BindingDB PrimarySearch

Found 36 hits of Enz. Inhib. data with enzyme = 'Cathepsin (B and K)' and Substrate = 'BDBM19485'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cathepsin (B and K) (Homo sapiens)	BDBM19778 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...				J Med Chem 49: 1597-612 (2006) Article DOI: 10.1021/jm050915u BindingDB Entry DOI: 10.7270/Q2SQ8XP5
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19770 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	32	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...				J Med Chem 49: 1597-612 (2006) Article DOI: 10.1021/jm050915u BindingDB Entry DOI: 10.7270/Q2SQ8XP5
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19813 (benzyl N-[(2S)-4-methyl-1-{3-[(2S)-4-methyl-2-(qui...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19810 (CHEMBL118449 \| benzyl N-[(1S)-1-({1-[(2S)-2-{[(ben...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	440	-8.58	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19769 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	500	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...				J Med Chem 49: 1597-612 (2006) Article DOI: 10.1021/jm050915u BindingDB Entry DOI: 10.7270/Q2SQ8XP5
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19807 (CHEMBL100563 \| benzyl N-[(1S)-1-({1-[(2S)-2-{[(ben...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	>-8.10	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19773 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...				J Med Chem 49: 1597-612 (2006) Article DOI: 10.1021/jm050915u BindingDB Entry DOI: 10.7270/Q2SQ8XP5
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19772 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...				J Med Chem 49: 1597-612 (2006) Article DOI: 10.1021/jm050915u BindingDB Entry DOI: 10.7270/Q2SQ8XP5
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19797 (CHEMBL301683 \| acyclic alkoxymethyl ketone inhibit...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+3	>-8.10	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19771 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...				J Med Chem 49: 1597-612 (2006) Article DOI: 10.1021/jm050915u BindingDB Entry DOI: 10.7270/Q2SQ8XP5
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19809 (benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.60E+3	-7.54	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19812 ([(2S)-1-{3-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	7.30E+3	-6.93	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19804 ((2S)-4-methyl-N-(4-oxooxolan-3-yl)-2-(quinolin-2-y...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.80E+3	-6.89	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19483 (1, 2, 3 -Triazole Nitrile Inhibitor, 11d \| N-[(1S)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-7.09	n/a	n/a	n/a	n/a	n/a	6.1	37
University of California at Berkeley					Assay Description The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...				J Med Chem 49: 6298-307 (2006) Article DOI: 10.1021/jm060701s BindingDB Entry DOI: 10.7270/Q2GF0RSV
University of California at Berkeley					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19482 (1, 2, 3 -Triazole Nitrile Inhibitor, 11c \| N-[(1S)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-7.09	n/a	n/a	n/a	n/a	n/a	6.1	37
University of California at Berkeley					Assay Description The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...				J Med Chem 49: 6298-307 (2006) Article DOI: 10.1021/jm060701s BindingDB Entry DOI: 10.7270/Q2GF0RSV
University of California at Berkeley					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19479 (1, 2, 3 -Triazole Nitrile Inhibitor, 11a \| N-[(2S)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-7.09	n/a	n/a	n/a	n/a	n/a	6.1	37
University of California at Berkeley					Assay Description The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...				J Med Chem 49: 6298-307 (2006) Article DOI: 10.1021/jm060701s BindingDB Entry DOI: 10.7270/Q2GF0RSV
University of California at Berkeley					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19481 (1, 2, 3 -Triazole Nitrile Inhibitor, 11b \| N-[(2S)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-7.09	n/a	n/a	n/a	n/a	n/a	6.1	37
University of California at Berkeley					Assay Description The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...				J Med Chem 49: 6298-307 (2006) Article DOI: 10.1021/jm060701s BindingDB Entry DOI: 10.7270/Q2GF0RSV
