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Compile Data Set for Download or QSAR

Found 226 hits of Enz. Inhib. data with enzyme = 'Cathepsin (H and K)' and Substrate = 'to-be-curated'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150650
PNG
(US8987249, 324 | US9713606, 324)
Show SMILES Fc1ccc2c3cc(F)c(C[C@H](NC(=O)[C@H]4N[C@@H]5CC[C@H]4C5)C#N)cc3c(=O)[nH]c2c1F
Show InChI InChI=1S/C23H19F3N4O2/c24-17-4-3-14-15-8-18(25)11(7-16(15)22(31)30-21(14)19(17)26)6-13(9-27)29-23(32)20-10-1-2-12(5-10)28-20/h3-4,7-8,10,12-13,20,28H,1-2,5-6H2,(H,29,32)(H,30,31)/t10-,12+,13-,20-/m0/s1
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n/an/a 800n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150649
PNG
(US8987249, 323 | US9713606, 323)
Show SMILES Fc1ccc2c(c1)[nH]c(=O)c1cc(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21
Show InChI InChI=1S/C23H20F2N4O2/c24-13-2-4-16-17-9-19(25)12(7-18(17)22(30)29-20(16)8-13)6-15(10-26)28-23(31)21-11-1-3-14(5-11)27-21/h2,4,7-9,11,14-15,21,27H,1,3,5-6H2,(H,28,31)(H,29,30)/t11-,14+,15-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150481
PNG
(US8987249, 155 | US9713606, 155)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H32FN5O3S/c1-32-10-12-33(13-11-32)37(35,36)24-8-5-18(6-9-24)19-2-3-20(25(28)16-19)14-23(17-29)31-27(34)26-21-4-7-22(15-21)30-26/h2-3,5-6,8-9,16,21-23,26,30H,4,7,10-15H2,1H3,(H,31,34)/t21-,22+,23-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150652
PNG
(US8987249, 326 | US9713606, 326)
Show SMILES Cn1c2ccccc2c2cc(F)c(C[C@H](NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)cc2c1=O
Show InChI InChI=1S/C24H23FN4O2/c1-29-21-5-3-2-4-17(21)18-11-20(25)14(10-19(18)24(29)31)9-16(12-26)28-23(30)22-13-6-7-15(8-13)27-22/h2-5,10-11,13,15-16,22,27H,6-9H2,1H3,(H,28,30)/t13-,15+,16-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150648
PNG
(US8987249, 322 | US9713606, 322)
Show SMILES Fc1cc2c3ccccc3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N
Show InChI InChI=1S/C23H21FN4O2/c24-19-10-17-16-3-1-2-4-20(16)28-22(29)18(17)9-13(19)8-15(11-25)27-23(30)21-12-5-6-14(7-12)26-21/h1-4,9-10,12,14-15,21,26H,5-8H2,(H,27,30)(H,28,29)/t12-,14+,15-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150604
PNG
(US8987249, 278 | US9713606, 278)
Show SMILES CN(C)CCN1C(=O)Cc2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H32FN5O2/c1-33(2)9-10-34-25-14-18(4-6-20(25)15-26(34)35)17-3-5-19(24(29)13-17)11-23(16-30)32-28(36)27-21-7-8-22(12-21)31-27/h3-6,13-14,21-23,27,31H,7-12,15H2,1-2H3,(H,32,36)/t21-,22+,23-,27-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150571
PNG
(US8987249, 245 | US9713606, 245)
Show SMILES CN1CCN(CC1)C(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H32FN5O2/c1-33-9-11-34(12-10-33)28(36)22-4-2-3-18(13-22)19-5-6-20(25(29)16-19)14-24(17-30)32-27(35)26-21-7-8-23(15-21)31-26/h2-6,13,16,21,23-24,26,31H,7-12,14-15H2,1H3,(H,32,35)/t21-,23+,24-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150355
PNG
(US8987249, 29 | US9713606, 29)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2CC(=O)Nc2c1
Show InChI InChI=1S/C24H23FN4O2/c25-20-9-13(14-2-4-16-11-22(30)29-21(16)10-14)1-3-15(20)7-19(12-26)28-24(31)23-17-5-6-18(8-17)27-23/h1-4,9-10,17-19,23,27H,5-8,11H2,(H,28,31)(H,29,30)/t17-,18+,19-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150657
PNG
(US8987249, 331 | US9713606, 331)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN(CC1)C1CCOC1
Show InChI InChI=1S/C24H32FN5O2/c25-22-13-20(29-6-8-30(9-7-29)21-5-10-32-15-21)4-2-16(22)11-19(14-26)28-24(31)23-17-1-3-18(12-17)27-23/h2,4,13,17-19,21,23,27H,1,3,5-12,15H2,(H,28,31)/t17-,18+,19-,21?,23-/m0/s1
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n/an/a 1.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150555
PNG
(US8987249, 229 | US9713606, 229)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1csc(c1)C(=O)N1CCN(CC1)C1CC1
Show InChI InChI=1S/C28H32FN5O2S/c29-24-13-17(20-14-25(37-16-20)28(36)34-9-7-33(8-10-34)23-5-6-23)1-2-18(24)11-22(15-30)32-27(35)26-19-3-4-21(12-19)31-26/h1-2,13-14,16,19,21-23,26,31H,3-12H2,(H,32,35)/t19-,21+,22-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150548
PNG
(US8987249, 222 | US9713606, 222)
Show SMILES CS(=O)(=NC#N)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-4-2-3-15(11-21)16-5-6-17(22(25)12-16)9-20(13-26)30-24(31)23-18-7-8-19(10-18)29-23/h2-6,11-12,18-20,23,29H,7-10H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1
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n/an/a 1.70E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150595
PNG
(US8987249, 269 | US9713606, 269)
Show SMILES CO[C@@H]1C[C@@H]2CN(CCN2C1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H32FN5O2/c1-32-21-10-20-13-29(6-7-30(20)14-21)19-5-3-15(22(25)11-19)8-18(12-26)28-24(31)23-16-2-4-17(9-16)27-23/h3,5,11,16-18,20-21,23,27H,2,4,6-10,13-14H2,1H3,(H,28,31)/t16-,17+,18-,20+,21+,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150562
PNG
(US8987249, 236 | US9713606, 236)
Show SMILES NC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H21FN4O2S/c22-16-9-12(17-5-6-18(29-17)20(24)27)2-1-11(16)7-15(10-23)26-21(28)19-13-3-4-14(8-13)25-19/h1-2,5-6,9,13-15,19,25H,3-4,7-8H2,(H2,24,27)(H,26,28)/t13-,14+,15-,19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150511
PNG
(US8987249, 185 | US9713606, 185)
Show SMILES CN1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H32FN5O2/c1-33-10-12-34(13-11-33)28(36)19-4-2-18(3-5-19)20-6-7-21(25(29)16-20)14-24(17-30)32-27(35)26-22-8-9-23(15-22)31-26/h2-7,16,22-24,26,31H,8-15H2,1H3,(H,32,35)/t22-,23+,24-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150608
PNG
(US8987249, 282 | US9713606, 282)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CC2COCCN2CC1
Show InChI InChI=1S/C24H29FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,11-12,18-21,23,27H,3-10,14H2,(H,28,30)/t18-,19+,20-,21?,23-/m0/s1
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n/an/a 1.80E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150607
PNG
(US8987249, 281 | US9713606, 281)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C1=CCN2CCOCC2C1
Show InChI InChI=1S/C24H29FN4O2/c25-22-12-15(16-5-6-29-7-8-31-14-21(29)11-16)1-2-17(22)9-20(13-26)28-24(30)23-18-3-4-19(10-18)27-23/h1-2,5,12,18-21,23,27H,3-4,6-11,14H2,(H,28,30)/t18-,19+,20-,21?,23-/m0/s1
