BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 96 hits of Enz. Inhib. data with enzyme = 'Coagulation factor VII' and Substrate = 'BDBM13777'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor VII


(Homo sapiens (human))
BDBM13778
PNG
(2-[3-(5-carbamimidoyl-1H-indol-2-yl)-4-hydroxy-5-(...)
Show SMILES NC(=N)c1ccc2[nH]c(cc2c1)-c1cc(CC(O)=O)cc(c1O)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C23H18N4O5/c24-23(25)14-4-5-19-15(9-14)11-20(26-19)18-7-12(8-21(28)29)6-17(22(18)30)13-2-1-3-16(10-13)27(31)32/h1-7,9-11,26,30H,8H2,(H3,24,25)(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4 -11.3n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 2270-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.017
BindingDB Entry DOI: 10.7270/Q2RF5S8X
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14898
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(F)ccc1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H19FN4O6/c25-12-2-4-19(30)14(8-12)15-5-11(13(24(34)35)9-20(31)32)6-16(21(15)33)23-28-17-3-1-10(22(26)27)7-18(17)29-23/h1-8,13,30,33H,9H2,(H3,26,27)(H,28,29)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
4 -11.3n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14899
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(Cl)ccc1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H19ClN4O6/c25-12-2-4-19(30)14(8-12)15-5-11(13(24(34)35)9-20(31)32)6-16(21(15)33)23-28-17-3-1-10(22(26)27)7-18(17)29-23/h1-8,13,30,33H,9H2,(H3,26,27)(H,28,29)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.40 -11.2n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14900
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(ccc1O)[N+]([O-])=O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H19N5O8/c25-22(26)10-1-3-17-18(7-10)28-23(27-17)16-6-11(13(24(34)35)9-20(31)32)5-15(21(16)33)14-8-12(29(36)37)2-4-19(14)30/h1-8,13,30,33H,9H2,(H3,25,26)(H,27,28)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
6 -11.1n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14904
PNG
(2-[3-(3-bromo-5-chloro-2-hydroxyphenyl)-5-(5-carba...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(Cl)cc(Br)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H18BrClN4O6/c25-16-7-11(26)6-14(21(16)34)13-3-10(12(24(35)36)8-19(31)32)4-15(20(13)33)23-29-17-2-1-9(22(27)28)5-18(17)30-23/h1-7,12,33-34H,8H2,(H3,27,28)(H,29,30)(H,31,32)(H,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
9 -10.9n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14901
PNG
(2-[3-(5-amino-2-hydroxyphenyl)-5-(5-carbamimidoyl-...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(N)ccc1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H21N5O6/c25-12-2-4-19(30)14(8-12)15-5-11(13(24(34)35)9-20(31)32)6-16(21(15)33)23-28-17-3-1-10(22(26)27)7-18(17)29-23/h1-8,13,30,33H,9,25H2,(H3,26,27)(H,28,29)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
10 -10.8n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14902
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(ccc1O)C#N)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C25H19N5O6/c26-10-11-1-4-20(31)15(5-11)16-6-13(14(25(35)36)9-21(32)33)7-17(22(16)34)24-29-18-3-2-12(23(27)28)8-19(18)30-24/h1-8,14,31,34H,9H2,(H3,27,28)(H,29,30)(H,32,33)(H,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
12 -10.7n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14903
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1ccccc1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H20N4O6/c25-22(26)11-5-6-17-18(9-11)28-23(27-17)16-8-12(14(24(33)34)10-20(30)31)7-15(21(16)32)13-3-1-2-4-19(13)29/h1-9,14,29,32H,10H2,(H3,25,26)(H,27,28)(H,30,31)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
13 -10.6n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14863
PNG
(({3-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-2...)
Show SMILES NC(=O)NCc1ccc(O)c(c1)-c1cccc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O
Show InChI InChI=1S/C22H20N6O3/c23-20(24)12-5-6-16-17(9-12)28-21(27-16)14-3-1-2-13(19(14)30)15-8-11(4-7-18(15)29)10-26-22(25)31/h1-9,29-30H,10H2,(H3,23,24)(H,27,28)(H3,25,26,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
13 -10.6n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14905
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cc(Cl)cc(Cl)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H18Cl2N4O6/c25-11-6-14(21(34)16(26)7-11)13-3-10(12(24(35)36)8-19(31)32)4-15(20(13)33)23-29-17-2-1-9(22(27)28)5-18(17)30-23/h1-7,12,33-34H,8H2,(H3,27,28)(H,29,30)(H,31,32)(H,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
14 -10.6n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM13776
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(CC(O)=O)cc(c1O)-c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C22H17N5O5/c23-21(24)13-4-5-17-18(10-13)26-22(25-17)16-7-11(8-19(28)29)6-15(20(16)30)12-2-1-3-14(9-12)27(31)32/h1-7,9-10,30H,8H2,(H3,23,24)(H,25,26)(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
15 -10.6n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 2270-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.017
BindingDB Entry DOI: 10.7270/Q2RF5S8X
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM13786
PNG
(2-(3-{5-amino-1H-pyrrolo[3,2-b]pyridin-2-yl}-4-hyd...)
Show SMILES Nc1ccc2[nH]c(cc2n1)-c1cc(CC(O)=O)cc(c1O)-c1cccc(CNC(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C29H25N5O4/c30-26-10-9-23-25(34-26)15-24(33-23)22-13-18(14-27(35)36)12-21(28(22)37)19-6-4-5-17(11-19)16-31-29(38)32-20-7-2-1-3-8-20/h1-13,15,33,37H,14,16H2,(H2,30,34)(H,35,36)(H2,31,32,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
20 -10.4n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 2270-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.017
BindingDB Entry DOI: 10.7270/Q2RF5S8X
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14907
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2cccc(CO)c2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C25H22N4O6/c26-23(27)14-4-5-19-20(9-14)29-24(28-19)18-8-15(17(25(34)35)10-21(31)32)7-16(22(18)33)13-3-1-2-12(6-13)11-30/h1-9,17,30,33H,10-11H2,(H3,26,27)(H,28,29)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
21 -10.4n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14908
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2cccc(c2)[N+]([O-])=O)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H19N5O7/c25-22(26)12-4-5-18-19(9-12)28-23(27-18)17-8-13(16(24(33)34)10-20(30)31)7-15(21(17)32)11-2-1-3-14(6-11)29(35)36/h1-9,16,32H,10H2,(H3,25,26)(H,27,28)(H,30,31)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
22 -10.3n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14909
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1ccccc1[N+]([O-])=O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H19N5O7/c25-22(26)11-5-6-17-18(9-11)28-23(27-17)16-8-12(14(24(33)34)10-20(30)31)7-15(21(16)32)13-3-1-2-4-19(13)29(35)36/h1-9,14,32H,10H2,(H3,25,26)(H,27,28)(H,30,31)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
22 -10.3n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14906
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1c(O)cc(Cl)cc1Cl)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H18Cl2N4O6/c25-11-6-15(26)20(18(31)7-11)13-3-10(12(24(35)36)8-19(32)33)4-14(21(13)34)23-29-16-2-1-9(22(27)28)5-17(16)30-23/h1-7,12,31,34H,8H2,(H3,27,28)(H,29,30)(H,32,33)(H,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
25 -10.3n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14910
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2cc(Cl)cc(Cl)c2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H18Cl2N4O5/c25-13-3-11(4-14(26)8-13)15-5-12(16(24(34)35)9-20(31)32)6-17(21(15)33)23-29-18-2-1-10(22(27)28)7-19(18)30-23/h1-8,16,33H,9H2,(H3,27,28)(H,29,30)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
27 -10.2n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14880
PNG
(1-(2,4-dimethoxyphenyl)-3-{[3-(2-hydroxy-3-{1H-pyr...)
Show SMILES COc1ccc(NC(=O)NCc2cccc(c2)-c2cccc(-c3cc4cnccc4[nH]3)c2O)c(OC)c1
Show InChI InChI=1S/C29H26N4O4/c1-36-21-9-10-25(27(15-21)37-2)33-29(35)31-16-18-5-3-6-19(13-18)22-7-4-8-23(28(22)34)26-14-20-17-30-12-11-24(20)32-26/h3-15,17,32,34H,16H2,1-2H3,(H2,31,33,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
28n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14911
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES Cc1cc(C)cc(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C26H24N4O5/c1-12-5-13(2)7-15(6-12)17-8-16(18(26(34)35)11-22(31)32)9-19(23(17)33)25-29-20-4-3-14(24(27)28)10-21(20)30-25/h3-10,18,33H,11H2,1-2H3,(H3,27,28)(H,29,30)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
29 -10.2n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14872
PNG
(1-(2,6-difluorophenyl)-3-{[3-(2-hydroxy-3-{1H-pyrr...)
Show SMILES Oc1c(cccc1-c1cccc(CNC(=O)Nc2c(F)cccc2F)c1)-c1cc2cnccc2[nH]1
Show InChI InChI=1S/C27H20F2N4O2/c28-21-8-3-9-22(29)25(21)33-27(35)31-14-16-4-1-5-17(12-16)19-6-2-7-20(26(19)34)24-13-18-15-30-11-10-23(18)32-24/h1-13,15,32,34H,14H2,(H2,31,33,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
33 -10.1n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14912
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES CC(=O)c1cccc(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C26H22N4O6/c1-12(31)13-3-2-4-14(7-13)17-8-16(18(26(35)36)11-22(32)33)9-19(23(17)34)25-29-20-6-5-15(24(27)28)10-21(20)30-25/h2-10,18,34H,11H2,1H3,(H3,27,28)(H,29,30)(H,32,33)(H,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
33 -10.1n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14913
PNG
(2-[3-(3-aminophenyl)-5-(5-carbamimidoyl-1H-1,3-ben...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2cccc(N)c2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H21N5O5/c25-14-3-1-2-11(6-14)15-7-13(16(24(33)34)10-20(30)31)8-17(21(15)32)23-28-18-5-4-12(22(26)27)9-19(18)29-23/h1-9,16,32H,10,25H2,(H3,26,27)(H,28,29)(H,30,31)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
36 -10.0n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14914
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES Cc1cccc(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C25H22N4O5/c1-12-3-2-4-13(7-12)16-8-15(17(25(33)34)11-21(30)31)9-18(22(16)32)24-28-19-6-5-14(23(26)27)10-20(19)29-24/h2-10,17,32H,11H2,1H3,(H3,26,27)(H,28,29)(H,30,31)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
38n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14877
PNG
(3-{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}...)
Show SMILES COc1ccccc1NC(=O)NCc1cccc(c1)-c1cccc(-c2cc3cnccc3[nH]2)c1O
Show InChI InChI=1S/C28H24N4O3/c1-35-26-11-3-2-10-24(26)32-28(34)30-16-18-6-4-7-19(14-18)21-8-5-9-22(27(21)33)25-15-20-17-29-13-12-23(20)31-25/h2-15,17,31,33H,16H2,1H3,(H2,30,32,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
47 -9.89n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14915
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES CC(=O)N(c1cccc(C)c1)c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C27H25N5O6/c1-13-4-3-5-17(8-13)32(14(2)33)22-11-16(18(27(37)38)12-23(34)35)9-19(24(22)36)26-30-20-7-6-15(25(28)29)10-21(20)31-26/h3-11,18,36H,12H2,1-2H3,(H3,28,29)(H,30,31)(H,34,35)(H,37,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
54n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14876
PNG
(1-(2-chlorophenyl)-3-{[3-(2-hydroxy-3-{1H-pyrrolo[...)
Show SMILES Oc1c(cccc1-c1cccc(CNC(=O)Nc2ccccc2Cl)c1)-c1cc2cnccc2[nH]1
Show InChI InChI=1S/C27H21ClN4O2/c28-22-9-1-2-10-24(22)32-27(34)30-15-17-5-3-6-18(13-17)20-7-4-8-21(26(20)33)25-14-19-16-29-12-11-23(19)31-25/h1-14,16,31,33H,15H2,(H2,30,32,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
57 -9.78n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14869
PNG
(1-(2-fluorophenyl)-3-{[3-(2-hydroxy-3-{1H-pyrrolo[...)
