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Compile Data Set for Download or QSAR

Found 1 hit of Enz. Inhib. data with enzyme = 'Cathepsin D' and Substrate = 'Cathepsin D FRET Substrate'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin D


(Homo sapiens (human))
BDBM17786
PNG
((4S)-4-(2-amino-6-phenoxy-3,4-dihydroquinazolin-3-...)
Show SMILES CN(C1CCCCC1)C(=O)CC[C@@H](C1CCCCC1)N1Cc2cc(Oc3ccccc3)ccc2N=C1N
Show InChI InChI=1S/C31H42N4O2/c1-34(25-13-7-3-8-14-25)30(36)20-19-29(23-11-5-2-6-12-23)35-22-24-21-27(17-18-28(24)33-31(35)32)37-26-15-9-4-10-16-26/h4,9-10,15-18,21,23,25,29H,2-3,5-8,11-14,19-20,22H2,1H3,(H2,32,33)/t29-/m0/s1
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Similars

Article
PubMed
n/an/a 110n/an/an/an/a4.022



Johnson & Johnson Pharmaceutical



Assay Description
Cathepsin D activity was measured at pH 4 using a FRET peptide substrate. Compounds were preincubated with recombinant human liver cathepsin D for 20...


J Med Chem 50: 4261-4 (2007)


Article DOI: 10.1021/jm0705408
BindingDB Entry DOI: 10.7270/Q24M92T2
More data for this
Ligand-Target Pair