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n/an/a 1.90E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150563
PNG
(US8987249, 237 | US9713606, 237)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(s1)C(=O)N1CCn2nccc2C1
Show InChI InChI=1S/C27H27FN6O2S/c28-22-13-17(23-5-6-24(37-23)27(36)33-9-10-34-21(15-33)7-8-30-34)2-1-16(22)11-20(14-29)32-26(35)25-18-3-4-19(12-18)31-25/h1-2,5-8,13,18-20,25,31H,3-4,9-12,15H2,(H,32,35)/t18-,19+,20-,25-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150570
PNG
(US8987249, 244 | US9713606, 244)
Show SMILES NC(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H23FN4O2/c24-20-11-14(13-2-1-3-17(8-13)22(26)29)4-5-15(20)9-19(12-25)28-23(30)21-16-6-7-18(10-16)27-21/h1-5,8,11,16,18-19,21,27H,6-7,9-10H2,(H2,26,29)(H,28,30)/t16-,18+,19-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150565
PNG
(US8987249, 239 | US9713606, 239)
Show SMILES NC(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H21FN4O3/c22-17-7-12(18-8-14(10-29-18)20(24)27)2-1-11(17)5-16(9-23)26-21(28)19-13-3-4-15(6-13)25-19/h1-2,7-8,10,13,15-16,19,25H,3-6H2,(H2,24,27)(H,26,28)/t13-,15+,16-,19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150554
PNG
(US8987249, 228 | US9713606, 228)
Show SMILES COCCN1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C28H34FN5O3S/c1-37-11-10-33-6-8-34(9-7-33)28(36)25-15-21(17-38-25)18-2-3-19(24(29)14-18)12-23(16-30)32-27(35)26-20-4-5-22(13-20)31-26/h2-3,14-15,17,20,22-23,26,31H,4-13H2,1H3,(H,32,35)/t20-,22+,23-,26-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150338
PNG
(US8987249, 12 | US9713606, 12)
Show SMILES CS(=O)(=O)c1ccc(cc1F)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H23F2N3O3S/c1-32(30,31)21-7-5-14(11-20(21)25)13-2-3-15(19(24)10-13)8-18(12-26)28-23(29)22-16-4-6-17(9-16)27-22/h2-3,5,7,10-11,16-18,22,27H,4,6,8-9H2,1H3,(H,28,29)/t16-,17+,18-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150589
PNG
(US8987249, 263 | US9713606, 263)
Show SMILES CS(=O)(=NC#N)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H24FN5O2S/c1-33(32,28-14-27)21-8-5-15(6-9-21)16-2-3-17(22(25)12-16)10-20(13-26)30-24(31)23-18-4-7-19(11-18)29-23/h2-3,5-6,8-9,12,18-20,23,29H,4,7,10-11H2,1H3,(H,30,31)/t18-,19+,20-,23-,33?/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150329
PNG
(US8987249, 3 | US9713606, 3)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150342
PNG
(US8987249, 16 | US9713606, 16)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H24FN3O3S/c1-31(29,30)20-8-5-14(6-9-20)15-2-3-16(21(24)12-15)10-19(13-25)27-23(28)22-17-4-7-18(11-17)26-22/h2-3,5-6,8-9,12,17-19,22,26H,4,7,10-11H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150614
PNG
(US8987249, 288 | US9713606, 288)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc(o1)C(=O)N1CCOCC1
Show InChI InChI=1S/C25H27FN4O4/c26-20-13-16(21-5-6-22(34-21)25(32)30-7-9-33-10-8-30)2-1-15(20)11-19(14-27)29-24(31)23-17-3-4-18(12-17)28-23/h1-2,5-6,13,17-19,23,28H,3-4,7-12H2,(H,29,31)/t17-,18+,19-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150369
PNG
(US8987249, 43 | US9713606, 43)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCN2CCOCC2C1