Show SMILES Oc1c(cccc1-c1cccc(CNC(=O)Nc2ccccc2F)c1)-c1cc2cnccc2[nH]1
Show InChI InChI=1S/C27H21FN4O2/c28-22-9-1-2-10-24(22)32-27(34)30-15-17-5-3-6-18(13-17)20-7-4-8-21(26(20)33)25-14-19-16-29-12-11-23(19)31-25/h1-14,16,31,33H,15H2,(H2,30,32,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
57 -9.78n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14883
PNG
(4-[({[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-y...)
Show SMILES OC(=O)c1ccc(NC(=O)NCc2cccc(c2)-c2cccc(-c3cc4cnccc4[nH]3)c2O)cc1
Show InChI InChI=1S/C28H22N4O4/c33-26-22(5-2-6-23(26)25-14-20-16-29-12-11-24(20)32-25)19-4-1-3-17(13-19)15-30-28(36)31-21-9-7-18(8-10-21)27(34)35/h1-14,16,32-33H,15H2,(H,34,35)(H2,30,31,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
58n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14881
PNG
(1-(3-acetylphenyl)-3-{[3-(2-hydroxy-3-{1H-pyrrolo[...)
Show SMILES CC(=O)c1cccc(NC(=O)NCc2cccc(c2)-c2cccc(-c3cc4cnccc4[nH]3)c2O)c1
Show InChI InChI=1S/C29H24N4O3/c1-18(34)20-6-3-8-23(14-20)32-29(36)31-16-19-5-2-7-21(13-19)24-9-4-10-25(28(24)35)27-15-22-17-30-12-11-26(22)33-27/h2-15,17,33,35H,16H2,1H3,(H2,31,32,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
60n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14868
PNG
(3-{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}...)
Show SMILES Oc1c(cccc1-c1cccc(CNC(=O)Nc2ccccc2)c1)-c1cc2cnccc2[nH]1
Show InChI InChI=1S/C27H22N4O2/c32-26-22(10-5-11-23(26)25-15-20-17-28-13-12-24(20)31-25)19-7-4-6-18(14-19)16-29-27(33)30-21-8-2-1-3-9-21/h1-15,17,31-32H,16H2,(H2,29,30,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
61.5 -9.73n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM13787
PNG
(2-(3-{5-amino-1H-pyrrolo[3,2-b]pyridin-2-yl}-4-hyd...)
Show SMILES Nc1ccc2[nH]c(cc2n1)-c1cc(CC(O)=O)cc(c1O)-c1cccc(CNC(=O)Nc2cccnc2)c1
Show InChI InChI=1S/C28H24N6O4/c29-25-7-6-22-24(34-25)13-23(33-22)21-11-17(12-26(35)36)10-20(27(21)37)18-4-1-3-16(9-18)14-31-28(38)32-19-5-2-8-30-15-19/h1-11,13,15,33,37H,12,14H2,(H2,29,34)(H,35,36)(H2,31,32,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
62 -9.73n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 2270-3 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.017
BindingDB Entry DOI: 10.7270/Q2RF5S8X
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14916
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES CSc1ccccc1-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C25H22N4O5S/c1-35-20-5-3-2-4-14(20)16-8-13(15(25(33)34)11-21(30)31)9-17(22(16)32)24-28-18-7-6-12(23(26)27)10-19(18)29-24/h2-10,15,32H,11H2,1H3,(H3,26,27)(H,28,29)(H,30,31)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
64n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14917
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2cccc(Cl)c2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H19ClN4O5/c25-14-3-1-2-11(6-14)15-7-13(16(24(33)34)10-20(30)31)8-17(21(15)32)23-28-18-5-4-12(22(26)27)9-19(18)29-23/h1-9,16,32H,10H2,(H3,26,27)(H,28,29)(H,30,31)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
66n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14918
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2cc(F)cc(F)c2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H18F2N4O5/c25-13-3-11(4-14(26)8-13)15-5-12(16(24(34)35)9-20(31)32)6-17(21(15)33)23-29-18-2-1-10(22(27)28)7-19(18)30-23/h1-8,16,33H,9H2,(H3,27,28)(H,29,30)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
68n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14896
PNG
(1-benzyl-1-hydroxy-3-{[3-(2-hydroxy-3-{1H-pyrrolo[...)