University of California at Berkeley					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19801 (benzyl N-[(1S)-3-methyl-1-[(2-oxocyclohexyl)carbam...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-6.75	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19800 (benzyl N-[(1S)-3-methyl-1-[(2-oxocyclopentyl)carba...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-6.75	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19799 (4-amidotetrahydropyran-3-one, 4 \| benzyl N-[(1S)-3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-6.75	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19798 (3-amidotetrahydrofuran-4-one, 3 \| CHEMBL61805 \| be...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+4	>-6.75	n/a	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				J Med Chem 44: 725-36 (2001) Article DOI: 10.1021/jm000320t BindingDB Entry DOI: 10.7270/Q2J67F6C
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19486 (2-[2-(2,3,4-trifluorophenyl)phenoxy]acetaldehyde \|...) Show SMILES Fc1ccc(c(F)c1F)-c1ccccc1OCC=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.50E+4	>-6.84	n/a	n/a	n/a	n/a	n/a	6.1	37
University of California at Berkeley					Assay Description The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...				J Med Chem 50: 2693-9 (2007) Article DOI: 10.1021/jm070111+ BindingDB Entry DOI: 10.7270/Q2BP012X
University of California at Berkeley					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19487 (2-[2-(2,3-difluoro-4-propylphenyl)phenoxy]acetalde...) Show SMILES CCCc1ccc(c(F)c1F)-c1ccccc1OCC=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.50E+4	>-6.84	n/a	n/a	n/a	n/a	n/a	6.1	37
University of California at Berkeley					Assay Description The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...				J Med Chem 50: 2693-9 (2007) Article DOI: 10.1021/jm070111+ BindingDB Entry DOI: 10.7270/Q2BP012X
University of California at Berkeley					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19488 (2-{2-[2,3-difluoro-4-(2-methylpropyl)phenyl]phenox...) Show SMILES CC(C)Cc1ccc(c(F)c1F)-c1ccccc1OCC=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.50E+4	>-6.84	n/a	n/a	n/a	n/a	n/a	6.1	37
University of California at Berkeley					Assay Description The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...				J Med Chem 50: 2693-9 (2007) Article DOI: 10.1021/jm070111+ BindingDB Entry DOI: 10.7270/Q2BP012X
University of California at Berkeley					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19484 (1, 2, 3 -Triazole Nitrile Inhibitor, 11e \| N-[(1S)...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>1.50E+4	>-6.84	n/a	n/a	n/a	n/a	n/a	6.1	37
University of California at Berkeley					Assay Description The proteolytic cleavage of N-acyl aminocoumarins by cathepsins was conducted in Dynatech Microfluor fluorescence 96-well microtiter plates, and read...				J Med Chem 49: 6298-307 (2006) Article DOI: 10.1021/jm060701s BindingDB Entry DOI: 10.7270/Q2GF0RSV
University of California at Berkeley					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19791 ((2S)-3,3-dimethyl-1-[3-(pyridin-4-yl)-1H-pyrazol-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19783 ((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19794 ((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19782 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(2...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19796 ((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19793 ((2S)-1-(5,6-dichloro-1H-1,3-benzodiazol-1-yl)-3,3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19790 ((2S)-3,3-dimethyl-1-{4-[4-(trifluoromethyl)phenyl]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19792 ((2S)-3,3-dimethyl-1-[3-(pyridin-3-yl)-1H-pyrazol-1...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19789 ((2S)-3,3-dimethyl-1-{4-[4-(trifluoromethyl)phenyl]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19786 ((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair
Cathepsin (B and K) (Homo sapiens)	BDBM19785 ((2S)-3,3-dimethyl-1-{3-[4-(trifluoromethyl)phenyl]...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	5.5	22
GSK					Assay Description Assays were carried out in the presence of variable concentrations of test compound. Reactions were initiated by addition of enzyme to buffered solut...				Bioorg Med Chem Lett 17: 22-7 (2007) Article DOI: 10.1016/j.bmcl.2006.10.102 BindingDB Entry DOI: 10.7270/Q2NZ85XC
GSK					More data for this Ligand-Target Pair