Show InChI InChI=1S/C23H30FN5O2/c24-21-11-19(29-6-5-28-7-8-31-14-20(28)13-29)4-2-15(21)9-18(12-25)27-23(30)22-16-1-3-17(10-16)26-22/h2,4,11,16-18,20,22,26H,1,3,5-10,13-14H2,(H,27,30)/t16-,17+,18-,20?,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150620
PNG
(US8987249, 294 | US9713606, 294)
Show SMILES Fc1cc2c3ccccc3[nH]c(=O)c2cc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N
Show InChI InChI=1S/C23H21FN4O2/c24-19-10-17-16-3-1-2-4-20(16)28-22(29)18(17)9-13(19)8-15(11-25)27-23(30)21-12-5-6-14(7-12)26-21/h1-4,9-10,12,14-15,21,26H,5-8H2,(H,27,30)(H,28,29)/t12-,14+,15?,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150519
PNG
(US8987249, 193 | US9713606, 193)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)N1CCC(CC1)N1CCOCC1
Show InChI InChI=1S/C25H34FN5O2/c26-23-15-22(30-7-5-21(6-8-30)31-9-11-33-12-10-31)4-2-17(23)13-20(16-27)29-25(32)24-18-1-3-19(14-18)28-24/h2,4,15,18-21,24,28H,1,3,5-14H2,(H,29,32)/t18-,19+,20-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150383
PNG
(US8987249, 57 | US9713606, 57)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCOCC2)c1
Show InChI InChI=1S/C25H30FN5O2/c26-23-11-17(20-13-28-31(15-20)14-16-5-7-33-8-6-16)1-2-18(23)9-22(12-27)30-25(32)24-19-3-4-21(10-19)29-24/h1-2,11,13,15-16,19,21-22,24,29H,3-10,14H2,(H,30,32)/t19-,21+,22-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150651
PNG
(US8987249, 325 | US9713606, 325)
Show SMILES Fc1cc2c3cc(cc(F)c3[nH]c(=O)c2cc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)C#N
Show InChI InChI=1S/C24H19F2N5O2/c25-19-8-16-17-3-11(9-27)4-20(26)22(17)31-23(32)18(16)7-13(19)6-15(10-28)30-24(33)21-12-1-2-14(5-12)29-21/h3-4,7-8,12,14-15,21,29H,1-2,5-6H2,(H,30,33)(H,31,32)/t12-,14+,15-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150441
PNG
(US8987249, 115 | US9713606, 115)
Show SMILES OC(=O)c1ccc(s1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H20FN3O3S/c22-16-9-12(17-5-6-18(29-17)21(27)28)2-1-11(16)7-15(10-23)25-20(26)19-13-3-4-14(8-13)24-19/h1-2,5-6,9,13-15,19,24H,3-4,7-8H2,(H,25,26)(H,27,28)/t13-,14+,15-,19-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150659
PNG
(US8987249, 333 | US9713606, 333)
Show SMILES CN1C2CCC1CN(C2)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H30FN5O/c1-28-19-6-7-20(28)13-29(12-19)18-5-3-14(21(24)10-18)8-17(11-25)27-23(30)22-15-2-4-16(9-15)26-22/h3,5,10,15-17,19-20,22,26H,2,4,6-9,12-13H2,1H3,(H,27,30)/t15-,16+,17-,19?,20?,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150395
PNG
(US8987249, 69 | US9713606, 69)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cn[nH]c1
Show InChI InChI=1S/C19H20FN5O/c20-17-7-11(14-9-22-23-10-14)1-2-12(17)5-16(8-21)25-19(26)18-13-3-4-15(6-13)24-18/h1-2,7,9-10,13,15-16,18,24H,3-6H2,(H,22,23)(H,25,26)/t13-,15+,16-,18-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150557
PNG
(US8987249, 231 | US9713606, 231)
Show SMILES CC(=O)N1CCN(CC1)C(=O)c1cc(cs1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C27H30FN5O3S/c1-16(34)32-6-8-33(9-7-32)27(36)24-13-20(15-37-24)17-2-3-18(23(28)12-17)10-22(14-29)31-26(35)25-19-4-5-21(11-19)30-25/h2-3,12-13,15,19,21-22,25,30H,4-11H2,1H3,(H,31,35)/t19-,21+,22-,25-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150568