Show SMILES ON(Cc1ccccc1)C(=O)NCc1cccc(c1)-c1cccc(-c2cc3cnccc3[nH]2)c1O
Show InChI InChI=1S/C28H24N4O3/c33-27-23(10-5-11-24(27)26-15-22-17-29-13-12-25(22)31-26)21-9-4-8-20(14-21)16-30-28(34)32(35)18-19-6-2-1-3-7-19/h1-15,17,31,33,35H,16,18H2,(H,30,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
72n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14897
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2ccccc2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H20N4O5/c25-22(26)13-6-7-18-19(10-13)28-23(27-18)17-9-14(16(24(32)33)11-20(29)30)8-15(21(17)31)12-4-2-1-3-5-12/h1-10,16,31H,11H2,(H3,25,26)(H,27,28)(H,29,30)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
74 -9.62n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14919
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES CC(C)c1cccc(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C27H26N4O5/c1-13(2)14-4-3-5-15(8-14)18-9-17(19(27(35)36)12-23(32)33)10-20(24(18)34)26-30-21-7-6-16(25(28)29)11-22(21)31-26/h3-11,13,19,34H,12H2,1-2H3,(H3,28,29)(H,30,31)(H,32,33)(H,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
76n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14920
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2cccc(c2)C#N)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C25H19N5O5/c26-11-12-2-1-3-13(6-12)16-7-15(17(25(34)35)10-21(31)32)8-18(22(16)33)24-29-19-5-4-14(23(27)28)9-20(19)30-24/h1-9,17,33H,10H2,(H3,27,28)(H,29,30)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
77n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14921
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2cccc(O)c2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H20N4O6/c25-22(26)12-4-5-18-19(9-12)28-23(27-18)17-8-13(16(24(33)34)10-20(30)31)7-15(21(17)32)11-2-1-3-14(29)6-11/h1-9,16,29,32H,10H2,(H3,25,26)(H,27,28)(H,30,31)(H,33,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
88n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14879
PNG
(3-{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}...)
Show SMILES COc1ccc(NC(=O)NCc2cccc(c2)-c2cccc(-c3cc4cnccc4[nH]3)c2O)cc1
Show InChI InChI=1S/C28H24N4O3/c1-35-22-10-8-21(9-11-22)31-28(34)30-16-18-4-2-5-19(14-18)23-6-3-7-24(27(23)33)26-15-20-17-29-13-12-25(20)32-26/h2-15,17,32-33H,16H2,1H3,(H2,30,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
88 -9.52n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14873
PNG
(1-(2,4-difluorophenyl)-3-{[3-(2-hydroxy-3-{1H-pyrr...)
Show SMILES Oc1c(cccc1-c1cccc(CNC(=O)Nc2ccc(F)cc2F)c1)-c1cc2cnccc2[nH]1
Show InChI InChI=1S/C27H20F2N4O2/c28-19-7-8-24(22(29)13-19)33-27(35)31-14-16-3-1-4-17(11-16)20-5-2-6-21(26(20)34)25-12-18-15-30-10-9-23(18)32-25/h1-13,15,32,34H,14H2,(H2,31,33,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
100 -9.45n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14878
PNG
(3-{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}...)
Show SMILES COc1cccc(NC(=O)NCc2cccc(c2)-c2cccc(-c3cc4cnccc4[nH]3)c2O)c1
Show InChI InChI=1S/C28H24N4O3/c1-35-22-8-3-7-21(15-22)31-28(34)30-16-18-5-2-6-19(13-18)23-9-4-10-24(27(23)33)26-14-20-17-29-12-11-25(20)32-26/h2-15,17,32-33H,16H2,1H3,(H2,30,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
100 -9.45n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14922
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2ccc(Cl)s2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C22H17ClN4O5S/c23-17-4-3-16(33-17)12-5-10(11(22(31)32)8-18(28)29)6-13(19(12)30)21-26-14-2-1-9(20(24)25)7-15(14)27-21/h1-7,11,30H,8H2,(H3,24,25)(H,26,27)(H,28,29)(H,31,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
110n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14923
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES CC(=O)Nc1cccc(c1)-c1cc(cc(-c2nc3ccc(cc3[nH]2)C(N)=N)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C26H23N5O6/c1-12(32)29-16-4-2-3-13(7-16)17-8-15(18(26(36)37)11-22(33)34)9-19(23(17)35)25-30-20-6-5-14(24(27)28)10-21(20)31-25/h2-10,18,35H,11H2,1H3,(H3,27,28)(H,29,32)(H,30,31)(H,33,34)(H,36,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
110n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14871
PNG
(1-(4-fluorophenyl)-3-{[3-(2-hydroxy-3-{1H-pyrrolo[...)
