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Found 103 hits of Enz. Inhib. data with enzyme = 'Calmodulin-domain protein kinase (CDPK1)' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148632
PNG
(CHEMBL3770409 | US9518026, Example 40)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)C)c(N)c1C(N)=O
Show InChI InChI=1S/C18H21N5O2/c1-4-25-13-6-5-11-7-12(9-21-14(11)8-13)16-15(18(20)24)17(19)23(22-16)10(2)3/h5-10H,4,19H2,1-3H3,(H2,20,24)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50446179
PNG
(CHEMBL3109011 | US9518026, Example 39)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C
Show InChI InChI=1S/C19H23N5O2/c1-5-26-13-7-6-11-8-12(10-22-14(11)9-13)16-15(18(21)25)17(20)24(23-16)19(2,3)4/h6-10H,5,20H2,1-4H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50389704
PNG
(CHEMBL2070081 | US9518026, Example 9)
Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(CC2CCN(C)CC2)c2ncnc(N)c12
Show InChI InChI=1S/C24H28N6O/c1-3-31-20-7-6-17-12-19(5-4-18(17)13-20)22-21-23(25)26-15-27-24(21)30(28-22)14-16-8-10-29(2)11-9-16/h4-7,12-13,15-16H,3,8-11,14H2,1-2H3,(H2,25,26,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50383379
PNG
(CHEMBL2030552 | CHEMBL2069958 | US9518026, Example...)
Show SMILES Nc1ncnc2n(CC3CCNCC3)nc(-c3ccc4ccccc4c3)c12
Show InChI InChI=1S/C21H22N6/c22-20-18-19(17-6-5-15-3-1-2-4-16(15)11-17)26-27(21(18)25-13-24-20)12-14-7-9-23-10-8-14/h1-6,11,13-14,23H,7-10,12H2,(H2,22,24,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148642
PNG
(CHEMBL3770676 | US9518026, Example 50)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC2CCCCC2)c(N)c1C(N)=O
Show InChI InChI=1S/C22H27N5O2/c1-2-29-17-9-8-15-10-16(12-25-18(15)11-17)20-19(22(24)28)21(23)27(26-20)13-14-6-4-3-5-7-14/h8-12,14H,2-7,13,23H2,1H3,(H2,24,28)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50446180
PNG
(CHEMBL3108998 | US9518026, Example 25)
Show SMILES COc1ccc2cc(ccc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C
Show InChI InChI=1S/C19H22N4O2/c1-19(2,3)23-17(20)15(18(21)24)16(22-23)13-6-5-12-10-14(25-4)8-7-11(12)9-13/h5-10H,20H2,1-4H3,(H2,21,24)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148653
PNG
(CHEMBL3771104 | US9518026, Example 58)
Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(C2CCCCCC2)c(N)c1C(N)=O
Show InChI InChI=1S/C22H27N5O2/c1-2-29-18-12-10-14-13-15(9-11-17(14)25-18)20-19(22(24)28)21(23)27(26-20)16-7-5-3-4-6-8-16/h9-13,16H,2-8,23H2,1H3,(H2,24,28)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148723
PNG
(CHEMBL3769459 | US9518026, Example 60)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(F)ccc2c1
Show InChI InChI=1S/C17H18FN5O/c1-17(2,3)23-15(19)13(16(20)24)14(22-23)10-6-9-4-5-11(18)7-12(9)21-8-10/h4-8H,19H2,1-3H3,(H2,20,24)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148729
PNG
(CHEMBL3770923 | US9518026, Example 66)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC(F)(F)F)ccc2c1
Show InChI InChI=1S/C18H18F3N5O2/c1-17(2,3)26-15(22)13(16(23)27)14(25-26)10-6-9-4-5-11(28-18(19,20)21)7-12(9)24-8-10/h4-8H,22H2,1-3H3,(H2,23,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148737
PNG
(CHEMBL3770076 | US9518026, Example 69)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OCC3CC3)ccc2c1
Show InChI InChI=1S/C21H25N5O2/c1-21(2,3)26-19(22)17(20(23)27)18(25-26)14-8-13-6-7-15(9-16(13)24-10-14)28-11-12-4-5-12/h6-10,12H,4-5,11,22H2,1-3H3,(H2,23,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286305
PNG
(5-amino-3-(2-ethoxyquinolin-6- yl)-1-(3-hydroxy-3-...)
Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(C(C)C(C)(C)O)c(N)c1C(N)=O
Show InChI InChI=1S/C20H25N5O3/c1-5-28-15-9-7-12-10-13(6-8-14(12)23-15)17-16(19(22)26)18(21)25(24-17)11(2)20(3,4)27/h6-11,27H,5,21H2,1-4H3,(H2,22,26)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148638
PNG
(CHEMBL3769623 | US9518026, Example 46)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCCC2)c(N)c1C(N)=O
Show InChI InChI=1S/C20H23N5O2/c1-2-27-15-8-7-12-9-13(11-23-16(12)10-15)18-17(20(22)26)19(21)25(24-18)14-5-3-4-6-14/h7-11,14H,2-6,21H2,1H3,(H2,22,26)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148752
PNG
(CHEMBL3769990 | US9518026, Example 73)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1ccc2nc(OC3CCC3)ccc2c1
Show InChI InChI=1S/C21H25N5O2/c1-21(2,3)26-19(22)17(20(23)27)18(25-26)13-7-9-15-12(11-13)8-10-16(24-15)28-14-5-4-6-14/h7-11,14H,4-6,22H2,1-3H3,(H2,23,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286284
PNG
(US9518026, Example 77)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc2nc(OC3CCC3)ccc2c1)C1CCCC1
Show InChI InChI=1S/C22H25N5O2/c23-21-19(22(24)28)20(26-27(21)15-4-1-2-5-15)14-8-10-17-13(12-14)9-11-18(25-17)29-16-6-3-7-16/h8-12,15-16H,1-7,23H2,(H2,24,28)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286300
PNG
(5-amino-3-(7-ethoxyquinolin-3- yl)-1-(3-hydroxy-3-...)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(C)C(C)(C)O)c(N)c1C(N)=O
Show InChI InChI=1S/C20H25N5O3/c1-5-28-14-7-6-12-8-13(10-23-15(12)9-14)17-16(19(22)26)18(21)25(24-17)11(2)20(3,4)27/h6-11,27H,5,21H2,1-4H3,(H2,22,26)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148651
PNG
(CHEMBL3771134 | US9518026, Example 56)
Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC2CC2)c(N)c1C(N)=O
Show InChI InChI=1S/C19H21N5O2/c1-2-26-15-8-6-12-9-13(5-7-14(12)22-15)17-16(19(21)25)18(20)24(23-17)10-11-3-4-11/h5-9,11H,2-4,10,20H2,1H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148652
PNG
(CHEMBL3770802 | US9518026, Example 57)
Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(C2CCCCC2)c(N)c1C(N)=O
Show InChI InChI=1S/C21H25N5O2/c1-2-28-17-11-9-13-12-14(8-10-16(13)24-17)19-18(21(23)27)20(22)26(25-19)15-6-4-3-5-7-15/h8-12,15H,2-7,22H2,1H3,(H2,23,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148639
PNG
(CHEMBL3770760 | US9518026, Example 47)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCCCC2)c(N)c1C(N)=O
Show InChI InChI=1S/C21H25N5O2/c1-2-28-16-9-8-13-10-14(12-24-17(13)11-16)19-18(21(23)27)20(22)26(25-19)15-6-4-3-5-7-15/h8-12,15H,2-7,22H2,1H3,(H2,23,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50446178
PNG
(CHEMBL3108913 | US9518026, Example 3)
Show SMILES CCOc1ccc2cc(ccc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C
Show InChI InChI=1S/C20H24N4O2/c1-5-26-15-9-8-12-10-14(7-6-13(12)11-15)17-16(19(22)25)18(21)24(23-17)20(2,3)4/h6-11H,5,21H2,1-4H3,(H2,22,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286307
PNG
(5-amino-3-(7-ethoxyquinolin-3- yl)-1-(1-methylcycl...)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C1(C)CCCCC1
Show InChI InChI=1S/C22H27N5O2/c1-3-29-16-8-7-14-11-15(13-25-17(14)12-16)19-18(21(24)28)20(23)27(26-19)22(2)9-5-4-6-10-22/h7-8,11-13H,3-6,9-10,23H2,1-2H3,(H2,24,28)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50446181
PNG
(CHEMBL3108912 | US9518026, Example 1)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C18H20N4O/c1-18(2,3)22-16(19)14(17(20)23)15(21-22)13-9-8-11-6-4-5-7-12(11)10-13/h4-10H,19H2,1-3H3,(H2,20,23)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286285
PNG
(US9518026, Example 78)
Show SMILES NC(=O)c1c(N)n(nc1-c1cnc2cc(OC3CCC3)ccc2c1)C1CCCCC1
Show InChI InChI=1S/C23H27N5O2/c24-22-20(23(25)29)21(27-28(22)16-5-2-1-3-6-16)15-11-14-9-10-18(12-19(14)26-13-15)30-17-7-4-8-17/h9-13,16-17H,1-8,24H2,(H2,25,29)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286281
PNG
(US9518026, Example 74)
Show SMILES NC(=O)c1c(N)n(nc1-c1cnc2cc(OC3CCC3)ccc2c1)C1CCC1
Show InChI InChI=1S/C21H23N5O2/c22-20-18(21(23)27)19(25-26(20)14-3-1-4-14)13-9-12-7-8-16(10-17(12)24-11-13)28-15-5-2-6-15/h7-11,14-15H,1-6,22H2,(H2,23,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148640
PNG
(CHEMBL3770885 | US9518026, Example 48)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCOCC2)c(N)c1C(N)=O
Show InChI InChI=1S/C20H23N5O3/c1-2-28-15-4-3-12-9-13(11-23-16(12)10-15)18-17(20(22)26)19(21)25(24-18)14-5-7-27-8-6-14/h3-4,9-11,14H,2,5-8,21H2,1H3,(H2,22,26)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148751
PNG
(CHEMBL3769798 | US9518026, Example 72)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC3CCC3)ccc2c1
Show InChI InChI=1S/C21H25N5O2/c1-21(2,3)26-19(22)17(20(23)27)18(25-26)13-9-12-7-8-15(10-16(12)24-11-13)28-14-5-4-6-14/h7-11,14H,4-6,22H2,1-3H3,(H2,23,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148636
PNG
(CHEMBL3769685 | US9518026, Example 45)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCC2)c(N)c1C(N)=O
Show InChI InChI=1S/C19H21N5O2/c1-2-26-14-7-6-11-8-12(10-22-15(11)9-14)17-16(19(21)25)18(20)24(23-17)13-4-3-5-13/h6-10,13H,2-5,20H2,1H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286302
PNG
(5-amino-1-(1,3-dihydroxypropan- 2-yl)-3-(7-ethoxyq...)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C(CO)CO)c(N)c1C(N)=O
Show InChI InChI=1S/C18H21N5O4/c1-2-27-13-4-3-10-5-11(7-21-14(10)6-13)16-15(18(20)26)17(19)23(22-16)12(8-24)9-25/h3-7,12,24-25H,2,8-9,19H2,1H3,(H2,20,26)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286283
PNG
(US9518026, Example 76)
Show SMILES NC(=O)c1c(N)n(nc1-c1cnc2cc(OC3CCC3)ccc2c1)C1CCCC1
Show InChI InChI=1S/C22H25N5O2/c23-21-19(22(24)28)20(26-27(21)15-4-1-2-5-15)14-10-13-8-9-17(11-18(13)25-12-14)29-16-6-3-7-16/h8-12,15-16H,1-7,23H2,(H2,24,28)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148635
PNG
(CHEMBL3769940 | US9518026, Example 44)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC2CC2)c(N)c1C(N)=O
Show InChI InChI=1S/C19H21N5O2/c1-2-26-14-6-5-12-7-13(9-22-15(12)8-14)17-16(19(21)25)18(20)24(23-17)10-11-3-4-11/h5-9,11H,2-4,10,20H2,1H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148649
PNG
(CHEMBL3771306 | US9518026, Example 55)
Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(c(N)c1C(N)=O)C(C)(C)C
Show InChI InChI=1S/C19H23N5O2/c1-5-26-14-9-7-11-10-12(6-8-13(11)22-14)16-15(18(21)25)17(20)24(23-16)19(2,3)4/h6-10H,5,20H2,1-4H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286289
PNG
(5-amino-1-(tert-butyl)-3-(7-(2- methoxyethoxy)quin...)
Show SMILES COCCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C
Show InChI InChI=1S/C20H25N5O3/c1-20(2,3)25-18(21)16(19(22)26)17(24-25)13-9-12-5-6-14(28-8-7-27-4)10-15(12)23-11-13/h5-6,9-11H,7-8,21H2,1-4H3,(H2,22,26)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286290
PNG
(5-amino-3-(7-ethoxyquinolin-3- yl)-1-(2-hydroxyeth...)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CCO)c(N)c1C(N)=O
Show InChI InChI=1S/C17H19N5O3/c1-2-25-12-4-3-10-7-11(9-20-13(10)8-12)15-14(17(19)24)16(18)22(21-15)5-6-23/h3-4,7-9,23H,2,5-6,18H2,1H3,(H2,19,24)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148631
PNG
(CHEMBL3769918 | US9518026, Example 41)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC(C)C)c(N)c1C(N)=O
Show InChI InChI=1S/C19H23N5O2/c1-4-26-14-6-5-12-7-13(9-22-15(12)8-14)17-16(19(21)25)18(20)24(23-17)10-11(2)3/h5-9,11H,4,10,20H2,1-3H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148731
PNG
(CHEMBL3771242 | US9518026, Example 68)
Show SMILES CCCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C
Show InChI InChI=1S/C20H25N5O2/c1-5-8-27-14-7-6-12-9-13(11-23-15(12)10-14)17-16(19(22)26)18(21)25(24-17)20(2,3)4/h6-7,9-11H,5,8,21H2,1-4H3,(H2,22,26)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148648
PNG
(CHEMBL3770743 | US9518026, Example 54)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O
Show InChI InChI=1S/C20H25N5O3/c1-4-28-14-6-5-12-7-13(9-23-15(12)8-14)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50200561
PNG
(CHEMBL3973192 | US9518026, Example 97)
Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(C2CCOC2)c(N)c1C(N)=O
Show InChI InChI=1S/C19H21N5O3/c1-2-27-15-6-4-11-9-12(3-5-14(11)22-15)17-16(19(21)25)18(20)24(23-17)13-7-8-26-10-13/h3-6,9,13H,2,7-8,10,20H2,1H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286308
PNG
(5-amino-1-(tert-butyl)-3-(6- ethoxyquinolin-3-yl)-...)
Show SMILES CCOc1ccc2ncc(cc2c1)-c1nn(c(N)c1C(N)=O)C(C)(C)C
Show InChI InChI=1S/C19H23N5O2/c1-5-26-13-6-7-14-11(9-13)8-12(10-22-14)16-15(18(21)25)17(20)24(23-16)19(2,3)4/h6-10H,5,20H2,1-4H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148722
PNG
(CHEMBL3770980 | US9518026, Example 59)
Show SMILES CCOc1ccc2cc(ccc2n1)-c1nn(CC(C)(C)CO)c(N)c1C(N)=O
Show InChI InChI=1S/C20H25N5O3/c1-4-28-15-8-6-12-9-13(5-7-14(12)23-15)17-16(19(22)27)18(21)25(24-17)10-20(2,3)11-26/h5-9,26H,4,10-11,21H2,1-3H3,(H2,22,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148724
PNG
(CHEMBL3771018 | US9518026, Example 61)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(Cl)ccc2c1
Show InChI InChI=1S/C17H18ClN5O/c1-17(2,3)23-15(19)13(16(20)24)14(22-23)10-6-9-4-5-11(18)7-12(9)21-8-10/h4-8H,19H2,1-3H3,(H2,20,24)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286282
PNG
(US9518026, Example 75)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc2nc(OC3CCC3)ccc2c1)C1CCC1
Show InChI InChI=1S/C21H23N5O2/c22-20-18(21(23)27)19(25-26(20)14-3-1-4-14)13-7-9-16-12(11-13)8-10-17(24-16)28-15-5-2-6-15/h7-11,14-15H,1-6,22H2,(H2,23,27)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286286
PNG
(US9518026, Example 79)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc2nc(OC3CCC3)ccc2c1)C1CCCCC1
Show InChI InChI=1S/C23H27N5O2/c24-22-20(23(25)29)21(27-28(22)16-5-2-1-3-6-16)15-9-11-18-14(13-15)10-12-19(26-18)30-17-7-4-8-17/h9-13,16-17H,1-8,24H2,(H2,25,29)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50200560
PNG
(CHEMBL3922900 | US9518026, Example 92)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCOC2)c(N)c1C(N)=O
Show InChI InChI=1S/C19H21N5O3/c1-2-27-14-4-3-11-7-12(9-22-15(11)8-14)17-16(19(21)25)18(20)24(23-17)13-5-6-26-10-13/h3-4,7-9,13H,2,5-6,10,20H2,1H3,(H2,21,25)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50446174
PNG
(CHEMBL3109010 | US9518026, Example 38)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2ccccc2c1
Show InChI InChI=1S/C17H19N5O/c1-17(2,3)22-15(18)13(16(19)23)14(21-22)11-8-10-6-4-5-7-12(10)20-9-11/h4-9H,18H2,1-3H3,(H2,19,23)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50446175
PNG
(CHEMBL3108986 | US9518026, Example 13)
Show SMILES CC(C)n1nc(c(C(N)=O)c1N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C17H18N4O/c1-10(2)21-16(18)14(17(19)22)15(20-21)13-8-7-11-5-3-4-6-12(11)9-13/h3-10H,18H2,1-2H3,(H2,19,22)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50446177
PNG
(CHEMBL3108991 | US9518026, Example 18)
Show SMILES NC(=O)c1c(N)n(CC(F)(F)F)nc1-c1ccc2ccccc2c1
Show InChI InChI=1S/C16H13F3N4O/c17-16(18,19)8-23-14(20)12(15(21)24)13(22-23)11-6-5-9-3-1-2-4-10(9)7-11/h1-7H,8,20H2,(H2,21,24)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148634
PNG
(CHEMBL3769900 | US9518026, Example 43)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC(F)(F)F)c(N)c1C(N)=O
Show InChI InChI=1S/C17H16F3N5O2/c1-2-27-11-4-3-9-5-10(7-23-12(9)6-11)14-13(16(22)26)15(21)25(24-14)8-17(18,19)20/h3-7H,2,8,21H2,1H3,(H2,22,26)
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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148633
PNG
(CHEMBL3769697 | US9518026, Example 42)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(CC(C)(C)C)c(N)c1C(N)=O
Show InChI InChI=1S/C20H25N5O2/c1-5-27-14-7-6-12-8-13(10-23-15(12)9-14)17-16(19(22)26)18(21)25(24-17)11-20(2,3)4/h6-10H,5,11,21H2,1-4H3,(H2,22,26)
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University of Washington Through its Center For Commercialization

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Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM286287
PNG
(US9518026, Example 80)
Show SMILES CC(C)(CO)Cn1nc(c(C(N)=O)c1N)-c1cnc2cc(OC3CCC3)ccc2c1
Show InChI InChI=1S/C22H27N5O3/c1-22(2,12-28)11-27-20(23)18(21(24)29)19(26-27)14-8-13-6-7-16(9-17(13)25-10-14)30-15-4-3-5-15/h6-10,15,28H,3-5,11-12,23H2,1-2H3,(H2,24,29)
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n/an/a 8n/an/an/an/an/an/a



University of Washington Through its Center For Commercialization

US Patent


Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148641
PNG
(CHEMBL3770649 | US9518026, Example 49)
Show SMILES CCOc1ccc2cc(cnc2c1)-c1nn(C2CCCCCC2)c(N)c1C(N)=O
Show InChI InChI=1S/C22H27N5O2/c1-2-29-17-10-9-14-11-15(13-25-18(14)12-17)20-19(22(24)28)21(23)27(26-20)16-7-5-3-4-6-8-16/h9-13,16H,2-8,23H2,1H3,(H2,24,28)
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n/an/a 8n/an/an/an/an/an/a



University of Washington Through its Center For Commercialization

US Patent


Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
Calmodulin-domain protein kinase (CDPK1)


(Cryptosporidium parvum)
BDBM50148749
PNG
(CHEMBL3770313 | US9518026, Example 70)
Show SMILES CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC3CC3)ccc2c1
Show InChI InChI=1S/C20H23N5O2/c1-20(2,3)25-18(21)16(19(22)26)17(24-25)12-8-11-4-5-14(27-13-6-7-13)9-15(11)23-10-12/h4-5,8-10,13H,6-7,21H2,1-3H3,(H2,22,26)
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UniChem

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US Patent
n/an/a 9n/an/an/an/an/an/a



University of Washington Through its Center For Commercialization

US Patent


Assay Description
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...


US Patent US9518026 (2016)

More data for this
Ligand-Target Pair
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