PNG
(US8987249, 242 | US9713606, 242)
Show SMILES CCNC(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H25FN4O3/c1-2-26-22(29)16-10-20(31-12-16)14-4-3-13(19(24)9-14)7-18(11-25)28-23(30)21-15-5-6-17(8-15)27-21/h3-4,9-10,12,15,17-18,21,27H,2,5-8H2,1H3,(H,26,29)(H,28,30)/t15-,17+,18-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150527
PNG
(US8987249, 201 | US9713606, 201)
Show SMILES CCN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H31FN4O/c1-2-28-9-7-15(8-10-28)16-3-4-17(21(24)13-16)11-20(14-25)27-23(29)22-18-5-6-19(12-18)26-22/h3-4,13,15,18-20,22,26H,2,5-12H2,1H3,(H,27,29)/t18-,19+,20-,22-/m0/s1
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n/an/a 2.50E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150417
PNG
(US8987249, 91 | US9713606, 91)
Show SMILES CS(=O)(=O)N1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H28FN5O3S/c1-31(29,30)27-8-6-26(7-9-27)18-5-3-14(19(22)12-18)10-17(13-23)25-21(28)20-15-2-4-16(11-15)24-20/h3,5,12,15-17,20,24H,2,4,6-11H2,1H3,(H,25,28)/t15-,16+,17-,20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150400
PNG
(US8987249, 74 | US9713606, 74)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(c1)C(=O)C1CCOCC1
Show InChI InChI=1S/C25H28FN5O3/c26-22-11-16(19-13-28-31(14-19)25(33)15-5-7-34-8-6-15)1-2-17(22)9-21(12-27)30-24(32)23-18-3-4-20(10-18)29-23/h1-2,11,13-15,18,20-21,23,29H,3-10H2,(H,30,32)/t18-,20+,21-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150385
PNG
(US8987249, 59 | US9713606, 59)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnc(s1)N1CCOCC1
Show InChI InChI=1S/C23H26FN5O2S/c24-19-11-15(20-13-26-23(32-20)29-5-7-31-8-6-29)2-1-14(19)9-18(12-25)28-22(30)21-16-3-4-17(10-16)27-21/h1-2,11,13,16-18,21,27H,3-10H2,(H,28,30)/t16-,17+,18-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150567
PNG
(US8987249, 241 | US9713606, 241)
Show SMILES CN1CCN(CC1)C(=O)c1coc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C26H30FN5O3/c1-31-6-8-32(9-7-31)26(34)19-13-23(35-15-19)17-3-2-16(22(27)12-17)10-21(14-28)30-25(33)24-18-4-5-20(11-18)29-24/h2-3,12-13,15,18,20-21,24,29H,4-11H2,1H3,(H,30,33)/t18-,20+,21-,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150360
PNG
(US8987249, 34 | US9713606, 34)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2COC(=O)c2c1
Show InChI InChI=1S/C24H22FN3O3/c25-21-10-14(13-2-4-17-12-31-24(30)20(17)9-13)1-3-15(21)7-19(11-26)28-23(29)22-16-5-6-18(8-16)27-22/h1-4,9-10,16,18-19,22,27H,5-8,12H2,(H,28,29)/t16-,18+,19-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150332
PNG
(US8987249, 6 | US9713606, 6)
Show SMILES CN1CCN(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C21H28FN5O/c1-26-6-8-27(9-7-26)18-5-3-14(19(22)12-18)10-17(13-23)25-21(28)20-15-2-4-16(11-15)24-20/h3,5,12,15-17,20,24H,2,4,6-11H2,1H3,(H,25,28)/t15-,16+,17-,20-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150330
PNG
(US8987249, 4 | US9713606, 4)
Show SMILES CS(=O)(=O)c1cccc(c1)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C23H24FN3O3S/c1-31(29,30)20-4-2-3-14(11-20)15-5-6-16(21(24)12-15)9-19(13-25)27-23(28)22-17-7-8-18(10-17)26-22/h2-6,11-12,17-19,22,26H,7-10H2,1H3,(H,27,28)/t17-,18+,19-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM263576
PNG
(US9713606, 5)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-n1cc(nn1)-c1ccc2[nH]ccc2c1
Show InChI InChI=1S/C26H24FN7O/c27-22-12-21(34-14-24(32-33-34)16-3-6-23-17(9-16)7-8-29-23)5-2-15(22)10-20(13-28)31-26(35)25-18-1-4-19(11-18)30-25/h2-3,5-9,12,14,18-20,25,29-30H,1,4,10-11H2,(H,31,35)/t18-,19+,20-,25-/m0/s1
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n/an/a 2.60E+3n/an/an/an/an/an/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150337
PNG
(US8987249, 11 | US9713606, 11)
Show SMILES Fc1cc(ccc1CC(NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1ccc2C(=O)OCc2c1
Show InChI InChI=1S/C24H22FN3O3/c25-21-10-14(13-4-6-20-17(7-13)12-31-24(20)30)1-2-15(21)8-19(11-26)28-23(29)22-16-3-5-18(9-16)27-22/h1-2,4,6-7,10,16,18-19,22,27H,3,5,8-9,12H2,(H,28,29)/t16-,18+,19?,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150336
PNG
(US8987249, 10 | US9713606, 10)
Show SMILES CN1C(=O)C(=O)c2ccc(cc12)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C25H23FN4O3/c1-30-21-11-14(5-7-19(21)23(31)25(30)33)13-2-3-15(20(26)10-13)8-18(12-27)29-24(32)22-16-4-6-17(9-16)28-22/h2-3,5,7,10-11,16-18,22,28H,4,6,8-9H2,1H3,(H,29,32)/t16-,17+,18-,22-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150443
PNG
(US8987249, 117 | US9713606, 117)
Show SMILES CN1CCC(CC1)c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C22H29FN4O/c1-27-8-6-14(7-9-27)15-2-3-16(20(23)12-15)10-19(13-24)26-22(28)21-17-4-5-18(11-17)25-21/h2-3,12,14,17-19,21,25H,4-11H2,1H3,(H,26,28)/t17-,18+,19-,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150340
PNG
(US8987249, 14 | US9713606, 14)
Show SMILES CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2N[C@@H]3CC[C@H]2C3)C#N)c(F)c1
Show InChI InChI=1S/C24H23FN4O3S/c1-33(31,32)22-11-15(3-5-18(22)12-26)14-2-4-16(21(25)10-14)8-20(13-27)29-24(30)23-17-6-7-19(9-17)28-23/h2-5,10-11,17,19-20,23,28H,6-9H2,1H3,(H,29,30)/t17-,19+,20-,23-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150619
PNG
(US8987249, 293 | US9713606, 293)
Show SMILES Fc1ccc2c(c1)[nH]c(=O)c1cc(CC(NC(=O)[C@H]3N[C@@H]4CC[C@H]3C4)C#N)c(F)cc21
Show InChI InChI=1S/C23H20F2N4O2/c24-13-2-4-16-17-9-19(25)12(7-18(17)22(30)29-20(16)8-13)6-15(10-26)28-23(31)21-11-1-3-14(5-11)27-21/h2,4,7-9,11,14-15,21,27H,1,3,5-6H2,(H,28,31)(H,29,30)/t11-,14+,15?,21-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
Cathepsin (H and K)


(Homo sapiens (human))
BDBM150354
PNG
(US8987249, 28 | US9713606, 28)
Show SMILES Fc1cc(ccc1C[C@H](NC(=O)[C@H]1N[C@@H]2CC[C@H]1C2)C#N)-c1cnn(CC2CCCCO2)c1
Show InChI InChI=1S/C25H30FN5O2/c26-23-11-16(19-13-28-31(14-19)15-22-3-1-2-8-33-22)4-5-17(23)9-21(12-27)30-25(32)24-18-6-7-20(10-18)29-24/h4-5,11,13-14,18,20-22,24,29H,1-3,6-10,15H2,(H,30,32)/t18-,20+,21-,22?,24-/m0/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Materials: Microtiterplates (Optiplate-384 F were purchased from PerkinElmer (Prod. No. 6007270). The substrate Z-Gly-Pro-Arg-AMC was from Biomol (Pr...


US Patent US9713606 (2017)

More data for this
Ligand-Target Pair
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