Show SMILES Oc1c(cccc1-c1cccc(CNC(=O)Nc2ccc(F)cc2)c1)-c1cc2cnccc2[nH]1
Show InChI InChI=1S/C27H21FN4O2/c28-20-7-9-21(10-8-20)31-27(34)30-15-17-3-1-4-18(13-17)22-5-2-6-23(26(22)33)25-14-19-16-29-12-11-24(19)32-25/h1-14,16,32-33H,15H2,(H2,30,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
110 -9.39n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14924
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-[...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1cccc(OC(F)F)c1)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C25H20F2N4O6/c26-25(27)37-14-3-1-2-11(6-14)15-7-13(16(24(35)36)10-20(32)33)8-17(21(15)34)23-30-18-5-4-12(22(28)29)9-19(18)31-23/h1-9,16,25,34H,10H2,(H3,28,29)(H,30,31)(H,32,33)(H,35,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
120n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14926
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-5-(...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(c1O)-c1ccc(F)c(Cl)c1)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C24H18ClFN4O5/c25-16-7-10(1-3-17(16)26)13-5-12(14(24(34)35)9-20(31)32)6-15(21(13)33)23-29-18-4-2-11(22(27)28)8-19(18)30-23/h1-8,14,33H,9H2,(H3,27,28)(H,29,30)(H,31,32)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
130n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14885
PNG
(1-{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}...)
Show SMILES Oc1c(cccc1-c1cccc(CNC(=O)Nc2ccsc2)c1)-c1cc2cnccc2[nH]1
Show InChI InChI=1S/C25H20N4O2S/c30-24-20(5-2-6-21(24)23-12-18-14-26-9-7-22(18)29-23)17-4-1-3-16(11-17)13-27-25(31)28-19-8-10-32-15-19/h1-12,14-15,29-30H,13H2,(H2,27,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
130n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14928
PNG
(2-[3-(5-carbamimidoyl-1H-1,3-benzodiazol-2-yl)-4-h...)
Show SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1cc(cc(-c2ccc(CO)s2)c1O)C(CC(O)=O)C(O)=O
Show InChI InChI=1S/C23H20N4O6S/c24-21(25)10-1-3-16-17(7-10)27-22(26-16)15-6-11(13(23(32)33)8-19(29)30)5-14(20(15)31)18-4-2-12(9-28)34-18/h1-7,13,28,31H,8-9H2,(H3,24,25)(H,26,27)(H,29,30)(H,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
130n/an/an/an/an/an/an/an/a



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 1596-600 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.040
BindingDB Entry DOI: 10.7270/Q2VX0DSZ
More data for this
Ligand-Target Pair
Coagulation factor VII


(Homo sapiens (human))
BDBM14870
PNG
(1-(3-fluorophenyl)-3-{[3-(2-hydroxy-3-{1H-pyrrolo[...)
Show SMILES Oc1c(cccc1-c1cccc(CNC(=O)Nc2cccc(F)c2)c1)-c1cc2cnccc2[nH]1
Show InChI InChI=1S/C27H21FN4O2/c28-20-6-2-7-21(14-20)31-27(34)30-15-17-4-1-5-18(12-17)22-8-3-9-23(26(22)33)25-13-19-16-29-11-10-24(19)32-25/h1-14,16,32-33H,15H2,(H2,30,31,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
130 -9.29n/an/an/an/an/a7.422



Celera



Assay Description
The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...


Bioorg Med Chem Lett 16: 3197-200 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.049
BindingDB Entry DOI: 10.7270/Q20P0X9Q
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 96 total )  |  Next  |  Last  >>
Jump to: