C26H19F3N4O2/c27-26(28,29)13-2-5-18-19(10-13)32-25(31-18)23-17-9-12-1-3-14(11-16(12)22(17)23)35-20-7-8-30-24-15(20)4-6-21(34)33-24/h1-3,5,7-8,10-11,17,22-23H,4,6,9H2,(H,31,32)(H,30,33,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210057
PNG
(US9273046, 2.35 | US9895376, Compound 2.35)
Show SMILES Cc1cc(Oc2ccnc3NC(=O)CCc23)cc2C3C(Oc12)C3c1nc2ccc(cc2[nH]1)C(F)(F)F
Show InChI InChI=1/C26H19F3N4O3/c1-11-8-13(35-18-6-7-30-24-14(18)3-5-19(34)33-24)10-15-20-21(23(20)36-22(11)15)25-31-16-4-2-12(26(27,28)29)9-17(16)32-25/h2,4,6-10,20-21,23H,3,5H2,1H3,(H,31,32)(H,30,33,34)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 12n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM185590
PNG
(US9156852, 105 | USRE47451, Example 105)
Show SMILES Cc1ccc2c(Nc3ccc(F)c(Cl)c3)nccc2c1NC(=O)c1csc2c(N)ncnc12
Show InChI InChI=1S/C23H16ClFN6OS/c1-11-2-4-14-13(6-7-27-22(14)30-12-3-5-17(25)16(24)8-12)18(11)31-23(32)15-9-33-20-19(15)28-10-29-21(20)26/h2-10H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/an/a



Hanmi Pharm. Co., Ltd

US Patent


Assay Description
The compounds prepared in Examples were tested for inhibitory activity against three subtypes of RAF, i.e., RAF1 Y340D Y341D (C-RAF), B-RAF normal ty...


US Patent USRE47451 (2019)

More data for this
Ligand-Target Pair
C-RAF (Y340D Y341D)


(Homo sapiens (Human))
BDBM210053
PNG
(US9273046, 3.5 | US9895376, Compound 3.5)
Show SMILES FC(F)(F)c1ccc2nc([nH]c2c1)C1C2Oc3ccc(Oc4ncnc5[nH]cnc45)cc3C12
Show InChI InChI=1/C22H13F3N6O2/c23-22(24,25)9-1-3-12-13(5-9)31-19(30-12)16-15-11-6-10(2-4-14(11)33-18(15)16)32-21-17-20(27-7-26-17)28-8-29-21/h1-8,15-16,18H,(H,30,31)(H,26,27,28,29)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 20n/an/an/an/an/an/a



BeiGene, Ltd

US Patent


Assay Description
Compounds disclosed herein were tested against B-Raf (V600E) (PV3849, from Invitrogen) or C-Raf (Y340D/Y341D) (PV3805, from Invitrogen) in a time-res...


US Patent US9895376 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 67 total )  |  Next  |  Last  >>
Jump to: